Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 60, Issue 8, 2005, Pages 970-975

  Ochoa, Julio J ^a,b   Quiles, José L ^a   Huertas, Jesús R ^a   Mataix, José ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Inst of Nutr and Food Technology   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CATALASE; CYTOCHROME A; CYTOCHROME B; CYTOCHROME C; CYTOCHROME C OXIDASE; CYTOCHROME C1; GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; POLYUNSATURATED FATTY ACID; UBIDECARENONE; UBIQUINONE; DRUG DERIVATIVE; EDIBLE OIL; LIPID PEROXIDE; UBIQUINONE 9; UNSATURATED FATTY ACID;

AGING; ANIMAL EXPERIMENT; ARTICLE; DIET SUPPLEMENTATION; ENZYME ACTIVITY; FAT INTAKE; FATTY ACID ANALYSIS; HEART MITOCHONDRION; LIFESPAN; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECT; METABOLISM; WISTAR RAT;

ANIMALIA;

AGING; ALPHA-TOCOPHEROL; ANIMALS; CATALASE; DIETARY FATS, UNSATURATED; ELECTRON TRANSPORT COMPLEX IV; FATTY ACIDS, UNSATURATED; GLUTATHIONE PEROXIDASE; LIPID PEROXIDES; MALE; MITOCHONDRIA, HEART; OXIDATIVE STRESS; RATS; RATS, WISTAR; UBIQUINONE;

EID: 24144489726     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/60.8.970     Document Type: Article

References (34)

1. Harman D. Extending functional life span. Exp Gerontol. 1998;33:95-112.
2. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78:547-581.
3. Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL. Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure. J Mol Cell Cardiol. 2001;33:1065-1089.
4. Salvioli S, Bonafe M, Capri M, Monti D, Franceschi C. Mitochondria, aging and longevity-a new perspective. FEBS Lett. 2001;492:9-13.
5. 10, and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med. 2004;27:273-277.
6. Lakatta EG, Sollott AJ. The "heartbreak" of older age. Mol Interv. 2002;2:431-446.
7. Lakatta EG, Levy A. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part II: Aging heart in health: links to heart disease. Circulation. 2003;107:346-354.
8. Oxeham H, Sharpe N. Cardiovascular aging and heart failure. Eur J Heart Fail. 2003;5:427-434.
9. Hornstra G, Barth CA, Galli C, et al. Functional food science and the cardiovascular system. Br J Nutr. 1998;80:S113-S146.
10. Hu FB, Manson JE, Willet WC. Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr. 2001;20:5-19.
11. Sevanian A, Hochstein P. Mechanisms and consequences of lipid peroxidation in biological systems. Ann Rev Nutr. 1985;5:365-390.
12. Ochoa JJ, Quiles JL, Ibáñez S, et al. Aging-related oxidative stress depends on dietary lipid source in rat postmitotic tissues. J Bioenerg Biomembr. 2003;35:267-275.
13. Quiles JL, Ochoa JJ, Ramirez-Tortosa C, et al. Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double-strand-breaks, antioxidant capacity and blood lipids in rats. Exp Gerontol. 2004;39:1189-1198.
14. Dallner G, Sindelar PJ. Regulation of ubiquinone metabolism. Free Radic Biol Med. 2000;29:285-294.
15. Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta. 2004;1660:171-199.
16. 10. Ann N Y Acad Sci. 2002;959:396-411.
17. Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol. 2004;39:189-194.
18. Reeves PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 1997;127:838S-841S.
19. Fleischer S, McIntire IO, Vidal JC. Large scale preparation of rat liver mitochondria in high yield. Methods Enzymol. 1979;55:32-39.
20. Lepage G, Roy CC. Direct transesterification of all classes of lipids in one-step reaction. J Lipid Res. 1986;27:114-120.
21. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992;202:384-389.
22. Kröger A. Determination of contents and redox state of ubiquinone and menaquinone. Methods Enzymol. 1978;53:579-591.
23. Aebi H. Catalase in vitro. Methods Enzymol. 1984;150:121-127.
24. Flohé L, Wolfgang AG. Assays of glulathione peroxidase. Methods Enzymol. 1984;105:114-121.
25. Quiles JL, Martínez E, Ibáñez S, et al. Aging-related tissue-specific alterations in mitochondrial composition and function are modulated by dietary fatty in the rat. J Bioenerg Biomembr. 2002;34:517-524.
26. Kwong LK, Kamzalov S, Rebrin I, et al. Effects of coenzyme Q10 administration on its tissue concentrations mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33:627-638.
27. Lee J, Yu BP, Herlihy JT. Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake. Free Radic Biol Med. 1999;26:260-265.
28. Miró O, Casademont J, Casals E, et al. Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzymes defects. Cardiovasc Res. 2000;47:624-631.
29. Cand F, Verdetti J. Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats. Free Radic Biol Med. 1989;7:59-63.
30. Van der Loo B, Labugger R, Aebischer CP, et al. Cardiovascular aging is associated with vitamin E increase. Circulation. 2002;105:1635-1638.
31. 10. Free Radic Biol Med. 1999;26:1375-1382.
32. Molina H, García M. Enzymatic defenses of the heart rat against lipid peroxidation. Mech Ageing Dev. 1997;97:1-7.
33. Tian L, Cai Q, Wei H. Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic Biol Med. 1998;24:1477-1484.
34. Lenaz G, Battino M, Castelluccione C, et al. Studies on the role of ubiquinone in the control of the mitochondrial respiratory chain. Free Radic Res. 1990;8:317-327.