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Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 1, 2001, Pages 33-37

Phthalazine PDE4 inhibitors. Part 2: The synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives

(7) Napoletano, Mauro a Norcini, Gabriele c Pellacini, Franco a Marchini, Francesco b Morazzoni, Gabriele a Ferlenga, Pierpaolo b Pradella, Lorenzo b

a Zambon Group (Switzerland)

b Zambon Group SpA (Italy)

c Lamberti SpA (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CILOMILAST; PHOSPHODIESTERASE IV INHIBITOR; PHTHALAZINE DERIVATIVE; PICLAMILAST; ROLIPRAM;

ACID SECRETION; ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; BENZAMIDES; BIOLOGICAL AVAILABILITY; ENZYME INHIBITORS; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MONOCYTES; NEUTROPHILS; PHTHALAZINES; PROTEIN BINDING; PYRIDINES; ROLIPRAM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035825344 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(00)00587-4 Document Type: Article

Times cited : (59)

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