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Volumn 33, Issue 8, 2005, Pages 1083-1096

Cancer chemotherapy and drug metabolism

Author keywords

[No Author keywords available]

Indexed keywords

1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; 3 AMINO 1,2,4 BENZOTRIAZINE 1 OXIDE; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYTOCHROME P450; DOXORUBICIN; DRUG METABOLIZING ENZYME; GLUTATHIONE; MITOMYCIN C; TIRAPAZAMINE;

EID: 22944471145     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.105.004374     Document Type: Conference Paper
Times cited : (60)

References (70)
  • 1
    • 0029975072 scopus 로고    scopus 로고
    • Modulation of the expression of constitutive rat hepatic cytochrome P450 isozymes by 5-fluorouracil
    • Afsar A, Lee C, and Riddick DS (1996) Modulation of the expression of constitutive rat hepatic cytochrome P450 isozymes by 5-fluorouracil. Can J Physiol Pharmacol 74:150-156.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 150-156
    • Afsar, A.1    Lee, C.2    Riddick, D.S.3
  • 2
    • 0344200002 scopus 로고    scopus 로고
    • Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P4502B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies
    • Aghi M, Chou TC, Suling K, Breakefield XO, and Chiocca EA (1999) Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P4502B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res 59:3861-3865.
    • (1999) Cancer Res , vol.59 , pp. 3861-3865
    • Aghi, M.1    Chou, T.C.2    Suling, K.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 3
    • 0032031001 scopus 로고    scopus 로고
    • Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin
    • Beaumont PO, Moore MJ, Ahmad K, Payne MM, Lee C, and Riddick DS (1998) Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin. Cancer Res 58:947-955.
    • (1998) Cancer Res , vol.58 , pp. 947-955
    • Beaumont, P.O.1    Moore, M.J.2    Ahmad, K.3    Payne, M.M.4    Lee, C.5    Riddick, D.S.6
  • 7
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM and Wilson WR (2004) Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4:437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 9
    • 0036015567 scopus 로고    scopus 로고
    • Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer
    • Chen L and Waxman DJ (2002) Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. Curr Pharm Des 8:1405-1416.
    • (2002) Curr Pharm des , vol.8 , pp. 1405-1416
    • Chen, L.1    Waxman, D.J.2
  • 10
    • 0029891878 scopus 로고    scopus 로고
    • Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat
    • Cheung RLH, Lee C, Jones EJ, and Riddick DS (1996) Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat. Xenobiotica 26:503-514.
    • (1996) Xenobiotica , vol.26 , pp. 503-514
    • Cheung, R.L.H.1    Lee, C.2    Jones, E.J.3    Riddick, D.S.4
  • 11
    • 0038779269 scopus 로고    scopus 로고
    • Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro
    • Chinje EC, Cowen RL, Feng J, Sharma SP, Wind NS, Harris AL, and Stratford IJ (2003) Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro. Mol Pharmacol 63:1248-1255.
    • (2003) Mol Pharmacol , vol.63 , pp. 1248-1255
    • Chinje, E.C.1    Cowen, R.L.2    Feng, J.3    Sharma, S.P.4    Wind, N.S.5    Harris, A.L.6    Stratford, I.J.7
  • 12
    • 0038134267 scopus 로고
    • Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats
    • Cowan KH, Batist G, Tulpule A, Sinha BK, and Myers CE (1986) Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proc Natl Acad Sci USA 83:9328-9332.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 9328-9332
    • Cowan, K.H.1    Batist, G.2    Tulpule, A.3    Sinha, B.K.4    Myers, C.E.5
  • 13
    • 0642379637 scopus 로고    scopus 로고
    • Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts
    • Cowen RL, Patterson AV, Telfer BA, Airley RE, Hobbs S, Phillips RM, Jaffar M, Stratford IJ, and Williams KJ (2003) Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts. Mol Cancer Ther 2:901-909.
    • (2003) Mol Cancer Ther , vol.2 , pp. 901-909
    • Cowen, R.L.1    Patterson, A.V.2    Telfer, B.A.3    Airley, R.E.4    Hobbs, S.5    Phillips, R.M.6    Jaffar, M.7    Stratford, I.J.8    Williams, K.J.9
  • 14
    • 1242271216 scopus 로고    scopus 로고
    • Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumor radioresistance and effecting cure
    • Cowen RL, Williams KJ, Chinje EC, Jaffar M, Sheppard FCD, Telfer BA, Wind NS, and Stratford IJ (2004) Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure. Cancer Res 64:1396-1402.
