Organic synthesis in micro reactors

Current Topics in Medicinal Chemistry

Volumn 4, Issue 7, 2004, Pages 707-727

  Feng, Xi Zeng ^a   Haswell, Stephen J ^a   Watts, Paul ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DINITROBENZENE; 2 AMINOTHIAZOLE DERIVATIVE; 2 NAPHTHOL; ANILINE; BENZENE; BENZENEBORONIC ACID; CARBON DIOXIDE; CARBOXYLIC ACID; ETHYLENEDIAMINE DERIVATIVE; FLUORINE; HALIDE; HEXANOL; HYDRAZINE; METHANOL; N,N DIMETHYLANILINE; NITROBENZENE; NITROBENZENE DERIVATIVE; PHOSPHONIUM DERIVATIVE; RUTHENIUM DERIVATIVE; TETRAHYDROFURAN; DRUG; ORGANIC COMPOUND;

AUTOMATION; BATCH REACTOR; CATALYSIS; CELL STRAIN CACO 2; CHEMICAL REACTION; CHEMICAL STRUCTURE; COMBINATORIAL LIBRARY; CONTINUOUS FLOW REACTOR; DRUG SYNTHESIS; ELECTRONICS; ELECTROOSMOSIS; ELECTROPHORETIC MOBILITY; FLUORINATION; IONIZATION; LIQUID PHASE MICROEXTRACTION; NITRATION; NONHUMAN; REACTOR OPTIMIZATION; REVIEW; DRUG DESIGN; EQUIPMENT DESIGN; GENETIC PROCEDURES; INSTRUMENTATION; PHARMACEUTICS; SYNTHESIS;

BIOSENSING TECHNIQUES; DRUG DESIGN; EQUIPMENT DESIGN; MINIATURIZATION; ORGANIC CHEMICALS; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 2342629326     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026043451041     Document Type: Review

References (113)

1. Bradley, D., Chemical reduction, European Chemist, 1999, 1, 17.
2. Fletcher, P. D. I.; Haswell, S. J., Downsizing synthesis, Chem. Br., 1999, 35, 38.
3. Cowen, S., Chip service, Chem. & Ind., 1999, 2 August, 584.
4. McCreedy, F., Reducing the risks of synthesis, Chem. & Ind., 1999, 2 August, 588.
5. Barrow, D.; Cefai, J.; Taylor, S., Shrinking to fit, Chem. & Ind., 1999, 2 August, 591.
6. Cooper, J.; Disley, D.; Cass, T., Lab-on-a-chip and microarrays, Chem. & Ind., 2001, 15 Oct., 653.
7. Haswell, S. J.; Middleton, R. J.; O'Sullivan, B.; Skelton, V.; Watts, P.; Styring, P., The application of micro reactors to synthetic chemistry, Chem. Commun., 2001, 5, 391.
8. Matlosz, M.; Ehrfeld, W.; Baselt J. P. (eds.), IMRET 5: Proceedings of the Fifth International Conference on Microreaction Technology, Springer, Berlin, 2002.
9. Ehrfeld, W.; Hessel, V.; Löwe, H., Microreactors: New Technology for Modern Chemistry, Wiley-VCH, 2000.
10. Haswell, S. J., Development and operating characteristics of micro flow injection analysis systems based on electroosmotic flow, Analyst, 1997, 122, 1R.
11. Manz, A.; Harrison, D. J.; Verpoone, E.; Fettinger, J. C.; Ludi, H.; Widmer, H. M., Miniaturization of chemical analysis systems - a look into next century technology or just a fashionable craze, Chimia, 1991, 45, 103.
12. Manz, A.; Harrison, D. J.; Verpoorte, E.; Widmer, H. M., Planar chip technology for miniaturization of separating systems - a developing perspective in chemical monitoring, Adv. Chromatogr., 1993, 33, 1.
13. Freemantle, M., Downsizing chemistry, C&EN, 1999, 22 February, 27.
14. Harrison, D. J.; van den Berg, A. (eds.), Proceedings of the Micro Total Analytical Systems '98 Workshop, Kluwer Academic Press, Dordrecht, 1998.
15. van den Berg, A.; Lammerink, T. S. J., Micro total analysis systems: microfluidic aspects, integration concept and applications, Topics of Curr. Chem., 1998, 194, 21.
