Different transcriptional activity and in vitro TNF-α production in psoriasis patients carrying the TNF-α 238A promoter polymorphism

Journal of Investigative Dermatology

Volumn 114, Issue 6, 2000, Pages 1180-1183

  Kaluza, Wiebke ^a   Reuss, Esther ^a   Hug, Rosula ^a   Galle, Peter R ^a   Maerker Hermann, Elisabeth ^a   Hoehler, Thomas ^a   Grossmann, Sabine ^a   Schopf, Rudolph E ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

PBMG; Promoter polymorphism; Psoriasis; TNF ; Transcriptional activity

Indexed keywords

ANTIBODY; ANTIGEN; LIPOPOLYSACCHARIDE; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOGENIC AGENT; PHORBOL MYRISTATE; PHYTOHEMAGGLUTININ; SUPERANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PSORIASIS;

EID: 0034099699     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00001.x     Document Type: Article

References (31)

1. Allen MH, Veal C, Faasesen A, Powis SH, Vaughan RW, Trembath RC, Barker JNW: A non-HLA gene within the MHC in psoriasis. Lancet 353:1589-1590, 1999
2. Arias AI, Giles B, Eiermann TH, Sterry W, Pandey JP: Tumor necrosis factor-alpha gene polymorphism in psoriasis. Exp Clin Immunogenet 14:118-122, 1997
3. Barker JN, Sarma V, Mitra RS, Dixit VM, Nickoloff BJ: Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest 85:605-608, 1990
4. Bhalero J, Bowcock AM: The genetics of psoriasis: a complex disorder of the skin and immune system. Hum Mol Genet 7:1537-1545, 1998
5. Bos JD, de Rie MA: The pathogenesis of psoriasis: immunological facts and speculations. Immunol Today 20:40-46, 1999
6. Bouma G, Crusius JBA, Oudkerk Pool M, et al: Secretion of TNF-alpha and LTα in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease. Scand J Immunol 43:456-463, 1996
7. D'Alfonso S, Richiardi PM: A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 39:150-154, 1994
8. Elder JT, Henseler T, Christophers E, Voorhees JJ, Nair RP: The genetics of psoriasis. Arch Dermatol 130:216-224, 1994
9. Ettehadi P, Greaves MW, Wallach D, Aderka K, Camp RD: Elevated tumor necrosis factor-alpha biological activity in psoriasis lesions. Clin Exp Immunol 96:145-151, 1994
10. Fong CW, Siddiqui AH, Mark DF: Identification and characterisation of a novel repressor site in the human tumor necrosis factor alpha gene. Nucl Acid Res 22:1108-1114, 1994
11. Fry L: Psoriasis. Br J Dermatol 119:445-461, 1998
12. Gallagher G, Eskdale J, Oh HH, Richards SD, Campbell DA, Field M: Polymorphisms in the TNF gene cluster and MHC serotypes in the West of Scotland. Immunogenetics 45:188-194, 1997
13. Gladman DD: Natural history of psoriatic disease. Baillere's Clin Rheum 8:379-394, 1994
14. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS: Genetic variability in the TNF-α promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun 211:833-839, 1995
15. Hoehler T, Kruger A, Schneider PM, et al: A TNF-alpha-promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis. J Invest Dermatol 109:562-556, 1997
16. Jenisch S, Henseler T, Nair RP, et al: Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region. Am J Hum Genet 63:191-199, 1998
17. Jenisch S, Westphal E, Nair RP, et al: Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC haplotypes. Tissue Antigens 53:135-146, 1999
18. Jongeneel CV, Briant L, Udalova IA, Sevin A, Nedospasov SA, Cambon-Thomsen A: Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. Proc Natl Sci USA 88:9717-9721, 1991
19. Knight JC, Udalova I, Hill AVS, Greenwood BM, Peshu N, Marsh K, Kwiatkowski D: A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nature Genet 22:145-150, 1999
20. Kroeger KM, Carville KS, Abraham LJ: The -308 tumor necrosis factor alpha promoter polymorphism effects transcription. Mol Immunol 34:391-399, 1997
21. Louis E, Franchimont D, Piron A, et al: TNF gene polymorphism influences TNF-α-production in LPS-stimulated whole blood cell cultures in healthy humans. Clin Exp Immunol 113:401-406, 1998
22. Nedospasov SA, Udalova IA, Kuprash DY, Tretskya RL: DNA sequence polymorphism at the human tumor necrosis factor locus. J Immunol 147:1053-1059, 1991
23. Pociot F, D'Alfonso S, Compasso S, Scorza R, Richiardi PM: Functional analysis of a new polymorphism in the human TNF-α gene promoter. Scand J Immunol 42:501-504, 1995
24. Raabe T, Bukrinsky M, Currie RA: Relative contribution of transcription and translation of the induction of tumor necrosis factos alpha by lipopolysaccharide. J Biol Chem 273:974-980, 1998
25. Skoog T, van't Hooft FM, Kallin B, et al: A common functional polymorphism (C to A substitution -863) in the promoter region of the TNF-α gene associated with reduced circulating levels of TNF-α. Hum Mol Genet 8:1443-1449, 1999
26. Stuber F, Udalova IA, Book M, et al: -308 TNF polymorphism is not associated with survival in severe sepsis and is unrelated to LPS inducibility of the huamn TNF promoter. J Inflammation 46:42-50, 1996
27. Turner DM, Grant SC, Lamb WR, Brenchley PE, Dyer PA, Sinnott PJ, Hutchinson IV: A genetic marker of high TNF-alpha production in heart transplant recipients. Transplantation 60:1113-1117, 1995
28. Valdimarsson H, Baker BS, Jonsdottir I, Powles A, Fry L: Psoriasis: a T-cell mediated autoimmune disease induced by streptococcal superantigens? Immunol Today 16:145-114, 1995
29. Westendorp RG, Langermans JAM, Huizinga TWJ, Elouali AH, Verweij CL, Boomsma DI, Vandenbrouke JP: Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349:170-173, 1997
30. Wilson AG, Di Giovine FS, Blakemore AIF, Duff GW: Single base change in the human tumour necrosis factor alpha gene detectable by Nco I restriction of the PCR product. Hum Mol Genet 1:353, 1992
31. Wilson AG, Symons JA, McDowell TL, Di Giovine FS, Duff GW: Effects of a TNF-alpha promoter base transition on transcriptional activity. Proc Natl Acad Sci USA 94:3195-3199, 1997