-
1
-
-
0022597650
-
Tropical or malnutrition-related diabetes: A real syndrome?
-
Abu-Bakare A, Taylor R, Gill GV & Alberti KC 1986 Tropical or malnutrition-related diabetes: a real syndrome? Lancet 17 1135-1138.
-
(1986)
Lancet
, vol.17
, pp. 1135-1138
-
-
Abu-Bakare, A.1
Taylor, R.2
Gill, G.V.3
Alberti, K.C.4
-
2
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, Johnson RS & Kahn CR 1994 Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372 186-190.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag III, B.5
Johnson, R.S.6
Kahn, C.R.7
-
3
-
-
0037145865
-
Blockade of IRS-1 in isolated rat pancreatic islets improves glucose-induced insulin secretion
-
Araujo EP, Amaral ME, Souza CT, Bordin S, Ferreira F, Saad MJ, Boschero AC, Magalhaes EC & Velloso LA 2002 Blockade of IRS-1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Letters 531 437-442.
-
(2002)
FEBS Letters
, vol.531
, pp. 437-442
-
-
Araujo, E.P.1
Amaral, M.E.2
Souza, C.T.3
Bordin, S.4
Ferreira, F.5
Saad, M.J.6
Boschero, A.C.7
Magalhaes, E.C.8
Velloso, L.A.9
-
5
-
-
0034698052
-
Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells
-
Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR & Kennedy RT 2000 Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells. Journal of Biological Chemistry 275 22331-22338.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 22331-22338
-
-
Aspinwall, C.A.1
Qian, W.J.2
Roper, M.G.3
Kulkarni, R.N.4
Kahn, C.R.5
Kennedy, R.T.6
-
6
-
-
0036264841
-
Pancreatic islet insulin secretion and metabolism in adult rats malnourished during neonatal life
-
Barbosa FB, Capito K, Kofod H & Thams P 2002 Pancreatic islet insulin secretion and metabolism in adult rats malnourished during neonatal life. British Journal of Nutrition 87 147-155.
-
(2002)
British Journal of Nutrition
, vol.87
, pp. 147-155
-
-
Barbosa, F.B.1
Capito, K.2
Kofod, H.3
Thams, P.4
-
7
-
-
0035856943
-
Diabetes mellitus and genetically programmed defects in beta-cell function
-
Bell GI & Polonsky KS 2001 Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 414 788-791.
-
(2001)
Nature
, vol.414
, pp. 788-791
-
-
Bell, G.I.1
Polonsky, K.S.2
-
8
-
-
0037376852
-
Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade
-
Bertelli DF, Ueno M, Amaral ME, Toyama MH, Carneiro EM, Marangoni S, Carvalho CR, Saad MJ, Velloso LA & Boschero AC 2003 Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. American Journal of Physiology, Endocrinology and Metabolism 284 E679-E687.
-
(2003)
American Journal of Physiology, Endocrinology and Metabolism
, vol.284
-
-
Bertelli, D.F.1
Ueno, M.2
Amaral, M.E.3
Toyama, M.H.4
Carneiro, E.M.5
Marangoni, S.6
Carvalho, C.R.7
Saad, M.J.8
Velloso, L.A.9
Boschero, A.C.10
-
9
-
-
0034128938
-
A high fructose diet affects the early steps of insulin action in muscle and liver of rats
-
Bezerra RM, Ueno M, Silva MS, Tavares DQ, Carvalho CR & Saad MJ 2000 A high fructose diet affects the early steps of insulin action in muscle and liver of rats. Journal of Nutrition 130 1531-1535.
-
(2000)
Journal of Nutrition
, vol.130
, pp. 1531-1535
-
-
Bezerra, R.M.1
Ueno, M.2
Silva, M.S.3
Tavares, D.Q.4
Carvalho, C.R.5
Saad, M.J.6
-
10
-
-
0028008978
-
GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes
-
Bjork E, Velloso LA, Kampe O & Karlsson FA 1994 GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes 43 161-165.