16. Harrison, D. J.; Fluri, K.; Seiler, K.; Fan, Z. H.; Effenhauser, C. S.; Manz A., Micromachining a miniaturized capillary electrophoresis-based chemical-analysis system on a chip, Science, 1993, 261, 895.
17. Jacobson, S. C.; Hergenroder, R.; Koutny, L. B.; Ramsey J. M., High-speed separations on a microchip, Anal. Chem., 1994, 66, 1114.
18. Woolley, A. T.; Hadley, D.; Ladre, P.; DeMello, A. J.; Mathies, R. A.; Northrup, M. A., Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device, Anal. Chem., 1996, 68, 4081.
19. Woolley A. T.; Mathies R. A., Ultra-high-speed DNA sequencing using capillary electrophoresis chips, Anal. Chem., 1995, 67, 3676.
20. Woolley, A. T.; Sensabaugh, G. F.; Mathies R. A., High-speed DNA genotyping using microfabricated capillary array electrophoresis chips. Anal. Chem., 1997, 69, 2181.
21. Jacobsen, S. C.; Ramsey J. M., Integrated microdevice for DNA restriction fragment analysis, Anal. Chem., 1996, 68, 720.
22. Effenhauser, C. S.; Paulus, A.; Manz, A.; Widmer, H. M., High-speed separation of antisense oligonucleotides on a micromachined capillary electrophoresis device, Anal. Chem., 1994, 66, 2949.
23. Schmalzing, D.; Adourian, A.; Koutny, L.; Ziagura, L.; Matsuclaria, P.; Ehrlich D., DNA sequencing on microfabricated electrophoretic devices, Anal. Chem., 1998, 70, 2303.
24. Spence, D. M.; Crouch S. R., Factors affecting zone variance in a capillary flow injection system, Anal. Chem., 1997, 69, 165.
25. Service, R. F., Microchip arrays put DNA on the spot, Science, 1998, 282, 396.
26. Madou, M. Fundamentals of Microfabrication, CRC Press, Boca Raton, 1997.
27. McCreedy, T., Fabrication techniques and materials commonly used for the production of micro reactors and micro total analytical systems, TrAC, 2000, 19, 396.
28. McCreedy, T., Rapid prototyping of glass and PDMS microstructures for micro total analytical systems and micro chemical reactors by microfabrication in the general laboratory, Anal. Chim. Acta., 2001, 427, 39.
29. Overbeek, J. Th.G. in Colloid Science, Vol. 1, Ed. H.R. Kruyt, Elsevier, Amsterdam, 1952, Chap. V, 195.
30. Rice, C. L.; Whitehead, R., Electrokinetic flow in a narrow cylindrical capillary, J. Phys. Chem., 1965, 69, 4017.
31. Hunter, R. J., Zeta Potential in Colloid Science, Academic Press, London, 1981.
32. Jednacak, J.; Pravdic, V.; Haller W., The electrokinetic potential of glasses in aqueous electrolyte solutions, J. Colloid Interface Sci., 1974, 49, 16.
33. Paul, P. H.; Garguilo, M. G.; Rakestraw, D. J., Imaging of pressure and electrokinetically driven flows through open capillaries, Anal. Chem., 1998, 70, 2459.
34. Salimi-Moosavi, H.; Tang, T.; Harrison, D. J., Electroosmotic pumping of organic solvents and reagents in microfabricated reactor chips, J. Am. Chem. Soc., 1997, 119, 8716.
35. Wootton, R. C. R.; Fortt, R.; de Mello, A. J., On-chip generation and reaction of unstable intermediates - monolithic nanoreactors for diazonium chemistry: Azo dyes, Lab on a Chip, 2002, 2, 5.
36. Doku, G. N.; Haswell, S. J.; McCreedy, T.; Greenway G. M., Electric field-induced mobilisation of multiphase solution systems based on the nitration of benzene in a micro reactor, Analyst, 2001, 126, 14.
37. Burns, J. R.; Ramshaw, C. G., IMRET 4: 4th International Conference of Micro Reaction Technology Topical Conference Proceedings, AIChE Spring National Meeting, March 5-9 2000, Atlanta GA, USA, p 133.
