메뉴 건너뛰기




Volumn 26, Issue 5, 1996, Pages 503-514

Lack of effect of methotrexate on the expression of constitutive hepatic cytochromes P450 in the male rat

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRINE N DEMETHYLASE; ANDROSTENEDIONE; CYTOCHROME P450 ISOENZYME; MESSENGER RNA; METHOTREXATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; STEROID MONOOXYGENASE;

EID: 0029891878     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046728     Document Type: Article
Times cited : (5)

References (53)
  • 1
    • 8944233994 scopus 로고
    • Effects of anticancer drugs on drug metabolism
    • Anticancer Drugs : Reactive Metabolism and Drug Interactions Section 141, edited by G. Powis (Oxford: Pergamon)
    • AARBAKKE, J., and SLORDAL, L., 1994, Effects of anticancer drugs on drug metabolism. In Anticancer Drugs : Reactive Metabolism and Drug Interactions (International Encyclopedia of Pharmacology and Therapeutics, Section 141), edited by G. Powis (Oxford: Pergamon), pp. 427-438.
    • (1994) International Encyclopedia of Pharmacology and Therapeutics , pp. 427-438
    • Aarbakke, J.1    Slordal, L.2
  • 2
    • 0022446374 scopus 로고
    • Pharmacokinetic drug interactions of commonly used anticancer drugs
    • BALIS, F. M., 1986, Pharmacokinetic drug interactions of commonly used anticancer drugs. Clinical Pharmacokinetics, 11, 223-235.
    • (1986) Clinical Pharmacokinetics , vol.11 , pp. 223-235
    • Balis, F.M.1
  • 3
    • 0016422751 scopus 로고
    • Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat
    • BASU, T. K., and WILLIAMS, D. C., 1975, Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat. Chemotherapy, 21, 33-40.
    • (1975) Chemotherapy , vol.21 , pp. 33-40
    • Basu, T.K.1    Williams, D.C.2
  • 4
    • 0023074623 scopus 로고
    • P-450 cytochromes: Structure and function
    • BLACK, S. D., and COON, M. J., 1987, P-450 cytochromes: structure and function. Advances in Enzymology, 60, 35-87.
    • (1987) Advances in Enzymology , vol.60 , pp. 35-87
    • Black, S.D.1    Coon, M.J.2
  • 5
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochrome-P-450-2B and cytochrome-P450-3A in human liver microsomes
    • CHANG, T. K. H., WEBER, G. F., CRESPI, C. L., and WAXMAN, D. J., 1993, Differential activation of cyclophosphamide and ifosphamide by cytochrome-P-450-2B and cytochrome-P450-3A in human liver microsomes. Cancer Research, 53, 5629-5637.
    • (1993) Cancer Research , vol.53 , pp. 5629-5637
    • Chang, T.K.H.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • CHOMCZYNSKI, P., and SACCHI, N., 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
    • (1987) Analytical Biochemistry , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 7
    • 0024533623 scopus 로고
    • Oxidative metabolism of cyclophosphamide: Identification of the hepatic monooxygenase catalysts of drug activation
    • CLARKE, L., and WAXMAN, D. J., 1989, Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation. Cancer Research, 49, 2344-2350.
    • (1989) Cancer Research , vol.49 , pp. 2344-2350
    • Clarke, L.1    Waxman, D.J.2
  • 9
    • 0002212075 scopus 로고
    • Rat and human liver cytochromes P450. Substrate and inhibitor specificities and functional markers
    • edited by P. R. Ortiz de Montellano (New York: Plenum)
    • CORREIA, M. A., 1995, Rat and human liver cytochromes P450. Substrate and inhibitor specificities and functional markers. In Cytochrome P450: Structure, Mechanism, and Biochemistry, 2nd edn, edited by P. R. Ortiz de Montellano (New York: Plenum), pp. 607-630.
    • (1995) Cytochrome P450: Structure, Mechanism, and Biochemistry, 2nd Edn , pp. 607-630
    • Correia, M.A.1
  • 12
    • 0015108964 scopus 로고
    • Drug metabolism after repeated treatments with cytotoxic agents
    • DONELLI, M. G., and GARATTINI, S., 1971, Drug metabolism after repeated treatments with cytotoxic agents. European Journal of Cancer, 7, 361-364.
