Characterization of ocular hypertension induced by adenosine agonists

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 9, 1996, Pages 1833-1839

  Crosson, Craig E ^a   Gray, Tracy ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

adenosine receptors; aqueous flow; aqueous protein; blood aqueous barrier; intraocular pressure

Indexed keywords

1,3 DIPROPYLXANTHINE DERIVATIVE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 ANILINOADENOSINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 7 METHYL 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE RECEPTOR STIMULATING AGENT; ALCOHOL; CYCLIC AMP; DIMETHYL SULFOXIDE; INDOMETACIN; PHENYLISOPROPYLADENOSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS HUMOR FLOW; ARTICLE; CAT; CONTROLLED STUDY; DOSE RESPONSE; INTRAOCULAR HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RABBIT; TOPICAL DRUG ADMINISTRATION;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; CATS; CORNEA; EYE PROTEINS; INTRAOCULAR PRESSURE; OCULAR HYPERTENSION; PHENETHYLAMINES; PHENYLISOPROPYLADENOSINE; RABBITS; RECEPTORS, PURINERGIC P1; TONOMETRY, OCULAR; VASODILATOR AGENTS;

EID: 0029841908     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Collins MG, Hourani MO. Adenosine receptor subtypes. Trends Pharmacol Sci. 1993;170:360.
2. Van Calker D, Muller M, Hamprecht B. Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cells. J Neurochem. 1979;33:999-1005.
3. Londos C, Cooper DMF, Wolfe J. Subclasses of external adenosine receptors. Proc Natl Acad Sci USA. 1980;77:2551-2554.
4. 3H] NECA in rat striatal membranes. Mol Pharmacol. 1986;29:331-346.
5. 2 receptor with physiological constitutive activity. Biochem Biophys Res Commun. 1990; 173:1169-1178.
6. 1 adenosine receptor. AMBO J. 1991;10:1677-1682.
7. 3 adenosine receptor. Proc Natl Acad Sci USA. 1992;89:7432-7436.
8. Blazyniski C, Woods C, Mathews GC. Evidence for the action of endogenous adenosine in the rabbit retina: Modulation of the light evoked release of acetylcholine. J Neurochem. 1992;58:761-767.
9. 3H]-noradrenaline release on rat iris. Naunyn-Schmiedeberg's Arch Pharmacol. 1992;345:417-423.
10. 2 adenosine receptors inhibits the ingestion of photoreceptors outer segments by retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1995;35:819-825.
11. Gidday JM, Park TS. Microcirculatory response to adenosine in the newborn pig retina. Pediatr Res. 1993;33:620-627.
12. Riely MV, Winkler BS, Peters MI, Starnes CA. Ionic dependence of adenosine-mediated stimulation of fluid transport in the corneal endothelium. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:S589.
13. Crosson CE. Ocular hypotensive activity of the adenosine agonist (R)-phenylisopropyladenosine in rabbits. Curr Eye Res. 1992;11:453-458.
14. Crosson CE, Gray T. Modulation of intraocular pressure by adenosine agonists. J Ocul Pharmacol. 1994; 10:379-383.
15. Crosson CE. Adenosine receptor activation modulates intraocular pressure in rabbits. J Pharmacol Exp Ther. 1995;273:320-326.
16. Tain B, Gabelt BT, Crosson CE, Kaufman PL. Effects of adenosine agonists in IOP and aqueous humor dynamics in cynomolgus monkeys. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:S3392.
17. Yablonski ME, Zimmerman TJ, Walman SR, Becker B. A fluorophotometric study of the effects of topical timolol on aqueous humor dynamics. Exp Eye Res. 1978;27:135-142.
18. Crosson CE, Heath A, De Vries GW, Potter DE. Pharmacological evidence for heterogeneity of ocular alpha-2-adrenoceptors. Curr Eye Res. 1992;11:963-970.
19. Camaras CB, Xhan GL, Wang YL, Toris CB, Yablonski ME. Effect of (R)-phenylisopropyladenosine, an adenosine A1 agonist, on aqueous humor dynamics in rabbits. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1994; 35:2052.
20. 2a receptors. J Pharmacol Exp Ther. 1995;272:511-518.
21. Camras CB, Bito LZ, Eakins KE. Reduction of intraocular pressure by prostaglandins applied topically to the eye of conscious rabbits. Invest Ophthalmol. 1977; 16:1125-1134.
22. Sen HA, Campochiaro PA. Intravitreous injection of adenosine or its agonists cause breakdown of the blood-retinal barrier. Arch Ophthalmol. 1989;107: 1364-1367.
23. Wax M, Sanghavi DM, Lee CH, Kapadia, M. Purinergic receptors in ocular ciliary epithelial cells. Exp Eye Res. 1993;57:89-95.