Are there any stem cells in the pancreas?

Pancreas

Volumn 31, Issue 2, 2005, Pages 108-118

  Yalniz, Mehmet ^a   Pour, Parviz M ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Pancreas; Stem cells; Transdifferentiation

Indexed keywords

BONE MARROW; CANCER CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; HUMAN; LIVER CELL; MEDICAL RESEARCH; NONHUMAN; PANCREAS; PANCREAS DISEASE; PANCREAS DUCT; PANCREAS ISLET; PRIORITY JOURNAL; REVIEW; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; HUMANS; PANCREAS; STEM CELLS;

EID: 23044488775     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000174939.97438.9f     Document Type: Review

References (103)

1. Vessey CJ, de la Hall PM. Hepatic stem cells: a review. Pathology. 2001; 33:130-141.
2. Cattaneo E, McKay R. Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature. 1990;347:762-765.
3. Niki T, Pekny M, Hellemans K, et al. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology. 1999;29:520-527.
4. Slack JM. Developmental biology of the pancreas. Development. 1995; 121:1569-1580.
5. Herrera PL, Huarte J, Sanvito F, et al. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development. 1991;113:1257-1265.
6. Gittes GK, Galante PE, Hanahan D, et al. Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development. 1996;122:439-447.
7. Pictet RL, Clark WR, Williams RH, et al. An ultrastructural analysis of the developing embryonic pancreas. Dev Biol. 1972;29:436-467.
8. Li Z, Manna P, Kobayashi H, et al. Multifaceted pancreatic mesenchymal control of epithelial lineage selection. Dev Biol. 2004;269:252-263.
9. Lukinius A, Ericsson JL, Grimelius L, et al. Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones. Dev Biol. 1992;153:376-385.
10. De Krijger RR, Aanstoot HJ, Kranenburg G, et al. The midgestational human fetal pancreas contains cells coexpressing islet hormones. Dev Biol. 1992;153:368-375.
11. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995;44:249-256.
12. Holland AM, Gonez LJ, Harrison LC. Progenitor cells in the adult pancreas. Diabetes Metab Res Rev. 2004;20:13-27.
13. Peters J, Jurgensen A, Kloppel G. Ontogeny, differentiation and growth of the endocrine pancreas. Virchows Arch. 2000;436:527-538.
14. Terazono K, Uchiyama Y, Ide M, et al. Expression of reg protein in rat regenerating islets and its co-localization with insulin in the beta cell secretory granules. Diabetologia. 1990;33:250-252.
15. Kandeel F, Smith CV, Todorov I, et al. Advances in islet cell biology: from stem cell differentiation to clinical transplantation: conference report. Pancreas. 2003;27:e63-e78.
16. Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001;292:1389-1394.
17. Soria B, Roche E, Berna G, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes. 2000;49:157-162.
18. Assady S, Maor G, Amit M, et al. Insulin production by human embryonic stem cells. Diabetes. 2001;50:1691-1697.
19. Ianus A, Holz GG, Theise ND, et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest. 2003;111:843-850.
20. Choi JB, Uchino H, Azuma K, et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia. 2003;46:1366-1374.
21. Lechner A, Yang YG, Blacken RA, et al. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes. 2004;53:616-623.
22. Sumi S, Gu Y, Hiura A, et al. Stem cells and regenerative medicine for diabetes mellitus. Pancreas. 2004;29:e85-e89.
23. Kim D, Gu Y, Ishii M, et al. In vivo functioning and transplantable mature pancreatic islet-like cell clusters differentiated from embryonic stem cell. Pancreas. 2003;27:e34-e41.
24. Swenne I. The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes. 1982;31: 754-760.
25. Dor Y, Brown J, Martinez OI, et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46.
26. Hunziker E, Stein M. Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun. 2000;271:116-119.
27. Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes. 2001;50:521-533.
28. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002;129:2447-2457.
29. Guz Y, Nasir I, Teitelman G. Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology. 2001;142:4956-4968.
30. Tomioka T, Fujii H, Hirota M, et al. The patterns of beta-cell regeneration in untreated diabetic and insulin-treated diabetic Syrian hamsters after streptozotocin treatment. Int J Pancreatol. 1991;8:355-366.
31. Feyrter F. Uber Die Pripheren Endokrinen (parakrinen) Drusen des Menschen. 1953.
32. Pour PM, Standop J, Batra SK. Are islet cells the gatekeepers of the pancreas? Pancreatol. 2002;2:440-448.
33. Schmied BM, Ulrich A, Matsuzaki H, et al. Transdifferentiation of human islet cells in a long-term culture. Pancreas. 2001;23:157-171.
34. Gu D, Sarvetnick N. Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development. 1993;118:33-46.
