Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: Serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis

Clinical and Experimental Immunology

Volumn 134, Issue 2, 2003, Pages 309-313

  Kagami, S ^a   Kakinuma, T ^a   Saeki, H ^a   Tsunemi, Y ^a   Fujita, H ^a   Nakamura, K ^b   Takekoshi, T ^a   Kishimoto, M ^a   Mitsui, H ^a   Torii, H ^a   Komine, M ^a   Asahina, A ^a   Tamaki, K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Atopic dermatitis; Disease activity; Eotaxin 2 CCL24 eotaxin 3 CCL26

Indexed keywords

CHEMOKINE; EOTAXIN;

ADULT; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DERMATITIS; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; SERUM;

ADULT; BIOLOGICAL MARKERS; CHEMOKINES, CC; DERMATITIS, ATOPIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; PSORIASIS; SEVERITY OF ILLNESS INDEX;

EID: 0242456288     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02273.x     Document Type: Article

References (17)

1. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venerol (Stock) 1980; 92 (Suppl.):44-7.
2. Leung DYM. Atopic dermatitis: immunobiology and treatment with immune modulators. Clin Exp Immunol 1997; 107 (Suppl.):25-30.
3. Kakinuma T, Nakamura K, Wakugawa M et al. Thymus and activation- regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001; 107:535-41.
4. Kakinuma T, Nakamura K, Wakugawa M et al. Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis. Clin Exp Immunol 2002; 127:270-3.
5. Jose PJ, Griffiths Johnson DA, Collins PD et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994; 179:881-7.
6. Ponath PD, Qin S, Ringler DJ et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest 1996; 97:604-12.
7. Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 1997; 185:2171-6.
8. White JR, Imuburgia C, Dul E et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J Leukoc Biol 1997; 62:667-75.
9. Kitaura M, Suzuki N, Imai T et al. Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem 1999; 274:27975-80.
10. Shinkai A, Yoshisue H, Koike M et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol 1999; 163:1602-10.
11. Elsner J, Petering H, Kluthe C, Kimmig D, Smolarski R, Ponath P, Kapp A. Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils. Eur J Immunol 1998; 28:2152-8.
12. Europian Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis. The SCORAD Index. Dermatology 1993; 186:23-31.
13. Kunz B, Oranje AP, Labrèze L, Stalder JF, Ring J, Taïeb A. Clinical validation and guidelines for the SCORAD index: Consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997; 195:10-9.
14. Butterfield JH, Lieferman KM. Eosinophil-Associated Diseases. In: Smith H, Cook RM, eds. Immunopharmacology of Eosinophils. San Diego, CA: Academic Press, 1993.
15. Kaburagi Y, Shimada Y, Nagaoka T, Hasegawa M, Takehara K, Sato S. Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1alpha, MIP-1beta, and eotaxin) in patients with atopic dermatitis. Arch Dermatol Res 2001; 293:350-5.
16. Yawalkar N, Uguccioni M, Scharer J, Braunwalder J, Karlen S, Dewald B, Braathen LR, Baggiolini M. Enhanced expression of eotaxin and CCR3 in atopic dermatitis. J Invest Dermatol 1999; 113:43-8.
17. Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, Johnston SL. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. Clin Exp Allergy 2001; 31:1060-6.