Disruption of the availability of amino acids induces a rapid reduction of serine phosphorylation of insulin receptor substrate-1 in vivo and in vitro

Bioscience, Biotechnology and Biochemistry

Volumn 69, Issue 5, 2005, Pages 989-998

  Ohne, Yoichiro ^a   Toyoshima, Yuka ^a   Kato, Hisanori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Amino acid; Insulin receptor substrate 1 (IRS 1); Protein free diet; Serine phosphorylation

Indexed keywords

BIOCHEMISTRY; CELLS; ENZYMES; INSULIN; MUSCLE; NUTRITION; SUBSTRATES;

DEPHOSPHORYLATION; FIBROBLASTS; KINASES; MYOTUBE CELLS; PHOSPHORYLATION;

AMINO ACIDS;

AMINO ACID; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; OKADAIC ACID; PHOSPHATASE; PHOSPHOPROTEIN; SERINE;

ANIMAL; ARTICLE; CELL CULTURE; MALE; METABOLISM; PHOSPHORYLATION; RAT; SKELETAL MUSCLE; WISTAR RAT;

AMINO ACIDS; ANIMALS; CELLS, CULTURED; MALE; MUSCLE, SKELETAL; OKADAIC ACID; PHOSPHOPROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RATS; RATS, WISTAR; SERINE;

MAMMALIA;

EID: 22444433118     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.69.989     Document Type: Article

References (29)

1. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., and Sabatini, D. M., RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. U. S. A., 95, 1432-1437 (1998).
2. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T., Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science, 277, 99-101 (1997).
3. Hara, K., Yonezawa, K., Weng, Q. P., Kozlowski, M. T., Belham, C., and Avruch, J., Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem., 273, 14484-14494 (1998).
4. Yamauchi, T., Tobe, K., Tamemoto, H., Ueki, K., Kaburagi, Y., Yamamoto-Honda, R., Takahashi, Y., Yoshizawa, F., Aizawa, S., Akanuma, Y., Sonenberg, N., Yazaki, Y., and Kadowaki, T., Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol., 16, 3074-3084 (1996).
5. Zick, Y., Insulin resistance: A phosphorylation-based uncoupling of insulin signaling. Trends Cell. Biol., 11, 437-441 (2001).
6. Sykiotis, G. P., and Papavassiliou, A. G., Serine phosphorylation of insulin receptor substrate-1: A novel target for the reversal of insulin resistance. Mol. Endocrinol., 15, 1864-1869 (2001).
7. Patti, M. E., Brambilla, E., Luzi, L., Landaker, E. J., and Kahn, C. R., Bidirectional modulation of insulin action by amino acids. J. Clin. Invest., 101, 1519-1529 (1998).
8. Tremblay, F., and Marette, A., Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J. Biol. Chem., 276, 38052-38060 (2001).
9. Toyoshima, Y., Ohne, Y., Takahashi, S., Noguchi, T., and Kato, H., Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substarate-1 in rat skeletal muscle. J. Mol. Endocrinol., 32, 519-531 (2004).
10. Endo, Y., Fu, Z., Abe, K., Arai, S., and Kato, H., Dietary protein quantity and quality affect rat hepatic gene expression. J. Nutr., 132, 3632-3637 (2002).
11. Faria, T. N., Blakesley, V. A., Kato, H., Stannard, B., LeRoith, D., and Roberts, C. T., Jr., Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J. Biol. Chem., 269, 13922-13928 (1994).
12. White, M. F., The IRS-signalling system: A network of docking proteins that mediate insulin action. Mol. Cell Biochem., 182, 3-11 (1998).
13. Aguirre, V., Uchida, T., Yenush, L., Davis, R., and White, M. F., The c-Jun NH (2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser (307). J. Biol. Chem., 275, 9047-9054 (2000).
14. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Karin, M., and Hotamisligil, G. S., A central role for JNK in obesity and insulin resistance. Nature, 420, 333-336 (2002).
15. Hemi, R., Paz, K., Wertheim, N., Karasik, A., Zick, Y., and Kanety, H., Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins. J. Biol. Chem., 277, 8961-8969 (2002).
16. Beugnet, A., Tee, A. R., Taylor, P. M., and Proud, C. G., Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J., 372, 555-566 (2003).
17. De Fea, K., and Roth, R. A., Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. Biochemistry, 36, 12939-12947 (1997).
18. De Fea, K., and Roth, R. A., Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase. J. Biol. Chem., 272, 31400-31406 (1997).
19. Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., and Kobayashi, M., Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol. Cell. Biol., 21, 5050-5062 (2001).
20. Peterson, R. T., Desai, B. N., Hardwick, J. S., and Schreiber, S. L., Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc. Natl. Acad. Sci. U.S.A., 96, 4438-4442 (1999).
21. Carlson, C. J., White, M. F., and Rondinone, C. M., Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem. Biophys. Res. Commun., 316, 533-539 (2004).
22. Edinger, A. L., Linardic, C. M., Chiang, G. G., Thompson, C. B., and Abraham, R. T., Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res., 63, 8451-8460 (2003).
23. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M., mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 110, 163-175 (2002).
24. Yonezawa, K., Tokunaga, C., Oshiro, N., and Yoshino, K., Raptor, a binding partner of target of rapamycin. Biochem. Biophys. Res. Commun., 313, 437-441 (2004).
25. Schalm, S. S., Fingar, D. C., Sabatini, D. M., and Blenis, J., TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr. Biol., 13, 797-806 (2003).
26. Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Hidayat, S., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., and Yonezawa, K., The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J. Biol. Chem., 278, 15461-15464 (2003).
27. Gual, P., Gremeaux, T., Gonzalez, T., Le Marchand-Brustel, Y., and Tanti, J. F., MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia, 46, 1532-1542 (2003).
28. Ozes, O. N., Akca, H., Mayo, L. D., Gustin, J. A., Maehama, T., Dixon, J. E., and Donner, D. B., A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. U.S.A., 98, 4640-4645 (2001).
29. Favre, B., Turowski, P., and Hemmings, B. A., Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J. Biol. Chem., 272, 13856-13863 (1997).