RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis

EMBO Reports

Volumn 3, Issue 12, 2002, Pages 1201-1208

  Meylan, Etienne ^b   Martinon, Fabio ^b   Thome, Margot ^b   Gschwendt, Michael ^a   Tschopp, Jürg ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ASPARTIC ACID; CASPASE; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; PROTEIN RIP4; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PHYLOGENY; PROTEIN KINASES; SEQUENCE ALIGNMENT;

EID: 0038824573     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf236     Document Type: Review

References (22)

1. Bähr, C., Rohwer, A., Stempka, L., Rincke, G., Marks, F. and Gschwendt, M. (2000) DIK, a novel protein kinase that interacts with protein kinase Cδ. Cloning, characterization, and gene analysis. J. Biol. Chem., 275, 36350-36357.
2. Bucher, P., Karplus, K., Moeri, N. and Hofmann, K. (1996) A flexible search technique based on generalized profiles. Comp. Chem., 20, 3-24.
3. Chen, L., Haider, K., Ponda, M., Cariappa, A., Rowitch, D. and Pillai, S. (2001) Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J. Biol. Chem., 276, 21737-21744.
4. Chin, A.I., Dempsey, P.W., Bruhn, K., Miller, J.F., Xu, Y. and Cheng, G. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature, 416, 190-194.
5. Hanks, S.K. and Hunter, T. (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J., 9, 576-596.
6. Hofmann, K. (1999) The modular nature of apoptotic signaling proteins. Cell. Mol. Life Sci., 55, 1113-1128.
7. Hsu, H., Huang, J., Shu, H.B., Baichwal, V. and Goeddel, D.V. (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity, 4, 387-396.
8. Inohara, N., del Peso, L., Koseki, T., Chen, S. and Nunez, G. (1998) RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem., 273, 12296-12300.
9. Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P.C., Chen, F.F., Ogura, Y. and Nunez, G. (2000) An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem., 275, 27823-27831.
10. Karin, M. and Delhase, M. (2000) The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin. Immunol., 12, 85-98.
11. Karin, M. and Lin, A. (2002) NF-κB at the crossroads of life and death. Nat. Immunol., 3, 221-227.
12. Kasof, G.M., Prosser, J.C., Liu, D., Lorenzi, M.V. and Gomes, B.C. (2000) The RIP-like kinase, RIP3, induces apoptosis and NF-κB nuclear translocation and localizes to mitochondria. FEBS Lett., 473, 285-291.
13. Kelliher, M.A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B.Z. and Leder, P. (1998) The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity, 8, 297-303.
14. Kobayashi, K., Inohara, N., Hernandez, L.D., Galan, J.E., Nunez, G., Janeway, C.A., Medzhitov, R. and Flavell, R.A. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature, 416, 194-199.
15. Lin, Y., Devin, A., Rodriguez, Y. and Liu, Z. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev., 13, 2514-2526.
16. Martinon, F., Holler, N., Richard, C. and Tschopp, J. (2000) Activation of a pro-apoptotic amplification loop through inhibition of NF-κB-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett., 468, 134-136.
17. McCarthy, J.V., Ni, J. and Dixit, V.M. (1998) RIP2 is a novel NF-κB-activating and cell death-inducing kinase. J. Biol. Chem., 273, 16968-16975.
18. Sun, X., Lee, J., Navas, T., Baldwin, D.T., Stewart, T.A. and Dixit, V.M. (1999) RIP3, a novel apoptosis-inducing kinase. J. Biol. Chem., 274, 16871-16875.
19. Sun, X., Yin, J., Starovasnik, M.A., Fairbrother, W.J. and Dixit, V.M. (2002) Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. J. Biol. Chem., 277, 9505-9511.
20. Thome, M., Hofmann, K., Burns, K., Martinon, F., Bodmer, J.L., Mattmann, C. and Tschopp, J. (1998) Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr. Biol., 8, 885-888.
21. Ting, A.T., Pimentel-Muinos, F.X. and Seed, B. (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J, 15, 6189-6196.
22. Yu, P.W., Huang, B.C., Shen, M., Quast, J., Chan, E., Xu, X., Nolan, G.P., Payan, D.G. and Luo, Y. (1999) Identification of RIP3, a RIP-like kinase that activates apoptosis and NFκB. Curr. Biol., 9, 539-542.