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Volumn 309, Issue 1, 2005, Pages 1-11

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cγ

Author keywords

Erythropoiesis; Erythropoietin; Extracellular signal regulated kinase; Hematopoietic signaling; Phospholipase C ; Signal transduction

Indexed keywords

ERYTHROPOIETIN RECEPTOR; ERYTHROPOIETIN RECEPTOR Y343; ERYTHROPOIETIN RECEPTOR Y401; ERYTHROPOIETIN RECEPTOR Y429; ERYTHROPOIETIN RECEPTOR Y431; ERYTHROPOIETIN RECEPTOR Y479; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PHOSPHOPEPTIDE; SOS PROTEIN; UNCLASSIFIED DRUG;

EID: 23944506056     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.04.030     Document Type: Article
Times cited : (16)

References (56)
  • 1
    • 0023784657 scopus 로고
    • Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells
    • M.J. Koury, and M.C. Bondurant Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells J. Cell. Physiol. 137 1988 65 74
    • (1988) J. Cell. Physiol. , vol.137 , pp. 65-74
    • Koury, M.J.1    Bondurant, M.C.2
  • 2
    • 0026019106 scopus 로고
    • Erythropoietin
    • S.B. Krantz Erythropoietin Blood 77 1991 419 434
    • (1991) Blood , vol.77 , pp. 419-434
    • Krantz, S.B.1
  • 3
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • B.A. Witthuhn, F.W. Quelle, O. Silvennoinen, T. Yi, B. Tang, O. Miura, and J.N. Ihle JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin Cell 74 1993 227 236
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6    Ihle, J.N.7
  • 4
    • 0028025641 scopus 로고
    • Erythropoietin and interleukin-2 activate distinct JAK kinase family members
    • D.L. Barber, and A.D. D'Andrea Erythropoietin and interleukin-2 activate distinct JAK kinase family members Mol. Cell Biol. 14 1994 6506 6514
    • (1994) Mol. Cell Biol. , vol.14 , pp. 6506-6514
    • Barber, D.L.1    D'Andrea, A.D.2
  • 5
    • 0026784103 scopus 로고
    • Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells
    • I. Dusanter-Fourt, N. Casadevall, C. Lacombe, O. Muller, C. Billat, S. Fischer, and P. Mayeux Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells J. Biol. Chem. 267 1992 10670 10675
    • (1992) J. Biol. Chem. , vol.267 , pp. 10670-10675
    • Dusanter-Fourt, I.1    Casadevall, N.2    Lacombe, C.3    Muller, O.4    Billat, C.5    Fischer, S.6    Mayeux, P.7
  • 6
    • 14744299761 scopus 로고    scopus 로고
    • Turning cells red: Signal transduction mediated by erythropoietin
    • T.D. Richmond, M. Chohan, and D.L. Barber Turning cells red: signal transduction mediated by erythropoietin Trends Cell Biol. 15 2005 146 155
    • (2005) Trends Cell Biol. , vol.15 , pp. 146-155
    • Richmond, T.D.1    Chohan, M.2    Barber, D.L.3
  • 7
    • 0028880455 scopus 로고
    • Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
    • H. Wu, X. Liu, R. Jaenisch, and H.F. Lodish Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor Cell 83 1995 59 67
    • (1995) Cell , vol.83 , pp. 59-67
    • Wu, H.1    Liu, X.2    Jaenisch, R.3    Lodish, H.F.4
  • 8
    • 0030050404 scopus 로고    scopus 로고
    • Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis
    • C.S. Lin, S.K. Lim, V. D'Agati, and F. Costantini Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis Genes Dev. 10 1996 154 164
    • (1996) Genes Dev. , vol.10 , pp. 154-164
    • Lin, C.S.1    Lim, S.K.2    D'Agati, V.3    Costantini, F.4
  • 10
    • 18244432009 scopus 로고    scopus 로고
    • Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis
    • H. Neubauer, A. Cumano, M. Muller, H. Wu, U. Huffstadt, and K. Pfeffer Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis Cell 93 1998 397 409
    • (1998) Cell , vol.93 , pp. 397-409
