4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 19, 2005, Pages 4221-4225

  Ishida, Junya ^a   Hattori, Kouji ^a   Yamamoto, Hirofumi ^a   Iwashita, Akinori ^b   Mihara, Kayoko ^b   Matsuoka, Nobuya ^b  

^a Med Chemistry Research Laboratories   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

4 phenyl 1,2,3,6 tetrahydropyridine; PARP 1; Poly(ADP ribose) polymerase

Indexed keywords

BENZAMIDE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANTIPYRINE; BENZAMIDES; HUMANS; INHIBITORY CONCENTRATION 50; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23944520391     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.094     Document Type: Article

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