    • (1971) European Journal of Cancer , vol.7 , pp. 361-364
    • Donelli, M.G.1    Garattini, S.2
  • 13
    • 0022839163 scopus 로고
    • The Nb transitional cell bladder carcinoma model: Dose response to methotrexate and adriamycin
    • DRAGO, J. R., and NESBITT, J. A., 1986, The Nb transitional cell bladder carcinoma model: dose response to methotrexate and adriamycin. Anticancer Research, 6, 1019-1020.
    • (1986) Anticancer Research , vol.6 , pp. 1019-1020
    • Drago, J.R.1    Nesbitt, J.A.2
  • 14
    • 0019496332 scopus 로고
    • Disposition of 5-methyltetrahydrohomofolate and methotrexate in rats
    • EL DAREER, S. M., TILLERY, K. F., and HILL, D. L., 1981, Disposition of 5-methyltetrahydrohomofolate and methotrexate in rats. Cancer Treatment Reports, 65, 101-106.
    • (1981) Cancer Treatment Reports , vol.65 , pp. 101-106
    • El Dareer, S.M.1    Tillery, K.F.2    Hill, D.L.3
  • 15
    • 0022968060 scopus 로고
    • Pregnenolone 16α-carbonitrile-inducible P-450 gene family: Gene conversion and differential regulation
    • GONZALEZ, F. J., SONG, B.-J., and HARDWICK, J. P., 1986, Pregnenolone 16α-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Molecular and Cellular Biology, 6, 2969-2976.
    • (1986) Molecular and Cellular Biology , vol.6 , pp. 2969-2976
    • Gonzalez, F.J.1    Song, B.-J.2    Hardwick, J.P.3
  • 16
    • 0026345076 scopus 로고
    • Drug metabolism in carcinogenesis and cancer chemotherapy
    • GRAHAM, M. A., RILEY, R. J., and KERR, D. J., 1991, Drug metabolism in carcinogenesis and cancer chemotherapy. Pharmacology and Therapeutics, 51, 275-289.
    • (1991) Pharmacology and Therapeutics , vol.51 , pp. 275-289
    • Graham, M.A.1    Riley, R.J.2    Kerr, D.J.3
  • 17
    • 0023951396 scopus 로고
    • Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
    • GUENGERICH, F. P., 1988, Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Research, 48, 2946-2954.
    • (1988) Cancer Research , vol.48 , pp. 2946-2954
    • Guengerich, F.P.1
  • 18
    • 0025895757 scopus 로고
    • Reactions and significance of cytochrome P-450 enzymes
    • GUENGERICH, F. P., 1991, Reactions and significance of cytochrome P-450 enzymes. Journal of Biological Chemistry, 266, 10019-10022.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 10019-10022
    • Guengerich, F.P.1
  • 19
    • 0020434524 scopus 로고
    • Purification and characterization of liver microsomal cytochromes P-450: Electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone
    • GUENGERICH, F. P., DANNAN, G. A., WRIGHT, S. T., MARTIN, M. V., and KAMINSKY, K. S., 1982, Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry, 21, 6019-6030.
    • (1982) Biochemistry , vol.21 , pp. 6019-6030
    • Guengerich, F.P.1    Dannan, G.A.2    Wright, S.T.3    Martin, M.V.4    Kaminsky, K.S.5
  • 21
    • 0023706607 scopus 로고
    • Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography
    • IMAOKA, S., INOUE, K., and FUNAE, Y., 1988, Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Archives of Biochemistry and Biophysics, 265, 159-170.
    • (1988) Archives of Biochemistry and Biophysics , vol.265 , pp. 159-170
    • Imaoka, S.1    Inoue, K.2    Funae, Y.3
  • 22
    • 0029033491 scopus 로고
    • Tubulin alterations in taxol-induced apoptosis parallel those observed with other drugs
    • IRELAND, C. M., and PITTMAN, S. M., 1995, Tubulin alterations in taxol-induced apoptosis parallel those observed with other drugs. Biochemical Pharmacology, 49, 1491-1499.
