TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso

Genes and Immunity

Volumn 6, Issue 6, 2005, Pages 472-480

  Flori, L ^a   Delahaye, N F ^a   Iraqi, F A ^b   Hernandez Valladares, M ^b   Fumoux, F ^a   Rihet, P ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

Author keywords

Association; Mild malaria attacks; P. falciparum; Parasitemia; Tumor necrosis factor genetic linkage

Indexed keywords

TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDEMIC DISEASE; FAMILY STUDY; FREQUENCY ANALYSIS; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; INFANT; KENYA; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SAMPLING; ALLELE; BURKINA FASO; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MALARIA FALCIPARUM; MALE;

PLASMODIUM FALCIPARUM;

ALLELES; BURKINA FASO; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALARIA, FALCIPARUM; MALE; PARASITEMIA; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 22544450545     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364231     Document Type: Article

References (40)

1. McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994; 371: 508-510.
2. Knight JC, Udalova I, Hill AV et al. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet 1999; 22: 145-150.
3. McGuire W, Knight JC, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. J Infect Dis 1999; 179: 287-290.
4. Ubalee R, Suzuki F, Kikuchi M et al. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. Tissue Antigens 2001; 58: 407-410.
5. Jepson A, Sisay JF, Banya W et al. Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: Study of affected sibling pairs. BMJ 1997; 315: 96-97.
6. Flori L, Sawadogo S, Esnault C, Delahaye NF, Fumoux F, Rihet P. Linkage of mild malaria to the major histocompatibility complex in families living in Burkina Faso. Hum Mol Genet 2003; 12: 375-378.
7. Grau GE, Taylor TE, Molyneux ME et al. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320: 1586-1591.
8. Kwiatkowski D, Hill AV, Sambou I et al. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 1990; 336: 1201-1204.
9. Kwiatkowski D, Molyneux ME, Stephens S et al. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 1993; 86 91-98.
10. Kremsner PG, Winkler S, Brandts C et al. Prediction of accelerated cure in Plasmodium falciparum malaria by the elevated capacity of tumor necrosis factor production. Am J Trop Med Hyg 1995; 53: 532-538.
11. Ferrante A, Kumaratilake L, Rzepczyk CM, Dayer JM. Killing of Plasmodium falciparum by cytokine activated effector cells (neutrophils and macrophages). Immunol Lett 1990; 25: 179-187.
12. Bouharoun TH, Oeuvray C, Lunel F, Druilhe P. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J Exp Med 1995; 182: 409-418.
13. Stirnadel HA, Stockle M, Felger I, Smith T, Tanner M, Beck HP. Malaria infection and morbidity in infants in relation to genetic polymorphisms in Tanzania. Trop Med Int Health 1999; 4: 187-193.
14. Migot-Nabias F, Mombo LE, Luty AJ et al. Human genetic factors related to susceptibility to mild malaria in Gabon. Genes Immun 2000; 1: 435-441.
15. Mombo LE, Ntoumi F, Bisseye C et al. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am J Trop Med Hyg 2003; 68: 186-190.
16. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
17. Sankoh AJ, Huque MF, Dubey SD. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat Med 1997; 16: 2529-2542.
18. Richardson A, Sisay-Joof F, Ackerman H et al. Nucleotide diversity of the TNF gene region in an African village. Genes Immun 2001; 2: 343-348.
19. Ackerman H, Usen S, Mott R et al. Haplotypic analysis of the TNF locus by association efficiency and entropy. Genome Biol 2003; 4: R24.
20. Taverne J, Sheikh N, de SJ, Playfair JH, Probert L, Kollias G. Anaemia and resistance to malaria in transgenic mice expressing human tumour necrosis factor. Immunology 1994; 82: 397-403.
21. May J, Lell B, Luty AJ, Meyer CG, Kremsner PG. Plasma interleukin-10: tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications. J Infect Dis 2000; 182: 1570-1573.
22. Drouet C, Shakhov AN, Jongeneel CV. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages. J Immunol 1991; 147: 1694-1700.
23. Pociot F, D'Alfonso S, Compasso S, Scorza R, Richiardi PM. Functional analysis of a new polymorphism in the human TNF alpha gene promoter. Scand J Immunol 1995; 42: 501-504.
24. Kaluza W, Reuss E, Grossmann S et al. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism. J Invest Dermatol 2000; 114: 1180-1183.
25. Bayley JP, de Rooij H, van den Elsen PJ, Huizinga TW, Verweij CL. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine 2001; 14: 316-323.
26. Fong CL, Siddiqui AH, Mark DF. Identification and characterization of a novel repressor site in the human tumor necrosis factor alpha gene. Nucleic Acids Res 1994; 22: 1108-1114.
27. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 1997; 94: 3195-3199.
28. Brinkman BM, Zuijdeest D, Kaijzel EL, Breedveld FC, Verweij CL. Relevance of the tumor necrosis factor alpha (TNF alpha) - 308 promoter polymorphism in TNF alpha gene regulation. J Inflamm 1995; 46: 32-41.
29. Stuber F, Udalova IA, Book M et al. 308 Tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 1995; 46: 42-50.
30. Wattavidanage J, Carter R, Perera KL et al. TNFalpha*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans. Clin Exp Immunol 1999; 115: 350-355.
31. Aidoo M, McElroy PD, Kolczak MS et al. Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with preterm delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX. Genet Epidemiol 2001; 21: 201-211.
32. Meyer CG, May J, Luty AJ, Lell B, Kremsner PG. TNFalpha-308A associated with shorter intervals of Plasmodium falciparum reinfections. Tissue Antigens 2002; 59: 287-292.
33. Knight JC, Keating BJ, Rockett KA, Kwiatkowski DP. In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading. Nat Genet 2003; 33: 469-475.
34. Rihet P, Abel L, Traore Y, Traore-Leroux T, Aucan C, Fumoux F. Human malaria: Segregation analysis of blood infection levels in a suburban area and a rural area in Burkina Faso. Genet Epidemiol 1998; 15: 435-450.
35. Schellenberg JR, Smith T, Alonso PL, Hayes RJ. What is clinical malaria? Finding case definitions for field research in highly endemic areas. Parasitol Today 1994; 10: 439-442.
36. Rogier C, Commenges D, Trape JF. Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations. Am J Trop Med Hyg 1996; 54: 613-619.
37. Aucan C, Traore Y, Tall F et al. High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria. Infect Immun 2000; 68: 1252-1258.
38. Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N. Whole genome amplification from a single cell: Implications for genetic analysis. Proc Natl Acad Sci USA 1992; 89: 5847-5851.
39. Abecasis GR, Cookson WO. GOLD - Graphical Overview of Linkage Disequilibrium. Bioinformatics 2000; 16: 182-183.
40. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.