Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells

Life Sciences

Volumn 77, Issue 16, 2005, Pages 2059-2070

  Young, Chul Park ^a,b   Jin, Hee Jeong ^a   Ki, Jae Park ^a   Hong, Jo Choi ^a   Yeong, Min Park ^b   Byung, Kap Jeong ^c   Higuchi, Yoshihiro ^d   Yoo, Young Hyun ^a  

^a Dong A University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Kosin University   (South Korea)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; HMW DNA fragments; HT 29; Nuclear translocation; Sulindac

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CELL NUCLEUS DNA; DNA FRAGMENT; ENDONUCLEASE; ENDONUCLEASE G; MITOCHONDRIAL PROTEIN; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN; PROTEIN P53; SULINDAC; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL STRAIN HT29; COLON CARCINOMA; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOLECULAR MECHANICS; MOLECULAR WEIGHT; POLYMERIZATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; PULSED FIELD GEL ELECTROPHORESIS;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; CASPASE 3; CASPASES; DEOXYRIBONUCLEASES; DNA FRAGMENTATION; ELECTROPHORESIS, GEL, PULSED-FIELD; ENDODEOXYRIBONUCLEASES; FLAVOPROTEINS; HT29 CELLS; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; SULINDAC;

EID: 23144445839     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.04.021     Document Type: Article

References (36)

