Human Bcl-2 protects against AMPA receptor-mediated apoptosis

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1613-1620

  Cheung, Nam S ^a   Beart, Philip M ^a   Pascoe, Catherine J ^a   John, Christopher A ^a   Bernard, Ora ^b  

^a MONASH UNIVERSITY   (Australia)

^b NONE

Author keywords

(S) Amino 3 hydroxy 5 methylisoxazole 4 propionate; Apoptosis; Bcl 2; Excitotoxicity; Glutamate; Necrosis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMPA RECEPTOR; DNA; EXCITOTOXIN; GLUTAMIC ACID; HYDROGEN PEROXIDE; INDOLE DERIVATIVE; IONOTROPIC RECEPTOR; NEUROTRANSMITTER; PROTEIN BCL 2; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; APOPTOSIS; CELLS, CULTURED; DNA; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GENOTYPE; GLUTAMIC ACID; HUMANS; HYDROGEN PEROXIDE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NECROSIS; NEOCORTEX; NEURONS; NEUROTOXINS; OXIDANTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, AMPA; STAUROSPORINE;

ANIMALIA; MUS MUSCULUS;

EID: 0034122404     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741613.x     Document Type: Article

References (52)

1. Akbarian S., Smith M. A., and Jones E. G. (1995) Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain Res. 699, 297-304.
2. Albrecht H., Tschopp J., and Jongeneel C. V. (1994) Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF. FEBS Lett. 351, 45-48.
3. Allsopp T. E., Wyatt S., Paterson H. F., and Davies A. M. (1993) The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73, 295-307.
4. Bakhshi A., Jensen J. P., Goldman P., Wright J. J., McBride O. W., Epstein A. L., and Korsmeyer S. J. (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41, 899-906.
5. Behl C., de Hovey L., Krajewski S., Schubert D., and Reed J. C. (1993) BCL-2 prevents killing of neuronal cells by glutamate but not by amyloid beta protein. Biochem. Biophys. Res. Commun. 197, 949-956.
6. Brewer G. J., Torricelli J. R., Evege E. K., and Price P. J. (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
7. Cheung N. S., Pascoe C. J., Giardina S. F., John C. A., and Beart P. M. (1998) Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones. Neuropharmacology 37, 1419-1429.
8. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
9. Choi D. W. (1996) Ischemia-induced neuronal apoptosis. Curr. Opin. Neurobiol. 6, 667-672.
10. Chou J. and Roizman B. (1992) The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proc. Natl. Acad. Sci. USA 89, 3266-3270.
11. Clarke P. G. (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. (Berl.) 181, 195-213.
12. Coyle J. T. (1983) Neurotoxic action of kainic acid. J. Neurochem. 41, 1-11.
13. Eastwood S. L., Kerwin R. W., and Harrison P. J. (1997) Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol. Psychiatry 41, 636-643.
14. Farlie P. G., Dringen R., Rees S. M., Kannourakis G., and Bernard O. (1995) Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. USA 92, 4397-4401.
15. Frandsen A. and Schousboe A. (1993) Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J. Neurochem. 60, 1202-1211.
16. Gill R. and Lodge D. (1997) Pharmacology of AMPA antagonists and their role in neuroprotection, in Neuroprotective Agents und Cerebral Ischaemia, Vol. 40 (Green A. R. and Cross A. J., eds), pp. 197-232. Academic Press, London.
17. Guenal I., Sidoti-de Fraisse C., Gaumer S., and Mignotte B. (1997) Bcl-2 and Hsp27 act at different levels to suppress programmed cell death. Oncogene 15, 347-360.
18. Haugland R. P. (1996) Nucleic acid detection, in Handbook of Fluorescent Probes and Research Chemicals, 6th edit. (Spence M. T. Z., ed), p. 149. Molecular Probes, Eugene, Oregon.
19. Heaton M. B., Moore D. B., Paiva M., Gibbs T., and Bernard O. (1999) Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Res. 817, 13-18.
20. Hockenbery D., Nunez G., Milliman C., Schreiber R. D., and Korsmeyer S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334-336.
21. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
22. Jacobson M. D. (1998) Anti-apoptosis therapy: a way of treating neural degeneration? Curr. Biol. 8, 418-421.
23. Jia W. W., Wang Y., Qiang D., Tufaro F., Remington R., and Cynader M. (1996) A bcl-2 expressing viral vector protects cortical neurons from excitotoxicity even when administered several hours after the toxic insult. Mol. Brain Res. 42, 350-353.
24. John C. A., Beart P. M., Giardina S. F., Pascoe C. J., and Cheung N. S. (1999) Cyclothiazide and GYKI 52466 modulate AMPA receptor-mediated apoptosis in cortical neuronal cultures. Neurosci. Lett. 268, 9-12.
