-
1
-
-
0026008409
-
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes
-
NICHOLSON CD, CHALLISS RAJ, SHAHID M: Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. (1991) 12:19-27.
-
(1991)
Trends Pharmacol.
, vol.12
, pp. 19-27
-
-
Nicholson, C.D.1
Challiss, R.A.J.2
Shahid, M.3
-
2
-
-
0028314313
-
Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - Their potential utility in the therapy of asthma
-
NICHOLSON CD, SHAHID M: Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma. Pulm. Pharmacol. (1994) 7:147.
-
(1994)
Pulm. Pharmacol.
, vol.7
, pp. 147
-
-
Nicholson, C.D.1
Shahid, M.2
-
3
-
-
0032605044
-
The molecular biology of cyclic nucleotide phosphodiesterases
-
CONTI M, JIN LS: The molecular biology of cyclic nucleotide phosphodiesterases. Prog. Nucleic Acid Res. Mol. Biol. (1999) 63:1-38.
-
(1999)
Prog. Nucleic Acid Res. Mol. Biol.
, vol.63
, pp. 1-38
-
-
Conti, M.1
Jin, L.S.2
-
4
-
-
0031914520
-
Phosphodiesterase isozymes: Molecular targets for novel anti-asthma agents
-
TORPHY TJ: Phosphodiesterase isozymes: molecular targets for novel anti-asthma agents. Am. J. Respir. Crit. Care Med. (1998) 157:351-370.
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.157
, pp. 351-370
-
-
Torphy, T.J.1
-
6
-
-
0030925148
-
A proposal for pharmacologically distinct conformers of PDE4
-
SOUNESS JE, RAO S: A proposal for pharmacologically distinct conformers of PDE4. Cell. signal. (1997) 9:227-236.
-
(1997)
Cell Signal
, vol.9
, pp. 227-236
-
-
Souness, J.E.1
Rao, S.2
-
7
-
-
0034733021
-
Conformational difference between PDE4 apoenzyme and holoenzyme
-
LALIBERTE F, HAN Y, GOVINDARAJAN A et al.: Conformational difference between PDE4 apoenzyme and holoenzyme. Biochemistry (2000) 39(21):6449-6458.
-
(2000)
Biochemistry
, vol.39
, Issue.21
, pp. 6449-6458
-
-
Laliberte, F.1
Han, Y.2
Govindarajan, A.3
-
8
-
-
0035964174
-
Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors
-
LIU S, LALIBERTE F, BOBECHKO B et al.: Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors. Biochemistry (2001) 40(34):10179-10186.
-
(2001)
Biochemistry
, vol.40
, Issue.34
, pp. 10179-10186
-
-
Liu, S.1
Laliberte, F.2
Bobechko, B.3
-
9
-
-
22744433150
-
GlaxoSmithKline receives FDA approvable letter for Ariflo (cilomilast) tablets 15 mg
-
GLAXOSMITHKLINE, INC.: Press release (27 October)
-
GLAXOSMITHKLINE, INC.: GlaxoSmithKline receives FDA approvable letter for Ariflo (cilomilast) tablets 15 mg. Press release (27 October 2003).
-
(2003)
-
-
-
10
-
-
14444268769
-
1,4-Cyclohexanecarboxylates: Potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma
-
CHRISTENSEN SB, GUIDER A, FORSTER CJ et al.: 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma. J. Med. Chem. (1998) 41:821-835.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 821-835
-
-
Christensen, S.B.1
Guider, A.2
Forster, C.J.3
-
11
-
-
18144418473
-
Cilomilast is efficacious in chronic obstructive pulmonary disease (COPD)
-
Abst. P530
-
REISNER T et al.: Cilomilast is efficacious in chronic obstructive pulmonary disease (COPD). Eur. Respir. J. (2003) 22(Suppl.5): Abst. P530.
-
(2003)
Eur. Respir. J.
, vol.22
, Issue.SUPPL. 5
-
-
Reisner, T.1
-
12
-
-
1542292142
-
Cardiovascular safety of cilomilast in patients with chronic obstructive pulmonary disease
-
FERGUSON G, FISCHER TL, MORIS A et al.: Cardiovascular safety of cilomilast in patients with chronic obstructive pulmonary disease. Chest (2003) 124(Suppl.4):171S.
