Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition

Biochemical Society Transactions

Volumn 33, Issue 4, 2005, Pages 689-693

  Scherer, S J ^a   Avdievich, E ^a   Edelmann, W ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Colorectal cancer; DNA damage; DNA mismatch repair (MMR); Mouse models

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CARCINOGENESIS; COLORECTAL CANCER; CONFERENCE PAPER; DNA DAMAGE; DNA REPLICATION; DNA RESPONSIVE ELEMENT; GENETIC ANALYSIS; GENETIC STABILITY; MISMATCH REPAIR; MISSENSE MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE PAIR MISMATCH; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MUTATION, MISSENSE;

MURINAE;

EID: 23844536173     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0330689     Document Type: Conference Paper

References (49)

1. Lynch, H.T. and Smyrk, T. (1996) Cancer 78, 1149-1167
2. Lucci-Cordisco, E., Zito, I., Gensini, F. and Genuardi, M. (2003) Am. J. Med. Genet. 122, 325-334
3. Peltomaki, P. and Vasen, H.F. (1997) Gastroenterology 113, 1146-1158
4. Peltomaki, P. (2003) J. Clin. Oncol. 21, 1174-1179
5. Vasen, H.F., Mecklin, J.P., Khan, P.M. and Lynch, H.T. (1991) Dis. Colon Rectum 34, 424-425
6. Aaltonen, L.A., Peltomaki, P., Leach, F.S., Sistonen, P., Pylkkanen, L., Mecklin, J.P., Jarvinen, H., Powell, S.M., Jen, J., Hamilton, S.R. et al. (1993) Science 260, 812-816
7. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. and Perucho, M. (1993) Nature (London) 363, 558-561
8. Thibodeau, S.N., Bren, G. and Schaid, D. (1993) Science 260, 816-819
9. Modrich, P. and Lahue, R. (1996) Annu. Rev. Biochem. 65, 101-133
10. Kolodner, R. (1996) Genes Dev. 10, 1433-1442
11. Marsischky, G.T., Filosi, N., Kane, M.F. and Kolodner, R. (1996) Genes Dev. 10, 407-420
12. Genschel, J., Littman, S.J., Drummond, J.T. and Modrich, P. (1998) J. Biol. Chem. 273, 19895-19901
13. Edelmann, W., Umar, A., Yang, K., Heyer, J., Kucherlapati, M., Lia, M., Kneitz, B., Avdievich, L, Fan, K., Wong, E. et al. (2000) Cancer Res. 60, 803-807
14. Hollingsworth, N.M., Ponte, L. and Halsey, C. (1995) Genes Dev. 9, 1728-1739
15. Ross-Macdonald, P. and Roeder, G.S. (1994) Cell 79, 1069-1080
16. Buermeyer, A.B., Deschênes, S.M., Baker, S.M. and Liskay, R.M. (1999) Annu. Rev. Genet. 33, 533-564
17. Kolodner, R.D. and Marsischky, G.T. (1999) Curr. Opin. Genet. Dev. 9, 89-96
18. Prolla, T.A., Pang, Q., Alani, E., Kolodner, R.D. and Liskay, R.M. (1994) Science 265, 1091-1093
19. Li, G.M. and Modrich, P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1950-1954
20. Flores-Rozas, H., Clark, D. and Kolodner, R.D. (2000) Nat. Genet. 26, 375-378
21. Wang, T.F., Kleckner, N. and Hunter, N. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 13914-13919
22. Jones, M. and Wagner, R. (1981) Mol. Gen. Genet. 184, 562-563
23. Karran, P. and Marinus, M.G. (1982) Nature (London) 296, 868-869
24. Drummond, J.T., Anthoney, A., Brown, R. and Modrich, P. (1996) J. Biol. Chem. 271, 19645-19648
25. Li, G.M. (1999) Oncol. Res. 11, 393-400
