Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil

European Journal of Pharmacology

Volumn 504, Issue 1-2, 2004, Pages 1-6

  Zhu, Chong Bin ^a   Hewlett, William A ^a   Francis, Sharron H ^a   Corbin, Jackie D ^a   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cGMP; PDE5; PKG; Serotonin; Sildenafil; Transporter

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR STIMULATING AGENT; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; N (2 METHYLAMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; PHOSPHODIESTERASE V INHIBITOR; SEROTONIN; SEROTONIN TRANSPORTER; SILDENAFIL; ZAPRINAST;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BINDING; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CHO CELLS; CRICETINAE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PROTEIN BINDING; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 6944255397     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.09.023     Document Type: Article

References (25)

1. S. Apparsundaram, U. Sung, R.D. Price, and R.D. Blakely Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells J. Pharmacol. Exp. Ther. 299 2001 666 677
2. R.D. Blakely, S. Ramamoorthy, S. Schroeter, Y. Qian, S. Apparsundaram, A. Galli, and L.J. DeFelice Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins Biol. Psychiatry 44 1998 169 178
3. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, H. Harrington, J. McClay, J. Mill, J. Martin, A. Braithwaite, and R. Poulton Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389
4. E.H. Cook, and B.L. Leventhal The serotonin system in autism Curr. Opin. Pediatr. 8 1996 348 354
5. 3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP Mol. Pharmacol. 63 2003 1364 1372
6. N.L. Flattem, and R.D. Blakely Modified structure of the human serotonin transporter promoter Mol. Psychiatry 5 2000 110 115
7. S.H. Francis, I.V. Turko, and J.D. Corbin Cyclic nucleotide phosphodiesterases: relating structure and function Prog. Nucleic Acid Res. Mol. Biol. 65 2001 1 52
8. J. Garthwaite, and C.L. Boulton Nitric oxide signaling in the central nervous system Annu. Rev. Physiol. 57 1995 683 706
9. B. Giros, S. el Mestikawy, N. Godinot, K. Zheng, H. Han, T. Yang-Feng, and M.G. Caron Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter Mol. Pharmacol. 42 1992 383 390
10. I. Goldstein, T.F. Lue, H. Padma-Nathan, R.C. Rosen, W.D. Steers, and P.A. Wicker Oral sildenafil in the treatment of erectile dysfunction New Engl. J. Med. 338 1998 1397 1404
11. J.M. Launay, D. Bondoux, M.J. Oset-Gasque, S. Emami, V. Mutel, M. Haimart, and C. Gespach Increase of human platelet serotonin uptake by atypical histamine receptors Am. J. Physiol. 266 1994 R526 R536
12. I. Lucki The spectrum of behaviors influenced by serotonin Biol. Psychiatry 44 1998 151 162
13. F. Kilic, D.L. Murphy, and G. Rudnick A human serotonin transporter mutation causes constitutive activation of transport activity Mol. Pharmacol. 64 2003 440 446
14. M.F. Marmor, and R. Kessler Sildenafil (Viagra) and ophthalmology Surv. Ophthalmol. 44 1999 153 162
15. K.J. Miller, and B.J. Hoffman Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP J. Biol. Chem. 269 1994 27351 27356
16. H.A. Milman, and S.B. Arnold Neurologic, psychological and aggressive disturbances with sildenafil Ann. Pharmacother. 36 2002 1129 1134
17. E.J. Nestler, S.E. Hyman, and R.C. Malenka Serotonin, acetylcholine, and histamine E.J. Nestler S.E. Hyman R.C. Malenka Molecular Neuropharmacology, a foundation for clinical neuroscience 2001 McGraw-Hill New York, NY 191 211
18. N. Ozaki, D. Goldman, W.H. Kaye, K. Plotnicov, B.D. Greenberg, J. Lappalainen, G. Rudnick, and D.L. Murphy Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype Mol. Psychiatry 8 2003 933 936
19. T. Pacholczyk, R.D. Blakely, and S.G. Amara Expression cloning of a cocaine and antidepressant-sensitive human noradrenaline transporter Nature 350 1991 350 354
20. Y. Qian, A. Galli, S. Ramamoorthy, S. Risso, L.J. DeFelice, and R.D. Blakely Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression J. Neurosci. 17 1997 45 57
21. S. Ramamoorthy, A.L. Bauman, K.R. Moore, H. Han, T. Yang-Feng, A.S. Chang, V. Ganapathy, and R.D. Blakely Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization Proc. Natl. Acad. Sci. U.S.A 90 1993 2542 2546
22. S. Ramamoorthy, and R.D. Blakely Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants Science 285 1999 763 766
23. S. Ramamoorthy, E. Giovanetti, Y. Qian, and R.D. Blakely Phosphorylation and regulation of antidepressant-sensitive serotonin transporters J. Biol. Chem. 273 1998 2458 2466
24. K.L. Simpson, B.D. Waterhouse, and R.C. Lin Differential expression of nitric oxide in serotonergic projection neurons: neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets J. Comp. Neurol. 466 2003 495 512
25. C.-B. Zhu, W.A. Hewlett, I. Feoktistov, I. Biaggioni, and R.D. Blakely Adenosine receptor, protein kinase G and p38 MAP kinase dependent upregulation of serotonin transporters involves both transporter trafficking and activation Mol. Pharmacol. 65 2004 1462 1474