-
(2003)
Chest
, vol.124
, Issue.SUPPL. 4
-
-
Ferguson, G.1
Fischer, T.L.2
Moris, A.3
-
13
-
-
11344262873
-
Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD
-
Abst. 267
-
RABE F, O'DONNELL D, MUIR F et al.: Roflumilast, an oral, once-daily PDE4 inhibitor, improves lung function and reduces exacerbation rates in patients with COPD. Eur. Respir. J. (2004) 24(Suppl.48): Abst. 267.
-
(2004)
Eur. Respir. J.
, vol.24
, Issue.SUPPL. 48
-
-
Rabe, F.1
O'donnell, D.2
Muir, F.3
-
14
-
-
14044253046
-
Long-term safety of roflumilast in the treatment of chronic obstructive pulmonary disease
-
BETHKE TD, BATEMAN ED, VAN NOORD JA et al.: Long-term safety of roflumilast in the treatment of chronic obstructive pulmonary disease. Chest (2004) 126(Suppl.4):805S.
-
(2004)
Chest
, vol.126
, Issue.SUPPL. 4
-
-
Bethke, T.D.1
Bateman, E.D.2
Van Noord, J.A.3
-
15
-
-
14044264400
-
Oral, once-daily roflumilast and its active N-oxide metabolite exhibit dose proportional pharmacokinetics between 250 μg and 500 μg
-
HUENNEMEYER A, ZECK K, BETHKE TD et al.: Oral, once-daily roflumilast and its active N-oxide metabolite exhibit dose proportional pharmacokinetics between 250 μg and 500 μg. Chest (2004) 126(Suppl.4):804S.
-
(2004)
Chest
, vol.126
, Issue.SUPPL. 4
-
-
Huennemeyer, A.1
Zeck, K.2
Bethke, T.D.3
-
16
-
-
22744437571
-
Pharmacokinetics of roflumilast and its active metabolite roflumilast N-oxide is not influenced by erythromycin
-
Abst. P867
-
MANEGOLD A, HAUNS B, HUENNEMEYER A et al.: Pharmacokinetics of roflumilast and its active metabolite roflumilast N-oxide is not influenced by erythromycin. Eur. Respir. J. (2004) 24(Suppl.48): Abst. P867
-
(2004)
Eur. Respir. J.
, vol.24
, Issue.SUPPL. 48
-
-
Manegold, A.1
Hauns, B.2
Huennemeyer, A.3
-
17
-
-
22744438128
-
Lack of pharmacokinetic interaction of roflumilast and its oxide metabolite, roflumilast N-oxide, with budesonide or salbutamol
-
4th World Asthma Meet (16 Feb- 19 Feb) Bangkok: Abst. P229-P230
-
HAUNS B, HUENNEMEYER A, KILIAN U et al.: Lack of pharmacokinetic interaction of roflumilast and its oxide metabolite, roflumilast N-oxide, with budesonide or salbutamol. 4th World Asthma Meet (16 Feb- 19 Feb 2004) Bangkok: Abst. P229-P230.
-
(2004)
-
-
Hauns, B.1
Huennemeyer, A.2
Kilian, U.3
-
18
-
-
22744449799
-
Inhibition of late asthmatic reaction in allergic asthma by roflumilast, a selective phosphodiesterase 4 inhibitor
-
4th World Asthma Meet (16-19 Feb) Bangkok: Abst. 0-228
-
BARDIN PG, VAN SCHALKWYK EM, VAN HEERDEN K et al.: Inhibition of late asthmatic reaction in allergic asthma by roflumilast, a selective phosphodiesterase 4 inhibitor. 4th World Asthma Meet (16-19 Feb 2004) Bangkok: Abst. 0-228.
