Foodborne illness in the elderly

Journal of Food Protection

Volumn 61, Issue 9, 1998, Pages 1229-1239

  Smith, James L ^a  

^a EASTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD; GASTROENTERITIS; MICROBIAL CONTAMINATION;

CAMPYLOBACTER; CLOSTRIDIUM PERFRINGENS; ENTERITIDIS; ESCHERICHIA COLI; SALMONELLA; SALMONELLA ENTERITIDIS; STAPHYLOCOCCUS AUREUS;

EID: 0032168763     PISSN: 0362028X     EISSN: None     Source Type: Journal    
DOI: 10.4315/0362-028X-61.9.1229     Document Type: Article

References (140)

1. Abrams, W. B., M. H. Beers, and R. Berkow (ed.). 1995. The Merck manual of geriatrics, 2nd ed. Merck & Co., Inc., Whitehouse Station, N.J.
2. Adal, K. A., C. R. Sterling, and R. L. Guerrant. 1995. Cryptosporidium and related species, p. 1107-1128. In M. J. Blaser, P. D. Smith, J. I. Ravdin, H. B. Greenberg, and R. L. Guerrant (ed.), Infections of the gastrointestinal tract. Raven Press, New York.
3. Al-Rayes, H., W. Pachas, N. Mirza, D. J. Ahern, R. S. Geha, and D. Vercelli. 1992. IgE regulation and lymphokine patterns in aging humans. J. Allergy Clin. Immunol. 90:630-636.
4. Arranz, E., S. O'Mahony, J. R. Barton, and A. Ferguson. 1992 Immunosenescence and mucosal immunity: significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts. Gut 33:882-886.
5. Arreaza, E. E., J. J. Gibbons, G. W. Siskind, and M. E. Weksler. 1993. Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans. Clin. Exp. Immunol. 92:169-173.
6. Bannister, P., and R. A. Mountford. 1989. Cryptosporidium in the elderly: a cause of life-threatening diarrhea. Am. J. Med. 86:507-508.
7. Bean, N. H., J. S. Goulding, C. Lao, and F. J. Angulo. 1996. Surveillance for foodborne-disease outbreaks - United States, 1988-1992. Morb. Mort. Weekly Rep. 45(SS-5):16-20.
8. Bean, N. H., P. M. Griffin, J. S. Goulding, and C. B. Ivey. 1990. Foodborne disease outbreaks, 5-year summary, 1983-1987. Morb. Mort. Weekly Rep. 39(SS-1):25-29.
9. Beisel, W. R. 1995. Herman Award Lecture, 1995: infection-induced malnutrition - from cholera to cytokines. Am. J. Clin. Nutr. 62:813-819.
10. Beisel, W. R. 1996. Nutrition and immune function: overview. J. Nutr. 126:2611S-2615S.
11. Bell, B. P., P. M. Griffin, P. Lozano, D. L. Christie, J. M. Kobayashi, and P. I. Tarr. 1997. Predictors of hemolytic uremic syndrome in children during a large outbreak of Escherichia coli O157:H7 infections. Pediatrics 100(1):e12.
12. Ben-Yehuda, A., and M. E. Weksler. 1992. Host resistance and the immune system. Clin. Geriatr. Med. 8:701-712.
13. Berkow, R. (ed.). 1992. The Merck manual of diagnosis and therapy, 16th ed. Merck & Co., Inc., Rahway, N.J.
14. Black, R. E., and C. F. Lanata. 1995. Epidemiology of diarrheal diseases in developing countries, p. 13-36. In M. J. Blaser, P. D. Smith, J. I. Ravdin, H. B. Greenberg, and R. L. Guerrant (ed.), Infections of the gastrointestinal tract. Raven Press, New York.
15. Bogden, J. D., A. Bendich, F. W. Kemp, K. S. Bruening, J. H. Skurnick, T. Denny, H. Baker, and D. B. Louria. 1994. Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people. Am. J. Clin. Nutr. 60:437-447.
16. Bula, C. J., J. Bille, and M. P. Glauser. 1995. An epidemic of food-borne listeriosis in western Switzerland: description of 57 cases involving adults. Clin. Infect. Dis. 20:66-72.
17. Butterton, J. R., and S. B. Calderwood. 1995. Vibrio cholerae O1, p. 649-670. In M. J. Blaser, P. D. Smith, J. I. Ravdin, H. B. Greenberg, and R. L. Guerrant (ed.), Infections of the gastrointestinal tract. Raven Press, New York.
