Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: Functional characterization of the activation and deactivation of aromatic amine carcinogens

Toxicology and Applied Pharmacology

Volumn 142, Issue 2, 1997, Pages 360-366

  Fretland, Adrian J ^a   Doll, Mark A ^a   Gray, Kevin ^a   Feng, Yi ^a   Hein, David W ^a  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; AROMATIC AMINE; ASPARAGINE; CARCINOGEN; FLUORENYLACETOHYDROXAMIC ACID; ISOLEUCINE; N HYDROXY 2 FLUORENYLAMINE; RECOMBINANT ENZYME;

ACETYLATION; ACETYLATOR PHENOTYPE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SPECIFICITY; GENE EXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; INBRED STRAIN; METABOLIC ACTIVATION; MICHAELIS MENTEN KINETICS; MOLECULAR CLONING; MOUSE; NONHUMAN; RECOMBINANT GENE;

ANIMALIA; ESCHERICHIA COLI; PROKARYOTA;

EID: 0031062306     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8036     Document Type: Article

References (41)

1. Bell, D. A., Badawi, A. F., Lang, N. P., Ilett, K. F., Kadlubar, F. F., and Hirvonen, A. (1995a). Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: Association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res. 55, 5226-5229.
2. Bell, D. A., Stephens, E. A., Castranio, T., Umbach, D. M., Watson, M., Deakin, M., Elder, J., Hendrickse, C., Duncan, H., and Strange, R. C. (1995b). Polyadenylation polymorphism in the acetylation gene (NAT1) increases risk of colorectal cancer. Cancer Res. 55, 3537-3542.
3. Cartwright, R. A., Glashan, R. W., Rogers, H. J., Ahmad, R. A., Barham-Hall, D., Higgins, E., and Kahn, M. A. (1982). Role of N-acetyltransferase phenotypes in bladder carcinogenesis: A pharmacogenetic approach to bladder cancer. Lancet 2, 842-846.
4. De Leon, J. H., Martell, K. J., Vatsis, K. P., and Weber, W. W. (1995). Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9). Drug Metab. Dispos. 23, 1354-1361.
5. Doll, M. A., and Hein, D. W. (1995). Cloning, sequencing, and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred rats. Pharmacogenetics 5, 247-251.
6. Ferguson, R. J., Doll, M. A., Rustan, T. D., Baumstark, B. R., and Hein, D. W. (1994). Syrian hamster monomorphic N-acetyltransferase (NAT1) alleles: Amplification, cloning, sequencing, and expression in E. coli. Pharmacogenetics 4, 82-90.
7. Ferguson, R. J., Doll, M. A., Rustan, T. D., and Hein, D. W. (1996). Cloning, expression and functional characterization of rapid and slow acetylator polymorphic N-acetyltransferase encoding genes of the Syrian hamster. Pharmacogenetics 6, 55-66.
8. Flammang, T. J., Couch, L. H., Levy, G. N., Weber, W. W., and Wise, C. K. (1992). DNA adduct levels in congenic rapid and slow acetylator mouse strains following chronic administration of 4-aminobiphenyl. Carcinogenesis 13, 1887-1891.
9. Fretland, A. J., Doll, M. A., Gray, K., Feng, Y., and Hein, D. W. (1996). Cloning, sequencing, and expression of NAT1 and NAT2 derived from C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse strains. FASEB J. 10, 456.
10. Glowinski, I. B., and Weber, W. W. (1982). Genetic regulation of aromatic amine N-acetylation in inbred mice. J. Biol. Chem. 257, 1424-1430.
11. Hein, D. W. (1988). Acetylator genotype and arylamine induced carcinogenesis. Biochim. Biophys. Acta 948, 37-66.
12. Hein, D. W., Doll, M. A., Rustan, T. D., and Ferguson, R. J. (1995). Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effect of 7 specific NAT2 nucleic acid substitutions. Cancer Res. 55, 3531-3536.
13. Hein, D. W. , Doll, M. A., Fretland, A. J., Gray, K., Deitz, A. C., Feng, Y., Jiang, W., Rustan, T. D., Satran, S., and Wilkie, T. R. (in press). Rodent models of the human acetylation polymorphism: Comparisons of recombinant acetyltransferases. Mutat. Res.
14. Hein, D.W., Ferguson, R. J., Doll, M. A., Rustan, T. D., and Gray, K. (1994). Molecular genetics of human polymorphic N-acetyltransferase: Enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes. Hum. Mol. Genet. 3, 720-734.
15. Hein, D. W., Flammang, T. J., Kirlin, W. G., Trinidad, A., and Ogolla, F. (1987). Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: Relationship to arylamine N-acetyltransferase. Carcinogenesis 8, 1767-1774.
16. Hein, D. W., Trinidad, A., Yerokun, T., Ferguson, R. J., Kirlin, W. G., and Weber, W. W. (1988). Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxyarylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse. Drug Metab. Dispos. 16, 341-347.
17. Hughes, N. C., McQueen, K. L., Janezic, S. A., Jewett, M. A. S., and Grant, D. M. (1996). Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in vivo/in vitro probe. Pharmacogenetics 6, in press.