-
(2004)
-
-
Bardin, P.G.1
Van Schalkwyk, E.M.2
Van Heerden, K.3
-
19
-
-
0347082477
-
Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma
-
Abst. 1393
-
BATEMAN D, IZQUIERDO L, VETTER N et al.: Roflumilast, a selective phosphodiesterase 4 inhibitor, shows efficacy and safety in the long-term treatment of asthma. Eur. Respir. J. (2003) 22(Suppl.45): Abst. 1393
-
(2003)
Eur. Respir. J.
, vol.22
, Issue.SUPPL. 45
-
-
Bateman, D.1
Izquierdo, L.2
Vetter, N.3
-
21
-
-
0036179542
-
The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-α ex vivo
-
TIMMER W, LECLERC V, BIRRAUX G et al.: The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS-stimulated TNF-α ex vivo. J. Clin. Pharmacol. (2002) 42(3):297.
-
(2002)
J. Clin. Pharmacol.
, vol.42
, Issue.3
, pp. 297
-
-
Timmer, W.1
Leclerc, V.2
Birraux, G.3
-
22
-
-
0029067662
-
Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships
-
CHIHIRO M, NAGAMOTO H, TAKEMURA I et al.: Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: synthesis and structure-activity relationships. J. Med. Chem. (1995) 38:353-358.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 353-358
-
-
Chihiro, M.1
Nagamoto, H.2
Takemura, I.3
-
24
-
-
11144247489
-
OPC-6535 inhibits human and porcine monocyte tumor necrosis factor-α production in vitro and in vivo
-
Abst. W1090
-
NAGAMOTO H, MAEDA T, SUEYOSHI H et al.: OPC-6535 inhibits human and porcine monocyte tumor necrosis factor-α production in vitro and in vivo. Gastroenterology (2004) 126(4, Suppl.2): Abst. W1090.
-
(2004)
Gastroenterology
, vol.126
, Issue.4 SUPPL. 2
-
-
Nagamoto, H.1
Maeda, T.2
Sueyoshi, H.3
-
25
-
-
9944262734
-
Randomized, double-blind, placebo-controlled, parallel arm, safety and efficacy trial of once-daily, oral OPC-6535 in the treatment of active ulcerative colitis (UC)
-
Abst. 814
-
HANAUER SB, MINER PB, KESHAVARZIAN A et al.: Randomized, double-blind, placebo-controlled, parallel arm, safety and efficacy trial of once-daily, oral OPC-6535 in the treatment of active ulcerative colitis (UC). Gastroenterology (2004) 126(4, Suppl.2): Abst. 814.
-
(2004)
Gastroenterology
, vol.126
, Issue.4 SUPPL. 2
-
-
Hanauer, S.B.1
Miner, P.B.2
Keshavarzian, A.3
-
26
-
-
8444227836
-
Disposition: Of CP-671,305, a selective phosphodiesterase 4 inhibitor in preclinical species
-
KALGUTKAR AS, CHOO E, TAYLOR TJ, MARFAT A: Disposition of CP-671,305, a selective phosphodiesterase 4 inhibitor in preclinical species. Xenobiotica (2004) 34(8):755-770.
-
(2004)
Xenobiotica
, vol.34
, Issue.8
, pp. 755-770
-
-
Kalgutkar, A.S.1
Choo, E.2
Taylor, T.J.3
Marfat, A.4
-
27
-
-
0037405662
-
The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice
-
LOHER F, SCHMALL K, FREYTAG P et al.: The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J. Pharmacol. Exp. Ther. (2003) 305(2):549-556.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, Issue.2
, pp. 549-556
-
-
Loher, F.1
Schmall, K.2
Freytag, P.3
-
28
-
-
0008966297
-
The pharmacological activity of AWD 12-281, a potent phosphodiesterase 4 (PDE4) inhibitor for the treatment of allergic rhinitis and asthma
-
MARX D, POPPE H, KUESTERS S, HEER S, SZELENYI I: The pharmacological activity of AWD 12-281, a potent phosphodiesterase 4 (PDE4) inhibitor for the treatment of allergic rhinitis and asthma. Pneumologie (1999) 53(9):443.
