Structural basis for the activation of cholera toxin by human ARF6-GTP

Science

Volumn 309, Issue 5737, 2005, Pages 1093-1096

  O'Neal, Claire J ^a   Jobling, Michael G ^c   Holmes, Randall K ^c   Hol, Wim G J ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CRYSTAL STRUCTURE; PROTEINS;

BINDING PROPERTIES; DIARRHEA; HUMAN SIGNALING PROTEINS; TOXINS;

DISEASES;

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; CHOLERA TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

CHOLERA;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; PRIORITY JOURNAL; SOLUBILITY; VIBRIO CHOLERAE;

ADP-RIBOSYLATION FACTORS; AMINO ACID SEQUENCE; BINDING SITES; CHOLERA TOXIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; EVOLUTION, MOLECULAR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

VIBRIO CHOLERAE;

EID: 23644438026     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113398     Document Type: Article

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41. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
42. +;ARF6-GTP, and CTA1:ARF6(Q67L)-GTP structures have been deposited in the Protein Data Bank under accession codes 2ASD, 2A5F, and 2ASG, respectively.