Aging, nutritional status, and infection in the developing world

Nutrition Reviews

Volumn 63, Issue 7, 2005, Pages 233-246

  Meydani, Ahou ^a   Ahmed, Tanvir ^b   Meydani, Simin Nikbin ^b,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

Developing world; Elderly; Immune senescence; Infection; Undernutrition

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; MINERAL; MULTIVITAMIN; PYRIDOXINE; RETINOL; RETINOL PALMITATE; SELENIUM; TRACE ELEMENT; ZINC; ZINC SULFATE;

AGING; CLINICAL TRIAL; DEVELOPING COUNTRY; DIET SUPPLEMENTATION; HEALTH CARE PLANNING; HEALTH STATUS; HUMAN; IMMUNE RESPONSE; INFECTION; MORBIDITY; MORTALITY; NUTRITION; NUTRITIONAL STATUS; PUBLIC HEALTH; REVIEW; RISK FACTOR;

ADULT; AGED; AGED, 80 AND OVER; AGING; COMMUNICABLE DISEASES; DEVELOPING COUNTRIES; HUMANS; MIDDLE AGED; NUTRITIONAL STATUS; RISK FACTORS;

EID: 22344448516     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1301/nr.2005.jul.223-246     Document Type: Review

References (99)

1. Mosley WH, Cowley P. The challenge of world health. Popul Bull. 1991;46:1-39.
2. Man SN, Adolfsson O, Lee C-K, Prolla TA, Ordovas J, Meydani SN. Vitamin E and gene expression in immune cells. Ann N Y Acad Sci. 2004;1031:96-101.
3. Diczfalusy E. The third age, the Third World and the third millennium. Contraception. 1996;53:1-7.
4. Oshomuvwe JO. Health services for the aged in Sub-Saharan Africa. Soc Sci Med. 1990;31:661-665.
5. Kumar SV. Economic security for the elderly in India: an overview. J Aging Soc Policy. 2003;15:45-65.
6. Bailey C, Turner J. Social security in Africa: a brief review. J Aging Soc Policy. 2002;14:105-114.
7. Manandhar MC. Functional ability and nutritional status of free-living elderly people. Proc Nutr Soc. 1995;54:677-691.
8. Shahar S, Earland J, Abd Rahman S. Social and health profiles of rural elderly Malays. Singapore Med J. 2001;42:208-213.
9. Warren KS. Rationalizing health care in a changing world: the need to know. Health Transit Rev. 1997;7:61-71.
10. Navarro V. The World Health Report 2000: can health care systems be Compared using a single measure of performance? Am J Public Health. 2002;92:33-34.
11. Coyne JS, Hilsenrath P. The World Health Report 2000: can health care systems be compared using a single measure of performance? Am J Public Health. 2002;92:32-33.
12. World Health Organization. Facts and figures. In: The World Health Report 2003: Shaping the Future. Available online at: http://www.who.int/whr/2003/en/ Facts_and_Figures-en.pdf. Accessed June 6, 2005.
13. Janssens JP, Herrmann F, MacGee W, Michel JP. Cause of death in older patients with anatomopathological evidence of chronic bronchitis or emphysema: a case-control study based on autopsy findings. J Am Geriatr Soc. 2001;49:571-576.
14. World Health Organization. The World Health Report 2002. Available online at: http://www.who.int/whr/2002/en/whr02_en.pdf. Accessed June 6, 2005.
15. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet. 1997;349:1269-1276.
16. Mets TF. The disease pattern of elderly medical patients in Rwanda, central Africa. J Trop Med Hyg. 1993;96:291-300.
17. Sempértegui F, Bertha E, Elmieh N, et al. Nutritional, immunological, and health status of the elderly population living in poor neighborhoods of Quito, Ecuador: a preliminary report. FASEB J. 2004;18(5 part 2):A899.
18. Tosi P, Kraft R, Luzi P, et al. Involution patterns of the human thymus. I Size of the cortical area as a function of age. Clin Exp Immunol. 1982;47:497-504.
19. Aspinall R, Andrew D. Thymic involution in aging. J Clin lmmunol. 2000;20:250-256.
20. Rodysill KJ, Hansen L, O'Leary JJ. Cutaneous-delayed hypersensitivity in nursing home and geriatric clinic patients. Implications for the tuberculin test. J Am Geriatr Soc. 1989;37:435-443.
21. Castle SC, Norman DC, Peris TT, Chang MP, Yoshikawa TT, Makinodan T. Analysis of cutaneous delayed-type hypersensitivity reaction and T cell proliferative response in elderly nursing home patients: an approach to identifying immunodeficient patients. Gerontology. 1990;36:217-229.
