Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 4, 2004, Pages 1641-1645

  Fuehrlein, Brian S ^a   Rutenberg, Michael S ^a   Silver, Jared N ^a   Warren, Matthew W ^a   Theriaque, Douglas W ^a   Duncan, Glen E ^b   Stacpoole, Peter W ^a   Brantly, Mark L ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; LOW DENSITY LIPOPROTEIN; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID;

ADULT; ARTICLE; CARBOHYDRATE DIET; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; INSULIN SENSITIVITY; KETOACIDOSIS; KETOGENIC DIET; LIPID BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; MALE; METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DIET; RANDOMIZATION; STATISTICAL SIGNIFICANCE;

3-HYDROXYBUTYRIC ACID; ADULT; CHOLESTEROL, LDL; DIET; DIETARY FATS; FATTY ACIDS; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; INSULIN RESISTANCE; KETONE BODIES; KETOSIS; LIPIDS; MALE;

EID: 1942440948     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031796     Document Type: Article

References (26)

1. Wilder RM 1921 The effects of ketonuria on the course of epilepsy. Mayo Clin Proc 2:307
2. Kinsman SL, Vining EPG, Quaskey SA, Mellits D, Freeman JM 1992 Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases. Epilepsia 33:1132-1136
3. Falk RE, Cederbaum SD, Blass JP, Gibson GE, Kark RA, Carrel RE 1976 Ketonic diet in the management of pyruvate dehydrogenase deficiency. Pediatrics 58:713-721
4. Wexler ID, Hemalatha SG, McConnell J, Buist NR, Dahl HH, Berry SA, Cederbaum SD, Patel MS, Kerr DS1997 Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets: studies in patients with identical mutations. Neurology 49:1655-1661
5. Weber TA, Antognetti MR, Stacpoole PW 2001 Caveats when considering ketogenic diets for the treatment of pyruvate dehydrogenase complex deficiency. J Pediatr 138:390-395
6. Swoboda KJ, Specht L, Jones HR, Shapiro F, DiMauro S, Korson M 1998 Infantile phosphofructokinase deficiency with arthrogryposis: clinical benefit of a ketogenic diet. J Pediatr 131:32-34
7. DeFronzo RA, Bonadonna RC, Ferrannini E 1992 Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15:318-368
8. Ballaban-Gil K, Callahan C, O'Dell C, Pappo M, Moshé S, Shinnar S 1998 Complications of the ketogenic diet. Epilepsia 39:744-748
9. Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF 2001 Ketone bodies, potential therapeutic uses. Life 51:241-247
10. VanItallie TB, Nufert TH 2003 Ketones: metabolism's ugly duckling. Nutr Rev 61:327-341
11. Denke MA 2001 Metabolic effects of high-protein, low-carbohydrate diets. Am J Cardiol 88:59-61
12. Hu FB, Manson JE, Willett WC 2001 Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 20:5-19
13. Vessby B, Uusitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, Nalsen C, Berglund L, Louheranta A, Rasmussen BM, Calvert GD, Maffetone A, Pedersen E, Gustafsson IB, Storlien LH 2001 Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study. Diabetologia 44:312-319
14. Harris WS, Connor WE, McMurry MP 1983 The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 32:179-184
15. Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, Pascoe WS 1987 Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237:885-888
16. Borkman M, Chisholm DJ, Furler SM, Storlien LH, Kraegen EW, Simons LA, Chesterman CN 1989 Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 38:1314-1319
17. Rivellese AA, de Natale C, Lilli S 2002 Type of dietary fat and insulin resistance. Ann NY Acad Sci 967:329-335
18. White PL 1937 A critique of low-carbohydrate ketogenic weight-reducing regimens. JAMA 224:1416-1419
19. Radzuik J 2000 Insulin sensitivity and its measurement: structural commonalities among the methods. J Clin Endocrinol Metab 85:4426-4433
20. Gilbert DL, Pyzik BA, Freeman MJ 2000 The ketogenic diet seizure control correlates better with serum β-hydroxybutyrate than with urine ketones. J Child Neurol 15:787-790
21. Likhodii SS, Musa K, Mendonca A, Dell C, Burnham WM, Cunnane SC 2000 Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia 41:1400-1410
22. Schwartz RM, Boyes S, Aynsley-Green A 1989 Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol 31:152-160
23. Fraser DD, Whiting S, Andrew RD, Macdonald EA, Musa-Veloso K, Cunnane SC 2003 Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. Neurology 60:1026-1029
24. Nordi DR, De Vivo DC 1997 The ketogenic diet revisited: back to the future. Epilepsia 38:743-749
25. Atkinson RL, Kaiser DL 1985 Effects of calorie restriction and weight loss on glucose and insulin levels in obese humans. J Am Coll Nutr 4:411-419
26. Vining EP, Freeman JM, Ballaban-Gil K, Camfield CS, Camfield PR, Holmes GL, Shinnar S, Shuman R, Trevanthan E, Wheless JW 1998 A multicenter study of the efficacy of the ketogenic diet. Arch Neurol 55:1433-1437