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Volumn 29, Issue 3, 2004, Pages e85-e89

Stem Cells and Regenerative Medicine for Diabetes Mellitus

Author keywords

Diabetes mellitus; Embryonic stem (ES) cells; Pancreas; Regeneration; Stem cell

Indexed keywords

BIOLOGICAL MARKER; TRANSCRIPTION FACTOR;

EID: 11444268427     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/00006676-200410000-00017     Document Type: Review
Times cited : (29)

References (49)
  • 1
    • 0034457490 scopus 로고    scopus 로고
    • Prospective: postnatal pancreatic cell growth.
    • Bonner-Weir S. Prospective: postnatal pancreatic β cell growth. Endocrinology. 2000;141:1926-1929.
    • (2000) Endocrinology , vol.141 , pp. 1926-1929
    • Bonner-Weir, S.1
  • 2
    • 0022918394 scopus 로고
    • Resectability of the pancreas without producing diabetes, with special reference to pancreatic regeneration.
    • Mizumoto R, Yano T, Sekoguchi T, et al. Resectability of the pancreas without producing diabetes, with special reference to pancreatic regeneration. Int J Pancreatol. 1986;1:185-193.
    • (1986) Int J Pancreatol , vol.1 , pp. 185-193
    • Mizumoto, R.1    Yano, T.2    Sekoguchi, T.3
  • 3
    • 0029944291 scopus 로고    scopus 로고
    • Induction and involvement of endogenous IGF-1 in pancreatic regeneration after partial pancreatectomy in the dog.
    • Hayakawa H, Kawarada Y, Mizumoto R, et al. Induction and involvement of endogenous IGF-1 in pancreatic regeneration after partial pancreatectomy in the dog. J Endocrinol. 1996;149:259-267.
    • (1996) J Endocrinol , vol.149 , pp. 259-267
    • Hayakawa, H.1    Kawarada, Y.2    Mizumoto, R.3
  • 4
    • 0029116567 scopus 로고
    • Pancreatic enlargement in obstructive jaundice. Effects of biliary stream diversion in humans.
    • Muranaka H, Ro T, Masuda Y, et al. Pancreatic enlargement in obstructive jaundice. Effects of biliary stream diversion in humans. Dig Dis Sci. 1995;40:1554-1560.
    • (1995) Dig Dis Sci , vol.40 , pp. 1554-1560
    • Muranaka, H.1    Ro, T.2    Masuda, Y.3
  • 5
    • 0033643581 scopus 로고    scopus 로고
    • Basic knowledge of interest: frontiers of pancreas regeneration.
    • Sumi S, Tamura K. Basic knowledge of interest: frontiers of pancreas regeneration. J Hepatobiliary Pancreat Surg. 2000;7:286-294.
    • (2000) J Hepatobiliary Pancreat Surg , vol.7 , pp. 286-294
    • Sumi, S.1    Tamura, K.2
  • 6
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9.
    • Li H, Arber S, Jessell TM, et al. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet. 1999;23:67-70.
    • (1999) Nat Genet , vol.23 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3
  • 7
    • 0031020002 scopus 로고    scopus 로고
    • Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells.
    • Ahlgren U, Pfaff SL, Jessell TM, et al. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature. 1997;385: 257-260.
    • (1997) Nature , vol.385 , pp. 257-260
    • Ahlgren, U.1    Pfaff, S.L.2    Jessell, T.M.3
  • 8
    • 0035072545 scopus 로고    scopus 로고
    • A bipotential precursor population for pancreas and liver within the embryonic endoderm.
    • Deutsch G, Jung J, Zheng M, et al. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development. 2001; 128:871-881.
    • (2001) Development , vol.128 , pp. 871-881
    • Deutsch, G.1    Jung, J.2    Zheng, M.3
  • 9
    • 0029557377 scopus 로고
    • IPF1, a homeodomain protein with a dual function in pancreas development.
    • Jonsson J, Ahlgren U, Edlund T, et al. IPF1, a homeodomain protein with a dual function in pancreas development. Int J Dev Biol. 1995;39:789-798.
    • (1995) Int J Dev Biol , vol.39 , pp. 789-798
    • Jonsson, J.1    Ahlgren, U.2    Edlund, T.3
  • 10
    • 0032417268 scopus 로고    scopus 로고
    • The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.
    • Krapp A, Knofler M, Ledermann B, et al. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998;12:3752-3763.
    • (1998) Genes Dev , vol.12 , pp. 3752-3763
    • Krapp, A.1    Knofler, M.2    Ledermann, B.3
  • 11
    • 0032573227 scopus 로고    scopus 로고
    • Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.
    • Kim S, Melton D. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci USA. 1998;95:13036-13041.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13036-13041
    • Kim, S.1    Melton, D.2
  • 12
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.
    • Kawaguchi Y, Cooper B, Gannon M, et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002;32:128-134.
    • (2002) Nat Genet , vol.32 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3
  • 13
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3 cells are islet progenitors and are distinct from duct progenitors.
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002;129:2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 14
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.
    • Gradwohl G, Dierich A, LeMeur M, et al. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA. 2000;97:1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3
  • 16
    • 79959845127 scopus 로고    scopus 로고
    • Expression of neuro-genin3 reveals an islet cell precursor population in the pancreas.
    • Schwitzgebel VM, Scheel DW, Conners JR, et al. Expression of neuro-genin3 reveals an islet cell precursor population in the pancreas. Development. 2000;27:2533-2542.
    • (2000) Development , vol.27 , pp. 2533-2542
    • Schwitzgebel, V.M.1    Scheel, D.W.2    Conners, J.R.3
  • 17
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.
    • Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development. 2000;127:2317-2322.
    • (2000) Development , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 18
    • 0033984886 scopus 로고    scopus 로고
    • Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors. A role for Notch pathway in repression of premature differentiation.
    • Jensen J, Heller RS, Fundel-Nielsen T, et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors. A role for Notch pathway in repression of premature differentiation. Diabetes. 2000;49:163-176.
    • (2000) Diabetes , vol.49 , pp. 163-176
    • Jensen, J.1    Heller, R.S.2    Fundel-Nielsen, T.3
  • 19
    • 0030960835 scopus 로고    scopus 로고
    • Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets.
    • Fernandes A, King LC, Guz Y, et al. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology. 1997;138:1750-1762.
    • (1997) Endocrinology , vol.138 , pp. 1750-1762
    • Fernandes, A.1    King, L.C.2    Guz, Y.3
  • 20
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones.
    • Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res. 1997;29:301-307.
    • (1997) Horm Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 21
    • 0033009460 scopus 로고    scopus 로고
    • The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.
    • Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999;48:507-513.
    • (1999) Diabetes , vol.48 , pp. 507-513
    • Sharma, A.1    Zangen, D.H.2    Reitz, P.3
  • 22
    • 0036054995 scopus 로고    scopus 로고
    • Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats.
    • Taguchi M, Yamaguchi T, Otsuki M. Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats. J Pathol. 2002;197:638-646.
    • (2002) J Pathol , vol.197 , pp. 638-646
    • Taguchi, M.1    Yamaguchi, T.2    Otsuki, M.3
  • 23
    • 85026159353 scopus 로고    scopus 로고
    • Experimental studies in the influence of partial resection and duct ligature of the pancreas on regeneration of rat pancreas in Japanese.
    • Sumi S, Kitamura Y, Endo S. Experimental studies in the influence of partial resection and duct ligature of the pancreas on regeneration of rat pancreas [in Japanese]. Jpn J Biliopancreatic Physiol. 2002;18:45-48.
    • (2002) Jpn J Biliopancreatic Physiol , vol.18 , pp. 45-48
    • Sumi, S.1    Kitamura, Y.2    Endo, S.3
  • 24
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic -cells are formed by self-duplication rather than stem-cell differentiation.
    • Dor Y, Brown J, Martinez OI, et al. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3
  • 25
    • 0034100823 scopus 로고    scopus 로고
    • Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells.
    • Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 2000;6:278-282.
    • (2000) Nat Med , vol.6 , pp. 278-282
    • Ramiya, V.K.1    Maraist, M.2    Arfors, K.E.3
  • 26
    • 0033815611 scopus 로고    scopus 로고
    • Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro. Further evidence for pluripotent pancreatic stem cells in humans.
    • Gmyr V, Kerr-Conte J, Belaich S, et al. Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro. Further evidence for pluripotent pancreatic stem cells in humans. Diabetes. 2000;49: 1671-1680.
    • (2000) Diabetes , vol.49 , pp. 1671-1680
    • Gmyr, V.1    Kerr-Conte, J.2    Belaich, S.3
  • 27
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue.
    • Bonner-Weir S, Taneja M, Weir GC, et al. in vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA. 2000;97: 7999-8004.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 28
    • 0043268785 scopus 로고    scopus 로고
    • Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.
    • Gao R, Ustinov J, Pulkkinen MA, et al. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes. 2003;52:2007-2015.
    • (2003) Diabetes , vol.52 , pp. 2007-2015
    • Gao, R.1    Ustinov, J.2    Pulkkinen, M.A.3
  • 29
    • 0035119871 scopus 로고    scopus 로고
    • Multipotent nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes.
    • Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotent nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes. 2001; 50:521-533.
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3
  • 30
    • 0036082806 scopus 로고    scopus 로고
    • Nestin expression in pancreatic stellate cells and angiogenic endothelial cells.
    • Lardon J, Rooman I, Bouwen L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol. 2002;117: 535-540.
    • (2002) Histochem Cell Biol , vol.117 , pp. 535-540
    • Lardon, J.1    Rooman, I.2    Bouwen, L.3
  • 31
    • 85026184400 scopus 로고    scopus 로고
    • Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.
    • Esni F, Stoffers DA, Takeuchi T, et al. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev. 2004;232:26-25.
    • (2004) Mech Dev , vol.232 , pp. 26-25
    • Esni, F.1    Stoffers, D.A.2    Takeuchi, T.3
  • 32
    • 0141643297 scopus 로고    scopus 로고
    • Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet.
    • Treutelaar MK, Skidmore JM, Dias-Leme CL, et al. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes. 2003;52:2503-2512.
    • (2003) Diabetes , vol.52 , pp. 2503-2512
    • Treutelaar, M.K.1    Skidmore, J.M.2    Dias-Leme, C.L.3
  • 33
    • 0037213235 scopus 로고    scopus 로고
    • Pancreatic-hepatic switches in vivo.
    • Grompe M. Pancreatic-hepatic switches in vivo. Mech Dev. 2003;120: 99-106.
    • (2003) Mech Dev , vol.120 , pp. 99-106
    • Grompe, M.1
  • 34
    • 0030338534 scopus 로고    scopus 로고
    • Expression of transcription factors and stem cell factor precedes hepatocyte differentiation in rat pancreas.
    • Rao MS, Yukawa M, Omori M, et al. Expression of transcription factors and stem cell factor precedes hepatocyte differentiation in rat pancreas. Gene Expr. 1996;6:15-22.
    • (1996) Gene Expr , vol.6 , pp. 15-22
    • Rao, M.S.1    Yukawa, M.2    Omori, M.3
  • 35
    • 0037062515 scopus 로고    scopus 로고
    • In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells.
    • Yang L, Li S, Hatch H, et al. in vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA. 2002;99:8078-8083.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8078-8083
    • Yang, L.1    Li, S.2    Hatch, H.3
  • 36
    • 0037033798 scopus 로고    scopus 로고
    • Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver.
    • Suzuki A, Zheng Y, Kaneko S, et al. Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol. 2002;156:173-184.
    • (2002) J Cell Biol , vol.156 , pp. 173-184
    • Suzuki, A.1    Zheng, Y.2    Kaneko, S.3
  • 37
    • 0036312398 scopus 로고    scopus 로고
    • Combined expression of pancreatic duodenal box 1 and islet factor 1 induces immature enterocytes to produce insulin.