-
(1994)
Diabetes
, vol.43
, pp. 161-165
-
-
Bjork, E.1
Velloso, L.A.2
Kampe, O.3
Karlsson, F.A.4
-
11
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annals of Biochemistry 72 248-254.
-
(1976)
Annals of Biochemistry
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
12
-
-
0034602675
-
Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
-
Chibalin AV, Yu M, Ryder JW, Song XM, Galuska D, Krook A, Wallberg-Henriksson H & Zierath JR 2000 Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. PNAS 97 38-43.
-
(2000)
PNAS
, vol.97
, pp. 38-43
-
-
Chibalin, A.V.1
Yu, M.2
Ryder, J.W.3
Song, X.M.4
Galuska, D.5
Krook, A.6
Wallberg-Henriksson, H.7
Zierath, J.R.8
-
13
-
-
0037371645
-
Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase c alpha expression
-
Ferreira F, Filiputti E, Arantes VC, Stoppiglia LF, Araujo EP, Delghingaro-Augusto V, Latorraca MQ, Toyama MH, Boschero AC & Carneiro EM 2003 Decreased cholinergic stimulation of insulin secretion by islets from rats fed a low protein diet is associated with reduced protein kinase c alpha expression. Journal of Nutrition 133 695-699.
-
(2003)
Journal of Nutrition
, vol.133
, pp. 695-699
-
-
Ferreira, F.1
Filiputti, E.2
Arantes, V.C.3
Stoppiglia, L.F.4
Araujo, E.P.5
Delghingaro-Augusto, V.6
Latorraca, M.Q.7
Toyama, M.H.8
Boschero, A.C.9
Carneiro, E.M.10
-
14
-
-
0030930924
-
Non-insulin-dependent diabetes mellitus
-
Hales CN 1997 Non-insulin-dependent diabetes mellitus. British Medical Bulletin 53 109-122.
-
(1997)
British Medical Bulletin
, vol.53
, pp. 109-122
-
-
Hales, C.N.1
-
16
-
-
0026935518
-
Alterations in insulin receptor and substrate phosphorylation in hypertensive rats
-
Kahn CK & Saad MJ 1992 Alterations in insulin receptor and substrate phosphorylation in hypertensive rats. Journal of the American Society of Nephrology 3 S69-S77.
-
(1992)
Journal of the American Society of Nephrology
, vol.3
-
-
Kahn, C.K.1
Saad, M.J.2
-
17
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI & Kadowaki T 2000 Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49 1880-1889.
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
Satoh, S.11
Sekihara, H.12
Sciacchitano, S.13
Lesniak, M.14
Aizawa, S.15
Nagai, R.16
Kimura, S.17
Akanuma, Y.18
Taylor, S.I.19
Kadowaki, T.20
more..
-
18
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
-
Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA & Kahn CR 1999a Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96 329-339.
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
19
-
-
0033379267
-
Altered Function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines
-
Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D & Kahn CR 1999b Altered Function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. Journal of Clinical Investigation 104 R69-R75.
-
(1999)
Journal of Clinical Investigation
, vol.104
-
-
Kulkarni, R.N.1
Winnay, J.N.2
Daniels, M.3
Bruning, J.C.4
Flier, S.N.5
Hanahan, D.6
Kahn, C.R.7
-
20
-
-
0031684038
-
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
-
Latorraca MQ, Reis MA, Carneiro EM, Mello MA, Velloso LA, Saad MJ & Boschero AC 1998 protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats. Journal of Nutrition 128 1643-1649.
-
(1998)
Journal of Nutrition
, vol.128
, pp. 1643-1649
-
-
Latorraca, M.Q.1
Reis, M.A.2
Carneiro, E.M.3
Mello, M.A.4
Velloso, L.A.5
Saad, M.J.6
Boschero, A.C.7
-
21
-
-
0035265835
-
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
-
Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM & Berggren PO 2001 Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Molecular Cell 7 559-570.
