Unilateral subcutaneous bee venom but not formalin injection causes contralateral hypersensitized wind-up and after-discharge of the spinal withdrawal reflex in anesthetized spinal rats

Experimental Neurology

Volumn 195, Issue 1, 2005, Pages 148-160

  You, Hao Jun ^a   Arendt Nielsen, Lars ^a  

^a AALBORG UNIVERSITY   (Denmark)

Author keywords

After discharge; Bee venom; Formalin; Inflammation; NMDA receptor antagonist; Non NMDA receptor antagonist; Wind up; Withdrawal reflex

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; BEE VENOM; DIZOCILPINE; FORMALDEHYDE; RECEPTOR;

AFTERDISCHARGE; ANAPHYLAXIS; ANESTHESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROMYOGRAPHY; ELECTROSTIMULATION; EVOKED RESPONSE; EXCITABILITY; GASTROCNEMIUS MUSCLE; HYPERSENSITIVITY; MALE; MOTOR UNIT; MUSCLE CONTRACTION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SENSITIZATION; SPINAL REFLEX; WITHDRAWAL REFLEX;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANESTHESIA; ANIMALS; BEE VENOMS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; FORMALDEHYDE; FUNCTIONAL LATERALITY; INJECTIONS, SUBCUTANEOUS; MALE; MUSCLE, SKELETAL; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; RATS, WISTAR; REFLEX; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS;

EID: 23644439195     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.04.009     Document Type: Article

References (50)