18. Buzby, J. C., T. Roberts, C.-T. J. Lin, and J. M. MacDonald. 1996. Bacterial foodborne disease: medical costs & productivity losses. ERS, USDA. Agricultural Economic Report, No. 741, Washington, D.C.
19. 2 T cell subpopulation in the elderly. Mech. Ageing Dev. 87:197-209.
20. Candore, G., G. Di Lorenzo, P. Mansueto, M. Melluso, G. Fradà, M. Li Vecchi, M. E. Pellitteri, A. Drago, A. Di Salvo, and C. Caruso. 1997. Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians. Mech. Ageing Dev. 94:183-190.
21. Carter, A. O., A. A. Borczyk, J. A. K. Carlson, B. Harvey, J. C. Hockin, M. A. Karmali, C. Krishinan, D. A. Korn, and H. Lior. 1987. A severe outbreak of Escherichia coli O157:H7-associated hemorrhagic colitis in a nursing home. N. Engl. J. Med. 317:1496-1500.
22. Caruso, C., G. Candore, D. Cigna, G. di Lorenzo, G. Sireci, F. Fieli, and A. Salerno. 1996. Cytokine production pathway in the elderly. Immunol. Res. 15:84-90.
23. Cash, R. A., S. I. Music, J. P. Libonati, M. J. Snyder, R. P. Wenzel, and R. B. Hornick. 1974. Response of man to infection with V. cholerae. I. Clinical, serologic, and bacteriologic response to a known inoculum. J. Infect. Dis. 129:45-52.
24. Castle, S., K. Uyemura, W. Wong, R. Modlin, and R. Effros. 1997. Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech. Ageing Dev. 94:7-16.
25. Catania, A., L. Airaghi, P. Motta, M. G. Manfredi, G. Annoni, C. Pettenati, F. Brambilla, and J. M. Lipton. 1997. Cytokine antagonists in aged subjects and their relation with cellular immunity. J. Gerontol. Ser. A Biol. Sci. 52A:B93-B97.
26. CDC (Centers for Disease Control and Prevention). 1994. Summary of notifiable diseases, United States, 1994. Morb. Mort. Weekly Rep. 43:10.
27. CDC (Centers for Disease Control and Prevention). 1995. Summary of notifiable diseases, United States, 1995. Morb. Mort. Weekly Rep. 44(53):4, 10, 13, 74-75.
28. CDC (Centers for Disease Control and Prevention). 1996. Outbreaks of Salmonella serotype enteritidis infection associated with consumption of raw shell eggs - United States, 1994-1995. Morb. Mort. Weekly Rep. 45:737-742.
29. Challacombe, S. J., R. S. Percival, and P. D. Marsh. 1995. Age-related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals. Oral Microbiol. Immunol. 10:202-207.
30. Chandra, R. 1995. Nutrition and immunity in the elderly: clinical significance. Nutr. Rev. 53(no. 4, part II):S80-S85.
31. Chandra, R. K. 1989. Nutritional regulation of immunity and risk of infection in old age. Immunology 67:141-147.
32. Chandra, R. K. 1992. Effect of vitamin and trace-element supplementation on immune response and infection in elderly subjects. Lancet 340:1124-1127.
33. Chandra, R. K. 1997. Graying of the immune system. Can nutrient supplements improve immunity in the elderly? J. Am. Med. Assoc. 277:1398-1399.
34. Chandra, R. K. 1997. Nutrition and the immune system: an introduction. Am. J. Clin. Nutr. 66:460S-463S.
35. Christiansen, J. L., and J. M. Grzybowski. 1993. Biology of aging. Mosby, St. Louis, Mo.
36. Cicirello, H. G., K. S. Kehl, D. G. Addiss, M. J. Chusid, R. I. Glassk, J. P. Davis, and P. L. Havens. 1997. Cryptosporidiosis in children during a massive, waterborne outbreak in Milwaukee, Wisconsin: clinical, laboratory and epidemiological findings. Epidemiol. Infect. 119:53-60.