    • (1995) Biochemical Pharmacology , vol.49 , pp. 1491-1499
    • Ireland, C.M.1    Pittman, S.M.2
  • 23
    • 0027143654 scopus 로고
    • cDNA cloning and characterization of a novel member of steroid- Induced cytochrome-P450 3A in rats
    • KIRITA, S., and MATSUBARA, T., 1993, cDNA cloning and characterization of a novel member of steroid- induced cytochrome-P450 3A in rats. Archives of Biochemistry and Biophysics, 307, 253-258.
    • (1993) Archives of Biochemistry and Biophysics , vol.307 , pp. 253-258
    • Kirita, S.1    Matsubara, T.2
  • 24
    • 8944230783 scopus 로고
    • Substrate binding and the reduction of cytochrome P-450
    • edited by T. Omura, Y. Ishimura, and Y. Fujii-Kuriyama (Tokyo: Kodansha/ Weinheim: VCH)
    • KOMINAMI, S., 1993, Substrate binding and the reduction of cytochrome P-450. In Cytochrome P-450, 2nd edn, edited by T. Omura, Y. Ishimura, and Y. Fujii-Kuriyama (Tokyo: Kodansha/ Weinheim: VCH), pp. 64-80.
    • (1993) Cytochrome P-450, 2nd Edn , pp. 64-80
    • Kominami, S.1
  • 25
    • 0028015588 scopus 로고
    • A major glucocorticoid-inducible P450 in rat liver is not P450 3A1
    • KOMORI, M., and ODA, Y., 1994, A major glucocorticoid-inducible P450 in rat liver is not P450 3A1. Journal of Biochemistry, 116, 114-120.
    • (1994) Journal of Biochemistry , vol.116 , pp. 114-120
    • Komori, M.1    Oda, Y.2
  • 26
    • 0022486240 scopus 로고
    • Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide
    • KROES, A. C. M., LINDEMANS, J., SCHOESTER, M., and ABELS, J., 1986, Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide. Cancer Chemotherapy and Pharmacology, 17, 114-120.
    • (1986) Cancer Chemotherapy and Pharmacology , vol.17 , pp. 114-120
    • Kroes, A.C.M.1    Lindemans, J.2    Schoester, M.3    Abels, J.4
  • 27
    • 0026575467 scopus 로고
    • Platinum anticancer drugs modulate P-450 messenger RNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats
    • LEBLANC, G. A., SUNDSETH, S. S., WEBER, G. F., and WAXMAN, D. J., 1992, Platinum anticancer drugs modulate P-450 messenger RNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer Research, 52, 540-547.
    • (1992) Cancer Research , vol.52 , pp. 540-547
    • Leblanc, G.A.1    Sundseth, S.S.2    Weber, G.F.3    Waxman, D.J.4
  • 28
    • 0023796707 scopus 로고
    • Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes
    • LEBLANC, G. A., and WAXMAN, D. J., 1988, Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes. Journal of Biological Chemistry, 263, 15732-15739.
    • (1988) Journal of Biological Chemistry , vol.263 , pp. 15732-15739
    • Leblanc, G.A.1    Waxman, D.J.2
  • 29
    • 0024439392 scopus 로고
    • Interaction of anticancer drugs with hepatic monooxygenase enzymes
    • LEBLANC, G. A., and WAXMAN, D. J., 1989, Interaction of anticancer drugs with hepatic monooxygenase enzymes. Drug Metabolism Reviews, 20, 395-439.
    • (1989) Drug Metabolism Reviews , vol.20 , pp. 395-439
    • Leblanc, G.A.1    Waxman, D.J.2
  • 30
    • 0024994181 scopus 로고
    • Mechanisms of cyclophosphamide action on hepatic P-450 expression
    • LEBLANC, G. A., and WAXMAN, D. J., 1990, Mechanisms of cyclophosphamide action on hepatic P-450 expression. Cancer Research, 50, 5720-5726.
    • (1990) Cancer Research , vol.50 , pp. 5720-5726
    • Leblanc, G.A.1    Waxman, D.J.2
  • 31
    • 0028235612 scopus 로고
    • Pharmacokinetic drug interactions with anticancer drugs
    • LOADMAN, P. M., and BIBBY, M. C., 1994, Pharmacokinetic drug interactions with anticancer drugs. Clinical Pharmacokinetics, 26, 486-500.
    • (1994) Clinical Pharmacokinetics , vol.26 , pp. 486-500
    • Loadman, P.M.1    Bibby, M.C.2
  • 33
    • 0003009327 scopus 로고
    • Experiments illustrating drug metabolism in vitro
    • edited by B. N. LaDu, H. G. Mandel, and E. L. Way (Baltimore: Williams & Wilkins)
    • MAZEL, P., 1971, Experiments illustrating drug metabolism in vitro. In Fundamentals of Drug Metabolism and Drug Disposition, edited by B. N. LaDu, H. G. Mandel, and E. L. Way (Baltimore: Williams & Wilkins), pp. 546-560.
    • (1971) Fundamentals of Drug Metabolism and Drug Disposition , pp. 546-560
    • Mazel, P.1
  • 34
    • 0022489271 scopus 로고
    • Properties of 17- to 19-day-old chick embryo liver microsomes: Induction of cytochrome P-450, effect of storage at low temperature, and resistance to lipid peroxidation
    • MCCLUSKEY, S. A., RACZ, W. J., and MARKS, G. S., 1986, Properties of 17- to 19-day-old chick embryo liver microsomes: induction of cytochrome P-450, effect of storage at low temperature, and resistance to lipid peroxidation. Journal of Pharmacological Methods, 16, 111-123.
    • (1986) Journal of Pharmacological Methods , vol.16 , pp. 111-123
    • Mccluskey, S.A.1    Racz, W.J.2    Marks, G.S.3
  • 35
    • 77049138167 scopus 로고
    • The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
    • NASH, T., 1953, The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochemical Journal, 55, 416-421.
    • (1953) Biochemical Journal , vol.55 , pp. 416-421
    • Nash, T.1
  • 37
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
    • OMURA, T., and SATO, R., 1964, The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. Journal of Biological Chemistry, 239, 2370-2378.
    • (1964) Journal of Biological Chemistry , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 39
    • 0025729024 scopus 로고
    • Hepatic P450 expression in hypothyroid rats: Differential responsiveness of male-specific P450 form-2a (IIIA2), form-2c (IIC11), and RLM2 (IIA2) to thyroid hormone
    • RAM, P. A., and WAXMAN, D. J., 1991, Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 form-2a (IIIA2), form-2c (IIC11), and RLM2 (IIA2) to thyroid hormone. Molecular Endocrinology, 5, 13-20.
    • (1991) Molecular Endocrinology , vol.5 , pp. 13-20
    • Ram, P.A.1    Waxman, D.J.2
  • 40
    • 0025139447 scopus 로고
    • Purification and characterization of hepatic microsomal cytochrome P-450
    • RYAN, D. E., and LEVIN, W., 1990, Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacology and Therapeutics, 45, 153-239.
    • (1990) Pharmacology and Therapeutics , vol.45 , pp. 153-239
    • Ryan, D.E.1    Levin, W.2
  • 41
    • 0001045460 scopus 로고
    • Age- and gender-related expression of rat liver cytochrome P450
    • Cytochrome P450 edited by J. B. Schenkman and H. Greim (Berlin: Springer)
    • RYAN, D. E., and LEVIN, W., 1993, Age- and gender-related expression of rat liver cytochrome P450. In Cytochrome P450 (Handbook of Experimental Pharmacology, vol. 105), edited by J. B. Schenkman and H. Greim (Berlin: Springer), pp. 461-476.
    • (1993) Handbook of Experimental Pharmacology , vol.105 , pp. 461-476
    • Ryan, D.E.1    Levin, W.2
  • 42
    • 0019445594 scopus 로고
    • Pharmacokinetics and organ distribution of methotrexate in the rat
    • SCHEUFLER, E., ZETLER, G., and IVEN, H., 1981, Pharmacokinetics and organ distribution of methotrexate in the rat. Pharmacology, 23, 75-81.
