Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering

Journal of Biological Chemistry

Volumn 276, Issue 39, 2001, Pages 36695-36702

  Faradji, Raquel N ^a   Havari, Evis ^a   Chen, Qian ^a   Gray, John ^c   Tornheim, Keith ^b   Corkey, Barbara E ^b   Mulligan, Richard C ^c   Lipes, Myra A ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; METABOLISM; PHYSIOLOGY; TOXICITY;

METABOLIC ENGINEERING;

CELLS;

ADENOSINE TRIPHOSPHATE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; HEXOSE PHOSPHATE; INSULIN; LACTIC ACID; GLUCOSE TRANSPORTER; ISOPROTEIN;

ADENOVIRUS; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUSION; CYTOTOXICITY; DIABETES MELLITUS; GLUCOSE METABOLISM; GLYCOLYSIS; HYPOPHYSIS CELL; HYPOPHYSIS INTERMEDIATE LOBE; INSULIN SYNTHESIS; METABOLIC ENGINEERING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS RECOMBINANT; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; GENETICS; HYPOPHYSIS; METABOLISM; NICK END LABELING; NONOBESE DIABETIC MOUSE; NORTHERN BLOTTING; PHOSPHORYLATION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALIA;

ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DEATH; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; IN SITU NICK-END LABELING; INSULIN; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MONOSACCHARIDE TRANSPORT PROTEINS; PHOSPHORYLATION; PITUITARY GLAND; PROTEIN ISOFORMS; TISSUE DISTRIBUTION;

EID: 0035965193     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102542200     Document Type: Article

References (39)