-
(1999)
Pneumologie
, vol.53
, Issue.9
, pp. 443
-
-
Marx, D.1
Poppe, H.2
Kuesters, S.3
Heer, S.4
Szelenyi, I.5
-
29
-
-
0141630489
-
In vivo efficacy in airway disease models of N-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl-5-hydroxy- indole-3-yl]-glyoxidic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
-
KUSS H, HOEFGEN N, JOHANSSEN S et al.: In vivo efficacy in airway disease models of N-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl-5- hydroxy-indole-3-yl]-glyoxidic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. J. Pharmacol. Exp. Ther. (2003) 307(1):373.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.307
, Issue.1
, pp. 373
-
-
Kuss, H.1
Hoefgen, N.2
Johanssen, S.3
-
30
-
-
22744453395
-
AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced 'early phase' bronchoconstriction in sensitized guinea pigs
-
Abst. 107S
-
KUSS H, HOEFGEN N, RUNDFELDT C et al.: AWD 12-281, a new PDE4-inhibitor, suppresses allergen-induced 'early phase' bronchoconstriction in sensitized guinea pigs. Eur. Respir. J. (2003) 22(Suppl.45): Abst. 107S.
-
(2003)
Eur. Respir. J.
, vol.22
, Issue.SUPPL. 45
-
-
Kuss, H.1
Hoefgen, N.2
Rundfeldt, C.3
-
31
-
-
22744452377
-
Phase II study of IC485 in COPD does not meet primary efficacy endpoint; ongoing PDE4 program to focus on preclinical candidates
-
ICOS CORP.: Press release (23 March)
-
ICOS CORP.: Phase II study of IC485 in COPD does not meet primary efficacy endpoint; ongoing PDE4 program to focus on preclinical candidates. Press release (23 March 2005).
-
(2005)
-
-
-
32
-
-
0345821007
-
Suppressive effect of novel phosphodiesterase 4 (PDE4) inhibitor ONO-6126 on TNF-α release was increased after repeated oral administration in healthy Japanese subjects
-
Abst. 2557
-
FURUIE H, NAKAGAWA S, KAWASHIMA M et al.: Suppressive effect of novel phosphodiesterase 4 (PDE4) inhibitor ONO-6126 on TNF-α release was increased after repeated oral administration in healthy Japanese subjects. Eur. Respir. J. (2003) 22(Suppl.45): Abst. 2557.
-
(2003)
Eur. Respir. J.
, vol.22
, Issue.SUPPL. 45
-
-
Furuie, H.1
Nakagawa, S.2
Kawashima, M.3
-
33
-
-
22744449499
-
Pharmacological profile of Ono-6126, a novel phosphodiesterase 4 (PDE4) inhibitor
-
Atlanta, USA (17 May - 22 May) Abst. H41
-
TAKEDA H et al.: Pharmacological profile of Ono-6126, a novel phosphodiesterase 4 (PDE4) inhibitor. 98th Int. Conf. Am. Thorac. Soc. Atlanta, USA (17 May - 22 May 2002): Abst. H41.
-
(2002)
98th Int. Conf. Am. Thorac. Soc.
-
-
Takeda, H.1
-
34
-
-
22744438431
-
Memory Pharmaceuticals provides update on PDE4 collaboration with Roche
-
MEMORY PHARM.: Press release (15 April)
-
MEMORY PHARM.: Memory Pharmaceuticals provides update on PDE4 collaboration with Roche. Press release (15 April 2005).
-
(2005)
-
-
-
35
-
-
22744445163
-
Helicon Therapeutic, Inc. commences Phase I human testing of the company's lead drug candidate
-
HELICON THERAPEUTICS, INC.: News Release (10 December)
-
HELICON THERAPEUTICS, INC.: Helicon Therapeutic, Inc. commences Phase I human testing of the company's lead drug candidate. News Release (10 December 2004).