22. Roberts-Thomson IC, Whittingham S, Youngchaiyud U, Mackay IR. Ageing, immune response and mortality. Lancet. 1974;2:368-370.
23. Makinodan T. Patterns of age-related immunologic changes. Nutr Rev. 1995;53(4 part 2):S27-S31.
24. Whittingham S, Buckley JD, MacKay IR. Factors influencing the secondary Ab response to flagellin in man. Clin Exp Immunol. 1978;34:170-178.
25. Tielen FJ, van Vliet AC, de Geus B, Nagelkerken L, Rozing J. Age-related changes in CD4+ T-cell subsets associated with prolonged skin graft survival in aging rats. Transplant Proc. 1993;25:2872-2874.
26. Meydani SN, Wu D, Santos MS, Hayek MG. Antioxidants and immune response in aged persons: overview of present evidence. Am J Clin Nutr. 1995;62(suppl 6):1462s-1476s.
27. Kirschmann DA, Murasko DM. Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli. Cell Immunol. 1992;139:426-437.
28. Hobbs MV, Ernst DN, Torbett BE, et al. Cell proliferation and cytokine production by CD4+ cells from old mice. J Cell Biochem. 1991;46:312-320.
29. Kariv I, Ferguson FG, Confer FL. Age- and strain-related differences in murine spleen cell responses to different activation signals. Cell Immunol. 1992;140:67-80.
30. Miller RA. Aging and immune function. In: Paul WE, ed. Fundamental Immunology. Philadelphia: Lippincott-Raven; 1999.
31. Miller RA. The aging immune system: primer and prospectus. Science. 1996;273:70-74.
32. Smith JL. Foodborne illness in the elderly. J Food Prot. 1998;61:1229-1239.
33. Lew JF, Glass RI, Gangarosa RE, Cohen IP, Bern C, Moe CL. Diarrheal deaths in the United States, 1979 through 1987. A special problem for the elderly. JAMA. 1991;265:3280-3284.
34. Gangarosa RE, Glass RI, Lew JF, Boring JR. Hospitalizations involving gastroenteritis in the United States, 1985: the special burden of the disease among the elderly. Am J Epidemiol. 1992;135:281-290.
35. Beharka AA, Paiva S, Leka LS, Ribaya-Mercado JD, Russell RM, Nibkin Meydani S. Effect of age on the gastrointestinal-associated mucosal immune response of humans. J Gerontol A Biol Sci Med Sci. 2001;56:B218-B223.
36. Beharka AA, Wu D, Man SN, Meydani SN. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech Ageing Dev 1997;93:59-77.
37. Scrimshaw NS, Taylor CE, Gordon JE. Interactions of nutrition and infection. Nutr Rev. 1990;48:402-405.
38. Excerpted from: Am J Med Sci. 1959;347:367-403.
39. Chandra RK. Nutrition, immunity, and infection: present knowledge and future directions. Lancet. 1983;1:688-691.
40. Keusch GT, Scrimshaw NS. Control of infection to reduce malnutrition. In: Walsh JA, Warren KS, eds. Strategies for Primary Health Care. Chicago: University of Chicago Press; 1986.
41. Brown KH, Solomons NW. Nutritional problems of developing countries. Infect Dis Clin North Am. 1991;5:297-317.
42. Lesourd BM. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997;66:478S-484S.
43. Lesourd BM. Protein undernutrition as the major cause of decreased immune function in the elderly: clinical and functional implications. Nutr Rev. 1995;53(suppl):S86-S94.
44. Meydani SN. Nutrition and immune function in the elderly. In: Joint WHO/Tufts University Consultation on Nutrition Guidelines for the Elderly. Geneva: World Health Organization; 1999.
45. Moulias R, Lesourd BM, Melani M, Thiollet M, Deslandes DJ. T-lymphocyte subsets changes during bacterial infections in elderly. In: Steinhagen-Thiessen E, Knook DL, eds. Trends in Biomedical Gerontology. Rijswijk, The Netherlands: TNO Institute for Experimental Gerontology; 1988;179-183.
46. Pinstrup-Anderson P, Burger S, Habicht JP, Peterson K. Protein-energy malnutrition. In: Jamison DT, Moseley WH, Measham AR, Bobadilla JL, eds. Disease Control Priorities in Developing Countries. Oxford: Oxford University Press; 1993;390-420.
47. Solomons NW. Nutrition and aging: potentials and problems for research in developing countries. Nutr Rev. 1992;50:224-229.
48. Solomons NW. Demographic and nutritional trends among the elderly in developed and developing regions. Eur J Clin Nutr. 2000;54(suppl 3):S2-S14.
49. Beaglehole R, Sanders D, Dal Poz M. The public health workforce in sub-Saharan Africa: challenges and opportunities. Ethn Dis. 2003;13:S24-S30.
50. Sekwat A. Health financing reform in sub-Saharan Africa: major constraints, goals, and strategies. J Health Care Finance. 2003;29:67-78.
51. Dangour AD, Ismail SJ. Ageing and nutrition in developing countries. Trop Med Int Health. 2003;8:287-289.
52. Tucker KL, Buranapin S. Nutrition and aging in developing countries. J Nutr. 2001;131:2417S-2423S.
53. Chilima DM, Ismail SJ. Anthropometric characteristics of older people in rural Malawi. Eur J Clin Nutr. 1998;52:643-649.
54. Chilima DM, Ismail SJ. Nutrition and handgrip strength of older adults in rural Malawi. Public Health Nutr. 2001;4:11-17.
55. Allain TJ, Wilson AO, Gomo ZA, Adamchak DJ, Matenga JA. Diet and nutritional status in elderly Zimbabweans. Age Ageing. 1997;26:463-470.
56. Russell RM, Rasmussen H, Lichtenstein AH. Modified Food Guide Pyramid for people over seventy years of age. J Nutr. 1999;129:751-753.
57. Talbott MC, Miller LT, Kerkvliet Nl. Pyridoxine supplementation: effect of lymphocyte response in elderly persons. Am J Clin Nutr. 1987;46:659-664.
58. Santos MS, Leka LS, Ribaya-Mercado JD, et al. Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons. Am J Clin Nutr. 1997;66:917-924.
59. Santos MS, Meydani SN, Leka L, et al. Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. Am J Clin Nutr. 1996;64:772-7.
60. Bogden JD, Bendich A, Kemp FW, et al. Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people. Am J Clin Nutr. 1994;60:437-447.
61. Meydani SN, Meydani M, Verdon CP, Shapiro AA, Blumberg JB, Hayes KC. Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice. Mech Ageing Dev. 1986;34:191-201.
62. Adolfsson O, Huber BT, Meydani SN. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. J Immunol. 2001;167:3809-3817.
63. Hayek MG, Taylor SF, Bender BS, et al. Vitamin E supplementation decreases lung virus titers in mice infected with influenza. J Infect Dis. 1997;176:273-276.
64. Meydani SN, Barklund MP, Liu S, et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr. 1990;52:557-563.
65. Meydani SN, Meydani M, Blumberg JB, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA. 1997;277:1380-1386.
66. Meydani SN, Leka LS, Fine BC, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2004;292:828-836.
67. Pallast EG, Schouten EG, de Waart FG, et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr. 1999;69:1273-1281.
68. Ziemlanski S, Wartanowicz M, Klos A, Raczka A, Klos M. The effect of ascorbic acid and alpha-tocopherol supplementation on serum proteins and immunoglobulin concentration in the elderly. Nutrition International. 1986;2:1-5.
69. Hemila H, Kaprio J, Albanes D, Heinonen OP, Virtamo J. Vitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers. Epidemiology. 2002;13:32-37.
70. Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA. 2002;288:715-721.
71. McGeer A, Campbell B, Emori TG, et al. Definition of infection for surveillance in long-term care facilities. Am J Infect Control. 1991;19:1-7.
72. Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet. 1992;340:1124-1127.
73. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab. 1997;41:98-107.
74. Chavance M, Herbeth B, Lemoine A, Zhu BP. Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial. Int J Vitam Nutr Res. 1993;63:11-16.
75. Chandra RK. Impact of nutritional status and nutrient supplements on immune responses and incidence of infection in older individuals. Ageing Res Rev. 2004;3:91-104.
76. Meydani SN, Santos MS. Aging: nutrition and immunity. In: Gershwin ME, German JB, Keen CL, eds. Nutrition and Immunology: Principles and Practice. Totowa, NJ: Humana Press; 2000;403-421.
