Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils

American Journal of Respiratory Cell and Molecular Biology

Volumn 33, Issue 3, 2005, Pages 254-261

  Vieira De Abreu, Adriana ^b   Assis, Edson F ^b   Gomes, Gleice S ^b   Castro Faria Neto, Hugo C ^b   Weller, Peter F ^b   Bandeira Melo, Christianne ^b   Bozza, Patrícia Torres ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b NONE

Author keywords

Allergy; CCR3; Eosinophils; Lipid bodies; LTC4

Indexed keywords

ALLERGEN; ARACHIDONATE 5 LIPOXYGENASE; CHEMOKINE RECEPTOR CCR3; EOTAXIN; ICOSANOID; LEUKOTRIENE C4; NEUTRALIZING ANTIBODY; RANTES;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTHMA; CELL COMPARTMENTALIZATION; CELL INFILTRATION; CELL ORGANELLE; CONTROLLED STUDY; EOSINOPHIL; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FEMALE; IMMUNOLOCALIZATION; IN VIVO STUDY; INFLAMMATION; LIPID BODY; MALE; MOUSE; NONHUMAN; PLEURISY; PROVOCATION TEST; SIGNAL TRANSDUCTION;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CELL COMPARTMENTATION; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; EOSINOPHILS; FEMALE; LEUKOTRIENE C4; LIPID METABOLISM; LIPIDS; MALE; MICE; MICE, INBRED C57BL; PLEURISY; RANTES; RESPIRATORY HYPERSENSITIVITY; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 24344450604     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0145OC     Document Type: Article

References (47)