-
(2001)
Molecular Cell
, vol.7
, pp. 559-570
-
-
Leibiger, B.1
Leibiger, I.B.2
Moede, T.3
Kemper, S.4
Kulkarni, R.N.5
Kahn, C.R.6
de Vargas, L.M.7
Berggren, P.O.8
-
22
-
-
0036224165
-
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation
-
Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR & Rhodes CJ 2002 Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes 51 966-976.
-
(2002)
Diabetes
, vol.51
, pp. 966-976
-
-
Lingohr, M.K.1
Dickson, L.M.2
McCuaig, J.F.3
Hugl, S.R.4
Twardzik, D.R.5
Rhodes, C.J.6
-
23
-
-
0036317019
-
Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway
-
Luciano E, Carneiro EM, Carvalho CK, Carvalheira JB, Peres SB, Reis MA, Saad MJ, Boschero AC & Velloso LA 2002 Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. European Journal of Endocrinology 147 149-157.
-
(2002)
European Journal of Endocrinology
, vol.147
, pp. 149-157
-
-
Luciano, E.1
Carneiro, E.M.2
Carvalho, C.K.3
Carvalheira, J.B.4
Peres, S.B.5
Reis, M.A.6
Saad, M.J.7
Boschero, A.C.8
Velloso, L.A.9
-
24
-
-
0014582538
-
Chronic effects of insulin and glucagon upon islet function
-
Malaisse W & Malaisse-Lagae F 1969 Chronic effects of insulin and glucagon upon islet function. Diabetologia 5 349-352.
-
(1969)
Diabetologia
, vol.5
, pp. 349-352
-
-
Malaisse, W.1
Malaisse-Lagae, F.2
-
25
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
-
Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, Klumperman J, Thorens B & Thomas G, 2000 Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 408 994-997.
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
Kozma, S.C.2
Jaquet, M.3
Oorschot, V.4
Burcelin, R.5
Le Marchand-Brustel, Y.6
Klumperman, J.7
Thorens, B.8
Thomas, G.9
-
26
-
-
0037116584
-
Insulin receptor activation inhibits insulin secretion from human islets of Langerhans
-
Persaud SJ, Asare-Anane H & Jones PM 2002 Insulin receptor activation inhibits insulin secretion from human islets of Langerhans. FEBS Letters 510 225-228.
-
(2002)
FEBS Letters
, vol.510
, pp. 225-228
-
-
Persaud, S.J.1
Asare-Anane, H.2
Jones, P.M.3
-
27
-
-
0035201068
-
A long-term high-carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in the neonatal rat
-
Petrik J, Srinivasan M, Aalinkeel R, Coukell S, Arany E, Patel MS & Hill DJ 2001 A long-term high-carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in the neonatal rat. Pediatric Research 49 84-92.
-
(2001)
Pediatric Research
, vol.49
, pp. 84-92
-
-
Petrik, J.1
Srinivasan, M.2
Aalinkeel, R.3
Coukell, S.4
Arany, E.5
Patel, M.S.6
Hill, D.J.7
-
28
-
-
0035225677
-
Protein deficiency attenuates the effects of alloxan on insulin secretion and glucose homeostasis in rats
-
Prada FJ, Luciano E, Carneiro EM, Boschero AC & Mello MA 2001 Protein deficiency attenuates the effects of alloxan on insulin secretion and glucose homeostasis in rats. Physiological Chemistry and Physics and Medical NMR 33 73-82.
-
(2001)
Physiological Chemistry and Physics and Medical NMR
, vol.33
, pp. 73-82
-
-
Prada, F.J.1
Luciano, E.2
Carneiro, E.M.3
Boschero, A.C.4
Mello, M.A.5
-
29
-
-
0023957628
-
Diabetes in the undernourished: Coincidence or consequence
-
Rao RH 1988 Diabetes in the undernourished: coincidence or consequence, Endocrine Reviews 9 67-87.