-
(2004)
-
-
-
36
-
-
0042337368
-
A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4
-
BOURTCHOULADZE R, LIDGE R, CATAPANO R et al.: A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4. Proc. Natl. Acad. Sci. USA (2003) 100(18):10518.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.18
, pp. 10518
-
-
Bourtchouladze, R.1
Lidge, R.2
Catapano, R.3
-
37
-
-
22744450101
-
The pharmacological and safety profile of a novel selective phosphodiesterase-4 (PDE4) inhibitor: GRC-3886
-
Abst. P1391
-
VAKKALANKA SK, BALASUBRAMANIAM G, GHARAT LA et al.: The pharmacological and safety profile of a novel selective phosphodiesterase-4 (PDE4) inhibitor: GRC-3886. Eur. Respir. J. (2004) 24(Suppl.48): Abst. P1391
-
(2004)
Eur. Respir. J.
, vol.24
, Issue.SUPPL. 48
-
-
Vakkalanka, S.K.1
Balasubramaniam, G.2
Gharat, L.A.3
-
38
-
-
0028289793
-
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophilia influx in guinea pigs
-
UNDERWOOD DC, KOTZER CJ, BOCHNOWICZ S et al.: Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophilia influx in guinea pigs. J. Pharmacol. Exp. Ther. (1994) 270(1):250-259.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.270
, Issue.1
, pp. 250-259
-
-
Underwood, D.C.1
Kotzer, C.J.2
Bochnowicz, S.3
-
39
-
-
0022628578
-
New positive inotropic agents in the treatment of congestive heart failure. Mechanism of action and recent clinical developments
-
COLUCCI WS, WRIGHT RF, BRAUNWALD E: New positive inotropic agents in the treatment of congestive heart failure. Mechanism of action and recent clinical developments. N. Engl. J. Med. (1986) 314(6):349-358.
-
(1986)
N. Engl. J. Med.
, vol.314
, Issue.6
, pp. 349-358
-
-
Colucci, W.S.1
Wright, R.F.2
Braunwald, E.3
-
40
-
-
0036199266
-
Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[ 1,2,5]-oxadiazol-5-yl-[1,7]-naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative with anti-inflammatory activities
-
TRIFILIEFF A, WYSS D, WALKER C et al.: Pharmacological profile of a novel phosphodiesterase 4 inhibitor, 4-(8-benzo[ 1,2,5]-oxadiazol-5-yl-[1,7]-naphthyridin-6-yl)-benzoic acid (NVP-ABE171), a 1,7-naphthyridine derivative with anti-inflammatory activities. J. Pharmacol. Exp. Ther. (2002) 301(1):241-248.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, Issue.1
, pp. 241-248
-
-
Trifilieff, A.1
Wyss, D.2
Walker, C.3
-
41
-
-
3843093840
-
Highly potent PDE4 inhibitors with therapeutic potential
-
OCHIAI H, OHTAMI T, ISHIDA A et al.: Highly potent PDE4 inhibitors with therapeutic potential. Bioorg. Med. Chem. (2004) 12(17):4645-4665.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, Issue.17
, pp. 4645-4665
-
-
Ochiai, H.1
Ohtami, T.2
Ishida, A.3
-
42
-
-
0034051217
-
Inhibition of cyclic phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism
-
ZHANG HT, CRISSMAN AM, DORAIRAJ NR et al.: Inhibition of cyclic phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology (2000) 23:198-204.
-
(2000)
Neuropsychopharmacology
, vol.23
, pp. 198-204
-
-
Zhang, H.T.1
Crissman, A.M.2
Dorairaj, N.R.3
-
43
-
-
0037188511
-
Induction of cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
-
JIN SL, CONTI M: Induction of cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses. Proc. Natl. Acad. Sci. USA (2002) 99(11):7628-7633.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, Issue.11
, pp. 7628-7633
-
-
Jin, S.L.1
Conti, M.2
-
44
-
-
0141445980
-
PDE4D plays a critical role in the control of airway smooth muscle contraction
-
MEHATS C, JIN SL, WAHLSTROM J et al.: PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB (2003) 17(13):1831-1841.
-
(2003)
FASEB
, vol.17
, Issue.13
, pp. 1831-1841
-
-
Mehats, C.1
Jin, S.L.2
Wahlstrom, J.3
-
45
-
-
0036790480
-
2-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
-
2-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J. Clin. Invest. (2002) 110(7):1045-1052.
