Central memory and effector memory subsets of human CD4+ and CD8+ T cells display differential sensitivity to TNF-α-induced apoptosis

Annals of the New York Academy of Sciences

Volumn 1050, Issue , 2005, Pages 108-114

  Gupta, Sudhir ^a,b   Bi, Ruifen ^a   Gollapudi, Sastry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; CD4+; CD8+; Memory; Sensitivity; T cells; Tumor necrosis factor (TNF )

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; APOPTOSIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURFACE; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; LYMPH NODE; LYMPHOCYTE HOMING; MEMORY CELL; PHENOTYPE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 23744495449     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1313.012     Document Type: Conference Paper

References (32)

1. KAECH, S.M. & R. AHMED. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2: 415-422.
2. MOSER, B. & P. LOETSCHER. 2001. Lymphocyte traffic control by chemokines. Nat. Immunol. 2: 123-128.
3. SCHLUNS, K.S. & L. LEFRANCOIS. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3: 269-279.
4. MASOPUST, D., V. VEZYS, A.L. MARZO & L. LEFRANCOIS. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291: 2413-2417.
5. SALLUSTO, F., D. LENIG, R. FORSTER, et al. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712.
6. WENINGER, W., M.A. CROWLEY, N. MANJUNATH & U.H. VON ANDRIAN. 2001. Migratory properties of naive, effector, and memory CD8(+) T cells. J. Exp. Med. 194: 953-966.
7. TOMIYAMA, H., T. MATSUDA & M. TAKIGUCHI. 2002. Differentiation of CD8+ T cells from a memory to memory/effector phenotype. J. Immunol. 168: 5538-5550.
8. GUPTA, S., R. BI, K. SU, et al. 2004. Characterization of naive, memory and effector CD8+ T cells: effect of age. Exp. Gerontol. 39: 545-550.
9. GUPTA, S. & S. GOLLAPUDI. 2005. Molecular mechanisms of TNF-α-induced apoptosis in aging human T cell subsets. Int. J. Biochem. Cell Biol. 37: 1034-1042.
10. LOCKSLEY, R.M., N. KILLEEN & M.J. LENARDO. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104: 487-501.
11. GUPTA, S. 2000. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci. 69: 2957-2964.
12. GUPTA, S. 2001. Molecular steps of tumor necrosis factor receptor-mediated apoptosis. Curr. Mol. Med. 1: 299-306.
13. GUPTA, S. 2002. A decision between life and death during TNF-α-induced signaling. J. Clin. Immunol. 22: 270-278.
14. GUPTA, S., R. BI & S. GOLLAPUDI. 2005. Differential sensitivity of naive and memory subsets of human CD8+ T cells to TNF-α-induced apoptosis. J. Immunol. Submitted.
15. BEG, A.A. & D. BALTIMORE. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782-784.
16. GHOSH, S., M.J. MAY & E.B. KOPP. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
17. BALDWIN, A.S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14: 649-681.
18. KARIN, M. & A. LIN. 2002. NF-κB at the crossroads of life and death. Nat. Immunol. 3: 221-227.
19. GHOSH, S. & M. KARIN. 2002. Missing pieces in the NF-κB puzzle. Cell 109: S81-S96.
20. ZANDI, E., Y.I. CHEN & M. KARIN. 1998. Direct phosphorylation of IκB by IKKα and IKKβ: discrimination between free and NF-κB-bound substrate. Science 281: 1360-1363.
21. BROWN, K., S. GERSTBERGER, L. CARLSON, et al. 1995. Control of IκB-a proteolysis by site-specific, signal-induced phosphorylation. Science 281: 1360-1363.
22. PAHL, H.L. 1999. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18: 6855-6866.
23. LI, Z.W., W.M. CHU, Y.L. HU, et al. 1999. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J. Exp. Med. 189: 1839-1845.
24. SENFTLEBEN, U., Z-W. LI, V. BAUD & M. KARIN. 2001. IKKβ is essential for protecting T cells from TNFα-induced apoptosis. Cell 14: 217-230.
25. BENTIRES-ALJ, M., E. DEJARDIN, P. VIATOUR, et al. 2001. Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines. Oncogene 20: 2805-2813.
26. PIMENTEL-MUINOS, F.X. & B. SEED. 1999. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity 11: 783-793.
27. KELLIHER, M.A., S. GRIMM, Y. ISHIDA, et al. 1998. The death domain kinase RIP mediates the TNF-induced NF-kappa B signal. Immunity 8: 297-303.
28. YANG, Y., J. MA, Y. CHEN & M. WU. 2004. Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. J. Biol. Chem. 279: 38820-38829.
29. ZHA, J., O. ZHOU, L.G. XU, et al. 2004. RIP5 is a RIP-homologous inducer of cell death. Biochem. Biophys. Res. Commun. 319: 298-303.
30. MEYLAN, E., F. MARTINON, M. THOME, et al. 2002. RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis. EMBO Rep. 3: 1201-1208.
31. SHEN, H.-M., Y. LIN, S. CHOKSI, et al. 2004. Essential role of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol. Cell. Immunol. 24: 5914-5922.
32. YOUNG, T., S. GOLLAPUDI, S. AGRAWAL & S. GUPTA. 2005. Oxidative stress-induced apoptosis in naive, central memory, and effector memory CD4+ and CD8+ T cells. FASEB J. 19: A959.