Adenovirus expressing RIZ1 in tumor suppressor gene therapy of microsatellite-unstable colorectal cancers

Cancer Research

Volumn 61, Issue 5, 2001, Pages 1796-1798

  Jiang, G L ^a   Huang, S ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS VECTOR; ZINC FINGER PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SILENCING; GENE THERAPY; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RETINOBLASTOMA; TUMOR SUPPRESSOR GENE; VIRUS INFECTION; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; MICROSATELLITE REPEATS; MUTATION; NUCLEAR PROTEINS; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035266378     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cancer statistics, 1999
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3. Cancer epigenetics comes of age
4. Microsatellite instability in cancer of the proximal colon
5. Clues to the pathogenesis of familial colorectal cancer
6. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
7. Microsatellite instability in inherited and sporadic neoplasms
8. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
9. The retinoblastoma protein binds to RIZ, a zinc finger protein that shares an epitope with the adenovirus E1A protein
10. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression
11. The yin-yang of PR-domain family genes in tumorigenesis
12. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain lacking product through an internal promoter
13. The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers
14. 2-M cell cycle arrest and/or apoptosis
15. Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1
16. Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis
17. Frequent frameshift mutations of RIZ in human gastrointestinal and endometrial carcinomas with microsatellite instability
18. RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum
19. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer