Functional subsets of CD4 T cells in rheumatoid synovitis

Arthritis and Rheumatism

Volumn 41, Issue 12, 1998, Pages 2108-2116

  Namekawa, Takashi ^a   Wagner, Ulf G ^a   Goronzy, Jörg J ^a   Weyand, Cornelia M ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL ARTICLE; FLOW CYTOMETRY; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVITIS; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD28; ANTIGENS, CD40; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CLONE CELLS; GRANZYMES; HUMANS; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; SERINE ENDOPEPTIDASES; SYNOVITIS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032417125     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199812)41:12<2108::AID-ART5>3.0.CO;2-Q     Document Type: Article

References (15)

1. Harris ED. Rheumatoid arthritis. Philadelphia: WB Saunders; 1997.
2. Kurosaka M, Ziff M. Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med 1983;158:1191-210.
3. Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
4. Feldmann M, Brennan FM, Maini RN. Rheumatoid arthritis. Cell 1996;85:307-10.
5. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
6. Winchester R. The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol 1994;56:389-466.
7. Todd JA, Acha-Orbea H, Bell JI, Chao N, Fronek Z, Jacob CO, et al. A molecular basis for MHC class II-associated autoimmunity. Science 1988;240:1003-9.
8. Nepom GT, Erlich H. MHC class-II molecules and autoimmunity. Annu Rev Immunol 1991;9:493-525.
9. Goronzy JJ, Weyand CM. T cells in rheumatoid arthritis: paradigms and facts. Rheum Dis Clin North Am 1995;21:655-74.
10. Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 1996;93:221-5.
11. Wagner UG, Kurtin PJ, Wahner A, Brackertz M, Berry DJ, Goronzy JJ, et al. The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis. J Immunol. In press.
12. Schmidt D, Goronzy JJ, Weyand CM. CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 1996;97:2027-37.
13. Martens PB, Goronzy JJ, Schaid D, Weyand CM. Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. Arthritis Rheum 1997;40:1106-14.
14. Goronzy JJ, Bartz-Bazzanella P, Hu W, Jendro MC, Walser-Kuntz DR, Weyand CM. Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis. J Clin Invest 1994;94:2068-76.
15. Vallejo AN, Nestel AR, Schirmer M, Weyand CM, Goronzy JJ. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene specific nuclear factor binding activity. J Biol Chem 1998;273:8119-29.