Steps toward understanding the inheritance of repressive methyl-lysine marks in histones

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 69, Issue , 2004, Pages 171-182

  Reinberg, D ^a   Chuikov, S ^a   Farnham, P ^b   Karachentsev, D ^c   Kirmizis, A ^b   Kuzmichev, A ^a   Margueron, R ^a   Nishioka, K ^a   Preissner, T S ^a,d   Sarma, K ^a   Abate Shen, C ^e   Steward, R ^c   Vaquero, A ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

^e RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; EZH2 PROTEIN; HISTONE; HISTONE H3; HISTONE H4; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; PR SET7 PROTEIN; UNCLASSIFIED DRUG; HISTONE ACETYLTRANSFERASE; HISTONE H4 LYSINE 20; METHYL GROUP; METHYLLYSINE; PROTEIN PR SET7; TRANSCRIPTION FACTOR EZH2;

AMINO ACID SEQUENCE; CHROMATIN STRUCTURE; CHROMOSOME; CONFERENCE PAPER; DROSOPHILA; ENZYME ACTIVITY; EUCHROMATIN; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REPRESSION; HETEROCHROMATIN; HUMAN; METHYLATION; MITOSIS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TISSUE CULTURE CELL; ARTICLE; CHROMOSOME SEGREGATION; DNA REPLICATION; ENZYME SPECIFICITY; HISTONE METHYLATION; INHERITANCE; MAMMAL CELL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; X CHROMOSOME;

AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; EPIGENESIS, GENETIC; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; LYSINE; MALE; METHYLATION; MICE; NUCLEAR PROTEINS; PROSTATIC NEOPLASMS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 23044498265     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2004.69.171     Document Type: Conference Paper

References (42)