26. Koi, M., Umar, A., Chauhan, O.P., Cherian, S.P., Carethers, J.M., Kunkel, T.A. and Boland, C.R. (1994) Cancer Res. 54, 4308-4312
27. Umar, A., Koi, M., Risinger, J.I., Glaab, W.E., Tindall, K.R., Kolodner, R.D., Boland, C.R., Barrett, J.C. and Kunkel, T.A. (1997) Cancer Res. 57, 3949-3955
28. de Wind, N., Dekker, M., Claij, N., Jansen, L., van Klink, Y., Radman, M., Riggins, G., van der Valk, M., van't Wout, K. and te Riele, H. (1999) Nat. Genet. 23, 359-362
29. Karran, P. and Bignami, M. (1994) BioEssays 16, 833-839
30. D'Atri, S., Tentori, L., Lacal, P.M., Graziani, G., Pagani, E., Benincasa, E., Zambruno, G., Bonmassar, E. and Jiricny, J. (1998) Mol. Pharmacol. 54, 334-341
31. Toft, N.J., Winton, D.J., Kelly, J., Howard, L.A., Dekker, M., te Riele, H., Arends, M.J., Wyllie, A.H., Margison, G.P. and Clarke, A.R. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 3911-3915
32. Colussi, C., Fiumicino, S., Giuliani, A., Rosini, S., Musiani, P., Macri, C., Rotten, C.S., Crescenzi, M. and Bignami, M. (2001) J. Natl. Cancer Inst. 93, 1534-1540
33. Caporali, S., Falcinelli, S., Starace, G., Russo, M.T., Bonmassar, E., Jiricny, J. and D'Atri, S. (2004) Mol. Pharmacol. 66, 478-491
34. Stojic, L., Mojas, N., Cejka, P., Di Pietro, M., Ferrari, S., Marra, G. and Jiricny, J. (2004) Genes Dev. 18, 1331-1344
35. Yan, T., Desai, A.B., Jacobberger, J.W., Sramkoski, R.M., Loh, T. and Kinsella, T.J. (2004) Mol. Cancer Ther. 3, 1147-1157
36. Gong, J.G., Costanzo, A., Yang, H.Q., Melino, G., Kaelin, Jr, W.G., Levrero, M. and Wang, J.Y. (1999) Nature (London) 399, 806-809
37. Hickman, M.J. and Samson, L.D. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 10764-10769
38. Shimodaira, H., Yoshioka-Yamashita, A., Kolodner, R.D. and Wang, J.Y. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 2420-2425
39. Edelmann, L. and Edelmann, W. (2004) Am. J. Med. Genet. C. Semin. Med. Genet. 129, 91-99
40. Lin, D.P., Wang, Y., Scherer, S.J., Clark, A.B., Yang, K., Avdievich, E., Jin, B., Werling, U., Parris, T., Kurihara, N. et al. (2004) Cancer Res. 64, 517-522
41. Alani, E., Sokolsky, T., Studamire, B., Miret, J.J. and Lahue, R.S. (1997) Mol. Cell Biol. 17, 2436-2447
42. Drotschmann, K., Clark, A.B., Tran, H.T., Resnick, M.A., Gordenin, D.A. and Kunkel, T.A. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 2970-2975
43. Wu, T.H. and Marinus, M.G. (1994) J. Bacteriol. 176, 5393-5400
44. Heinen, C.D., Schmutte, C. and Fishel, R. (2002) Cancer Biol. Ther. 1, 477-485
45. Yang, G., Scherer, S.J., Shell, S.S., Yang, K., Kim, M., Lipkin, M., Kucherlapati, R., Kolodner, R.D. and Edelmann, W. (2004) Cancer Cell 6, 139-150
46. Hess, M.T., Gupta, R.D. and Kolodner, R.D. (2002) J. Biol. Chem. 277, 25545-25553
47. Das Gupta, R. and Kolodner, R.D. (2000) Nat. Genet. 24, 53-56
48. Berends, M.J., Wu, Y., Sijmons, R.H., Mensink, R.G., van der Sluis, T., Hordijk-Hos, J.M., de Vries, E.G., Hollema, H., Karrenbeld, A., Buys, C.H., et al. (2002) Am. J. Hum. Genet. 70, 26-37
49. Brown, K.D., Rathi, A., Kamath, R., Beardsley, D.I., Zhan, Q., Mannino, J.L. and Baskaran, R. (2003) Nat. Genet. 33, 80-84