In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo

Acta Tropica

Volumn 95, Issue 3, 2005, Pages 219-225

  Mayengue, Pembe Issamou ^a,b   Ndounga, Mathieu ^c   Davy, Matondo Maya ^a,b   Tandou, Ntsonde ^c   Ntoumi, Francine ^a,b  

^a ALBERT SCHWEITZER HOSPITAL   (Gabon)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c c/o Lab de Botanique   (Congo)

Author keywords

Chloroquine; Congo; Malaria; P. falciparum; Pfcrt

Indexed keywords

CARRIER PROTEIN; CHLOROQUINE; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER PROTEIN; UNCLASSIFIED DRUG;

DDT; DRUG RESISTANCE; ECOLOGICAL ZONATION; MUTATION; PYRETHROID;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CODON; CONGO; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ENDEMIC DISEASE; GENETIC VARIABILITY; HUMAN; IN VIVO STUDY; INFANT; MALARIA; PLASMODIUM FALCIPARUM; PREVALENCE; TREATMENT FAILURE; VOMITING;

ANIMALS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; CONGO; DNA, PROTOZOAN; GENOTYPE; HUMANS; INFANT; MALARIA, FALCIPARUM; MEMBRANE PROTEINS; PLASMODIUM FALCIPARUM; PREVALENCE; PROTOZOAN PROTEINS;

AFRICA; CENTRAL AFRICA; CONGO; EASTERN HEMISPHERE; SUB-SAHARAN AFRICA; WORLD;

PLASMODIUM FALCIPARUM;

EID: 23944521755     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2005.06.001     Document Type: Article

References (37)