    • Neubauer, H.1    Cumano, A.2    Muller, M.3    Wu, H.4    Huffstadt, U.5    Pfeffer, K.6
  • 11
    • 0032006788 scopus 로고    scopus 로고
    • Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo
    • G.D. Longmore, Y. You, J. Molden, K.D. Liu, A. Mikami, S.Y. Lai, P. Pharr, and M.A. Goldsmith Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo Blood 91 1998 870 878
    • (1998) Blood , vol.91 , pp. 870-878
    • Longmore, G.D.1    You, Y.2    Molden, J.3    Liu, K.D.4    Mikami, A.5    Lai, S.Y.6    Pharr, P.7    Goldsmith, M.A.8
  • 12
    • 0033570956 scopus 로고    scopus 로고
    • A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development
    • C.P. Miller, Z.Y. Liu, C.T. Noguchi, and D.M. Wojchowski A minimal cytoplasmic subdomain of the erythropoietin receptor mediates erythroid and megakaryocytic cell development Blood 94 1999 3381 3387
    • (1999) Blood , vol.94 , pp. 3381-3387
    • Miller, C.P.1    Liu, Z.Y.2    Noguchi, C.T.3    Wojchowski, D.M.4
  • 13
    • 0030996142 scopus 로고    scopus 로고
    • The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors
    • M. Socolovsky, I. Dusanter-Fourt, and H.F. Lodish The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors J. Biol. Chem. 272 1997 14009 14012
    • (1997) J. Biol. Chem. , vol.272 , pp. 14009-14012
    • Socolovsky, M.1    Dusanter-Fourt, I.2    Lodish, H.F.3
  • 14
    • 0031052477 scopus 로고    scopus 로고
    • Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation
    • H. Wu, U. Klingmuller, A. Acurio, J.G. Hsiao, and H.F. Lodish Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation Proc. Natl. Acad. Sci. U. S. A. 94 1997 1806 1810
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1806-1810
    • Wu, H.1    Klingmuller, U.2    Acurio, A.3    Hsiao, J.G.4    Lodish, H.F.5
  • 15
    • 0030929322 scopus 로고    scopus 로고
    • STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line
    • K. Iwatsuki, T. Endo, H. Misawa, M. Yokouchi, A. Matsumoto, M. Ohtsubo, K.J. Mori, and A. Yoshimura STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line J. Biol. Chem. 272 1997 8149 8152
    • (1997) J. Biol. Chem. , vol.272 , pp. 8149-8152
    • Iwatsuki, K.1    Endo, T.2    Misawa, H.3    Yokouchi, M.4    Matsumoto, A.5    Ohtsubo, M.6    Mori, K.J.7    Yoshimura, A.8
  • 16
    • 0032529520 scopus 로고    scopus 로고
    • Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization
    • R.C. Gregory, N. Jiang, K. Todokoro, J. Crouse, R.E. Pacifici, and D.M. Wojchowski Erythropoietin receptor and STAT5-specific pathways promote SKT6 cell hemoglobinization Blood 92 1998 1104 1118
    • (1998) Blood , vol.92 , pp. 1104-1118
    • Gregory, R.C.1    Jiang, N.2    Todokoro, K.3    Crouse, J.4    Pacifici, R.E.5    Wojchowski, D.M.6
  • 18
    • 0033597715 scopus 로고    scopus 로고
    • Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) induction
    • M. Socolovsky, A.E. Fallon, S. Wang, C. Brugnara, and H.F. Lodish Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction Cell 98 1999 181 191
    • (1999) Cell , vol.98 , pp. 181-191
    • Socolovsky, M.1    Fallon, A.E.2    Wang, S.3    Brugnara, C.4    Lodish, H.F.5
  • 19
    • 0035760889 scopus 로고    scopus 로고
    • Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts
    • M. Socolovsky, H. Nam, M.D. Fleming, V.H. Haase, C. Brugnara, and H.F. Lodish Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts Blood 98 2001 3261 3273
    • (2001) Blood , vol.98 , pp. 3261-3273
    • Socolovsky, M.1    Nam, H.2    Fleming, M.D.3    Haase, V.H.4    Brugnara, C.5    Lodish, H.F.6
  • 20