    • Kojima H, Nakamura T, Fujita Y, et al. Combined expression of pancreatic duodenal box 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes. 2002;51:1398-1408.
    • (2002) Diabetes , vol.51 , pp. 1398-1408
    • Kojima, H.1    Nakamura, T.2    Fujita, Y.3
  • 38
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.
    • Kojima H, Nakamura T, Fujita Y, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003;9:596-603.
    • (2003) Nat Med , vol.9 , pp. 596-603
    • Kojima, H.1    Nakamura, T.2    Fujita, Y.3
  • 39
    • 0043165142 scopus 로고    scopus 로고
    • Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice.
    • Wei JP, Zhang TS, Kawa S, et al. Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice. Cell Transplant. 2003;12:545-552.
    • (2003) Cell Transplant , vol.12 , pp. 545-552
    • Wei, J.P.1    Zhang, T.S.2    Kawa, S.3
  • 40
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.
    • Ianus A, Holz GG, Theise ND, et al. in vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest. 2003;111:843-850.
    • (2003) J Clin Invest , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3
  • 41
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.
    • Soria B, Roche E, Berna G, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes. 2000;49:157-162.
    • (2000) Diabetes , vol.49 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3
  • 42
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin- secretion structures similar to pancreatic islets.
    • Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin- secretion structures similar to pancreatic islets. Science. 2001;292:1389-1394.
    • (2001) Science , vol.292 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3
  • 43
    • 0035434048 scopus 로고    scopus 로고
    • Insulin production by human embryonic stem cells.
    • Assady S, Maor G, Amit M, et al. Insulin production by human embryonic stem cells. Diabetes. 2001;50:1691-1697.
    • (2001) Diabetes , vol.50 , pp. 1691-1697
    • Assady, S.1    Maor, G.2    Amit, M.3
  • 44
    • 17644444812 scopus 로고    scopus 로고
    • In vivo functioning and transplantable mature pancreatic islet-like cell clusters differentiated from embryonic stem cell.
    • Kim D, Gu Y, Ishii M, et al. in vivo functioning and transplantable mature pancreatic islet-like cell clusters differentiated from embryonic stem cell. Pancreas. 2003;27:e34-e41.
    • (2003) Pancreas , vol.27
    • Kim, D.1    Gu, Y.2    Ishii, M.3
  • 45
    • 0037449573 scopus 로고    scopus 로고
    • Insulin staining of ES cell progeny from insulin uptake.
    • Rajagopal J, Anderson WJ, Kume S, et al. Insulin staining of ES cell progeny from insulin uptake. Science. 2003;299:363.
    • (2003) Science , vol.299 , pp. 363
    • Rajagopal, J.1    Anderson, W.J.2    Kume, S.3
  • 47
    • 0037080757 scopus 로고    scopus 로고
    • Reversal of diabetes in mice by xeno-transplantation of a bioartificial pancreas in a prevascularized subcutaneous site.
    • Wang W, Gu Y, Tabata Y, et al. Reversal of diabetes in mice by xeno-transplantation of a bioartificial pancreas in a prevascularized subcutaneous site. Transplantation. 2002;73:122-129.
    • (2002) Transplantation , vol.73 , pp. 122-129
    • Wang, W.1    Gu, Y.2    Tabata, Y.3
  • 48
    • 0041766187 scopus 로고    scopus 로고
    • Subcutaneous transplantation of macroencapsulated porcine pancreatic endocrine cells normalizes hyperglycemia in diabetic mice.
    • Wang W, Gu Y, Hori H, et al. Subcutaneous transplantation of macroencapsulated porcine pancreatic endocrine cells normalizes hyperglycemia in diabetic mice. Transplantation. 2003;76:290-296.
    • (2003) Transplantation , vol.76 , pp. 290-296
    • Wang, W.1    Gu, Y.2    Hori, H.3
  • 49
    • 2542461057 scopus 로고    scopus 로고
    • PVA hydrogel sheet macroencapsulation for the bioartificial pancreas.
    • Qi M, Gu Y, Sakata N, et al. PVA hydrogel sheet macroencapsulation for the bioartificial pancreas. Biomaterials. 2004;25:5885-5892.
    • (2004) Biomaterials , vol.25 , pp. 5885-5892
    • Qi, M.1    Gu, Y.2    Sakata, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.