37. Ciesielski, C. A., A. W. Hightower, S. K. Parsons, and C. V. Broome. 1988. Listeriosis in the United States: 1980-1982. Arch. Intern. Med. 148:1416-1419.
38. Collen, M. J., J. D. Abdulian, and Y. K. Chen. 1994. Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease. Am. J. Gastroenterol. 89:712-716.
39. Conner, J. R., and J. L. Beard. 1997. Dietary iron supplements in the elderly: to use or not to use. Nutr. Today 32:102-109.
40. Crossley, K. B., and P. K. Peterson. 1996. Infections in the elderly. Clin. Infect. Dis. 22:209-215.
41. Cunha, B. A. (ed.). 1988. Infectious diseases in the elderly. PSG Publishing Co., Inc., Littleton, Mass.
42. Dare, R., J. T. Magee, and G. E. Mathison. 1972. In-vitro studies on the bactericidal properties of natural and synthetic gastric juices. J. Med. Microbiol. 5:395-406.
43. Dubey, J. P., and C. P. Beattie. 1988. Toxoplasmosis of animals and man. CRC Press, Inc., Boca Raton, Fia.
44. DuPont, H. L., and R. B. Hornick. 1973. Adverse effect of Lomotil therapy in shigellosis. J. Am. Med. Assoc. 226:1525-1528.
45. Emmerling, P., H. Hof, and H. Finger. 1979. Age-related defense against infections with intracellular pathogens. Gerontology 25:327-336.
46. Ernst, D. N., W. O. Weigle, and M. V. Hobbs. 1993. Aging and lymphokine produced by T cell subsets. Stem Cells 11:487-498.
47. Feldman, M., B. Cryer, K. E. McArthur, B. A. Huet, and E. Lee. 1996. Effect of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study. Gastroenterology 110:1043-1052.
48. Fitch, F. W., D. W. Lancki, and T. F. Gajewski. 1993. Cell-mediated immune regulation: help and suppression, p. 733-761. In W. E. Paul (ed.), Fundamental immunology, 3rd ed. Raven Press, New York.
49. Frenkel, J. K. 1990. Toxoplasmosis in human beings. J. Am. Vet. Med. Assoc. 196:240-248.
50. Furuta, G. T., and W. A. Walker. 1995. Nonimmune defense mechanisms of the gastrointestinal tract, p. 89-97. In M. J. Blaser, P. D. Smith, J. I. Ravdin, H. B. Greenberg, and R. L. Guerrant (ed.), Infections of the gastrointestinal tract. Raven Press, New York.
51. Gangarosa, R., R. I. Glass, J. F. Lew, and J. R. Boring. 1992. Hospitalization involving gastroenteritis in the United States, 1985: the special burden of the disease among the elderly. Am. J. Epidemiol. 135:281-290.
52. Gardner, I. D., and J. S. Remington. 1977. Age-related decline in the resistance of mice to infection with intracellular pathogens. Infect. Immun. 16:593-598.
53. Gardner, I. D., and J. S. Remington. 1978. Aging and the immune response. I. Antibody formation and chronic infection in Toxoplasma gondii-infected mice. J. Immunol. 120:939-943.
54. Gershon, H. 1997. The anti-inflammatory role of the erythrocyte impairment in the elderly. Arch. Gerontol. Geriatr. 24:157-165.
55. Giannella, R. A., S. A. Broitman, and N. Zamcheck. 1973. Influence of gastric acidity on bacterial and parasitic enteric infections. Ann. Intern. Med. 78:271-276.
56. Gitelson, S. 1971. Gastrectomy, achlorhydria and cholera. Isr. J. Med. Sci. 7:663-667.
57. Goldschmiedt, M., C. C. Barnett, B. E. Schwartz, W. E. Karnes, J. S. Redfern, and M. Feldman. 1991. Effect of age on gastric acid secretion and serum gastric concentrations in healthy men and women. Gastroenterology 199:977-990.
58. Gon, Y., S. Hashimoto, S. Hayashi, T. Koura, K. Matsumoto, and T. Horie. 1996. Lower serum concentration of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exp. Immunol. 106:120-126.