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • Y. Cui, G. Riedlinger, K. Miyoshi, W. Tang, C. Li, C.X. Deng, G.W. Robinson, and L. Hennighausen Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation Mol. Cell. Biol. 24 2004 8037 8047
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.X.6    Robinson, G.W.7    Hennighausen, L.8
  • 21
    • 0034927336 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C
    • S.G. Rhee Regulation of phosphoinositide-specific phospholipase C Annu. Rev. Biochem. 70 2001 281 312
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 281-312
    • Rhee, S.G.1
  • 22
    • 0030995012 scopus 로고    scopus 로고
    • Regulation of phosphoinositide-specific phospholipase C isozymes
    • S.G. Rhee, and Y.S. Bae Regulation of phosphoinositide-specific phospholipase C isozymes J. Biol. Chem. 272 1997 15045 15048
    • (1997) J. Biol. Chem. , vol.272 , pp. 15045-15048
    • Rhee, S.G.1    Bae, Y.S.2
  • 23
    • 0024403320 scopus 로고
    • Studies of inositol phospholipid-specific phospholipase C
    • S.G. Rhee, P.G. Suh, S.H. Ryu, and S.Y. Lee Studies of inositol phospholipid-specific phospholipase C Science 244 1989 546 550
    • (1989) Science , vol.244 , pp. 546-550
    • Rhee, S.G.1    Suh, P.G.2    Ryu, S.H.3    Lee, S.Y.4
  • 24
    • 0025759035 scopus 로고
    • Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation
    • S.G. Rhee, H. Kim, P.G. Suh, and W.C. Choi Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation Biochem. Soc. Trans. 19 1991 337 341
    • (1991) Biochem. Soc. Trans. , vol.19 , pp. 337-341
    • Rhee, S.G.1    Kim, H.2    Suh, P.G.3    Choi, W.C.4
  • 25
    • 0024420921 scopus 로고
    • Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C
    • Y. Homma, T. Takenawa, Y. Emori, H. Sorimachi, and K. Suzuki Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C Biochem. Biophys. Res. Commun. 164 1989 406 412
    • (1989) Biochem. Biophys. Res. Commun. , vol.164 , pp. 406-412
    • Homma, Y.1    Takenawa, T.2    Emori, Y.3    Sorimachi, H.4    Suzuki, K.5
  • 26
    • 0028142585 scopus 로고
    • Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line
    • H.Y. Ren, N. Komatsu, R. Shimizu, K. Okada, and Y. Miura Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line J. Biol. Chem. 269 1994 19633 19638
    • (1994) J. Biol. Chem. , vol.269 , pp. 19633-19638
    • Ren, H.Y.1    Komatsu, N.2    Shimizu, R.3    Okada, K.4    Miura, Y.5
  • 27
    • 0033607511 scopus 로고    scopus 로고
    • Erythropoietin induces glycosylphosphatidylinositol hydrolysis. Possible involvement of phospholipase c-gamma(2)
    • C. Boudot, E. Petitfrere, Z. Kadri, S. Chretien, P. Mayeux, B. Haye, and C. Billat Erythropoietin induces glycosylphosphatidylinositol hydrolysis. Possible involvement of phospholipase c-gamma(2) J. Biol. Chem. 274 1999 33966 33972
    • (1999) J. Biol. Chem. , vol.274 , pp. 33966-33972
    • Boudot, C.1    Petitfrere, E.2    Kadri, Z.3    Chretien, S.4    Mayeux, P.5    Haye, B.6    Billat, C.7
  • 28
    • 0035996595 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells
    • C. Boudot, Z. Kadri, E. Petitfrere, E. Lambert, S. Chretien, P. Mayeux, B. Haye, and C. Billat Phosphatidylinositol 3-kinase regulates glycosylphosphatidylinositol hydrolysis through PLC-gamma(2) activation in erythropoietin-stimulated cells Cell Signalling 14 2002 869 878
    • (2002) Cell Signalling , vol.14 , pp. 869-878
    • Boudot, C.1    Kadri, Z.2    Petitfrere, E.3    Lambert, E.4    Chretien, S.5    Mayeux, P.6    Haye, B.7    Billat, C.8
  • 30
    • 0037088684 scopus 로고    scopus 로고
    • Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
    • H.J. Liao, T. Kume, C. McKay, M.J. Xu, J.N. Ihle, and G. Carpenter Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice J. Biol. Chem. 277 2002 9335 9341