38. Skelton, V.; Greenway, G. M.; Haswell, S. J.; Styring, P.; Morgan, D. O.; Warrington, B.; Wong S. Y. F., The preparation of a series of nitrostilbene ester compounds using micro reactor technology, Analyst, 2001, 126, 7.
39. Skelton, V.; Greenway, G. M.; Haswell, S. J.; Styring, P.; Morgan, D. O., Warrington, B.; Wong, S. Y. F., The generation of concentration gradients using electroosmotic flow in micro reactors allowing stereoselective chemical synthesis, Analyst, 2001, 126, 11.
40. Sands, M.; Haswell, S. J.; Kelly, S. M.; Skelton, V.; Morgan, D. O.; Styring, P.; Warrington, B. H., The investigation of an equilibrium dependent reaction for the formation of enamines in a microchemical system, Lab on a Chip, 2001, 1, 64.
41. Wiles, C.; Watts, P.; Haswell, S. J.; Pombo-Villar E., The aldol reaction of silyl enol ethers within a micro reactor, Lab on a Chip, 2001, 1, 100.
42. Wiles, C.; Watts, P.; Haswell, S. J.; Pombo-Villar E., 1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor, Lab on a Chip, 2002, 2, 62.
43. Garcia-Egido, E.; Wong, S. Y. F.; Warrington, B. H., Synthesis of a three-member array of cycloadducts in a glass microchip under pressure driven flow, Lab on a Chip, 2002, 2, 170.
44. Fernandez-Suarez, M.; Wong, S. Y. F.; Warrington, B. H., A Hantzsch synthesis of 2-aminothiazoles performed in a heated microreactor system, Lab on a Chip, 2002, 2, 31.
45. Lu, H.; Schmidt, M. A.; Jenson K. F., Photochemical reactions and on-line UV detection in microfabricated reactors, Lab on a Chip, 2001, 1, 22.
46. Pitts, J. N.; Letsinger, R. L.; Taylor, R. P.; Patterson, J. M.; Recktenwald, G.; Martin, R. B., Photochemical reactions of benzophenone in alcohols, J. Am. Chem. Soc., 1959, 81, 1068.
47. Wootton, R. C. R.; Fortt, R.; de Mello, A. J., A microfabricated nanoreactor for safe, continuous generation and use of singlet oxygen, Organic Process Research and Development, 2002, 6, 187.
48. Hisamoto, H.; Saito, T.; Tokeshi, M.; Hibara, A.; Kitamori, T., Fast and high conversion phase-transfer synthesis exploiting the liquid-liquid interface formed in a microchannel chip, J. Chem. Soc., Chem. Commun., 2001, 2662.
49. Watts, P.; Wiles, C.; Haswell, S. J.; Pombo-Villar, E.; Styring, P., The synthesis of peptides using micro reactors, J. Chem. Soc., Chem. Commun., 2001, 990.
50. Watts, P.; Wiles, C.; Haswell, S. J.; Pombo-Villar, E., Solution phase synthesis of β-peptides using micro reactors, Tetrahedron, 2002, 58, 5427.
51. Carpino, L. A.; Han G. Y., 9-Fluorenylmethoxycarbonyl amino-protecting group, J. Org. Chem., 1972, 37, 3404.
52. t solid-phase chemistry, J. Chem. Soc., Chem. Commun., 1995, 2209.
53. Watts, P.; Wiles, C.; Haswell, S. J.; Pombo-Villar, E., Investigation of racemisation in peptide synthesis within a micro reactor, Lab on a Chip, 2002, 2, 141.
54. Greenway, G. M.; Haswell, S. J.; Morgan, D. O.; Skelton, V.; Styring, P., The use of a novel microreactor for high throughput continuous flow organic synthesis, Sensors & Actuators B, 2000, 63, 153.
55. Wilson, N. G.; McCreedy T., On-chip catalysis using a lithographically fabricated glass microreactor-the dehydration of alcohols using sulfated zirconia, J. Chem. Soc., Chem. Commun., 2000, 733.
56. McCreedy, T.; Wilson, N. G., Microfabricated reactors for on-chip heterogeneous catalysis, Analyst, 2001, 126, 21.
57. Haswell, S. J.; O'Sullivan, B.; Styring, P., Kumada-Corriu reactions in a pressure-driven microflow reactor, Lab on a Chip, 2001, 1, 164.
