Receptor revision in T cells: An open question?

Trends in Immunology

Volumn 25, Issue 6, 2004, Pages 276-279

  Mostoslavsky, Raul ^a   Alt, Frederick W ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN PRESENTING CELL; B LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; INTERNALIZATION; NONHUMAN; REVIEW; STEM CELL; T LYMPHOCYTE;

EID: 2342517251     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2004.04.001     Document Type: Article

References (40)

1. Gorman J.R., Alt F.W. Regulation of immunoglobulin light chain isotype expression. Adv. Immunol. 69:1998;113-181
2. Berg L.J., Kang J. Molecular determinants of TCR expression and selection. Curr. Opin. Immunol. 13:2001;232-241
3. Grawunder U., et al. Down-regulation of RAG1 and RAG2 gene expression in pre-B cell after functional immunoglobulin heavy chain rearrangement. Immunity. 3:1996;601-608
4. Wilson A., et al. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1994;1355-1360
5. Schatz D.G., et al. The V(D)J recombination activating gene, RAG1. Cell. 59:1989;1035-1048
6. Turka L.A., et al. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science. 253:1991;778-781
7. Borgulya P., et al. Exclusion and inclusion of α and β T cell receptor alleles. Cell. 69:1992;529-537
8. Nemazee D., Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:1989;562-566
9. Murakami M., et al. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature. 357:1992;77-80
10. Rathmell J.C., Thompson C.B. Pathways of apoptosisin lymphocyte development, homeostasis and disease. Cell. 109:2000;S97-107
11. Gay D., et al. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:1993;999-1008
12. Tiegs S.L., et al. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1993;1009-1020
13. Pelanda R., et al. Receptor editing in a transgenic mouse model: site, efficiency and role in B cell tolerance and antibody diversification. Immunity. 7:1997;765-775
14. Casellas R., et al. Contribution of receptor editing to the antibody repertoire. Science. 291:2001;1541-1544
15. Nemazee D., Hogquist K.A. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol. 15:2003;182-189
16. Hikida M., et al. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science. 274:1996;2092-2094
17. Han S., et al. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science. 274:1996;2094-2097
18. Papavasiliou F., et al. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 278:1997;298-301
19. Han S., et al. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:1997;301-305
20. Monroe R.J., et al. RAG2-GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 11:1999;201-211
21. Yu W., et al. Continued RAG-expression in late stages of B cell development and no apparent re-induction after immunization. Nature. 400:1999;682-687
22. Nagaoka H., et al. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. J. Exp. Med. 191:2000;2113-2120
23. Gartner F., et al. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleen of immunized mice. J. Exp. Med. 192:2000;1745-1754
24. Igarashi H., et al. Localization of recombination activating gene1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice. Blood. 97:2001;2680-2687
25. Wang F., et al. Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation. Proc. Natl. Acad. Sci. U. S. A. 95:1998;11834-11839
26. McGargill M.A., et al. Receptor editing in developing T cells. Nat. Immun. 4:2000;336-341
27. Buch T., et al. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity. 16:2002;707-718
28. Holman P.O., et al. The central tolerance response to male antigen in normal mice is deletion and not receptor editing. J. Immunol. 171:2003;4048-4053
29. Mayerova D., Hogquist K.A. Central tolerance to self-antigen expressed by cortical epithelial cells. J. Immunol. 172:2004;851-856
30. + T cells. Immunity. 9:1998;637-647
31. low mature T lymphocytes. J. Immunol. 164:2000;3455-3459
32. Roose J.P., et al. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 1:2003;271-287. (10.1371/journal.pbio.0000053)
33. Keren Z., et al. Modification of ligand independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J. Biol. Chem. 279:2004;13418-13424
34. Vaitaitis G.M., et al. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG 2: a mechanism for the generation of autoaggressive T cells in the periphery. J. Immunol. 170:2003;3455-3459
35. + T lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 99:2002;15566-15571
36. Huang C.-Y., et al. Superantigen-induced TCRα locus secondary rearrangement: role in tolerance induction. J. Immunol. 168:2002;3259-3265
37. Cooper C.J., et al. T cell receptor revision does not solely target recent thymic emigrants. J. Immunol. 171:2003;226-233
38. Kondo E., et al. Expression of recombination-activating gene in mature peripheral T cells in Peyer's patch. Int. Immunol. 15:2003;393-402
39. Bassing C.H., et al. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109:(Suppl.):2002;S45-S55
40. Guy-Grand D., et al. Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 197:2003;333-341