Suppression of TNFα-mediated NFκB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells

Journal of Cellular Biochemistry

Volumn 74, Issue 4, 1999, Pages 606-615

  Tsai, Shu Huei ^a   Liang, Yu Chih ^a   Lin Shiau, Shoei Yn ^b   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

ECV304 cell; Flavonoids; I B kinase; Myricetin; NF B

Indexed keywords

APIGENIN; FLAVONOID; GENISTEIN; KAEMPFEROL; MYRICETIN; QUERCETIN; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA; CHUK PROTEIN, HUMAN; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE;

ARTICLE; BLOOD VESSEL INJURY; CELL IMMORTALIZATION; CELL MIGRATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENETIC REGULATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION; CELL ADHESION; CELL LINE; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MONOCYTE; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; VASCULAR ENDOTHELIUM;

BASE SEQUENCE; CELL ADHESION; CELL LINE; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; FLAVONOIDS; HUMANS; I-KAPPA B KINASE; MONOCYTES; NF-KAPPA B; OLIGONUCLEOTIDE PROBES; PROTEIN-SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033567458     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19990915)74:4<606::AID-JCB10>3.0.CO;2-W     Document Type: Article

References (35)

1. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, Chap H, Payrastre B. 1997. Relationship between flavonoids structure and inhibition of phosphatidylinositol 3-kinase: a comprision with tyrosine kinase and protein kinase C inhibiton. Biochem Pharmacol 53:1649-1657.
2. Baeuerle P, Henkel T. 1994. Function and activation of NFκB in the immune system. Annu Res Immunol 12:141-179.
3. Baeuerle PA, Baltimore D. 1996. NFκB: Ten years after. Cell 87:13-20.
4. Beg AA, Ruben AM, Scheinman RI, Haskill S, Rosen CA, Baldwin Jr AS. 1992. IκB interacts with the nuclear localization sequences of the subunits of NFκB: a mechanism for cytoplasmic retention. Genes Dev 6:1899-1913.
5. Brandi ML. 1992. Flavonoids: Biochemical effects and therapeutic applications. Bone and Miner 19:S3-S14.
6. Cody V, Middleton E, Harborne JB, Beretz A. 1990. Plant flavonoids in biology and medicine II. New York: Alan R. Liss.
7. Collins T. 1993. Endothelial nuclear factor-κB and the initiation of the atherosclerosis lesion. Lab Invest 5:499-508.
8. Collins T, Palmer HJ, Whitley MZ, Neish AS, Williams AJ. 1993a. A common theme in endothelial activation. Trends Cardiovasc Med 3:92-97.
9. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NFkB and cytokine-inducible enhancers. FASEB J 9:899-909.
10. Cybulsky MI, Gimbrone Jr MA. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251:788-791.
11. Davies MJ, Gordon JL, Gearing AJH, Pigott R, Woolf N, Katz D Kyriakopoulos. 1993. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 171:223-229.
12. Didonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. 1997. Acytokine-responsive IκB kinase that activates the transcription factor NFκB. Nature 388:548-554.
13. Finco TS, Beg AA, Baldwin, JrAS. 1994. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NFκB and is inhibited by protease inhibitors. Proc Natl Acad Sci USA 91:11884-11888.
14. 1B) and Calcitonon (C1a) receptor in CHO cells to a cyclic AMP-responsive luciferase reporter gene. J Neurochem 69:1278-1285.
15. Grilli M, Chiu J-S, Lenardo M. 1993. NFκB and Rel, participants in a multiform transcriptional regulatory system. In: International review of cytology: a survey of cell biology. California: San Diego. p 1-62.
16. Havsteen B. 1983. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 32: 1141-1148.
17. Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB. 1998. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface of adhesion molecules and of nuclear factor-κB activation. Biochem Pharmacol 55:775-783.
18. Lafrenic RM, Wahl LM, Epstein JS, Hewlett IK, Yamada KM, Dhawan S. 1996. HIV-1-tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. J Immunol 156:1638-1645.
19. Lin YI, Lin JK. 1997. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-κB. Mol Pharmacol 52:465-472.
20. Lindner V, Collins T. 1996. Expression of NFκB and IκBα by arotic endothelium in an arterial injury model. Am J Pathol 148:427-438.
21. Liou HC, Baltimore D. 1993. Regulation of the NFκB/Rel transcription factor and IκB inhibitor system. Curr Opin Cell Biol 5:477-487.
22. Matsubara T, Ziff M. 1986. Increased superoxide anion release from human endothelial cells in response to cytokines. J Immunol 137:3295-3298.
23. Mackay CR, Imhof BA. 1993. Cell adhesion in the immune system. Immunol Today 3:99-102.
24. Maniatis T. 1997. Catalysis by a multiprotein IκB kinase complex. Science 278:818-819.
25. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, Alexander RW, Medford RM. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 92:1866-1874.
26. Mercurio F, Zhu H, Murray BM, Shevchenko A, Bennett BL, Li JW, Young DB, Barbosa M, Mann M. 1997. IKK1 and IKK2: Cytokine activated IκB kinases essential for NF-κB activation. Science 278:860-869.
27. Middleton EJ, Kandaswami C. 1992. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol 43:1167-1179.
28. Pober JS, Cotran RS. 1991. What can be learned from the expression of endothelial adhesion molecules in tissue? Lab Invest 64:301-305.
29. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. 1997. Identification and characterization of an IκB kinase. Cell 90:373-383.
30. Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NFκB transcription factor and HIV-1. EMBO J 10:2247-2258.
31. Smith CW. 1993. Leukocyte-endothelial cell interactions. Semin Hematol 30:Sup4,45-55.
32. Spiecker M, Darius H, Kaboth K, Hubner F, Liao JK. 1998. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol 63:732-739.
33. Weber C, Erl W, Pietsch A, Srobel M, Ziegler-Heitbrock HWL, Weber PC. 1994. Antioxidants inhibit monocyte adhesion by supressing nuclear factor-κB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 14:1665-1673.
34. Zabel U, Baeuerle PA. 1990. Purified human IκB can rapidly dissociate the complex of the NFκB transcription factor with its cognate DNA. Cell 61:255-265.
35. Zandi E, Rothwar DM, Delhase M, Hayakawa M, Karin M. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phophorylation and NFκB activation. Cell 91:243-252.