Hydrophobicity engineering of cholera toxin A1 subunit in the strong adjuvant fusion protein CTA1-DD

Protein Engineering

Volumn 12, Issue 2, 1999, Pages 173-178

  Ågren, Lena ^a   Norin, Martin ^b   Lycke, Nils ^a   Löwenadler, Björn ^c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b PFIZER INC   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Adjuvant; ADP ribosylation; CTA1; Fusion protein; Protein engineering

Indexed keywords

CHOLERA TOXIN; DIMER; GLUTAMINE; HISTIDINE; HYBRID PROTEIN; IMMUNOGLOBULIN BINDING FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENYLALANINE; PROLINE; SERINE; STAPHYLOCOCCUS PROTEIN A;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STABILITY; GENETIC ENGINEERING; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR MODEL; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOLUBILITY;

ANIMALIA; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; TRIXIS;

EID: 0032934598     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/12.2.173     Document Type: Article

References (26)

1. Agren, L.C., Ekman, L., Lowenadler, B. and Lycke, N.Y. (1997). J. Immunol., 158, 3936.
2. Agren, L., Lowenadler, B. and Lycke, N. (1998). Immunol. Cell Biol., 76, 280.
3. Bromander, A.K., Ekman, L., Kopf, M., Nedrud, J.G. and Lycke, N.Y. (1996). J. Immunol., 156, 4290.
4. Burnette, W.N., Kaslow, H.R. and Moss, J. (1995). Adv. Exp. Med. Biol., 2, 1513.
5. De Magistris, M.T., Pizza, M., Douce, G., Ghiara, P., Dougan, G. and Rappuoli, R. (1998). Dev. Biol. Stand., 92, 123.
6. Domerighini, M., Montecucco, C., Ripka, W.C. and Rappuoli, R. (1991). Mol. Biol., 5, 23.
7. Donaldson, J.G. and Klausner, R.D. (1994). Curr. Opin. Cell Biol., 6, 527.
8. Douce, G., Fontana, M., Pizza, M., Rappuoli, R. and Dougan, G. (1997). Infect. Immun., 65, 2821.
9. Eisenberg, D. and McLachlan, A.D. (1986). Nature, 319, 199.
10. Elson, C.O. and Dertzbaugh, M.T. (1994). In Ogra, P.L., Mestecky, J., Lamm, M.E., Strober, W., McGhee R. and Bienenstock, J. (eds), Handbook of Mucosal Immunology. San Diego, p. 391.
11. Francis, M.L., Okazaki, I., Moss, J., Kurosky, A., Pecanha, L.M. and Mond, J.J. (1995). J. Immunol., 154, 4956.
12. Giuliani, M.M., Del Giudice, G., Giannelli, V., Dougan, G., Douce, G., Rappuoli, R. and Pizza, M. (1998). J. Exp. Med., 187, 1123.
13. Levine, M.M., Kaper, J.B., Black, R.E. and Clements, M.L. (1983). Microbiol. Rev., 47, 510.
14. Ljungberg, U.K., Jansson, B., Niss, U., Nilsson, R., Sandberg, B.E. and Nilsson, B. (1993). Mol. Immunol., 30, 1279.
15. Lycke, N. (1996). In Kagnoff, M. and Kiyono, H. (eds), Essentials in Mucosal Immunology. Academic Press, San Diego, p. 563.
16. Mekalanos, J.J., Swartz, D.J., Pearson, G., Harford, N., Groyne, F. and Wilde, M. (1983). Nature, 306, 551.
17. Merritt, E.A., Sarfaty, S., van den Akker, F., L'Hoir, C., Martial, J.A. and Hol, W.G.J. (1994). Protein Sci., 3, 166.
18. Moss, J., Tsai, S.C. and Vaughan, M. (1994). Methods Enzymol., 235, 640.
19. Nilsson, B., Moks, T., Jansson, B., Abrahamsén, L., Elmblad, A., Holmgren, E., Henrichson, C., Jones, A.T. and Uhlén, M. (1987). Protein Engng, 1, 107.
20. Sixma, T.K., Pronk, S.E., et al. (1991). Nature 351, 371.
21. Sixma, T.K., Kalk, K.H., van Zanten, B.A., Dauter, Z., Kingma, J., Witholt, B. and Hol, W.G. (1993). J. Mol. Biol., 230, 890.
22. Sofer, A. and Futerman, A.H. (1996). J. Neurochem., 67, 2134.
23. Spangler, B.D. (1992). Microbiol. Rev., 56, 622.
24. Tsuji, T., Inoue, T., Miyama, A., Okamoto, K., Honda, T. and Miwatani, T. (1990). J. Biol. Chem., 265, 22520.
25. Yamamoto, S., Takeda, Y., Yamamoto, M., Kurazono, H., Imaoka, K., Yamamoto, M., Fujihashi, K., Noda, M., Kiyono, H. and McGhee, J.R. (1997). J. Exp. Med., 185, 1203.
26. Zhang, R.G., Scott, D.L., Westbrook, M.L., Nance, S., Spangler, B.D., Shipley, G.G. and Westbrook, E.M. (1995). J. Mol. Biol., 251, 563.