    • (2004) Cancer Res , vol.64 , pp. 1396-1402
    • Cowen, R.L.1    Williams, K.J.2    Chinje, E.C.3    Jaffar, M.4    Sheppard, F.C.D.5    Telfer, B.A.6    Wind, N.S.7    Stratford, I.J.8
  • 16
    • 0032699908 scopus 로고    scopus 로고
    • Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin
    • Di Re J, Lee C, and Riddick DS (1999) Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin. Can J Physiol Pharmacol 77:589-597.
    • (1999) Can J Physiol Pharmacol , vol.77 , pp. 589-597
    • Di Re, J.1    Lee, C.2    Riddick, D.S.3
  • 17
    • 0027931173 scopus 로고
    • Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR4233) to DNA-damaging species: A direct role for NADPH:cytochrome P450 oxidoreductase
    • Fitzsimmons SA, Lewis AD, Riley RJ, and Workman P (1994) Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR4233) to DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase. Carcinogenesis 15:1503-1510.
    • (1994) Carcinogenesis , vol.15 , pp. 1503-1510
    • Fitzsimmons, S.A.1    Lewis, A.D.2    Riley, R.J.3    Workman, P.4
  • 18
    • 0029985411 scopus 로고    scopus 로고
    • Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice
    • Forkert PG, Lord JA, and Parkinson A (1996) Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice. Carcinogenesis 17:127-132.
    • (1996) Carcinogenesis , vol.17 , pp. 127-132
    • Forkert, P.G.1    Lord, J.A.2    Parkinson, A.3
  • 20
    • 0033006172 scopus 로고    scopus 로고
    • A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin
    • Gewirtz DA (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin. Biochem Pharmacol 57:727-741.
    • (1999) Biochem Pharmacol , vol.57 , pp. 727-741
    • Gewirtz, D.A.1
  • 21
    • 0027732229 scopus 로고
    • Cytochrome P450-2B1-mediated one-electron reduction of Adriamycin: A study with rat liver microsomes and purified enzymes
    • Goeptar AR, Koppele JMT, Lamme EK, Pique JM, and Vermeulen NPE (1993) Cytochrome P450-2B1-mediated one-electron reduction of Adriamycin: a study with rat liver microsomes and purified enzymes. Mol Pharmacol 44:1267-1277.
    • (1993) Mol Pharmacol , vol.44 , pp. 1267-1277
    • Goeptar, A.R.1    Koppele, J.M.T.2    Lamme, E.K.3    Pique, J.M.4    Vermeulen, N.P.E.5
  • 23
    • 0029561598 scopus 로고
    • The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
    • Hayes JD and Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600.
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 445-600
    • Hayes, J.D.1    Pulford, D.J.2
  • 24
    • 0036283121 scopus 로고    scopus 로고
    • PPARs: Transcriptional effectors of fatty acids and their derivatives
    • Hihi AK, Michalik L, and Wahli W (2002) PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 59:790-798.
    • (2002) Cell Mol Life Sci , vol.59 , pp. 790-798
    • Hihi, A.K.1    Michalik, L.2    Wahli, W.3
  • 26
    • 0035116213 scopus 로고    scopus 로고
    • Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector
    • Ichikawa T, Petros WP, Ludeman SM, Fangmeier J, Hochberg FH, Colvin OM, and Chiocca EA (2001) Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer Res 61:864-868.
    • (2001) Cancer Res , vol.61 , pp. 864-868
    • Ichikawa, T.1    Petros, W.P.2    Ludeman, S.M.3    Fangmeier, J.4    Hochberg, F.H.5    Colvin, O.M.6    Chiocca, E.A.7
  • 27
    • 0026459859 scopus 로고
    • The ATP-dependent glutathione S-conjugate export pump
    • Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-468.
    • (1992) Trends Biochem Sci , vol.17 , pp. 463-468
    • Ishikawa, T.1
  • 28
    • 0028001416 scopus 로고
    • ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein
    • Jedlitschky G, Leier I, Buchholz U, Center M, and Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836.
    • (1994) Cancer Res , vol.54 , pp. 4833-4836
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Center, M.4    Keppler, D.5
  • 29
    • 0034660849 scopus 로고    scopus 로고
    • Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
    • Jounaidi Y and Waxman DJ (2000) Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res 60:3761-3769.
    • (2000) Cancer Res , vol.60 , pp. 3761-3769
    • Jounaidi, Y.1    Waxman, D.J.2
  • 30
    • 0035360868 scopus 로고    scopus 로고
    • Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy
    • Jounaidi Y and Waxman DJ (2001) Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. Cancer Res 61:4437-4444.
