Some comments on frequently used multiple endpoint adjustment methods in clinical trials

Statistics in Medicine

Volumn 16, Issue 22, 1997, Pages 2529-2542

  Sankoh, A J ^a   Huque, M F ^a   Dubey, S D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLINICAL TRIAL; ERROR; STATISTICS; SYSTEM ANALYSIS;

ALGORITHMS; CLINICAL TRIALS; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MONTE CARLO METHOD; STATISTICS;

EID: 0030670944     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0258(19971130)16:22<2529::AID-SIM692>3.0.CO;2-J     Document Type: Article

References (22)

1. Bauer, P. 'Multiple testing in clinical trials', Statistics in Medicine, 10, 871-890 (1991).
2. D'Agostino, R. B. and Hereen, T. C. 'Multiple comparisons in over-the-counter (OTC) drug clinical trials with both positive and placebo controls', Statistics in Medicine, 10, 1-6 (1991).
3. Perry, J. N. 'Multiple comparison procedures: a dissenting view', Journal of Economic Entomology, 79, 1149-1155 (1986).
4. Rothman, K. J. 'No adjustments are needed for multiple comparisons', Epidemiology, 1, 43-46 (1990).
5. Salsburg, D. S. 'Using multiple endpoints to answer clinically relevant questions', Invited presentation at the ENAR meetings, Cleveland, Ohio, 1994.
6. Holm, S. 'A simple sequentially rejective multiple test procedure', Scandinavian Journal of Statistics, 6, 65-70 (1979).
7. Simes, R. J. 'An improved Bonferroni procedure for multiple tests of significance', Biometrika, 73, 751-754 (1988).
8. Hochberg, Y. 'A sharper Bonferroni procedure for multiple tests of significance', Biometrika, 75, 800-802 (1988).
9. Hommel, G. 'A comparison of two modified Bonferroni procedures', Biometrika, 76, 624-625 (1989).
10. Marcus, R., Peritz, E. and Gabriel, K. R. 'On closed testing procedures with special reference to ordered analysis of variance', Biometrika, 67, 655-660 (1976).
11. Hommel, G. 'A stagewise rejective multiple test procedure based on a modified Bonferroni test', Biometrika, 75, 383-386 (1988).
12. Dunnett, C. W. and Tamhane, A. C. 'A step-up multiple test procedure', Journal of the American Statistical Association, 87, 162-170 (1993).
13. Tukey, J. W., Ciminera, J. L. and Heyse, J. F. 'Testing the statistical certainty of a response to increasing doses of a drug', Biometrics, 41, 295-301 (1985).
14. Dubey, S. D. 'Adjustment of p-values for multiplicities of intercorrelating symptoms', Proceedings of the VIth International Society for Clinical Biostatisticians, Germany, 1985.
15. Armitage, P. and Parmar, M. 'Some approaches to the problem of multiplicity in clinical trials', Proceedings of the XIIth International Biometrics Conference, Seattle, 1986.
16. O'Brien, P. C. 'Procedures for comparing samples with multiple endpoints', Biometrics, 40, 1079-1089 (1984).
17. Tang, D. I., Gnecco, C. and Geller, N. L. 'An approximate likelihood ratio test for a normal mean vector with nonnegative components with application to clinical trials', Biometrika, 76, 751-754 (1989).
18. Tang, D. I. and Lin, S. 'On improving some methods for multiple endpoints' Invited presentation at the ENAR meetings, Cleveland, Ohio, 1994.
19. Lehmacher, W., Wassmer, G. and Reitmeir, P. 'Procedures for two-sample comparisons with multiple endpoints controlling the experimentwise error rate', Biometrics, 47, 511-521 (1991).
20. Pocock, S. J., Geller, N. L. and Tsiatis, A. A. 'The analysis of multiple endpoints in clinical trials', Biometrics, 43, 487-493 (1987).
21. Westfall, P. H. and Young, S. S. 'p-value adjustments for multiple tests in multivariate binomial models, Journal of the American Statistical Association, 84, 780-786 (1989).
22. Capizzi, T. and Zhang, J. 'Testing the hypothesis that matters', Invited presentation at the ENAR meetings, Cleveland, Ohio, 1994.