1. F.V. Abbott, K.B.J. Franklin, and R.F. Westbrook The formalin test: scoring properties of the first and second phases of the pain response in rats Pain 60 1995 91 102
2. L. Bardin, J.P. Tarayre, N. Malfetes, W. Koek, and F.C. Colpaert Profound, non-opioid analgesia produced by the high-efficacy 5-HT1A agonist F 13640 in the formalin model of tonic nociceptive pain Pharmacology 67 2003 182 194
3. F. Cervero, J.M. Laird, and E. Garcia-Nicas Secondary hyperalgesia and presynaptic inhibition: an update Eur. J. Pain 7 2003 345 351
4. V. Chapman, and A.H. Dickenson The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat Eur. J. Pharmacol. 219 1992 427 433
5. J. Chen, H.L. Li, C. Luo, Z. Li, and J.H. Zheng Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat Brain Res. 844 1999 98 105
6. J. Chen, C. Luo, H.L. Li, and H.S. Chen Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hind paw in the conscious rat: a comparative study with the formalin test Pain 83 1999 67 76
7. H.S. Chen, J. Chen, and Y.Y. Sun Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: a behavioral study in the conscious rat Neurosci. Lett. 284 2000 45 48
8. H.S. Chen, M.M. Li, J. Shi, and J. Chen Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat Anesthesiology 98 2003 1231 1236
9. T.J. Coderre, and J. Katz Peripheral and central hyperexcitability: differential signs and symptoms in persistent pain Behav. Brain Sci. 20 1997 404 419
10. T.J. Coderre, A.L. Vaccarino, and R. Melzack Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection Brain Res. 353 1990 155 158
11. R. Dallel, P. Raboisson, P. Clavelou, M. Saade, and A. Woda Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin Pain 61 1995 11 16
12. C.J. De Ruiter, A. De Haan, and A.J. Sargeant Physiological characteristics of two extreme muscle compartments in gastrocnemius medialis of the anaesthetized rat Acta Physiol. Scand. 153 1995 313 324
13. C.J. De Ruiter, A. De Haan, and A.J. Sargeant Fast-twitch muscle unit properties in different rat medial gastrocnemius muscle compartments J. Neurophysiol. 75 1996 2243 2254
14. A.H. Dickenson, and A.F. Sullivan Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones Neurosci. Lett. 83 1987 203 211
15. A.H. Dickenson, and A.F. Sullivan Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin Pain 30 1987 349 360
16. L.F. Donaldson Unilateral arthritis: contralateral effects Trends Neurosci. 22 1999 495 496
17. D. Dubuisson, and S.G. Dennis The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats Pain 4 1977 161 174
18. M. Fitzgerald Alterations in the ipsi- and contralateral afferent inputs of dorsal horn cells produced by capsaicin treatment of one sciatic nerve in the rat Brain Res. 248 1982 97 107
19. J.D. Hardy, H.G. Wolff, and H. Goodell Pain Sensations and Reactions 1952 Williams and Wilkins New York
20. J.L. Henry, K. Yashpal, G.M. Pitcher, and T.J. Coderre Physiological evidence that the 'interphase' in the formalin test is due to active inhibition Pain 82 1999 57 63
21. M. Klede, H.O. Handwerker, and M. Schmelz Central origin of secondary mechanical hyperalgesia J. Neurophysiol. 90 2003 353 359
22. W.R. Lariviere, and R. Melzack The bee venom test: a new tonic-pain test Pain 66 1996 271 277
23. D. Le Bars, M. Gozariu, and S.W. Cadden Animal models of nociception Pharmacol. Rev. 53 2001 597 652
24. K.C. Li, and J. Chen Altered pain-related behaviors and spinal neuronal responses produced by s.c. injection of melittin in rats Neuroscience 126 2004 753 762
25. A.R. Light, and E.R. Perl Reexamination of the dorsal root projection to the spinal dorsal horn including observation on the differential termination of course and fine fibers J. Comp. Neurol. 186 1979 117 132
26. T. Lewis Pain 1942 Macmillan London
27. C. Luo, J. Chen, H.L. Li, and J.S. Li Spatial and temporal expression of c-Fos protein in the spinal cord of anesthetized rat induced by subcutaneous bee venom injection Brain Res. 806 1998 175 185
28. W.D. McCall, K.D. Tanner, and J.D. Levine Formalin induces biphasic activity in C-fibers in the rat Neurosci. Lett. 208 1996 45 48
29. C.A. Parada, C.H. Tambeli, F.Q. Cunha, and S.H. Ferreira The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception Neuroscience 102 2001 937 944
30. G.M. Pitcher, and J.L. Henry Second phase of formalin-induced excitation of spinal dorsal horn neurons in spinalized rats is reversed by sciatic nerve block Eur. J. Neurosci. 15 2002 1509 1515
31. A. Poon, and J. Sawynok Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration Eur. J. Pharmacol. 286 1995 177 184
32. S. Puig, and L.S. Sorkin Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity Pain 64 1996 345 355
33. R. Radhakrishnan, S.A. Moore, and K.A. Sluka Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats Pain 104 2003 567 577
34. C.S. Sherrington The Integrative Action of the Nervous System 1906 Yale University Press New Haven
35. J. Schouenborg, and H.R. Weng Sensorimotor transformation in a spinal motor system Exp. Brain Res. 100 1994 170 174
36. H. Sumikura, O.K. Andersen, A.M. Drewes, and L. Arendt-Nielsen A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans Neurosci. Lett. 337 2003 147 150
37. A. Tjølsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
38. R.D. Treede, and W. Magerl Multiple mechanisms of secondary hyperalgesia Prog. Brain Res. 129 2000 331 341
39. R.D. Treede, R.A. Meyer, S.N. Raja, and J.N. Campbell Peripheral and central mechanisms of cutaneous hyperalgesia Prog. Neurobiol. 38 1992 397 421
40. W.D. Willis Hyperalgesia and allodynia: summary and overview W.D. Willis Hyperalgesia and Allodynia 1992 Raven Press New York, NY 1 11
41. T. Yamamoto, and N. Nozaki-Taguchi The role of cyclooxygenase-1 and -2 in the formalin test Anesth. Analg. 94 2002 962 967
42. D.K. Yi, and G.A. Barr Formalin-induced c-fos expression in the spinal cord of fetal rats Pain 73 1997 347 354
43. H.J. You, and J. Chen Differential effects of subcutaneous injection of formalin and bee venom on responses of wide-dynamic-range neurons in spinal dorsal horn of the rat Eur. J. Pain 3 1999 177 180
44. H.J. You, J. Chen, C.D. Morch, and L. Arendt-Nielsen Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization Brain Res. Bull. 58 2002 561 567
45. H.J. You, C.D. Mørch, J. Chen, and L. Arendt-Nielsen Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in rats Brain Res. 960 2003 235 245
46. H.J. You, C.D. Mørch, J. Chen, and L. Arendt-Nielsen Role of central NMDA versus non-NMDA receptor in spinal withdrawal reflex in spinal anesthetized rats under normal and hyperexcitable conditions Brain Res. 981 2003 12 22
47. H.J. You, C.D. Mørch, J. Chen, and L. Arendt-Nielsen Differential antinociceptive effects induced by a selective cyclooxygenase-2 inhibitor (SC-236) on dorsal horn neurons and spinal withdrawal reflexes in anesthetized spinal rats Neuroscience 121 2003 459 472
48. H.J. You, C.D. Mørch, and L. Arendt-Nielsen Electrophysiological characterization of facilitated spinal withdrawal reflex to repetitive electrical stimuli and its modulation by central glutamate receptor in spinal anesthetized rats Brain Res. 1009 2004 110 119
49. E.A. Ziegler, W. Magerl, R.A. Meyer, and R.D. Treede Secondary hyperalgesia to punctate mechanical stimuli. Central sensitization to A-fibre nociceptor input Brain 122 1999 2245 2257
50. M. Zimmermann Ethical guidelines for investigation of experimental pain in conscious animals Pain 16 1983 109 110