1. E. Castano, M. Dalmau, M. Barragan, G. Pueyo, R. Bartrons, and J. Gil Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells British Journal Cancer 81 1999 294 299
2. H.J. Choi, H.H. Kim, H.S. Lee, G.Y. Huh, S.Y. Seo, J.H. Jeong, J.M. Kim, and Y.H. Yoo Lactacystin augments the sulindac-induced apoptosis in HT-29 cells Apoptosis 8 2003 301 305
3. E. Daugas, S.A. Susin, N. Zamzami, K.F. Ferri, T. Irinopoulou, N. Larochette, M. Prévost, B. Leber, D. Andrews, J. Penninger, and G. Kroemer Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis Federation of American Societies for Experimental Biology Journal 14 2000 729 739
4. D.J. Elder, A. Hague, D.J. Hicks, and C. Paraskeva Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma cell lines Cancer Research 56 1996 2273 2276
5. Y. Goldberg, I.I. Nassif, A. Pittas, L.L. Tsai, D.D. Dynlacht, B. Rigas, and S.J. Shiff The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins Oncogene 12 1996 893 901
6. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science (Wash. D.C.) 281 1998 1309 1312
7. A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes and Development 13 1999 1899 1911
8. Y. Higuchi, and S. Matsukawa Appearance of 1∼2 Mbp giant DNA fragments as an early common response leading to cell death induced by various substances that cause oxidative stress Free Radical Biology & Medicine 23 1997 90 99
9. B. Hoh, G. Hinz, B.K. Jeong, and D.G. Robinson Protein storage vacuoles form de novo during pea cotyledon development Journal of Cell Science 108 1995 299 310
10. G. Kroemer, P. Petit, N. Zamzami, J.L. Vayssiere, and B. Mignotte The biochemistry of programmed cell death Federation of American Societies for Experimental Biology Journal 9 1995 1277 1287
11. L.Y. Li, X. Luo, and X. Wang Endonuclease G is an apoptotic DNase when released from mitochondria Nature 412 2001 95 99
12. J.C. Martinou, and D.R. Green Breaking the mitochondrial barrier Nature Reviews. Molecular Cell Biology 2 2001 63 67
13. B.S. Park, S.J. Baek, K.H. Song, K.H. Kim, S.J. Jeong, M.H. Jeong, S.Y. Seo, S.W. Lee, K.S. Yoo, and Y.H. Yoo Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin Nutrition and Cancer 42 2002 248 255
14. P.J. Pasricha, A. Bedi, and K. O'Connor The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis Gastroenterology 109 1995 994 998
15. G.A. Piazza, A.K. Rahm, and T.S. Finn Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction Cancer Research 57 1997 2452 2459
16. M. Piqué, M. Barragán, M. Dalmau, B. Bellosillo, G. Pons, and J. Gil Aspirin induces apoptosis through mitochondrial cytochrome c release Federation of European Biochemical Societies Letters 480 2000 193 196
17. L. Qiao, M. Koutsos, L.L. Tsai, V. Kozoni, J. Guzman, S.J. Shiff, and B. Rigas Staurosporine inhibits the proliferation, alters the cell cycle distribution and induces apoptosis in HT-29 human colon adenocarcinoma cells Cancer Letter 107 1996 83 89
18. L. Qiao, S.J. Shiff, and B. Rigas Sulindac sulfide induces several subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks Biochimica et Biophysica Acta 1359 1997 222 232
19. L. Qiao, R. Hanif, E. Sphicas, S.J. Shiff, and B. Rigas Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells Biochemical Pharmacology 55 1998 53 64
20. J.C. Reed Double identity for proteins of the Bcl-2 family Nature (Lond.) 387 1997 773 776
21. L. Rosenberg, J.R. Palmer, A.G. Zauber, M.E. Warshauer, P.D. Stolley, and S.J. Shapiro A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer National Cancer Institute 83 1991 355 358
22. S.Y. Seo, E.J. Jun, S.M. Jung, K. Kim, Y.J. Lim, B.S. Park, J. Kim, S. Lee, H. Suh, N.D. Kim, and Y.H. Yoo Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin Anticancer Drugs 14 2003 219 225
23. R.G. Shao, T. Shimizu, and Y. Pommier 7-hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53 Experimental Cell Research 234 1997 388 397
24. S.J. Shiff, and B. Rigas Nonsteroidal anti-inflammatory drugs and colorectal cancer: evolving concepts of their chemopreventive actions Gastroenterology 113 1997 1992 1998
25. S.J. Shiff, L. Qiao, L.L. Tsai, and B. Rigas Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells Journal of Clinical Investigation 96 1995 491 503
26. S.J. Shiff, M.I. Koutsos, L. Qiao, and R. Basil Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis Experimental Cell Research 222 1996 179 188
27. S.A. Susin, H.K. Lorenzo, N. Zamzami, I. Marzo, B.E. Snow, G.M. Brothers, J. Mangion, E. Jacotot, P. Costantini, and M. Loeffler Molecular characterization of mitochondrial apoptosis-inducing factor Nature (Lond.) 397 1999 441 446
28. S.A. Susin, E. Daugas, L. Ravagnan, K. Samejima, N. Zamzami, M. Loeffler, P. Costantini, K.F. Ferri, T. Irinopoulou, M.C. Prevost, G. Brothers, T.W. Mak, J. Penninger, W.C. Earnshaw, and G. Kroemer Two distinct pathways leading to nuclear apoptosis Journal of Experimental Medicine 192 2000 571 580
29. N.A. Thornberry, A. Rosen, and D.W. Nicholson Control of apoptosis by proteases Advances in Pharmacology 41 1997 155 177
30. G. van Loo, X. Saelens, M. van Gurp, M. MacFarlane, S.J. Martin, and P. Vandenabeele The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet Cell Death and Differentiation 9 2002 1031 1042
31. X. Wang The expanding role of mitochondria in apoptosis Genes and Development 15 2001 2922 2933
32. W. Wang, and A. Passaniti Extracellular matrix inhibits apoptosis and enhances endothelial cell differentiation by a NFκB-dependent mechanism Journal of Cellular Biochemistry 73 1999 321 331
33. G.T. Williams Programmed cell death: apoptosis and oncogenesis Cell 65 1991 1097 1098
34. A.H. Wyllie, J.F. Kerr, and A.R. Currie Cell death: the significance of apoptosis International Review of Cytology 68 1980 251 306
35. J. Yuan Evolutionary conservation of a genetic pathway of programmed cell death Journal of Cellular Biochemistry 60 1996 4 11
36. N. Zamzami, and G. Kroemer The mitochondrion in apoptosis: how Pandora's box opens Nature Reviews. Molecular Cell Biology 2 2001 67 71