1. Lipes, M. A., Cooper, E. M., Skelly, R., Rhodes, C. J., Boschetti, E., Weir, G. C., and Davalli, A. M. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8595-8600
2. Chen, R., Meseck, M., McEvoy, R. C., and Woo, S. L. (2000) Gene Ther. 7, 1802-1809
3. Cheung, A. T., Dayanandan B., Lewis J. T., Korbutt G. S., Rajotte R. V., Bryer-Ash M., Boylan M. O., Wolfe M. M., and Keiffer T. J. (2000) Science 290, 1959-1962
4. Meglasson, M. D., and Matschinsky, F. M. (1986) Diabetes Metab. Rev. 2, 163-214
5. Newgard, C. B., and McGarry, J. D. (1995) Annu. Rev. Biochem. 64, 689-719
6. Trus, M. D., Zawalich, W. S., Burch, P. T., Berner, D. K., Weill, V. A., and Matschinsky, F. M. (1981) Diabetes 30, 911-922
7. Thorens, B., Deriaz, N., Bosco, D., DeVos, A., Pipeleers, D., Schuit, F., Meda, P., and Porret, A. (1996) J. Biol. Chem. 271, 8075-8081
8. Sweet, I. R., and Matschinsky, F. M. (1997) Diabetologia 40, 112-119
9. Hughes, S. D., Johnson, J. H., Quaade, C., and Newgard, C. B. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 688-692
10. Motoyoshi, S., Shirotani, T., Araki, E., Sakai, K., Kaneko, K., Motoshima, H., Yoshizato, K., Shirakami, A., Kishikawa, H., and Shichiri, M. (1998) Diabetologia 41, 1492-1501
11. Schuit, F. C., Huypens, P., Heimberg, H., and Pipeleers, D. G. (2001) Diabetes 50, 1-11
12. Clark, S. A., Quade, C., Constandy, H., Hansen, P., Halban, P., Ferber, S., Newgard, C. B., and Normington, K. (1997) Diabetes 46, 958-967
13. Feng, S., Quickel, R. R., Hollister-Lock, J., McLeod, M., Bonner-Weir, S., Mulligan, R. C., and Weir, G. C. (1999) Transplantation 67, 1607-1613
14. Thorens, B., Sarkar, H. K., Kaback, H. R., and Lodish, H. F. (1988) Cell 55, 281-290
15. Liang, Y., Jetton, T. L., Zimmerman, E. C., Najafi, H., Matschinsky, F. M., and Magnuson, M. A. (1991) J. Biol. Chem. 266, 6999-7007
16. Thomas, P., Surprenant, A., and Almers, W. (1990) Neuron 5, 723-733
17. Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., and Yamamura, K. (1990) Endocrinology 127, 126-132
18. Liang, Y., Bai, G., Doliba, N., Buettger, C., Wang, L., Berner, D. K., and Matschinsky, F. M. (1996) Am. J. Physiol. 270, E846-E857
19. Ashcroft, S. J., Weerasinghe, L. C., Bassett, J. M., and Randle, P. J. (1972) Biochem. J. 126, 525-532
20. Lowry, O. H., and Passonneau, J. V. (1972) A Flexible Systern of Enzymatic Analysis, pp. 68-92, Academic Press, Inc., New York
21. Hughes, S. D., Quaade, C., Milburn, J. L., Cassidy, L., and Newgard, C. B. (1991) J. Biol. Chem. 266, 4521-4530
22. Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., and Bryan, J. (1995) Science 270, 1166-1170
23. Prentki, M., and Matschinsky, F. M. (1987) Physiol. Rev. 67, 1185-1248
24. Garnier, M., Lamacz, M., Galas, L., Lenglet, S., Tonon, M. C., and Vaudry, H. (1998) Endocrinology 139, 3525-3533
25. Gembal, M., Gilon, P., and Henquin, J. C. (1992) J. Clin. Invest. 89, 1288-1295
26. Morita, H., Yano, Y., Niswender, K. D., May, J. M., Whitesell, R. R., Wu, L., Printz, R. L., Granner, D. K., Magnuson, M. A., and Powers, A. C. (1994) J. Clin. Invest. 94, 1373-1382
27. Teusink, B., Walsh, M. C., van Dam, K., and Westerhoff, H. V. (1998) Trends Biochem. Sci. 23, 162-169
28. Tornheim, K. (1979) J. Theor. Biol. 79, 491-541
29. Meglasson, M. D., and Matschinsky, F. M. (1984) Am. J. Physiol. 246, E1-E13
30. Iynedjian, P. B. (1998) Trends Biochem. Sci. 23, 467-468
31. Hughes, S. D., Quaade, C., Johnson, J. H., Ferber, S., and Newgard, C. B. (1993) J. Biol. Chem. 268, 15205-15212
32. Malaisse, W. J., and Bodur, H. (1991) Int. J. Biochem. 23, 955-959
33. Bakker, B. M., Mensonides, F. I., Teusink, B., van Hoek, P., Michels, P. A., and Westerhoff, H. V. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2087-2092
34. Gitzelman, R., Steinman, B., and Van den Bergue, G. (1995) in The Metabolic and Molecular Basis of Inherited Disease (Scriver, C. R., Baudet, A. L., Sly, W. S., and Valle, D., eds) pp. 904-934, McGraw Hill, Inc., New York
35. Wang, H., and Iynedjian, P. B. (1997) J. Biol. Chem. 272, 25731-25736
36. Wang, H., and Iynedjian, P. B. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4372-4377
37. Raff, M. (1998) Nature 396, 119-122
38. Efanova, I., Zaitsev, S., Zhivotovsky, B., Kohler, M., Efendic, S., Orrenius, S., and Berggren, P. O. (1998) J. Biol. Chem. 273, 33501-33507
39. Federici, M., Hribal, M., Perego, L., Ranalli, M., Caradonna, Z., Perego, C., Usellini, L., Nano, R., Bonini, P., Bertuzzi, F., Marlier, L. N. J. L., Davalli, A. M., Carandente, O., Pontiroli, A. E., Melino, G., Marchetti, P., Lauro, R., Sesti, G., and Folli, F. (2001) Diabetes 50, 1290-1301