1. Wardlaw AJ. Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 1999;104:917-926.
2. Weller PF. Human eosinophils. J Allergy Clin Immunol 1997;100:283-287.
3. Costa JJ, Weller PF, Galli SJ. The cells of the allergic response: mast cells, basophils, and eosinophils. JAMA 1997;278:1815-1822.
4. Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, et al. A critical role for eosinophils in allergic airways remodeling. Science 2004;305:1776-1779.
5. Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004;305:1773-1776.
6. 4 production by eosinophils from asthmatic and from normal subjects. Am Rev Respir Dis 1988;138:799-804.
7. 4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 1998;101:834-846.
8. 4. Proc Natl Acad Sci USA 1983;80:7626-7630.
9. Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 1990;323:645-655.
10. Laitinen LA, Laitinen A, Haahtela T, Vilkka V, Spur BW, Lee TH. Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 1993;341:989-990.
11. 4. Proc Natl Acad Sci USA 1992;89:11598-11602.
12. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol 2004;173:1503-1510.
13. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM, Weller PF. Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. J Exp Med 1997;186:909-920.
14. 4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J Immunol 1999;162:1669-1676.
15. 4 production in eosinophils and basophils. J Biol Chem 2001;276:22779-22787.
16. Bozza PT, Bandeira-Melo C. Mechanisms of leukocyte lipid body formation and function in inflammation. Mem Inst Oswaldo Cruz 2005; 100:113-120.
17. Solley GO, Maldonado JE, Gleich GJ, Giuliani ER, Hoagland HC, Pierre RV, Brown AL Jr. Endomyocardiopathy with eosinophilia. Mayo Clin Proc 1976;51:697-708.
18. Bozza PT, Yu W, Cassara J, Weller PF. Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. J Leukoc Biol 1998;64:563-569.
19. Bartemes KR, McKinney S, Gleich GJ, Kita H. Endogenous platelet-activating factor is critically involved in effector functions of eosinophils stimulated with IL-5 or IgG. J Immunol 1999;162:2982-2989.
20. Lloyd CM, Gonzalo JA, Nguyen T, Delaney T, Tian J, Oettgen H, Coyle AJ, Gutierrez-Ramos JC. Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis. J Immunol 2001;166:2033-2040.
21. Penido C, Castro-Faria-Neto HC, Vieira-de-Abreu A, Figueiredo RT, Pelled A, Martins MA, Jose PJ, Williams TJ, Bozza PT. LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin. Am J Respir Cell Mol Biol 2001:25:707-716.
22. Rothenberg ME. Eotaxin: an essential mediator of eosinophil trafficking into mucosal tissues. Am J Respir Cell Mol Biol 1999;21:291-295.
23. Pease JE, Williams TJ. Eotaxin and asthma. Curr Opin Pharmacol 2001; 1:248-253.
24. Bandeira-Melo C, Weller PF. Eosinophils and cysteinyl leukotrienes. Prostaglandins Leukot Essent Fatty Acids 2003;69:135-143.
25. Heid HW, Moll R, Schwetlick I, Rackwitz HR, Keenan TW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 1998;294:309-321.
26. Chu SJ, Tang LO, Watney E, Chi EY, Henderson WR Jr. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. J Immunol 2000;165:4640-4648.
27. Koshino T, Takano S, Houjo T, Sano Y, Kudo K, Kihara H, Kitani S, Takaishi T, Hirai K, Ito K, et al. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Biochem Biophys Res Commun 1998;247:510-513.
28. Yu W, Bozza PT, Tzizik DM, Gray JP, Cassara J, Dvorak AM, Weller PF. Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies. Am J Pathol 1998;152:759-769.
29. Yu W, Cassara J, Weller PF. Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood 2000;95:1078-1085.
30. Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, Higashi Y, Kojima S, Takano T. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta 2004;1644:47-59.
31. Liu P, Ying Y, Zhao Y, Mundy DI, Zhu M, Anderson RG. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 2004;279:3787-3792.
32. Brasaemle DL, Dolios G, Shapiro L, Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically-stimulated 3T3-L1 adipocytes. J Biol Chem 2004;274:46835-46842.
33. Weinstein J. Synovial fluid leukocytosis associated with intracellular lipid inclusions. Arch Intern Med 1980;140:560-561.
34. Bozza PT, Payne JL, Morham SG, Langenbach R, Smithies O, Weller PF. Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase- independent inhibition by aspirin. Proc Natl Acad Sci USA 1996;93:11091-11096.
35. Triggiani M, Oriente A, Seeds MC, Bass DA, Marone G, Chilton FH. Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool. J Exp Med 1995;182:1181-1190.
36. Pacheco P, Bozza FA, Gomes RN, Bozza M, Weller PF, Castro-Faria-Neto HC, Bozza PT. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. J Immunol 2002;169:6498-6506.
37. Beil WJ, Weller PF, Peppercorn MA, Galli SJ, Dvorak AM. Ultrastructural immunogold localization of subcellular sites of TNF-alpha in colonic Crohn's disease. J Leukoc Biol 1995;58:284-298.
38. de Assis EF, Silva AR, Caiado LF, Marathe GK, Zimmerman GA, Prescott SM, McIntyre TM, Bozza PT, de Castro-Faria-Neto HC. Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. J Immunol 2003;171:2090-2098.
39. Silva AR, de Assis EF, Caiado LF, Marathe GK, Bozza MT, McIntyre TM, Zimmerman GA, Prescott SM, Bozza PT, Castro-Faria-Neto HC. Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. J Immunol 2002;168:4112-4120.
40. Bozza PT, Payne JL, Goulet JL, Weller PF. Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids. J Exp Med 1996;183:1515-1525.
41. Bandeira-Melo C, Herbst A, Weller PF. Eotaxins: contributing to the diversity of eosinophil recruitment and activation. Am J Respir Cell Mol Biol 2001;24:653-657.
42. Tauchi-Sato K, Ozeki S, Houjou T, Taguchi R, Fujimoto T. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 2002;277:44507-44512.
43. Weller PF, Dvorak AM. Arachidonic acid incorporation by cytoplasmic lipid bodies of human eosinophils. Blood 1985;65:1269-1274.
44. Lim KG, Wan HC, Bozza PT, Resnick MB, Wong DT, Cruikshank WW, Kornfeld H, Center DM, Weller PF. Human eosinophils elaborate the lymphocyte chemoattractants. IL-16 (lymphocyte chemoattractant factor) and RANTES. J Immunol 1996;156:2566-2570.
45. Woods JW, Evans JF, Ethier D, Scott S, Vickers PJ, Hearn L, Heibein JA, Charleson S, Singer II. 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 1993;178:1935-1946.
46. Tedla N, Bandeira-Melo C, Tassinari P, Sloane DE, Samplaski M, Cosman D, Borges L, Weller PF, Arm JP. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc Natl Acad Sci USA 2003;100:1174-1179.
47. Bandeira-Melo C, Woods LJ, Phoofolo M, Weller PF. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. J Exp Med 2002;196:841-850.