1. Abate-Shen C. and Shen M.M. 2002. Mouse models of prostate carcinogenesis. Trends Genet. 18: S1.
2. Abate-Shen C., Banach-Petrosky W.A., Sun X., Economides K.D., Desai N., Gregg J.P., Borowsky A.D., Cardiff R.D., and Shen M.M. 2003. Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res. 63: 3886.
3. Bannister A.J., Schneider R., and Kouzarides T. 2002. Histone methylation: Dynamic or static? Cell 109: 801.
4. Berger S.L. 2002. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12: 142.
5. Brownell J.E., Zhou J., Ranalli T., Kobayashi R., Edmondson D.G., Roth S.Y., and Allis C.D. 1996. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84: 843.
6. Czermin B., Schotta G., Hulsmann B.B., Brehm A., Becker P.B., Reuter G., and Imhof A. 2001. Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila. EMBO Rep. 2: 915.
7. DeLange R.J., Hooper J.A., and Smith E.L. 1973. Histone 3. 3. Sequence studies on the cyanogen bromide peptides; complete amino acid sequence of calf thymus histone 3. J. Biol. Chem. 248: 3261.
8. Denisenko O., Shnyreva M., Suzuki H., and Bomsztyk K. 1998. Point mutations in the WD40 domain of Eed block its interaction with Ezh2. Mol. Cell. Biol. 18: 5634.
9. Jacobs J.J. and van Lohuizen M. 1999. Cellular memory of transcriptional states by Polycomb-group proteins. Semin. Cell Dev. Biol. 10: 227.
10. Jenuwein T. and Allis C.D. 2001. Translating the histone code. Science 293: 1074.
11. Karachentsev D., Sarma K., Reinberg D., and Steward R. 2005. PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev. 19: 431.
12. Kirmizis A., Bartley S.M., Kuzmichev A., Margueron R., Rein-berg D., Green R., and Farnham P.J. 2004. Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev. 18: 1592.
13. Kleer C.G., Cao Q., Varambally S., Shen R., Ota I., Tomlins S.A., Ghosh D., Sewalt R.G., Otte A.P., Hayes D.F., Sabel M.S., Livant D., Weiss S.J., Rubin M.A., and Chinnaiyan A.M. 2003. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl. Acad. Sci. 100: 11606.
14. Kohlmaier A., Savarese F., Lachner M., Martens J., Jenuwein T., and Wutz A. 2004. A chromosomal memory triggered by xist regulates histone methylation in x inactivation. PLoS Biol. 2: E171.
15. Krogan N.J., Kim M., Tong A., Golshani A., Cagney G., Canadien V., Richards D.P., Beattie B.K., Emili A., Boone C., Shilatifard A., Buratowski S., and Greenblatt J. 2003. Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol. Cell. Biol. 23: 4207.
16. Kubicek S. and Jenuwein T. 2004. A crack in histone lysine methylation. Cell 119: 903.
17. Kuzmichev A. and Reinberg D. 2001. Role of histone deacetylase complexes in the regulation of chromatin metabolism. Curr. Top. Microbiol. Immunol. 254: 35.
18. Kuzmichev A., Jenuwein T., Tempst P., and Reinberg D. 2004. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol. Cell 14: 183.
19. Kuzmichev A., Nishioka K., Erdjument-Bromage H., Tempst P., and Reinberg D. 2002. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16: 2893.
20. Kuzmichev A., Margueron R., Vaquero A., Preissner T., Scher M., Kirmizis A., Ouyang X., Brockdorff N., Abate-Shen C., Farnham P.J., and Reinberg D. 2005. Composition and histone substrates of polycomb regressive group complexes change during cellular differentiation. Proc. Natl. Acad. Sci. 102: 1859.
21. Laible G., Wolf A., Dorn R., Reuter G., Nislow C., Lebersorger A., Popkin D., Pillus L., and Jenuwein T. 1997. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. EMBO J. 16: 3219.
22. Lund A.H. and van Lohuizen M. 2004. Polycomb complexes and silencing mechanisms. Curr. Opin. Cell Biol. 16: 239.
23. Ng H.H., Xu R.M., Zhang Y., and Struhl K. 2002. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J. Biol. Chem. 277: 34655.
24. Ng J., Hart C.M., Morgan K., and Simon J.A. 2000. A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC. Mol. Cell. Biol. 20: 3069.
25. Nishioka K., Rice J.C., Sarma K., Erdjument-Bromage H., Werner J., Wang Y., Chuikov S., Valenzuela P., Tempst P., Steward R., Lis J.T., Allis C.D., and Reinberg D. 2002. PRSet7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 9: 1201.
26. Pirrotta V. and Rastelli L. 1994. White gene expression, repressive chromatin domains, and homeotic gene regulation in Drosophila. Bioessays 16: 549.
27. Rea S., Eisenhaber F., O'Carroll D., Strahl B.D., Sun Z.W., Schmid M., Opravil S., Mechtler K., Ponting C.P., Allis C.D., and Jenuwein T. 2000. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406: 593.
28. Rice J.C., Nishioka K., Sarma K., Steward R., Reinberg D., and Allis C.D. 2002. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 16: 2225.
29. Rosenberg M.I. and Parkhurst S.M. 2002. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell 109: 447.
30. Schotta G., Lachner M., Sarma K., Ebert A., Sengupta R., Reuter G., Reinberg D., and Jenuwein T. 2004. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18: 1251.
31. Shankaranarayana G.D., Motamedi M.R., Moazed D., and Grewal S.I. 2003. Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr. Biol. 13: 1240.
32. Shao Z., Raible F., Mollaaghababa R., Guyon J.R., Wu C.T., Bender W., and Kingston R.E. 1999. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98: 37.
33. Silva J., Mak W., Zvetkova I., Appanah R., Nesterova T.B., Webster Z., Peters A.H., Jenuwein T., Otte A.P., and Brockdorff N. 2003. Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev. Cell 4: 481.
34. Sims R.J., III, Nishioka K., and Reinberg D. 2003. Histone lysine methylation: A signature for chromatin function. Trends Genet. 19: 629.
35. Sterner D.E. and Berger S.L. 2000. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64: 435.
36. Struhl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12: 599.
37. Sun Z.W. and Allis C.D. 2002. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418: 104.
38. Taunton J., Hassig C.A., and Schreiber S.L. 1996. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272: 408.
39. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. 2004. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16: 93.
40. Varambally S., Dhanasekaran S.M., Zhou M., Barrette T.R., Kumar-Sinha C., Sanda M.G., Ghosh D., Pienta K.J., Sewalt R.G., Otte A.P., Rubin M.A., and Chinnaiyan A.M. 2002. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624.
41. Wood A., Krogan N.J., Dover J., Schneider J., Heidt J., Boateng M.A., Dean K., Golshani A., Zhang Y., Greenblatt J.F., Johnston M., and Shilatifard A. 2003. Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol. Cell 11: 267.
42. Zhang Y. and Reinberg D. 2001. Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails. Genes Dev. 15: 2343.