    • (1981) Pharmacology , vol.23 , pp. 75-81
    • Scheufler, E.1    Zetler, G.2    Iven, H.3
  • 43
    • 0017795019 scopus 로고
    • Purification and properties of NADPH-cytochrome P-450 reductase
    • STROBEL, H. W., and DIGNAM, J. D., 1978, Purification and properties of NADPH-cytochrome P-450 reductase. Methods in Enzymology, 52, 89-96.
    • (1978) Methods in Enzymology , vol.52 , pp. 89-96
    • Strobel, H.W.1    Dignam, J.D.2
  • 44
    • 0028953631 scopus 로고
    • Effects of 5-fluorouracil treatment on rat liver microsomal enzymes
    • STUPANS, I., RICHARDS, D. A., and MCCLURE, M. T., 1995, Effects of 5-fluorouracil treatment on rat liver microsomal enzymes. Xenobiotica, 25, 1-8.
    • (1995) Xenobiotica , vol.25 , pp. 1-8
    • Stupans, I.1    Richards, D.A.2    Mcclure, M.T.3
  • 45
    • 0013893582 scopus 로고
    • Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals
    • TARNOWSKI, G. S., SCHMID, F. A., CAPPUCCINO, J. G., and STOCK, C. C., 1966, Chemotherapy studies in an animal tumor spectrum. II. Sensitivity of tumors to fourteen antitumor chemicals. Cancer Research, 26, 181-206.
    • (1966) Cancer Research , vol.26 , pp. 181-206
    • Tarnowski, G.S.1    Schmid, F.A.2    Cappuccino, J.G.3    Stock, C.C.4
  • 46
    • 0021688840 scopus 로고
    • Rat hepatic cytochrome P-450 isozyme 2c. Identification as a male-specific, developmentally induced steroid 16α-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme
    • WAXMAN, D. J., 1984, Rat hepatic cytochrome P-450 isozyme 2c. Identification as a male-specific, developmentally induced steroid 16α-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme. Journal of Biological Chemistry, 259, 15481-15490.
    • (1984) Journal of Biological Chemistry , vol.259 , pp. 15481-15490
    • Waxman, D.J.1
  • 47
    • 0023837746 scopus 로고
    • Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression
    • WAXMAN, D. J., 1988, Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochemical Pharmacology, 37, 71-84.
    • (1988) Biochemical Pharmacology , vol.37 , pp. 71-84
    • Waxman, D.J.1
  • 48
    • 0026326789 scopus 로고
    • Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes
    • WAXMAN, D. J., 1991, Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. Methods in Enzymologv, 206, 249-267.
    • (1991) Methods in Enzymologv , vol.206 , pp. 249-267
    • Waxman, D.J.1
  • 49
    • 0021947032 scopus 로고
    • Regulation of rat hepatic cytochrome P-450: Age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes
    • WAXMAN, D. J., DANNAN, G. A., and GUENGERICH, F. P., 1985, Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. Biochemistry, 24, 4409-4417.
    • (1985) Biochemistry , vol.24 , pp. 4409-4417
    • Waxman, D.J.1    Dannan, G.A.2    Guengerich, F.P.3
  • 50
    • 0020624336 scopus 로고
    • Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver
    • WAXMAN, D. J., KO, A., and WALSH, C., 1983, Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. Journal of Biological Chemistry, 258, 11937-11947.
    • (1983) Journal of Biological Chemistry , vol.258 , pp. 11937-11947
    • Waxman, D.J.1    Ko, A.2    Walsh, C.3
  • 51
    • 0027174822 scopus 로고
    • Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes
    • WEBER, G. F., and WAXMAN, D. J., 1993, Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes. Biochemical Pharmacology, 45, 1685-1694.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 1685-1694
    • Weber, G.F.1    Waxman, D.J.2
  • 53
    • 0027415546 scopus 로고
    • Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation: Metabolic drug interactions
    • ZHOU, X.-J., ZHOU-PAN, X.-R., GAUTHIER, T., PLACIDI, M., MAUREL, P., and RAHMANI, R., 1993, Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation: metabolic drug interactions. Biochemical Pharmacology, 45, 853-861.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 853-861
    • Zhou, X.-J.1    Zhou-Pan, X.-R.2    Gauthier, T.3    Placidi, M.4    Maurel, P.5    Rahmani, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.