Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie

Neuroscience Letters

Volumn 388, Issue 2, 2005, Pages 106-111

  Kocisko, David A ^a   Engel, Abbi L ^a   Harbuck, Kristin ^a   Arnold, Kevin M ^a   Olsen, Emily A ^a   Raymond, Lynne D ^a   Vilette, Didier ^b   Caughey, Byron ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Inhibitors; Mouse scrapie; Prion; Sheep scrapie; Therapeutics

Indexed keywords

3 HYDROXYFLAVONE; 6,3' DIMETHOXYFLAVONE; 6,4' DIMETHOXYFLAVONE; ACACETIN; AMODIAQUINE; BIOCHANIN A; CURCUMIN; DEUTEROPORPHYRIN DERIVATIVE; DIBENZOTHIOPHENE DERIVATIVE; DIOSMETIN; DOMPERIDONE; FLAVANONE; FLAVONE DERIVATIVE; FORMONONETIN; GENISTEIN; HARMINE; IRON DEUTEROPORPHYRIN 2,4 BISETHYLENEGLYCOL; PENTOSAN POLYSULFATE; PRION PROTEIN INHIBITOR; PROTEIN INHIBITOR; PROTEINASE; PRUNETIN; QUERCETIN DERIVATIVE; RESVERATROL; RHAMNETIN; TANNIN; THIORIDAZINE; TIOTIXENE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RODENT; SCRAPIE; SHEEP; SPECIES DIFFERENCE;

EID: 23944480892     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.06.053     Document Type: Article

References (28)

1. K.T. Adjou, N. Privat, S. Demart, J.P. Deslys, M. Seman, J.J. Hauw, and D. Dormont MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters J. Comp. Pathol. 122 2000 3 8
2. A. Aguzzi, M. Glatzel, F. Montrasio, M. Prinz, and F.L. Heppner Interventional strategies against prion diseases Nat. Rev. Neurosci. 2 2001 745 749
3. P. Brown Drug therapy in human and experimental transmissible spongiform encephalopathy Neurology 58 2002 1720 1725
4. M.E. Bruce, P.A. McBride, and C.F. Farquhar Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie Neurosci. Lett. 102 1989 1 6
5. D.A. Butler, M.R.D. Scott, J.M. Bockman, D.R. Borchelt, A. Taraboulos, K.K. Hsiao, D.T. Kingsbury, and S.B. Prusiner Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins J. Virol. 62 1988 1558 1564
6. N.R. Cashman, and B. Caughey Prion diseases-close to effective therapy? Nature Rev. Drug Discov. 3 2004 874 884
7. B. Caughey, and P.T. Lansbury Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders Annu. Rev. Neurosci. 26 2003 267 298
8. B. Caughey, and R.E. Race Potent inhibition of scrapie-associated PrP accumulation by Congo red J. Neurochem. 59 1992 768 771
9. B. Caughey, and G.J. Raymond Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells J. Virol. 67 1993 643 650
10. B. Caughey, L.D. Raymond, G.J. Raymond, L. Maxson, J. Silveira, and G.S. Baron Inhibition of protease-resistant prion protein accumulation in vitro by curcumin J. Virol. 77 2003 5499 5502
11. W.S. Caughey, L.D. Raymond, M. Horiuchi, and B. Caughey Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines Proc. Natl. Acad. Sci. U.S.A. 95 1998 12117 12122
12. R. Demaimay, K.T. Adjou, V. Beringue, S. Demart, C.I. Lasmezas, J.-P. Deslys, M. Seman, and D. Dormont Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals J. Virol. 71 1997 9685 9689
13. H. Diringer, and B. Ehlers Chemoprophylaxis of scrapie in mice J. Gen. Virol. 72 1991 457 460
14. K. Doh-ura, K. Ishikawa, I. Murakami-Kubo, K. Sasaki, S. Mohri, R. Race, and T. Iwaki Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models J. Virol. 78 2004 4999 5006
15. D. Dormont Approaches to prophylaxis and therapy Br. Med. Bull. 66 2003 281 292
16. G. Forloni, S. Iussich, T. Awan, L. Colombo, N. Angeretti, L. Girola, I. Bertani, G. Poli, M. Caramelli, M. Grazia Bruzzone, L. Farina, L. Limido, G. Rossi, G. Giaccone, J.W. Ironside, O. Bugiani, M. Salmona, and F. Tagliavini Tetracyclines affect prion infectivity Proc. Natl. Acad. Sci. U.S.A. 99 2002 10849 10854
17. K. Ishikawa, K. Doh-ura, Y. Kudo, N. Nishida, I. Murakami-Kubo, Y. Ando, T. Sawada, and T. Iwaki Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies J. Gen. Virol. 85 2004 1785 1790
18. D.A. Kocisko, G.S. Baron, R. Rubenstein, J. Chen, S. Kuizon, and B. Caughey New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products J. Virol. 77 2003 10288 10294
19. D.A. Kocisko, J.D. Morrey, R.E. Race, J. Chen, and B. Caughey Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice J. Gen. Virol. 85 2004 2479 2483
20. A. Ladogana, P. Casaccia, L. Ingrosso, M. Cibati, M. Salvatore, Y.G. Xi, C. Masullo, and M. Pocchiari Sulphate polyanions prolong the incubation period of scrapie-infected hamsters J. Gen. Virol. 73 1992 661 665
21. B.C. May, A.T. Fafarman, S.B. Hong, M. Rogers, L.W. Deady, S.B. Prusiner, and F.E. Cohen Potent inhibition of scrapie prion replication in cultured cells by bis-acridines Proc. Natl. Acad. Sci. U.S.A. 100 2003 3416 3421
22. M. Pocchiari, S. Schmittinger, and C. Masullo Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters J. Gen. Virol. 68 1987 219 223
23. S.A. Priola, A. Raines, and W. Caughey Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice J. Infect. Dis. 188 2003 699 705
24. S.A. Priola, A. Raines, and W.S. Caughey Porphyrin and phthalocyanine anti-scrapie compounds Science 287 2000 1503 1506
25. R.E. Race, B. Caughey, K. Graham, D. Ernst, and B. Chesebro Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones J. Virol. 62 1988 2845 2849
26. R.E. Race, L.H. Fadness, and B. Chesebro Characterization of scrapie infection in mouse neuroblastoma cells J. Gen. Virol. 68 1987 1391 1399
27. D. Vilette, O. Andreoletti, F. Archer, M.F. Madelaine, J.L. Vilotte, S. Lehmann, and H. Laude Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein Proc. Natl. Acad. Sci. U.S.A. 98 2001 4055 4059
28. I. Vorberg, A. Raines, B. Story, and S.A. Priola Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents J. Infect. Dis. 189 2004 431 439