25. Kane D. J., Sarafian T. A., Anton R., Hahn H., Gralla E. B., Valentine J. S., Ord T., and Bredesen D. E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274-1277.
26. Kane D. J., Ord T., Anton R., and Bredesen D. E. (1995) Expression of bcl-2 inhibits necrotic neural cell death. J. Neurosci. Res. 40, 269-275.
27. Kerr J. F. R. and Harmon B. V. (1991) Definition and incidence of apoptosis: an historical perspective, in Apoptosis: The Molecular Basis of Cell Death (Tomei L. D. and Cope F. O., eds), pp. 5-29. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
28. Koh J. Y., Wie M. B., Gwag B. J., Sensi S. L., Canzoniero L. M., Demaro J., Csernansky C., and Choi D. W. (1995) Staurosporine-induced neuronal apoptosis. Exp. Neurol. 135, 153-159.
29. Kure S., Tominaga T., Yoshimoto T., Tada K., and Narisawa K. (1991) Glutamate triggers internucleosomal DNA cleavage in neuronal cells. Biochem. Biophys. Res. Commun. 179, 39-45.
30. Lipton S. A. and Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
31. Mah S. P., Zhong L. T., Liu Y., Roghani A., Edwards R. H., and Bredesen D. E. (1993) The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J. Neurochem. 60, 1183-1186.
32. Mattson M. P. and Scheff S. W. (1994) Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapy. J. Neurotrauma 11, 3-33.
33. Meldrum B. and Garthwaite J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11, 379-387.
34. Monaghan P., Robertson D., Amos T. A., Dyer M. J., Mason D. Y., and Greaves M. F. (1992) Ultrastructural localization of bcl-2 protein. J. Histochem. Cytochem. 40, 1819-1825.
35. Math R., Probert A. Jr., McGinnis K. M., and Wang K. K. W. (1998) Evidence for activation of caspase-3-like protease in excitotoxin-and hypoxia/hypoglycemia-injured neurons. J. Neurochem. 71, 186-195.
36. Nicotera P., Ankarcrona M., Bonfoco E., Orrenius S., and Lipton S. A. (1997) Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Adv. Neurol. 72, 95-101.
37. Offen D., Beart P. M., Cheung N. S., Pascoe C. J., Hochman A., Gorodin S., Melamed E., Bernard R., and Bernard O. (1998) Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Proc. Natl. Acad. Sci. USA 95, 5789-5794.
38. Olney J. W. (1978) Neurotoxicity of excitatory amino acids, in Kainic Acid as a Tool in Neurobiology (McGeer E. G., Olney J. W., and McGeer P. L., eds), pp. 95-121. Raven Press, New York.
39. Pollard H., Charriaut-Marlangue C., Cantagrel S., Represa A., Robain O., Moreau J., and Ben-Ari Y. (1994) Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 63, 7-18.
40. Portera-Cailliau C., Price D. L., and Martin L. J. (1997) Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. J. Comp. Neurol. 378, 88-104.
41. Reed J. C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124, 1-6.
42. Simonian N. A. and Coyle J. T. (1996) Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36, 83-106.
43. Simonian N. A., Getz R. L., Leveque J. C., Konradi C., and Coyle J. T. (1996) Kainic acid induces apoptosis in neurons. Neuroscience 75, 1047-1055.
44. Strasser A., Harris A. W., and Cory S. (1991) Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67, 889-899.
45. Susin S. A., Zamzami N., Castedo M., Hirsch T., Marchetti P., Macho A., Daugas E., Geuskens M., and Kroemer G. (1996) Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184, 1331-1341.
46. Talley A. K., Dewhurst S., Perry S. W., Dollard S. C., Gummuluru S., Fine S. M., New D., Epstein L. G., Gendelman H. E., and Gelbard H. A. (1995) Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol. Cell. Biol. 15, 2359-2366.
47. Tsujimoto Y., Gorham J., Cossman J., Jaffe E., and Croce C. M. (1985) The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393.
48. Vaux D. L. and Korsmeyer S. J. (1999) Cell death in development. Cell 96, 245-254.
49. Williams T. L., Day N. C., Ince P. G., Kamboj R. K., and Shaw P. J. (1997) Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann. Neurol. 42, 200-207.
50. Wong E. H. and Kemp J. A. (1991) Sites for antagonism on the N-methyl-D-aspartate receptor channel complex. Annu. Rev. Pharmacol. Toxicol. 31, 401-425.
51. Zhong L. T., Kane D. J., and Bredesen D. E. (1993a) BCL-2 blocks glutamale toxicity in neural cell lines. Brain Res. Mol. Brain Res. 19, 353-355.
52. Zhong L. T., Sarafian T., Kane D. J., Charles A. C., Mah S. P., Edwards R. H., and Bredesen D. E. (1993b) Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc. Natl. Acad. Sci. USA 90, 4533-4537.