Investigation of the catalytic triad of arylamine N-acetyltransferases: Essential residues required for acetyl transfer to arylamines

Biochemical Journal

Volumn 390, Issue 1, 2005, Pages 115-123

  Sandy, James ^a   Mushtaq, Adeel ^a,b   Holton, Simon J ^a,c   Schartau, Pamela ^a,d   Noble, Martin E M ^a   Sim, Edith ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF WASHINGTON   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Arylamine N acetyltransferase (NAT); Bioinformatics; Crystallography; Site directed mutagenesis

Indexed keywords

ACETYLENE; BACTERIA; CATALYSIS; CRYSTALLOGRAPHY; HYDRAZINE;

ARYLAMINE N-ACETYLTRANSFERASES; BIOINFORMATICS; SITE-DIRECTED MUTAGENESIS;

AMINES;

ACETYL COENZYME A; ACYLTRANSFERASE; AROMATIC AMINE; ARYLAMINE ACETYLTRANSFERASE; ASPARTIC ACID; CYSTEINE; HISTIDINE;

ACETYLATION; ARTICLE; BIOINFORMATICS; CATALYSIS; ENZYME BINDING; EUKARYOTE; GENE MUTATION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ARYLAMINE N-ACETYLTRANSFERASE; CONSERVED SEQUENCE; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM SMEGMATIS; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM;

CELLULAR ORGANISMS; EUKARYOTA; MYCOBACTERIUM SMEGMATIS; PROKARYOTA;

EID: 23944518412     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050277     Document Type: Article

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