    • (2001) Cancer Res , vol.61 , pp. 4437-4444
    • Jounaidi, Y.1    Waxman, D.J.2
  • 31
    • 0346310513 scopus 로고    scopus 로고
    • Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy
    • Jounaidi Y and Waxman DJ (2004) Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy. Cancer Res 64:292-303.
    • (2004) Cancer Res , vol.64 , pp. 292-303
    • Jounaidi, Y.1    Waxman, D.J.2
  • 33
    • 0029582977 scopus 로고
    • The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: Implications for drug interactions
    • Kivisto KT, Kroemer HK, and Eichelbaum M (1995) The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions. Br J Clin Pharmacol 40:523-530.
    • (1995) Br J Clin Pharmacol , vol.40 , pp. 523-530
    • Kivisto, K.T.1    Kroemer, H.K.2    Eichelbaum, M.3
  • 36
    • 4444325481 scopus 로고    scopus 로고
    • Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial
    • Lohr M, Kroger JC, Hoffmeyer A, Freund M, Hain J, Holle A, Knofel WT, Liebe S, Nizze H, Renner M, et al. (2003) Safety, feasibility and clinical benefit of localized chemotherapy using microencapsulated cells for inoperable pancreatic carcinoma in a phase I/II trial. Cancer Ther 1:121-131.
    • (2003) Cancer Ther , vol.1 , pp. 121-131
    • Lohr, M.1    Kroger, J.C.2    Hoffmeyer, A.3    Freund, M.4    Hain, J.5    Holle, A.6    Knofel, W.T.7    Liebe, S.8    Nizze, H.9    Renner, M.10
  • 37
    • 11244311919 scopus 로고    scopus 로고
    • Anti-tumor activity of methoxymorpholinyl doxorubicin: Potentiation by cytochrome P450 3A metabolism
    • Lu H and Waxman DJ (2005) Anti-tumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism. Mol Pharmacol 67:1-8.
    • (2005) Mol Pharmacol , vol.67 , pp. 1-8
    • Lu, H.1    Waxman, D.J.2
  • 39
    • 0019430035 scopus 로고
    • Depression of cytochrome P-450-dependent drug biotransformation by Adriamycin
    • Marchand DJ and Renton KW (1981) Depression of cytochrome P-450-dependent drug biotransformation by Adriamycin. Toxicol Appl Pharmacol 58:83-88.
    • (1981) Toxicol Appl Pharmacol , vol.58 , pp. 83-88
    • Marchand, D.J.1    Renton, K.W.2
  • 41
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G, Musso T, Sica A, Taylor LS, Cox GW, and Varesio LA (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 182:1683-1693.
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.A.6
  • 42
    • 0019778964 scopus 로고
    • The effects of Adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: Role of microsomal lipid peroxidation
    • Mimnaugh EG, Trush MA, Ginsburg E, Hirokata Y, and Gram TE (1981) The effects of Adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: role of microsomal lipid peroxidation. Toxicol Appl Pharmacol 61:313-325.
    • (1981) Toxicol Appl Pharmacol , vol.61 , pp. 313-325
    • Mimnaugh, E.G.1    Trush, M.A.2    Ginsburg, E.3    Hirokata, Y.4    Gram, T.E.5
  • 43
    • 0031867669 scopus 로고    scopus 로고
    • Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity
    • Morrow CS, Diah S, Smitherman PK, Schneider E, and Townsend AJ (1998a) Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity. Carcinogenesis 19:109-115.
    • (1998) Carcinogenesis , vol.19 , pp. 109-115
    • Morrow, C.S.1    Diah, S.2    Smitherman, P.K.3    Schneider, E.4    Townsend, A.J.5
  • 44
    • 0032493638 scopus 로고    scopus 로고
    • Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification: Mechanism of GST Al-l- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells
    • Morrow CS, Smitherman PK, Diah K, Schneider E, and Townsend AJ (1998b) Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification: mechanism of GST Al-l- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells. J Biol Chem 273:20114-20120.
    • (1998) J Biol Chem , vol.273 , pp. 20114-20120
    • Morrow, C.S.1    Smitherman, P.K.2    Diah, K.3    Schneider, E.4    Townsend, A.J.5
  • 45
    • 0033653893 scopus 로고    scopus 로고
    • Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells
    • Morrow CS, Smitherman PK, and Townsend AJ (2000) Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells. Mol Carcinog 29:170-178.