-
(1988)
Endocrine Reviews
, vol.9
, pp. 67-87
-
-
Rao, R.H.1
-
30
-
-
0027308683
-
Chronic malnutrition impairs insulin sensitivity through both receptor and postreceptor defects in rats with mild streptozocin diabetes
-
Rao RH & Menon RK 1993 Chronic malnutrition impairs insulin sensitivity through both receptor and postreceptor defects in rats with mild streptozocin diabetes. Metabolism 42 772-779.
-
(1993)
Metabolism
, vol.42
, pp. 772-779
-
-
Rao, R.H.1
Menon, R.K.2
-
31
-
-
0027487229
-
AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
-
Reeves PG, Nielsen FH & Fahey GC Jr 1993 AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition 123 1939-1951.
-
(1993)
Journal of Nutrition
, vol.123
, pp. 1939-1951
-
-
Reeves, P.G.1
Nielsen, F.H.2
Fahey Jr., G.C.3
-
32
-
-
0030998522
-
Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
-
Reis MA, Carneiro EM, Mello MA, Boschero AC, Saad MJ & Velloso LA 1997 Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats. Journal of Nutrition 127 403-410.
-
(1997)
Journal of Nutrition
, vol.127
, pp. 403-410
-
-
Reis, M.A.1
Carneiro, E.M.2
Mello, M.A.3
Boschero, A.C.4
Saad, M.J.5
Velloso, L.A.6
-
33
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR & Kahn CR 2001 Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
34
-
-
0029559161
-
Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
-
Velloso LA, Carneiro EM, Crepaldi SC, Boschero, AC & Saad MJ 1995 Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets. FEBS Letters 377 353-357.
-
(1995)
FEBS Letters
, vol.377
, pp. 353-357
-
-
Velloso, L.A.1
Carneiro, E.M.2
Crepaldi, S.C.3
Boschero, A.C.4
Saad, M.J.5
-
35
-
-
0029959818
-
Cross-talk between the insulin and angiotensin signaling systems
-
Velloso LA, Folli F, Sun XJ, White MF, Saad MJ & Kahn CK 1996 Cross-talk between the insulin and angiotensin signaling systems. PNAS 93 12490-12495.
-
(1996)
PNAS
, vol.93
, pp. 12490-12495
-
-
Velloso, L.A.1
Folli, F.2
Sun, X.J.3
White, M.F.4
Saad, M.J.5
Kahn, C.K.6
-
36
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S & White MF 1998 Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391 900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
37
-
-
0032841435
-
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
-
Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL & White MF 1999 Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genetics 23 32-40.
-
(1999)
Nature Genetics
, vol.23
, pp. 32-40
-
-
Withers, D.J.1
Burks, D.J.2
Towery, H.H.3
Altamuro, S.L.4
Flint, C.L.5
White, M.F.6
-
39
-
-
0031912845
-
Insulin-like growth factor-I-induced DNA synthesis in insulin-secreting cell line RINm5F is associated with phosphorylation of the insulin-like growth factor-I receptor and the insulin receptor substrate-2
-
Zhang Q, Berggren PO, Hansson A & Tally M 1998 Insulin-like growth factor-I-induced DNA synthesis in insulin-secreting cell line RINm5F is associated with phosphorylation of the insulin-like growth factor-I receptor and the insulin receptor substrate-2. Journal of Endocrinology 156 573-581.
-
(1998)
Journal of Endocrinology
, vol.156
, pp. 573-581
-
-
Zhang, Q.1
Berggren, P.O.2
Hansson, A.3
Tally, M.4
-
40
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P, Alberti KG & Shaw J 2001 Global and societal implications of the diabetes epidemic. Nature 414 782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
|