Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 30, 2005, Pages 10640-10645

  Wu, Kai Da ^a   Cho, Young Shin ^a   Katz, Jonathan ^a   Ponomarev, Vladimir ^a   Chen Kiang, Selina ^b   Danishefsky, Samuel J ^a   Moore, Malcolm A S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cancer therapy; Microtubule; Mouse model; Multiple myeloma; Targeting

Indexed keywords

12,13 DESOXYEPOTHILONE B; CASPASE 8; CASPASE 9; CD34 ANTIGEN; DNA; EPOTHILONE DERIVATIVE; FLUDELONE; MITOCHONDRIAL PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL CYCLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; HUMAN; MICROTUBULE; MOUSE; MULTIPLE MYELOMA; MYELOMA; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; XENOGRAFT;

ANIMALS; ANNEXIN A5; APOPTOSIS; BONE MARROW CELLS; CASPASE 8; CASPASE 9; CASPASES; CELL CYCLE; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOTHILONES; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MULTIPLE MYELOMA;

TRIFLUORO;

EID: 23044482259     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504512102     Document Type: Article

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