    • (2000) Mol Carcinog , vol.29 , pp. 170-178
    • Morrow, C.S.1    Smitherman, P.K.2    Townsend, A.J.3
  • 46
    • 4444355902 scopus 로고    scopus 로고
    • Drug resistance and its clinical circumvention
    • Kufe D, Pollock R, Weischselbaum R, Bast R, Gansler T, Holland J, and Frei E eds BC Decker Inc, Hamilton, ON, Canada
    • Moscow JA, Morrow CS, and Cowan KH (2003) Drug resistance and its clinical circumvention, in Cancer Medicine, 6th ed (Kufe D, Pollock R, Weischselbaum R, Bast R, Gansler T, Holland J, and Frei E eds) pp 711-725, BC Decker Inc, Hamilton, ON, Canada.
    • (2003) Cancer Medicine, 6th Ed , pp. 711-725
    • Moscow, J.A.1    Morrow, C.S.2    Cowan, K.H.3
  • 47
    • 0033948989 scopus 로고    scopus 로고
    • Anticancer derivative of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity
    • Niitsu N, Kasukabe T, Yokoyama A, Okabe-Kado J, Yamamoto-Yamaguchi Y, Umeda M, and Honma Y (2000) Anticancer derivative of butyric acid (pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity. Mol Pharmacol 58:27-36.
    • (2000) Mol Pharmacol , vol.58 , pp. 27-36
    • Niitsu, N.1    Kasukabe, T.2    Yokoyama, A.3    Okabe-Kado, J.4    Yamamoto-Yamaguchi, Y.5    Umeda, M.6    Honma, Y.7
  • 48
    • 0028867912 scopus 로고
    • Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233)
    • Patterson AV, Barham HM, Chinje EC, Adams GE, Harris AL, and Stratford IJ (1995) Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233). Br J Cancer 72:1144-1150.
    • (1995) Br J Cancer , vol.72 , pp. 1144-1150
    • Patterson, A.V.1    Barham, H.M.2    Chinje, E.C.3    Adams, G.E.4    Harris, A.L.5    Stratford, I.J.6
  • 49
    • 0030692717 scopus 로고    scopus 로고
    • Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
    • Patterson AV, Saunders MP, Chinje EC, Talbot DC, Harris AL, and Stratford IJ (1997) Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br J Cancer 76:1338-1347.
    • (1997) Br J Cancer , vol.76 , pp. 1338-1347
    • Patterson, A.V.1    Saunders, M.P.2    Chinje, E.C.3    Talbot, D.C.4    Harris, A.L.5    Stratford, I.J.6
  • 51
    • 0035896509 scopus 로고    scopus 로고
    • Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance: Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity
    • Paumi CM, Ledford DG, Smitherman PK, Townsend AJ, and Morrow CS (2001) Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance: kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. J Biol Chem 276:7952-7956.
    • (2001) J Biol Chem , vol.276 , pp. 7952-7956
    • Paumi, C.M.1    Ledford, D.G.2    Smitherman, P.K.3    Townsend, A.J.4    Morrow, C.S.5
  • 54
    • 0036721374 scopus 로고    scopus 로고
    • Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene
    • Pawlik TM, Nakamura H, Mullen JT, Kasuya H, Yoon SS, Chandrasekhar S, Chiocca EA, and Tanabe KK (2002) Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer 95:1171-1181.
    • (2002) Cancer , vol.95 , pp. 1171-1181
    • Pawlik, T.M.1    Nakamura, H.2    Mullen, J.T.3    Kasuya, H.4    Yoon, S.S.5    Chandrasekhar, S.6    Chiocca, E.A.7    Tanabe, K.K.8
  • 55
    • 4344604014 scopus 로고    scopus 로고
    • Pharmacogenomics in cancer therapy: Is host genome variability important?
    • Petros WP and Evans WE (2004) Pharmacogenomics in cancer therapy: is host genome variability important? Trends Pharmacol Sci 25:457-464.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 457-464
    • Petros, W.P.1    Evans, W.E.2
  • 56
    • 0142157665 scopus 로고    scopus 로고
    • Human NADPH-cytochrome P450 reductase overexpression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines
    • Ramji S, Lee C, Inaba T, Patterson AV, and Riddick DS (2003) Human NADPH-cytochrome P450 reductase overexpression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines. Cancer Res 63:6914-6919.
    • (2003) Cancer Res , vol.63 , pp. 6914-6919
    • Ramji, S.1    Lee, C.2    Inaba, T.3    Patterson, A.V.4    Riddick, D.S.5
  • 58
    • 0036894385 scopus 로고    scopus 로고
    • Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35
    • Schwartz PS, Chen CS, and Waxman DJ (2002) Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35. Cancer Res 62:6928-6937.
    • (2002) Cancer Res , vol.62 , pp. 6928-6937
    • Schwartz, P.S.1    Chen, C.S.2    Waxman, D.J.3
  • 59
    • 0035210529 scopus 로고    scopus 로고
    • Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells
    • Schwartz PS and Waxman DJ (2001) Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol 60:1268-1279.