18. Ilett, K. F., David. B. M., Dethon, P., Castleden, W. M., and Kwa, R. (1987). Acetylation phenotype in colorectal carcinoma. Cancer Res. 47, 1466-1469.
19. Kadlubar, F. F. (1994). Biochemical individuality and its implications for drug and carcinogen metabolism: Recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans. Drug Metab. Rev. 26, 37-47.
20. Kelly, S. L., and Sim, E. (1994). Arylamine N-acetyltransferase in Balb/c mice: Identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem. J. 302, 347-353.
21. Ladero, J. M., Gonzales, J. F., Benetiz, J., Vargas, E., Fernandez, M. J., Baki, W., and Diaz-Rubio, M. (1991). Acetylator polymorphism in human colorectal carcinoma. Cancer Res. 51, 2098-2100.
22. Lang, N. P., Butler, M. A., Massengell, J., Lawson, M., Stotts, R. C., Hauer-Jensen, M., and Kadlubar, F. F. (1994). Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-bourne heterocyclic amines increases risk for colorectal cancer or polyps. Cancer Epid. Biomarkers Prev. 3, 675-682.
23. Lang, N. P., Chu, D. Z., Hunter, C. F., Kendall, D. C., Flammang, T. J., and Kadlubar, F. F. (1986). Role of aromatic amine acetyltransferase in human colorectal cancer. Arch. Surg. 121, 1259-1261.
24. Levy, G. N., and Weber, W. W. (1989). 2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines. Carcinogenesis 10, 705-709.
25. Levy, G. N., and Weber, W. W. (1992). 2-Aminofluorene-DNA adducts in mouse urinary bladder: Effect of age, sex, and acetylator phenotype. Carcinogenesis 13, 159-164.
26. Lower, G. M., (1982). Concepts in causality: Chemically induced human urinary bladder cancer. Cancer 49, 1056-1066.
27. Martell, K. J., Levy, G. N., and Weber, W. W. (1992). Cloned mouse N-acetyltransferases: Enzymatic properties of expressed Nat-1 and Nat-2 gene products. Mol. Pharmacol. 42, 265-272.
28. Martell, K. J., Vatsis, K. P., and Weber, W. W. (1991). Molecular genetic basis of rapid and slow acetylation in mice. Mol. Pharmacol. 40, 218-227.
29. Mattano, S. S., Land, S., King, C. M., and Weber, W. W. (1989). Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: Identity with arylhydroxamic acid N,O-acetyltransferase and N-hydroxyarylamine O-acetyltransferase. Mol. Pharmacol. 35, 599-609.
30. Miller, E. C., and Miller, J. A. (1981). Searches for the ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer 47, 2327-2345.
31. Probst-Hensch, N. M., Haile, R. W., Ingles, S. A., Longnecker, M. P., Han, C. Y., Lin, B. K., Lee, D. B., Sakamato, G. T., Franksl, H. D., Lee, E. R., and Lin, H. J. (1995). Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res. 55, 2017-2020.
32. Risch, A., Wallace, D. M. A., Bathers, S., and Sim, E. (1995). Slow acetylator genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum. Mol. Genet. 4, 231-236.
33. Roberts-Thomson, I. C., Ryan, P., Khoo, K. K., Hart, W. J., McMichael, A. J., and Butler, R. H., (1996). Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet 347, 1372-1374.
34. Rodriguez, J. W., Kirlin, W. G., Ferguson, R. J., Doll, M. A., Gray, K., Rustan, T. D., Lee, M. E., Kemp, K., Urso, P., and Hein, D. W. (1993). Human acetylator genotype: Relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol. Arch. Toxicol. 67, 445-452.
35. Taylor, J. A., Umbach, D. M., Stephens, E., Paulson, D., Robertson, C., Mohler, J. C., and Bell, D. A. (1995). The role of N-acetylation at NAT1 and NAT2 in smoking associated bladder cancer. Proc. Am. Assoc. Cancer Res. 36, 282.
36. Trinidad, A, Kirlin, W. G., Ogolla, F., Andrews, A. F., Yerokun, T., Ferguson, R. J., Brady, P. K., and Hein, D. W. (1989). Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol. Drug Metab. Dispos. 17, 238-247.
37. Vatsis, K. P., and Weber, W. W. (1993). Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. Arch. Biochem. Biophys. 301, 71-76.
38. Vatsis, K. P., Weber, W. W., Bell, D. A., Dupret, J. M., Price-Evans, D. A., Grant, D. M., Hein, D. W., Lin, H. J., Meyer, U. A., Relling, M. V., Sim, E., Suzuki, T., and Yamazoe, Y. (1995). Nomenclature for N-acetyltransferases. Pharmacogenetics 5, 1-17.
39. Watson, A. P., Wang, P. D., and Sim, E. (1990). Arylamine N-acetyltransferase from fast (C57BL/6J) and slow (A/J) N-acetylating strains of mice. Biochem. Pharmacol. 39, 647-654.
40. Weber, W. W., and Hein, D. W. (1985). N-Acetylation pharmacogenetics. Pharmacol. Rev. 37, 25-79.
41. Zenser, T. V., Lakshmi, V. M., Rustan, T. D., Doll, M. A., Deitz, A. C., Davis, B. B., and Hein, D. W. (1996). Human N-acetylation of benzidine: Role of NAT1 and NAT2. Cancer Res. 56, 3941-3947.