35. Bonner-Weir S. beta-cell turnover: its assessment and implications. Diabetes. 2001;50(Suppl 1):S20-S24.
36. Bonner-Weir S, Baxter LA, Schuppin GT, et al. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 1993;42:1715-1720.
37. Wang RN, Kloppel G, Bouwens L. Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia. 1995;38:1405-1411.
38. Rosenberg L. Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc Res Tech. 1998;43:337-346.
39. Bonner-Weir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 2000;97: 7999-8004.
40. Dudek RW, Lawrence IE Jr, Hill RS, et al. Induction of islet cytodifferentiation by fetal mesenchyme in adult pancreatic ductal epithelium. Diabetes. 1991;40:1041-1048.
41. Pour PM. Pancreatic centroacinar cells. The regulator of both exocrine and endocrine function. Int J Pancreatol. 1994;15:51-64.
42. Bouwens L, Pipeleers DG. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia. 1998;41: 629-633.
43. Githens S. Pancreatic duct cell cultures. Annu Rev Physiol. 1994;56:419-443.
44. Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech. 1998; 43:332-336.
45. Zimmermann A, Gloor B, Kappeler A, et al. Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans. Gut. 2002;51:574-578.
46. Scharfmann R. Neurotrophin and neurotrophin receptors in islet cells. Horm Metab Res. 1997;29:294-296.
47. Lardon J, Rooman I, Bouwens L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol. 2002;117: 535-540.
48. Kruse C, Birth M, Rohwedel J, et al. Pluripotency of adult stem cells derived from human and rat pancreas. Appl Phys. A. (in press).
49. Poliakova L, Pirone A, Farese A, et al. Presence of nonhematopoietic side population cells in the adult human and nonhuman primate pancreas. Transplant Proc. 2004;36:1166-1168.
50. Lechner A, Leech CA, Abraham EJ, et al. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem Biophys Res Commun. 2002; 293:670-674.
51. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284:1168-1170.
52. Germain L, Blouin MJ, Marceau N. Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, alpha-fetoprotein, albumin, and cell surface-exposed components. Cancer Res. 1988;48:4909-4918.
53. Reddy JK, Rao MS, Qureshi SA, et al. Induction and origin of hepatocytes in rat pancreas. J Cell Biol. 1984;98:2082-2090.
54. Rao MS, Reddy JK. Hepatic transdifferentiation in the pancreas. Semin Cell Biol. 1995;6:151-156.
55. Bonner-Weir S, Sharma A. Pancreatic stem cells. J Pathol. 2002;197: 519-526.
56. Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 2000;6:278-282.
57. Faris RA, Monfils BA, Dunsford HA, et al. Antigenic relationship between oval cells and a subpopulation of hepatic foci, nodules, and carcinomas induced by the "resistant hepatocyte" model system. Cancer Res. 1991;51:1308-1317.
58. Bonner-Weir S, Stubbs M, Reitz P, et al. Partial pancreatectomy as a model of pancreatic regeneration. In: Sarvetnick N, ed. Pancreatic Growth and Regeneration. Basel, Switzerland: Karger Landes Systems; 1997:138.
59. Alison MR. Liver regeneration with reference to stem cells. Semin Cell Dev Biol. 2002;13:385-387.
60. Oh SH, Hatch HM, Petersen BE. Hepatic oval 'stem' cell in liver regeneration. Semin Cell Dev Biol. 2002;13:405-409.
61. Ashizawa S, Brunicardi FC, Wang XP. PDX-1 and the pancreas. Pancreas. 2004;28:109-120.
62. Guz Y, Montminy MR, Stein R, et al. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development. 1995;121:11-18.
63. Jensen J, Heller RS, Funder-Nielsen T, et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes. 2000;49:163-176.
64. Holland AM, Hale MA, Kagami H, et al. Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA. 2002;99:12236-12241.
65. Upchurch BH, Aponte GW, Leiter AB. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994;120:245-252.
66. Teitelman G, Joh TH, Reis DJ. Transformation of catecholaminergic precursors into glucagon (A) cells in mouse embryonic pancreas. Proc Natl Acad Sci USA. 1981;78:5225-5229.
67. Beattie GM, Levine F, Mally MI, et al. Acid beta-galactosidase: a developmentally regulated marker of endocrine cell precursors in the human fetal pancreas. J Clin Endocrinol Metab. 1994;78:1232-1240.
68. Schwitzgebel VM, Scheel DW, Conners JR, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000;127:3533-3542.
69. Bouwens L. Cytokeratins and cell differentiation in the pancreas. J Pathol. 1998;184:234-239.
70. Schmied BM, Liu G, Matsuzaki H, et al. Differentiation of islet cells in long-term culture. Pancreas. 2000;20:337-347.
71. Ko SH, Suh SH, Kim BJ, et al. Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells. Pancreas. 2004;28:121-128.
72. Selander L, Edlund H. Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas. Mech Dev. 2002;113: 189-192.
73. Esni F, Stoffers DA, Takeuchi T, et al. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev. 2004;121:15-25.
74. Treutelaar MK, Skidmore JM, Dias-Leme CL, et al. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes. 2003;52:2503-2512.
75. Iovanna JL, Lechene de la Porte P, Dagorn JC. Expression of genes associated with dedifferentiation and cell proliferation during pancreatic regeneration following acute pancreatitis. Pancreas. 1992;7:712-718.
76. Bouwens L, De Blay E. Islet morphogenesis and stem cell markers in rat pancreas. J Histochem Cytochem. 1996;44:947-951.
77. Gu D, Arnush M, Sarvetnick N. Endocrine/exocrine intermediate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice. Pancreas. 1997; 15:246-250.
78. Gu D, Lee MS, Krahl T, et al. Transitional cells in the regenerating pancreas. Development. 1994;120:1873-1881.
79. Bockman DE. Toward understanding pancreatic disease: from architecture to cell signaling. Pancreas. 1995;11:324-329.
80. Bockman DE, Merlino G. Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 1992;103:1883-1892.
81. Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999;48:507-513.
82. Pour PM, Bell RH. Alteration of pancreatic endocrine cell patterns and their secretion during pancreatic carcinogenesis in the hamster model. Cancer Res. 1989;49:6396-6400.
83. Pour PM, Permert J, Mogaki M, et al. Endocrine aspects of exocrine cancer of the pancreas. Their patterns and suggested biologic significance. Am J Clin Pathol. 1993;100:223-230.
84. Pour PM. Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model. An electron-microscopic and immunohistochemical study. Am J Pathol. 1988;130:335-344.
85. Yuan S, Rosenberg L, Paraskevas S, et al. Transdifferentiation of human islets to pancreatic ductal cells in collagen matrix culture. Differentiation. 1996;61:67-75.
86. Laine VJ, Ekfors TO, Gullichsen R, et al. Immunohistochemical characterization of an amphicrine mucinous islet-cell carcinoma of the pancreas. Case report. APMIS. 1992;100:335-340.
87. Ordonez NG, Balsaver AM, Mackay B. Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarrhea and hypokalemia syndrome. Hum Pathol. 1988;19:1458-1461.
88. Schmied BM, Ulrich A, Matsuzaki H, et al. In vitro pancreatic carcinogenesis. Ann Oncol. 1999;10(Suppl 4):41-45.
89. Schmied B, Liu G, Moyer MP, et al. Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro. Carcinogenesis. 1999;20:317-324.
90. Pour PM, Schmied BM. One thousand faces of Langerhans islets. Int J Pancreatol. 1999;25:181-193.
91. Pour PM, Schmied B. The link between exocrine pancreatic cancer and the endocrine pancreas. Int J Pancreatol. 1999;25:77-87.
92. Cuilliere P, Lazure T, Bui M, et al. Solid adenoma with exclusive hepatocellular differentiation: a new variant among pancreatic benign neoplasms? Virchows Arch. 2002;441:519-522.
93. Rao MS, Scarpelli DG, Reddy JK. Transdifferentiated hepatocytes in rat pancreas. Curr Top Dev Biol. 1986;20:63-78.
94. Scarpelli DG, Rao MS. Differentiation of regenerating pancreatic cells into hepatocyte-like cells. Proc Natl Acad Sci USA. 1981;78:2577-2581.
95. Paner GP, Thompson KS, Reyes CV. Hepatoid carcinoma of the pancreas. Cancer. 2000;88:1582-1589.
96. Rao MS, Dwivedi RS, Yeldandi AV, et al. Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment. Am J Pathol. 1989;134: 1069-1086.
97. Usuda N, Reddy JK, Hashimoto T, et al. Immunocytochemical localization of liver-specific proteins in pancreatic hepatocytes of rat. Eur J Cell Biol. 1988;46:299-306.
98. Kimura W, Morikane K, Esaki Y, et al. Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy. Cancer. 1998;82:1839-1849.
99. Pour PM, Schmied BM, Ulrich AB, et al. Abnormal differentiation of islet cells in pancreatic cancer. Pancreatol. 2001;1:110-116.
100. Murakami T, Fujita T, Taguchi T, et al. The blood vascular bed of the human pancreas, with special reference to the insulo-acinar portal system. Scanning electron microscopy of corrosion casts. Arch Histol Cytol. 1992;55:381-395.
101. Murakami T, Hitomi S, Ohtsuka A, et al. Pancreatic insulo-acinar portal systems in humans, rats, and some other mammals: scanning electron microscopy of vascular casts. Microsc Res Tech. 1997;37:478-488.
102. Ulrich AB, Schmied BM, Standop J, et al. Differences in the expression of glutathione S-transferases in normal pancreas, chronic pancreatitis, secondary chronic pancreatitis, and pancreatic cancer. Pancreas. 2002; 24:291-297.
103. Hegyi P, Takacs T, Jarmay K, et al. Spontaneous and cholecystokinin- octapeptide-promoted regeneration of the pancreas following L-arginine-induced pancreatitis in rat. Int J Pancreatol. 1997;22:193-200.