Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference of the Activated TβRI Kinase

Biochemistry

Volumn 43, Issue 19, 2004, Pages 5698-5706

  Ottesen, Jennifer J ^a   Huse, Morgan ^a   Sekedat, Matthew D ^a   Muir, Tom W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYME INHIBITION; ENZYMES; GENES; OLIGOMERS; SYNTHESIS (CHEMICAL);

CELLULAR PROCESSES; PHOSPHORYLATION; PHOSPHOVARIANTS; SIGNALING PATHWAYS;

BIOCHEMISTRY;

DIMER; HOMOTRIMER; MEMBRANE PROTEIN; PEPTIDE; PHOSPHATE; PHOSPHOAMINO ACID; PROTEIN; SERINE; SMAD ANCHOR FOR RECEPTOR ACTIVATION; SMAD PROTEIN; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR I KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; GENE EXPRESSION; GENE TARGETING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; ENZYME STABILITY; LIGANDS; OLIGOPEPTIDES; PHOSPHORYLATION; PHOSPHOSERINE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 2442457100     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0498407     Document Type: Article

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