58. Dietzsch, E.; Hönicke, D.; Fichtner, M.; Schubert, K.; Weißmeier, G., IMRET 4: 4th International Conference of Micro Reaction Technology Topical Conference Proceedings, AIChE Spring National Meeting, March 5-9 2000, Atlanta GA, USA, p 89.
59. Rozen, S., Elemental fluorine: not only for fluoroorganic chemistry, Acc. Chem. Res., 1996, 21, 243.
60. Purrington, S. T.; Kagen, B. S.; Patrick T. B., The application of elemental fluorine in organic synthesis, Chem. Rev., 1986, 86, 997.
61. Chambers, R. D.; Spink, R. C. H., Microreactors for elemental fluorine, J. Chem. Soc., Chem. Commun., 1999, 883.
62. Chambers, R. D.; Holling, D.; Spink, R. C. H.; Sandford, G., Elemental fluorine. Part 13. Gas-liquid thin film microreactors for selective direct fluorination,Lab on a Chip, 2001, 1, 132.
63. Chambers, R. D.; Greenhall, M. P.; Hutchinson, J., Direct Fluorination of 1,3-Dicarbonyl Compounds, Tetrahedron, 1996, 52, 1.
64. Chambers, R. D.; Grievson, B.; Drakesmith, F. G.; Powell, R. L., Free radical chemistry. Part 5. [1] A new approach to the synthesis of perfluorinated ethers. J. Fluorine Chem., 1985, 29, 323.
65. de Mas, N.; Jackman, R. J.; Schmidt, M. A.; Jenson K. F., IMRET 5: Proceedings of the Fifth International Conference on Microreaction Technology, Springer, Berlin, 2002, 60.
66. Srinivasan, R.; Hsing, I.-M.; Berger, P. E.; Jensen, K. F.; Firebaugh, S. L.; Schmidt, M. A.; Harold, M. P.; Lerou, J. J.; and Ryley, J. F., Micromachined reactors for catalytic partial oxidation reactions, AIChE J., 1997, 43 (11), 3059.
67. Hessel, V.: Ehrfeld, W.; Golbig, K.; Hofman, C.; Jungwirth, S.; Löwe, H.; Richter, T.; Storz, M.; Wolf, A., IMRET 3: Proceedings of the third conference on microtechnology, 2000, 151.
68. Xia, Y.; Whitesides, G. M., Soft lithography, Annu. Rev. Mater. Sci. 1998, 28, 153-184.
69. Mrksich, M.; Whitesides, G. M., Patterning self-assembled monolayers using microcontact printing - a new technology for biosensors, Trends Biotechnol., 1995, 13, 228-235.
70. Anderson, H.; Jonsson, C.; Moberg, C.; Stemme, G., Consecutive microcontact printing - ligands for asymmetric catalysis in silicon channels, Sens. Actuators B, 2001, 79, 78-84.
71. Fodor, S. P. A.; Reed, J. L.; Pirrung, M. C.; Stryer, L.; Lu, A. T.; Solas, D., Light-directed, spatially addressable parallel chemical synthesis, Science, 1991, 251, 767-773.
72. Patel, N.; Padera, R.; Sanders, G. H. W.; Cannizzaro, S. M.; Davies, M. C.; Langer, R.; Roberts, C. J.; Tendler, S. J. B.; Williams, P. M.; Shakesheff, K. M., Spatially controlled cell engineering on biodegradable polymer surfaces, FASEB, J., 1998, 112, 1447-1454.
73. Aga, D. S.; Thyrman, E. M., Immunochemical Technology for Environmental Applications, ACS Symposium Series 657, American chemical Society: Washington, DC 1996.
74. Diamandis, E. P.; Christopoulos, T. K., Immunoassay, Academic Press: San Diego, 1996.
75. Gosling, J. P., A decade of development in immunoassay methodlogy, Clin. Chem., 1990, 36, 1408-1427.
76. Proudnikov, D.; Timofeev, E.; Mirzabekov, A., Immobilization of DNA in polyacrylamide gel for the manufacture of DNA and DNA-oligonucleotide microchips, Anal. Biochem., 1998, 259, 34-41.
