A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain

Gene

Volumn 203, Issue 1, 1997, Pages 1-9

  Ruan, Xiaoan ^a   Stassi, Diane ^a   Lax, Stuart A ^a   Katz, Leonard ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Acyltransferase; DAHP synthase; HTH motif; Ligase; Pteridine dependent dioxygenase

Indexed keywords

2 DEHYDRO 3 DEOXYPHOSPHOHEPTONATE ALDOLASE; FUNGAL DNA; PHENAZINE; RAPAMYCIN; SYNTHETASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA TRANSCRIPTION; DRUG MANUFACTURE; GENE CLUSTER; GENE ISOLATION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; STREPTOMYCES HYGROSCOPICUS;

EID: 0030729349     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(97)00450-2     Document Type: Article

References (33)

1. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. Amy C.M., Witkowski A., Naggert J., Williams B., Randhawa Z., Smith S. Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase. Proc. Natl. Acad. Sci. USA. 86:1989;3114-3118.
3. Aparicio J.F., Molnar I., Schwecke T., Konig A., Haydock S.F., Khaw L.E., Staunton J., Leadlay P.F. Organization of biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene. 169:1996;9-16.
4. Caffrey P., Bevitt D.J., Staunton J., Leadlay P.F. Identification of DEBS1, DEBS2 AND DEBS3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. FEBS Lett. 304:1992;225-228.
5. Campbell M.M., Sainsbury M., Searle P.A. The biosynthesis and synthesis of shikimic acid, chorismic acid and related compounds. Synthesis. 2:1993;179-193.
6. Carreras C.W., Pieper R., Khosla C. The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis. Top. Curr. Chem. 188:1997;85-126.
7. Dairi T., Nakano T., Aisaka K., Katsumata R., Hasegawa M. Cloning and nucleotide sequence of the responsible for chlorination of tetracycline. Biosci. Biotechnol. Biochem. 59:1995;1009-1106.
8. Dewitt J.P. Evidence for a sex factor in Streptomyces erythreus. J. Bacteriol. 164:1985;969-971.
9. Donadio S., Katz L. Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. Gene. 111:1992;51-60.
10. Haydock S., Aparicio J.F., Molnar I., Schwecke T., Konig A., Marsden A.F.A., Galloway I.S., Staunton J., Leadlay P.F. Divergent structural motifs correlated with the substrate specificity of (methyl)malonyl-CoA: acylcarrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374:1995;246-248.
11. Keith B., Dong X., Ausubel F.M., Fink G.R. Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack. Proc. Natl. Acad. Sci. USA. 88:1991;8821-8825.
12. Kunzler M., Paravicini G., Egli C.M., Irniger S., Braus G.H. Cloning, primary structure and regulation of the ARO4 gene, encoding the tyrosine-inhibited 3- deoxy-D-arabino-heptulosonate-7-phosphate synthase of Saccharomyces cerevisiae. Gene. 113:1992;67-74.
13. Leblond P., Redenbach M., Cullum J. Physical map of the Streptomyces lividans 66 genome and comparison with that of the related strain Streptomyces ceolicolor A3(2). J. Bacteriol. 175:1993;3422-3429.
14. Lomovskaya N., Fonstein L., Ruan X., Stassi D., Katz L., Hutchinson C.R. Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253. Microbiology. 143:1997;875-883.
15. Lowden P.A.S., Bohm G.A., Staunton J., Leadlay P.F. The nature of the starter unit for the rapamycin polyketide synthase. Angew. Chem. Int. Ed. Engl. 35:1996;2249-2251.
16. MacNeil D.J., Occi J. L, Gewain K.M., MacNeil T., Gibbons P.H., Ruby C.L., Danis S.J. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. Gene. 115:1992;119-125.
17. Maniatis, T., Fritsch, E.F., Sambrook, J., 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Molnar I., Aparicio J.F., Haydock S.F., Khaw L.E., Schwecke T., Konig A., Staunton J., Leadlay P.F. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene. 169:1996;1-7.
19. Motamedi H., Cai S.J., Shafiee A., Elliston K.O. Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. Eur. J. Biochem. 244:1997;74-80.
20. Paiva N.L., Robert M.F., Demain A.L. The cyclohexane moiety of rapamycin is derived from shikimic acid in Streptomyces hygroscopicus. J. Ind. Microbiol. 12:1993;423-428.
21. Pierson III L.S., Gaffney T., Lam S., Gong F. Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium Pseudomonas aureofaciens 30-84. FEMS Microbiol. Lett. 134:1995;299-307.
22. Saraste M., Sibbald P.R., Wittinghofer A. The P-loop: a common motif in ATP-binding and GTP-binding proteins. Trends Biol. Sci. 15:1990;430-434.
23. Schwecke T., Aparicio J.F., Molnar I., Konig A., Khaw L.E., Haydock S.F., Oliynyk M., Caffrey P., Cortes J., Lester J.B., Bohm G.A., Staunton J., Leadlay P.F. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA. 92:1995;7839-7843.
24. Schultz J., Hermondson M.A., Garner C.C., Herrmann K.M. The nucleotide sequence of the AroF gene of Escherichia coli and the amino acid sequence of the encoded protein, the tyrosine-sensitive 3-deoxy-D-arabino-heptulosonate-7- phosphate synthase. J. Biol. Chem. 259:1984;9655-9661.
25. Scrutton N.S., Berry A., Perham R.N. Redesign of the coenzyme specificity of a dehydrogenase by protein engineering. Nature. 343:1990;38-43.
26. Strohl W.R. Compilation and analysis of DNA sequences associated with apparent Streptomycete promoters. Nucleic Acids Res. 20:1992;961-974.
27. Swan D.G., Rodriguez A.M., Vilches C., Mendez C., Salas J.A. Characterization of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence. Mol. Gen. Genet. 242:1994;358-362.
28. Tuan J.S., Weber J.M., Staver M.J., Leung J.O., Donadio S., Katz L. Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid. Gene. 90:1990;21-29.
29. Turgay K., Krause M., Marahiel M.A. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Mol. Microbiol. 6:1992;529-546.
30. Walker G.E., Dunbar B., Hunter I., Nimmo H.G., Coggins J. Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2) Streptomyces rimosus and Neurospora crassa. Microbiology. 142:1996;1973-1982.
31. Wang Y., Herrmann K.M., Weller S.C., Doldsbrough P.B. Cloning and nucleotide sequence of a complementary DNA encoding 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases from tobacco. Plant Physiol. 97:1991;847-848.
32. Yamamoto H., Maurer K.H., Hutchinson C.R. Transformation of Streptomyces erythraeus. J. Antibiot. 39:1986;1304-1313.
33. Zhao J., Herrmann K.M. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Solanum tuberosum L. Plant Physiol. 100:1992;1075-1076.