1. A. Aubouy, F. Migot-Nabias, and P. Deloron Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon Malar. J. 2 2003 12
2. H.A. Babiker, S.J. Pringle, A. Abdel-Muhsin, M. Mackinnon, P. Hunt, and D. Walliker High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1 J. Infect. Dis. 183 2001 1535 1538
3. L.K. Basco, and P. Ringwald Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde Cameroon J. Infect. Dis. 183 2001 1828 1831
4. L.K. Basco, and P. Ringwald Molecular epidemiology of malaria in Yaounde, Cameroon. VIII. Multiple Plasmodium falciparum infections in symptomatic patients Am. J. Trop. Med. Hyg. 65 2001 798 803
5. L.K. Basco, M. Ndounga, V.F. Ngane, and G. Soula Molecular epidemiology of malaria in Cameroon. XIV. Plasmodium falciparum chloroquine resistance transporter (PFCRT) gene sequences of isolates before and after chloroquine treatment Am. J. Trop. Med. Hyg. 67 2002 392 395
6. R.K. Binder, S. Borrmann, A.A. Adegnika, M.A. Missinou, P.G. Kremsner, and J.F. Kun Polymorphisms in the parasite genes for pfcrt and pfmdr-1 as molecular markers for chloroquine resistance in Plasmodium falciparum in Lambarene Gabon. Parasitol. Res. 88 2002 475 476
7. S. Borrmann, R.K. Binder, A.A. Adegnika, M.A. Missinou, S. Issifou, M. Ramharter, W.H. Wernsdorfer, and P.G. Kremsner Reassessment of the resistance of Plasmodium falciparum to chloroquine in Gabon: implications for the validity of tests in vitro versus in vivo Trans. R. Soc. Trop. Med. Hyg. 96 2002 660 663
8. B. Carme, D. Kenmogne, N. Copin, and A. Mbitsi Indices plasmodiques et charges parasitaires chez les donneurs de sang à Brazzaville Congo. Ann. Soc. belge Méd. trop. 73 1993 179 187
9. A. Djimde, O.K. Doumbo, J.F. Cortese, K. Kayentao, S. Doumbo, Y. Diourte, A. Dicko, X.Z. Su, T. Nomura, D.A. Fidock, T.E. Wellems, C.V. Plowe, and D. Coulibaly A molecular marker for chloroquine-resistant falciparum malaria N. Engl. J. Med. 344 2001 257 263
10. A. Djimde, O.K. Doumbo, R.W. Steketee, and C.V. Plowe Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria Lancet 358 2001 890 891
11. A.A. Djimde, A. Dolo, A. Ouattara, S. Diakite, C.V. Plowe, and O.K. Doumbo Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones J. Infect. Dis. 190 2004 853 855
12. G. Dorsey, M.R. Kamya, A. Singh, and P.J. Rosenthal Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala Uganda J. Infect. Dis. 183 2001 1417 1420
13. P. Durand, Y. Michalakis, S. Cestier, B. Oury, M.C. Leclerc, M. Tibayrenc, and F. Renaud Significant linkage disequilibrium and high genetic diversity in a population of Plasmodium falciparum from an area (Republic of the Congo) highly endemic for malaria Am. J. Trop. Med. Hyg. 68 2003 345 349
14. D.A. Fidock, T. Nomura, A.K. Talley, R.A. Cooper, S.M. Dzekunov, M.T. Ferdig, L.M. Ursos, A.B. Sidhu, B. Naude, K.W. Deitsch, X.Z. Su, J.C. Wootton, P.D. Roepe, and T.E. Wellems Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance Mol. Cell. 6 2000 861 871
15. T. Jelinek, A.H. Kilian, A. Westermeier, S. Proll, G. Kabagambe, H.D. Nothdurft, F. von Sonnenburg, and T. Loscher Population structure of recrudescent Plasmodium falciparum isolates from western Uganda Trop. Med. Int. Health 4 1999 476 480
16. T. Jelinek, A.O. Aida, G. Peyerl-Hoffmann, S. Jordan, A. Mayor, C. Heuschkel, A.O. el Valy, F. von Sonnenburg, and E.M. Christophel Diagnostic value of molecular markers in chloroquine-resistant falciparum malaria in Southern Mauritania Am. J. Trop. Med. Hyg. 67 2002 449 453
17. P.G. Kremsner, S. Winkler, C. Brandts, W. Graninger, and U. Bienzle Curing of chloroquine-resistant malaria with clindamycin Am. J. Trop. Med. Hyg. 49 1993 650 654
18. P.G. Kremsner, S. Winkler, C. Brandts, S. Neifer, U. Bienzle, and W. Graninger Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon J. Infect. Dis. 169 1994 467 470
19. J.G. Kublin, J.F. Cortese, E.M. Njunju, R.A. Mukadam, J.J. Wirima, P.N. Kazembe, A.A. Djimde, B. Kouriba, T.E. Taylor, and C.V. Plowe Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi J. Infect. Dis. 187 2003 1870 1875
20. J.F. Kun, R.J. Schmidt-Ott, L.G. Lehman, B. Lell, D. Luckner, B. Greve, P. Matousek, and P.G. Kremsner Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarene Gabon. Trans. R. Soc. Trop. Med. Hyg. 92 1998 110 114
21. A.G. Mayor, X. Gomez-Olive, J.J. Aponte, S. Casimiro, S. Mabunda, M. Dgedge, A. Barreto, and P.L. Alonso Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique J. Infect. Dis. 183 2001 1413 1416
22. B. Nsimba, D.A. Malonga, A.M. Mouata, F. Louya, J. Kiori, M. Malanda, D. Yocka, J. Oko-Ossho, S. Ebata-Mongo, and J. Le Bras Efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Republic of Congo Am. J. Trop. Med. Hyg. 70 2004 133 138
23. F. Ntoumi, H. Contamin, C. Rogier, S. Bonnefoy, J.F. Trape, and O. Mercereau-Puijalon Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections Am. J. Trop. Med. Hyg. 52 1995 81 88
24. F. Ntoumi, O. Mercereau-Puijalon, A. Luty, A. Georges, and P. Millet High prevalence of the third form of merozoite surface protein-1 in Plasmodium falciparum in asymptomatic children in Gabon Trans. R. Soc. Trop. Med. Hyg. 90 1996 701 702
25. F. Ntoumi, J. Ngoundou-Landji, F. Lekoulou, A. Luty, P. Deloron, and P. Ringwald Site-based study on polymorphism of Plasmodium falciparum MSP-1 and MSP-2 genes in isolates from two villages in Central Africa Parassitologia 42 2000 197 203
26. P.E. Olumese, O.K. Amodu, A. Bjorkman, A.A. Adeyemo, R.A. Gbadegesin, and O. Walker Chloroquine resistance of Plasmodium falciparum is associated with severity of disease in Nigerian children Trans. R. Soc. Trop. Med. Hyg. 96 2002 418 420
27. L.C. Ranford-Cartwright, J. Taylor, T. Umasunthar, L.H. Taylor, H.A. Babiker, B. Lell, J.R. Schmidt-Ott, L.G. Lehman, D. Walliker, and P.G. Kremsner Molecular analysis of recrudescent parasites in a Plasmodium falciparum drug efficacy trial in Gabon Trans. R. Soc. Trop. Med. Hyg. 91 1997 719 724
28. R. Shretta, J. Omumbo, B. Rapuoda, and R.W. Snow Using evidence to change antimalarial drug policy in Kenya Trop. Med. Int. Health 5 2000 755 764
29. A.B. Sidhu, D. Verdier-Pinard, and D.A. Fidock Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations Science 298 2002 210 213
30. S.M. Thomas, O. Ndir, T. Dieng, S. Mboup, D. Wypij, J.H. Maguire, and D.F. Wirth In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal Am. J. Trop. Med. Hyg. 66 2002 474 480
31. J.F. Trape, P. Peelman, and B. Morault-Peelman Criteria for diagnosing clinical malaria among a semi-immune population exposed to intense and perennial transmission Trans. R. Soc. Trop. Med. Hyg. 79 1985 435 442
32. J.F. Trape, and A. Zoulani Malaria and urbanization in central Africa: the example of Brazzaville. Part II: Results of entomological surveys and epidemiological analysis Trans. R. Soc. Trop. Med. Hyg. 81 Suppl 2 1987 10 18
33. J.F. Trape The public health impact of chloroquine resistance in Africa Am. J. Trop. Med. Hyg. 64 2001 12 17
34. D.C. Warhurst A molecular marker for chloroquine-resistant falciparum malaria N Engl. J. Med. 344 2001 299 302
35. W.H. Wernsdorfer Epidemiology of drug resistance in malaria Acta Trop. 56 1994 143 156
36. S. Winkler, C. Brandts, W.H. Wernsdorfer, W. Graninger, U. Bienzle, and P.G. Kremsner Drug sensitivity of Plasmodium falciparum in Gabon. Activity correlations between various antimalarials Trop. Med. Parasitol. 45 1994 214 218
37. World Health Organisation, 2002. Monitoring Antimalarial Drug resistance. WHO Document WHO/CDS/EPH/2002.17, Geneva.