Signalling DNA damage by regulating p53 co-factor activity

Cell Cycle

Volumn 4, Issue 1, 2005, Pages 30-32

  Smith, Linda ^a   La Thangue, Nicholas B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

ATM strap; Co factors; DNA damage; JMY; p300; p53; Transcription

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53;

ACETYLATION; COMPLEX FORMATION; DNA DAMAGE; DOWNSTREAM PROCESSING; EFFECTOR CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 22844447061     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.1.1397     Document Type: Short Survey

References (27)

1. Zhou BB, Elledge S. The DNA damage response: Putting checkpoints in perspective. Nature 2000; 408:433-9.
2. Shiloh Y. ATM and ATR: Networking cellular responses to DNA damage. Curr Opin Cell Biol 2001; 11:71-7.
3. Walworth NC. Cell-cycle checkpoint kinases: Checking in on the cell cycle. Curr Opin Cell Biol 2000; 12:697-704.
4. Hainaut P, Hollstein M. P53 and human cancer: The first ten thousand mutations. Adv Cancer Res 2000; 77:81-137.
5. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene 1999; 18:7644-55.
6. Giaccia AJ, Kastan MB. The complexity of p53 modulation: Emerging patterns from divergent signals. Genes Dev 1998; 12:2973-83.
7. Abraham RT. Cell cycle checkpoint signalling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
8. Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, Lubratovich M, Verselis SJ, Isselbacher KJ, Fraumeni JF, Birch JM, Li FP, Garber JE, Haber DA. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 1999; 286:2528-31.
9. Stevens C, LaThangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair 2004; 3:1071-9.
10. La Thangue NB. Theyin and yang of E2F-1: Balancing life and death. Nat Cell Biol 2003; 5:587-8.
11. Stevens C, LaThangue NB. A new role for E2F-1 in checkpoint control. Cell Cycle 2003; 2:435-7.
12. Stevens C, Smith L, La Thangue NB. Checkpoint kinase activates E2F-1 in response to DNA damage. Nat Cell Biol 2003; 5:401-9.
13. Stevens C, La Thangue NB. E2F and cell cycle control: A double-edged sword. Arch Biochem Biophysics 2003; 412:157-69.
14. Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin Jr WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996; 85:549-61.
15. Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson N. Mutation of E2F-1 suppresses apoptosis in mice lacking E2F-1. Cell 1996; 85:537-47.
16. Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999; 19:3704-13.
17. Lin WC, Lin FT, Nevins JR. Selective induction of E2F-1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001; 15:1833-44.
18. Maser RS, Mirzoeva OK, Wells J, Olivares H, Williams BR, Zinkel RA, Farnham PJ, Petrini JH. Mrel 1 complex and DNA replication: Linkage of E2F and sites of DNA synthesis. Mol Cell Biol 2001; 21:6006-16.
19. Vousden KH, Lu X. Live or let die: The cells response to p53. Nature Reviews Cancer 2002; 2:594-604.
20. Chan H-M, La Thangue NB. P300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci 2001; 114:2363-73.
21. Gu W, Roeder RG. Activation of p53 sequence specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997; 90:595-606.
22. Shikama N, Lee C-W, Delavaine L, France S, Lyon J, Krstic-Demonacos M, La Thangue NB. A novel cofactor for p300 that regulates the p53 response. Mol Cell 1999; 4:365-76.
23. Demonacos C, Krstic-Demonacos M, La Thangue, NB. A TPR motif cofactor contributes to p300 activity in the p53 response. Mol Cell 2001; 8:71-84.
24. D'Andrea LD, Regan L. TPR proteins: the versatile helix. Trends Biochem Sci 2003; 28:655-62.
25. Demonacos C, Krstic-Demonacos M, Smith L, Xu D, O'Connor P, Jansson M, La Thangue NB. A new effector pathway links ATM kinase with the DNA damage response. Nature Cell Biol 2004; 6:968-76.
26. An W, Kim J, Roeder RG. Ordered cooperative functions of PRNT1, p300 and CARM1 in transcriptional activation by p53. Cell 2004; 117:735-48.
27. Coutts A, La Thangue NB. The p53 response: Emerging levels of cofactor complexity 2004; In press.