    • (2002) J. Biol. Chem. , vol.277 , pp. 9335-9341
    • Liao, H.J.1    Kume, T.2    McKay, C.3    Xu, M.J.4    Ihle, J.N.5    Carpenter, G.6
  • 34
    • 0028785505 scopus 로고
    • Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity
    • J.E. Damen, R.L. Cutler, H. Jiao, T. Yi, and G. Krystal Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity J. Biol. Chem. 270 1995 23402 23408
    • (1995) J. Biol. Chem. , vol.270 , pp. 23402-23408
    • Damen, J.E.1    Cutler, R.L.2    Jiao, H.3    Yi, T.4    Krystal, G.5
  • 35
    • 0024563574 scopus 로고
    • Expression cloning of the murine erythropoietin receptor
    • A.D. D'Andrea, H.F. Lodish, and G.G. Wong Expression cloning of the murine erythropoietin receptor Cell 57 1989 277 285
    • (1989) Cell , vol.57 , pp. 277-285
    • D'Andrea, A.D.1    Lodish, H.F.2    Wong, G.G.3
  • 37
    • 0034635485 scopus 로고    scopus 로고
    • The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor
    • J.M. Mason, B.K. Beattie, Q. Liu, D.J. Dumont, and D.L. Barber The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor J. Biol. Chem. 275 2000 4398 4406
    • (2000) J. Biol. Chem. , vol.275 , pp. 4398-4406
    • Mason, J.M.1    Beattie, B.K.2    Liu, Q.3    Dumont, D.J.4    Barber, D.L.5
  • 38
    • 0020562225 scopus 로고
    • A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice
    • G. Krystal A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice Exp. Hematol. 11 1983 649 660
    • (1983) Exp. Hematol. , vol.11 , pp. 649-660
    • Krystal, G.1
  • 39
    • 0037053316 scopus 로고    scopus 로고
    • Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases
    • R. Haq, A. Halupa, B.K. Beattie, J.M. Mason, B.W. Zanke, and D.L. Barber Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases J. Biol. Chem. 277 2002 17359 17366
    • (2002) J. Biol. Chem. , vol.277 , pp. 17359-17366
    • Haq, R.1    Halupa, A.2    Beattie, B.K.3    Mason, J.M.4    Zanke, B.W.5    Barber, D.L.6
  • 40
    • 0035980056 scopus 로고    scopus 로고
    • TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
    • M.H. Nguyen, J.M. Ho, B.K. Beattie, and D.L. Barber TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3′-kinase/protein kinase B signaling pathway J. Biol. Chem. 276 2001 32704 32713
    • (2001) J. Biol. Chem. , vol.276 , pp. 32704-32713
    • Nguyen, M.H.1    Ho, J.M.2    Beattie, B.K.3    Barber, D.L.4
  • 42
    • 0028289502 scopus 로고
    • Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocyte-macrophage colony-stimulating factor and interleukin-3
    • T. Bittorf, R. Jaster, and J. Brock Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocyte-macrophage colony-stimulating factor and interleukin-3 Cell Signalling 6 1994 305 311
    • (1994) Cell Signalling , vol.6 , pp. 305-311
    • Bittorf, T.1    Jaster, R.2    Brock, J.3
  • 43
    • 0028073675 scopus 로고
    • Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor
    • Y. Miura, O. Miura, J.N. Ihle, and N. Aoki Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor J. Biol. Chem. 269 1994 29962 29969
    • (1994) J. Biol. Chem. , vol.269 , pp. 29962-29969
    • Miura, Y.1    Miura, O.2    Ihle, J.N.3    Aoki, N.4
  • 44
    • 0028109466 scopus 로고
    • Activation of mitogen-activated protein kinase cascade through erythropoietin receptor
    • K. Todokoro, M. Sugiyama, E. Nishida, and K. Nakaya Activation of mitogen-activated protein kinase cascade through erythropoietin receptor Biochem. Biophys. Res. Commun. 203 1994 1912 1919
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 1912-1919
    • Todokoro, K.1    Sugiyama, M.2    Nishida, E.3    Nakaya, K.4
  • 45
    • 0031037359 scopus 로고    scopus 로고
    • Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells
    • D.L. Barber, C.N. Corless, K. Xia, T.M. Roberts, and A.D. D'Andrea Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells Blood 89 1997 55 64
    • (1997) Blood , vol.89 , pp. 55-64
    • Barber, D.L.1    Corless, C.N.2    Xia, K.3    Roberts, T.M.4    D'Andrea, A.D.5
  • 46
    • 0029943191 scopus 로고    scopus 로고
    • Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
    • T. Tauchi, J.E. Damen, K. Toyama, G.S. Feng, H.E. Broxmeyer, and G. Krystal Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis Blood 87 1996 4495 4501
    • (1996) Blood , vol.87 , pp. 4495-4501
    • Tauchi, T.1    Damen, J.E.2    Toyama, K.3    Feng, G.S.4    Broxmeyer, H.E.5    Krystal, G.6
  • 48
    • 0027485538 scopus 로고
    • Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells
    • R.L. Cutler, L. Liu, J.E. Damen, and G. Krystal Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells J. Biol. Chem. 268 1993 21463 21465
    • (1993) J. Biol. Chem. , vol.268 , pp. 21463-21465
    • Cutler, R.L.1    Liu, L.2    Damen, J.E.3    Krystal, G.4
  • 49
    • 0033151527 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells)
    • H. Bao, S.M. Jacobs-Helber, A.E. Lawson, K. Penta, A. Wickrema, and S.T. Sawyer Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells) Blood 93 1999 3757 3773
    • (1999) Blood , vol.93 , pp. 3757-3773
    • Bao, H.1    Jacobs-Helber, S.M.2    Lawson, A.E.3    Penta, K.4    Wickrema, A.5    Sawyer, S.T.6
  • 50
    • 0035437146 scopus 로고    scopus 로고
    • DNA damage-induced cell-cycle arrest of hematopoietic cells in overridden by activation of the PI-3 kinase/Akt signaling pathway
    • M.K. Henry, J.T. Lynch, A.K. Eapen, and F.W. Quelle DNA damage-induced cell-cycle arrest of hematopoietic cells in overridden by activation of the PI-3 kinase/Akt signaling pathway Blood 98 2001 834 841
    • (2001) Blood , vol.98 , pp. 834-841
    • Henry, M.K.1    Lynch, J.T.2    Eapen, A.K.3    Quelle, F.W.4
  • 53
    • 0344653108 scopus 로고    scopus 로고
    • Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
    • Y.S. Bae, L.G. Cantley, C.S. Chen, S.R. Kim, K.S. Kwon, and S.G. Rhee Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 4465 4469
    • (1998) J. Biol. Chem. , vol.273 , pp. 4465-4469
    • Bae, Y.S.1    Cantley, L.G.2    Chen, C.S.3    Kim, S.R.4    Kwon, K.S.5    Rhee, S.G.6
  • 54
    • 0036464667 scopus 로고    scopus 로고
    • Erythropoietin receptor-dependent erythroid colony-forming unit development: Capacities of Y343 and phosphotyrosine-null receptor forms
    • C.P. Miller, D.W. Heilman, and D.M. Wojchowski Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms Blood 99 2002 898 904
    • (2002) Blood , vol.99 , pp. 898-904
    • Miller, C.P.1    Heilman, D.W.2    Wojchowski, D.M.3
  • 55
    • 0035876167 scopus 로고    scopus 로고
    • The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis
    • H. Zang, K. Sato, H. Nakajima, C. McKay, P.A. Ney, and J.N. Ihle The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis Embo J. 20 2001 3156 3166
    • (2001) Embo J. , vol.20 , pp. 3156-3166
    • Zang, H.1    Sato, K.2    Nakajima, H.3    McKay, C.4    Ney, P.A.5    Ihle, J.N.6
  • 56
    • 0142245612 scopus 로고    scopus 로고
    • Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells
    • K. Li, M.P. Menon, V.G. Karur, S. Hegde, and D.M. Wojchowski Attenuated signaling by a phosphotyrosine-null Epo receptor form in primary erythroid progenitor cells Blood 102 2003 3147 3153
    • (2003) Blood , vol.102 , pp. 3147-3153
    • Li, K.1    Menon, M.P.2    Karur, V.G.3    Hegde, S.4    Wojchowski, D.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.