    • (2001) Mol Pharmacol , vol.60 , pp. 1268-1279
    • Schwartz, P.S.1    Waxman, D.J.2
  • 60
    • 0032478957 scopus 로고    scopus 로고
    • Cell line designation change: Multidrugresistant cell line in the NCI anticancer screen
    • Scudiero DA, Monks A, and Sausville EA (1998) Cell line designation change: multidrugresistant cell line in the NCI anticancer screen. J Natl Cancer Inst 90:862.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 862
    • Scudiero, D.A.1    Monks, A.2    Sausville, E.A.3
  • 62
    • 0030871773 scopus 로고    scopus 로고
    • Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: Relationship to tumor hypoxia
    • Siim BG, Menke DR, Dorie MJ, and Brown JM (1997) Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. Cancer Res 57:2922-2928.
    • (1997) Cancer Res , vol.57 , pp. 2922-2928
    • Siim, B.G.1    Menke, D.R.2    Dorie, M.J.3    Brown, J.M.4
  • 63
    • 1642475109 scopus 로고    scopus 로고
    • Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317
    • Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, and Wilson WR (2004) Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Cancer Res 64:736-742.
    • (2004) Cancer Res , vol.64 , pp. 736-742
    • Siim, B.G.1    Pruijn, F.B.2    Sturman, J.R.3    Hogg, A.4    Hay, M.P.5    Brown, J.M.6    Wilson, W.R.7
  • 64
    • 0346497684 scopus 로고    scopus 로고
    • Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity
    • Smitherman PK, Townsend AJ, Kute TE, and Morrow CS (2004) Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther 308:260-267.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 260-267
    • Smitherman, P.K.1    Townsend, A.J.2    Kute, T.E.3    Morrow, C.S.4
  • 65
    • 0030589523 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy (GDEPT): Choice of prodrugs
    • Springer CJ and Niculescu-Duvaz I (1996) Gene-directed enzyme prodrug therapy (GDEPT): choice of prodrugs. Adv Drug Deliv Rev 22:351-364.
    • (1996) Adv Drug Deliv Rev , vol.22 , pp. 351-364
    • Springer, C.J.1    Niculescu-Duvaz, I.2
  • 66
    • 0037267664 scopus 로고    scopus 로고
    • Combining bioreductive drugs and radiation for the treatment of solid tumors
    • Stratford IJ, Williams KJ, Cowen RL, and Jaffar M (2003) Combining bioreductive drugs and radiation for the treatment of solid tumors. Semin Radiat Oncol 13:42-52.
    • (2003) Semin Radiat Oncol , vol.13 , pp. 42-52
    • Stratford, I.J.1    Williams, K.J.2    Cowen, R.L.3    Jaffar, M.4
  • 67
    • 0031900542 scopus 로고    scopus 로고
    • Role of nitric oxide in tumor progression: Lessons from human tumors
    • Thomsen LL and Miles DW (1998) Role of nitric oxide in tumor progression: lessons from human tumors. Cancer Metastasis Rev 17:107-118.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 107-118
    • Thomsen, L.L.1    Miles, D.W.2
  • 68
    • 0035677961 scopus 로고    scopus 로고
    • Treatment resistance of solid tumors: Role of hypoxia and anemia
    • Vaupel P, Thews O, and Hoeckel M (2001) Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 18:243-259.
    • (2001) Med Oncol , vol.18 , pp. 243-259
    • Vaupel, P.1    Thews, O.2    Hoeckel, M.3
  • 69
    • 0032941798 scopus 로고    scopus 로고
    • Glutathione S-transferases in wild-type and doxorubicin-resistant MCF-7 human breast cancer cell lines
    • Wang K, Ramji S, Bhathena A, Lee C, and Riddick DS (1999) Glutathione S-transferases in wild-type and doxorubicin-resistant MCF-7 human breast cancer cell lines. Xenobiotica 29:155-170.
    • (1999) Xenobiotica , vol.29 , pp. 155-170
    • Wang, K.1    Ramji, S.2    Bhathena, A.3    Lee, C.4    Riddick, D.S.5
  • 70
    • 0346059610 scopus 로고    scopus 로고
    • Harnessing apoptosis for improved anticancer gene therapy
    • Waxman DJ and Schwartz PS (2003) Harnessing apoptosis for improved anticancer gene therapy. Cancer Res 63:8563-8572.
    • (2003) Cancer Res , vol.63 , pp. 8563-8572
    • Waxman, D.J.1    Schwartz, P.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.