77. Burns EA, Lum LG, L'Hommedieu G, Goodwin JS. Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol. 1993;48:B231-B236.
78. Fulop T Jr, Wagner JR, Khalil A, Weber J, Trottier L, Payette H. Relationship between the response to influenza vaccination and the nutritional status in institutionalized elderly subjects. J Gerontol A Biol Sci Med Sci. 1999;54:M59-M64.
79. Neralla S, Meyer KC. Drug treatment of pneumococcal pneumonia in the elderly. Drugs Aging. 2004;21:851-864.
80. Meyer KC. Lung infections and aging. Ageing Res Rev. 2004;3:55-67.
81. United Nations: World Population Prospects: The 2002 Revision. New York: United Nations; 2002. Highlights available online at: http://www.un.org/esa/ population/publications/wpp2002/WPP2002-HIGHLIGHTSrev1.PDF. Accessed June 6, 2005.
82. Nyaruhucha CN, Msuya JM, Matrida E. Nutritional status, functional ability and food habits of institutionalised and non-institutionalised elderly people in Morogoro Region, Tanzania. East Afr Med J. 2004;81:248-253.
83. Suzana S, Earland J, Suriah AR, Warnes AM. Social and health factors influencing poor nutritional status among rural elderly Malays. J Nutr Health Aging. 2002;6:363-369.
84. Pedro MR, Barba CV. Nutritional issues and status of older persons of the Philippines: the IUNS, CRO-NOS and other studies. J Nutr Health Aging. 2001;5:92-96.
85. Tavares EL, Anjos LA. Anthropometric profile of the elderly Brazilian population: results of the National Health and Nutrition Survey, 1989 [in Portuguese]. Cad Saude Publica. 1999;15:759-768.
86. Visvanathan R, Zaiton A, Sherina MS, Muhamad YA. The nutritional status of 1081 elderly people residing in publicly funded shelter homes in Peninsular Malaysia. Eur J Clin Nutr. 2004;59:318-324.
87. Barreto SM, Passos VM, Lima-Costa MF. Obesity and underweight among Brazilian elderly: the Bambui Health and Aging Study. Cad Saude Publica. 2003;19:605-612.
88. Zohoori N, Jackson M, Wilks R, Walker S, Forrester TE. Nutritional status of older adults in urban Jamaica. West Indian Med J. 2003;52:111-117.
89. Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991;53:1275-1280.
90. Corridan BM, O'Donoghue M, Hughes DA, Morrissey PA. Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans. Eur J Clin Nutr. 2001;55:627-635.
91. Santos MS, Gaziano JM, Leka LS, Beharka AA, Hennekens CH, Meydani SN. Beta-carotene-induced enhancement of natural killer cell activity in elderly men: an investigation of the role of cytokines. Am J Clin Nutr. 1998;68:164-170.
92. De Waart F, Portengen L, Doekes G, Verwaal CJ, Kok FJ. Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects. Br J Nutr. 1997;78:761-774.
93. Duchateau J, Delpesse G, Vrijens R, Collet H. Beneficial effects of oral zinc supplementation on the immune response of old people. Am J Med. 1981;70:1001-1004.
94. Fortes C, Forastiere F, Agabiti N, et al. The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc. 1998;46:19-26.
95. Cossack ZT. T-lymphocyte dysfunction in the elderly associated with zinc deficiency and subnormal nucleoside phosphorylase activity: effect of zinc supplementation. Eur J Cancer Clin Oncol. 1989;25:973-976.
96. Girodon F, Galan P, Monget A-L, et al. Impact of trace elements and vitamin E supplementation on immunity and infections in institutionalized elderly patients. Arch Intern Med. 1999;159:748-754.
97. Bogden JD, Oleske JM, Lavenhar MA, et al. Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am Coll Nutr. 1990;9:214-225.
98. Penn ND, Perkins L, Kelleher J, Heatley RV, Mascie-Taylor BH, Belfield PW. The effect of dietary supplementation with vitamins A, C, and E on cell-mediated immune function in elderly long-stay patients: A randomized, controlled trial. Age Ageing. 1991;20:169-174.
99. Pike J, Chandra RK. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res. 1995;65:117-121.