77. Schena, M.; Sharon, D.; Heller, R.; Chai, A.; Brown, P. O.; Davis, R. W., Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes, Proc. Natl. Acad. Sci. U.S.A., 1996, 93, 10614-10619.
78. Guo, Z.; Guilfoyle, R. A.; Thiel, A. J.; Wang, R.; Smith, L. M., Direct fluorescence analysis of genetic polymorphisms by hybridization with oligonucleonucleotide, Nucleic Acids Res., 1994, 22 (24), 5456-5465.
79. Hacia, J. G.; Woski, S. A.; Fidanza, J.; Edgemon, K.; Hunt, N.; McGall, G.; Fodor, S. P. A.; Collins, F. S., Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates, Nucleic Acids Res., 1998, 26 (21), 4975-4982.
80. Hacia, J. G.; Makalowski, W.; Edgemon, K.; Erdos, M. R.; Robbins, C. M.; Fodor, S. P.; Brody, J. L.; Collins, F. S., Evolutionary sequence comparisons using high-density oligonucleotide arrays, Nat. Genet., 1998, 18 (2), 155-158.
81. Uetz, P.; Giot, L.; Cagney, G.; Mansfield, T. A.; Judson, R. S.; Knight, G. P.; Lockshon, D.; Narayan, V.; Srinivason, M.; Pochart, P.; Qureshi-Emili, A.; Li, Y.; Godwin, B.; Conover, D.; Kalbfleisch, T.; Vijayada-modar, G.; Yang, M.; Johnston, M.; Fields, S.; Rothberg, J. M., A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae, Nature, 2000, 403, 623-627.
82. Lyer, V. R.; Horak, C. E.; Scafe, C. S.; Botstein, D.; Snyder, M.; Brown, P. O., Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF, Nature, 2001, 409, 533-538.
83. Piunno, P. A. E.; Krull, U. J.; Hudson, R. H. E.; Damha, M. J.; Cohen, H., Fibre optic biosensor for fluorometric detection of DNA hybridization, Anal. Chim. Acta, 1994, 288, 205-214.
84. Liedberg, B.; Nylander, C.; Lundstrom, I., Surface-plasmon resonance for gas-detection and biosensing, Sens. Actuators, 1983, 4, 299-304.
85. Kielar, D.; Dietmaier, W.; Langmann, T.; Aslanidis, C.; Probst, M.; Naruszewicz, M.; Schmitz, G., Rapid quantification of human ABCA1 mRNA in various cell types and tissues by real-time reverse transcription-PCR, Clin. Chem., 2001, 47, 2089-2097.
86. Kumke, M. U.; Guang Li, G.; McQown, L. B., Hybridization of Fluorescein-Labeled DNA Oligomers Detected by Fluorescence Anisotropy with Protein Binding Enhancement, Anal. Chem., 1995, 67, 3945-3951.
87. Vaitukaitis, J. L., Radioimmunoassay of human chorio-gonadotropin, Clin. Chem., 1985, 31, 1749.
88. Hynes, R. O., Integrins-versatility, modulation, and signaling in cell adhesion, Cell, 1992, 69, 11-25.
89. Faull, R. J.; Kovach, N. L.; Harlan, J.; Ginsberg, M. H., Affinity modulation of integrin alpha-5-beta-1-regulation of the functional-response by soluble fibronectin, J. Cell Biol. 1993, 121, 155-162.
90. Garcia, A. J.; Huber, F.; Boettiger, D., Force required to break alpha(5)beta(1) integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state. J. Biol. Chem. 1998, 273, 10988-10993.
91. Lotz, M. M.; Burdsal, C. A.; Erickson, H. P.; McClay, D. R., Cell-adhesion to fibronectin and tenascin-quantitative measurements of initial binding and subsequent strengthening response, J. Cell Biol. 1989, 109, 1795-1805.
92. Choquet, D.; Felsenfield, D. P.; Sheetz, M. P., Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages, Cell 1997, 88, 39-48.
93. Garcia, A. J.; Takagi, J.; Boettiger, D., Two-stage activation for alpha(5)beta(1) integrin binding to surface-adsorbed fibronectin, J. Biol. Chem. 1998, 273, 34710-34715.