-
(2002)
J. Clin. Invest.
, vol.110
, Issue.7
, pp. 1045-1052
-
-
Robichaud, A.1
Stamatiou, A.2
Jin, S.L.3
-
46
-
-
0034625541
-
Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity
-
XU RX, HASSELL AM, VANDERWALL D et al.: Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity. Science (2000) 288:1822-1825.
-
(2000)
Science
, vol.288
, pp. 1822-1825
-
-
Xu, R.X.1
Hassell, A.M.2
Vanderwall, D.3
-
47
-
-
0242401840
-
The crystal structure of AMP-bound PDE.4D suggests a mechanism for phosphodiesterase catalysis
-
HUAI Q, COLICELLI J, KE H: The crystal structure of AMP-bound PDE.4D suggests a mechanism for phosphodiesterase catalysis. Biochemistry (2003) 42(45):13220-13226.
-
(2003)
Biochemistry
, vol.42
, Issue.45
, pp. 13220-13226
-
-
Huai, Q.1
Colicelli, J.2
Ke, H.3
-
48
-
-
0037163858
-
Crystal structure of phosphodiesterase 4D and inhibitor complex
-
LEE ME, MARKOWITZ J, LEE JO et al.: Crystal structure of phosphodiesterase 4D and inhibitor complex. FEBS Lett. (2002) 530:53-58.
-
(2002)
FEBS Lett.
, vol.530
, pp. 53-58
-
-
Lee, M.E.1
Markowitz, J.2
Lee, J.O.3
-
49
-
-
0038154006
-
Three-dimensional structures of PDE4D in complex with rolipram and implications on inhibitor selectivity
-
HUAI Q, WANG H, KIM H-Y et al.: Three-dimensional structures of PDE4D in complex with rolipram and implications on inhibitor selectivity. Structure (2003) 11(7):865-873.
-
(2003)
Structure
, vol.11
, Issue.7
, pp. 865-873
-
-
Huai, Q.1
Wang, H.2
Kim, H.-Y.3
-
50
-
-
1442323778
-
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram
-
XU RX, ROCQUE WJ, LAMBERT MH et al.: Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J. Mol. Biol. (2004) 337(2):355-365
-
(2004)
J. Mol. Biol.
, vol.337
, Issue.2
, pp. 355-365
-
-
Xu, R.X.1
Rocque, W.J.2
Lambert, M.H.3
-
51
-
-
20844442458
-
Structural basis for the activity of drugs that inhibit phosphodiesterases
-
CARD GL, ENGLAND BP, SUZUKI Y et al.: Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure (2004) 12(12):2233-2247
-
(2004)
Structure
, vol.12
, Issue.12
, pp. 2233-2247
-
-
Card, G.L.1
England, B.P.2
Suzuki, Y.3
-
52
-
-
20844437061
-
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
-
CARD G, BLASDEL L, ENGLAND BP et al.: A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat. Biotechnol. (2005) 23(2):201-207.
-
(2005)
Nat. Biotechnol.
, vol.23
, Issue.2
, pp. 201-207
-
-
Card, G.1
Blasdel, L.2
England, B.P.3
-
53
-
-
22744454880
-
Robust discovery platform accelerates developments of selective inhibitors for respiratory disease
-
PLEXXIKON, INC.: Press release (13 November)
-
PLEXXIKON, INC.: Robust discovery platform accelerates developments of selective inhibitors for respiratory disease. Press release (13 November 2003).
-
(2003)
-
-
-
54
-
-
4344676386
-
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases
-
ZHANG KY, CARD GL, SUZUKI Y et al.: A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. Mol. Cell (2004) 15:279-286.
-
(2004)
Mol. Cell
, vol.15
, pp. 279-286
-
-
Zhang, K.Y.1
Card, G.L.2
Suzuki, Y.3
-
55
-
-
18644376713
-
The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases
-
MANALLACK DT, HUGHES RA, THOMPSON PE: The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J. Med. Chem. (2005) 48(10):3449-3462.
-
(2005)
J. Med. Chem.
, vol.48
, Issue.10
, pp. 3449-3462
-
-
Manallack, D.T.1
Hughes, R.A.2
Thompson, P.E.3
|