SCOPUS 정보 검색 플랫폼

Volumn 12, Issue 17, 2004, Pages 4645-4665

Highly potent PDE4 inhibitors with therapeutic potential

(13) Ochiai, Hiroshi a Ohtani, Tazumi a Ishida, Akiharu a Kusumi, Kensuke a Kato, Masashi a Kohno, Hiroshi a Odagaki, Yoshihiko a Kishikawa, Katuya a Yamamoto, Susumu a Takeda, Hiroshi a Obata, Takaaki a Nakai, Hisao a Toda, Masaaki a

a ONO PHARMACEUTICAL CO (Japan)

Author keywords

Difluoromethoxy; Hydroxamic acid; PDE4 inhibitor; Pharmacokinetic data; Piperidine analog

Indexed keywords

1 [4 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL)PIPERIDIN 1 YL] CYCLOPROPANECARBOXYLIC ACID; 1 [4 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL)PIPERIDIN 1 YL] N HYDROXYCYCLOPROPANECARBOXAMIDE; 1 [4 CYANO 4 [3 (CYCLOBUTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYCYCLOPROPANECARBOXAMIDE; 1 [4 CYANO 4 [3 (CYCLOBUTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]CYCLOPROPANECARBOXYLIC ACID; 1 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYCYCLOPROPANECARBOXAMIDE; 1 [4 CYANO 4 [3 (CYCLOPENTYOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]CYCLOPROPANECARBOXYLIC ACID; 1 [4 CYANO 4 [3 (CYCLOPROPYLMETHOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYCYCLOPROPANECARBOXAMIDE; 1 [4 CYANO 4 [3 (CYCLOPROPYLMETHOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]CYCLOPROPANECARBOXYLIC ACID; 2 [4 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL)PIPERIDIN 1 YL] N HYDROXYACETAMIDE; 2 [4 CYANO 4 (3,4 DIMETHOXYPHENYL)PIPERIDIN 1 YL] N HYDROXYACETAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] 2 METHYLPROPANOIC ACID; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXY 2 METHYLPROPANAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYACETAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYPROPANAMIDE; 2 [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]PROPANOIC ACID; 2 [4 CYANO 4 [3 (CYCLOPROPYLMETHOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL] N HYDROXYACETAMIDE; 4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 (DIFLUOROMETHOXY)PHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 (3 ETHOXY 4 METHOXYPHENYL)PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 (3 ISOPROPOXY 4 METHOXYPHENYL)PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 (3,4 DIMETHOXYPHENYL)PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (2,3 DIHYDRO 1H INDEN 2 YLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (CYCLOBUTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 ETHOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 ISOPROPOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; [4 CYANO 4 [3 (CYCLOPROPYLMETHOXY) 4 METHOXYPHENYL]PIPERIDIN 1 YL]ACETIC ACID; CILOMILAST; PHOSPHODIESTERASE IV INHIBITOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHILICITY; ISOMERISM; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ACETIC ACIDS; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHELATING AGENTS; CYCLOHEXANECARBOXYLIC ACIDS; HUMANS; HYDROXAMIC ACIDS; ISOMERISM; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3843093840 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2004.06.032 Document Type: Article

Times cited : (12)

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