94. Lopez, G. P.; Albers, M. W.; Schreiber, S. L.; Carroll, R.; Peralta, E.; Whitesides, G. M., Convenient methods for patterning the adhesion of mammallan-cell to surfaces using self-assembled monolayers of alkanethiolates on gold, J. Am. Chem. Soc. 1993, 115, 5877-5878.
95. Singhvi, R.; Kumar, A.; Lo'pez, G. P.; Stephanopoulos, G. N.; Wang, D. I. C.; Whitesides, G. M.; Ingber, D. E., Engineering cell-shape and function, Science, 1994, 264, 696-698.
96. Mrksich, M.; Chen, C. S.; Xia, Y.; Dike, L. E.; Ingber, D. E.; Whitesides, G. M., Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold, Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 10775-10778.
97. Mrksich, M.; Dike, L. E.; Tien, J.; Ingber, D. E.; Whitesides, G. M., Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver, Exp. Cell Res. 1997, 235, 305-313.
98. Chen, C. S.; Mrksich, M.; Huang, S.; Whitesides, G. M.; Ingber, D. E., Geometric control of cell life and death, Science 1997, 276, 1425-1428.
99. Yousaf, M. N.; Houseman, B. T.; Mrksich, M., Using electroactive substrates to pattern the attachment of two different cell populations, Proc. Natl. Acad. Sci. USA 2001, 98, 5992-5996.
100. Amirpour, M. L.; Ghosh, P.; Lackowski, W. M.; Crooks, R. M.; Pishko, M. V., Mammalian cell cultures on micropatterned surfaces of weak-acid, polyelectrolyte hyperbranched thin films on gold, Anal. Chem. 2001, 73, 1560-1566.
101. Folch, A.; Ayon, A.; Hurtado, O.; Schmidt, M. A.; Toner, M., Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications, J. Biomech. Eng. 1999, 121, 28-34.
102. Delamarche, E., Bernard, A., Schmid, H., Michel, B., Biebuyck, H. A., Patterned delivery of immunoglobulins to surfaces using microfluidic networks, Science, 1997, 276, 779-781.
103. Delamarche, E., Bernard, A., Schmid, H., Michel, B., Biebuyck, H. A., Microfluidic networks for chemical patterning of substrate: Design and application to bioassays, J. Am. Chem. Soc., 1998, 120, 500-508.
104. Rowe, C. A.; Scruggs, S. B.; Feldstein, M. J.; Golden, J. P.; Ligler, F. S., An array immunosensor for simultaneous detection of clinical analytes, Anal. Chem., 1999, 71, 433-439.
105. Bernard, A.; Renault, J. P.; Michel, B.; Bosshard, H. R.; Delamarche, E., Microcontact printing of proteins, Adv. Mater., 2000, 12, 1067-1070.
106. Geissler, M.; Bernard, A.; Bietsch, A.; Schmid, H.; Michel, B.; Delamarche, E., Microcontact-printing chemical patterns with flat stamps, J. Am. Chem. Soc., 2000, 122, 6303-6304.
107. Singhvi, R.; Kumar, A.; Lopez, G. P.; Stephanopoulos, G. N.; Wang, D. I. C.; Whitesides, G. M.; Ingber, D. E., Engineering cell-shape and function, Science, 1994, 264, 696-698.
108. Kovacs, G. T. A.; Petersen, K.; Albin, M., Silicon micromachining - Sensors to systems, Anal. Chem., 1996, 68, A407-A412.
109. Grunze, M., Surface science - Driven liquids, Science, 1999, 283, 41-42.
110. Jacobson, S. C., Ramsey, J. M., Integrated microdevice for DNA restriction fragment analysis, Anal. Chem., 1996, 68, 720-723.
111. Blankenstein, G.; Larsen, U. D., Modular concept of a laboratory on a chip for chemical and biochemical analysis, Biosens. Bioelectron, 1998, 13, 427-438.
112. Kopp, M. U., De Mello, A. J., Manz, A., Chemical amplification: Continuous-flow PCR on a chip, Science, 1998, 280, 1046-1048.
113. van der Schoot, B. H.; Jeanneret, S.; van den Berg, A.; de Rooij, N. F., A Modular miniaturized chemical-analysis system, Sens. Actuators B, 1993, 13, 333-335.