59. Goodwin, J. S. 1995. Decreased immunity and increased morbidity in the elderly. Nutr. Rev. 53 (no. 4, part II):S41-S46.
60. Goulet, V., and P. Marchetti. 1996. Listeriosis in 225 non-pregnant patients in 1992: clinical aspects and outcome in relation to predisposing conditions. Scand. J. Infect. Dis. 28:367-374.
61. Hargrett-Bean, N. T., A. T. Pavia, and R. V. Tauxe. 1988. Salmonella isolates from humans in the United States, 1984-1986. Morb. Mort. Weekly Rep. 37(SS-2):25-31.
62. Henderson, C. T. 1988. Nutrition and malnutrition in the elderly nursing home patient. Clin. Geriatr. Med. 4:527-547.
63. Hensler, T., H. Hecker, K. Heeg, C.-D. Heidecke, H. Bartels, W. Barthelen, H. Wagner, J.-R. Siewert, and B. Holzmann. 1997. Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect. Immun. 65:2283-2291.
64. Hirokawa, K. 1992. Understanding the mechanism of the age-related decline in immune function. Nutr. Rev. 50:361-366.
65. Ho, J. L., K. N. Shanda, G. Friedland, P. Eckind, and D. W. Fraser. 1986. An outbreak of type 4b Listeria monocytogenes infection involving patients from eight Boston hospitals. Arch. Intern. Med. 146:520-524.
66. Hoogkamp-Korstanje, J. A. A., and V. M. M. Stolk-Engelaar. 1995. Yersinia enterocolitica infection in children. Pediatr. Infect. Dis. J. 14:771-775.
67. Hurwitz, A., D. A. Brady, S. E. Schaal, I. M. Samloff, J. Dedon, and C. E. Ruhl. 1997. Gastric acidity in older adults. J. Am. Med. Assoc. 278:659-662.
68. Johnson, L. L., G. W. Gibson, and P. C. Sayles. 1995. Preimmune resistance to Toxoplasma gondii in aged and young adult mice. J. Parasitol. 81:894-899.
69. Johnson, M. A., J. G. Fischer, B. A. Bowman, and E. W. Gunter. 1994. Iron nutrition in elderly individuals. FASEB J. 8:609-621.
70. Johnson, M. W., C. M. Green, G. J. Jaffe, H. Sudhalkar, and A. K. Vine. 1997. Atypical, severe toxoplasmic retinochoroiditis in elderly patients. Ophthalmology 104:48-57.
71. Jones, S. R., D. F. Parker, E. S. Liebow, R. C. Kimbrough, and R. S. Frear. 1987. Appropriateness of antibiotic therapy in long-term care facilities. Am. J. Med. 83:499-502.
72. Katelaris, P., F. Seow, B. P. C. Lin, J. Napoli, M. C. Ngu, and D. B. Jones. 1993. Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut 34:1032-1037.
73. Katz, D. R., T. R. Beam, F. Brand, and K. Boyce. 1990. Antibiotic use in the nursing home. Physician practice patterns. Arch. Intern. Med. 150:1465-1468.
74. Kudlacek, S., S. Jahandideh-Kazempour, W. Graninger, R. Willvanseder, and P. Pietschmann. 1995. Differential expression of various T cell surface markers in young and elderly subjects. Immunobiology 192:198-204.
75. Lesourd, B. 1995. Protein undernutrition as the major cause of decreased immune function in the elderly: clinical and functional implications. Nutr. Rev. 53(no. 4, part II):S86-S94.
76. Lesourd, B. M., C. Laisney, R. Salvatore, S. Meaume, and R. Moulias. 1994. Decreased maturation of T-cell populations in the healthy elderly: influence of nutritional factors on the appearance of double negative CD4-, CD8-, CD2+ cells. Arch. Gerontol. Geriatr. (suppl. 4):139-154.
77. Lesourd, B. M., and L. Mazari. 1997. Immune responses during recovery from protein-energy malnutrition. Clin. Nutr. 16(suppl. 1):37-46.
78. Lesourd, B. M., and S. Meaume. 1994. Cell mediated immunity changes in aging, relative importance of cell subpopulation switches and of nutritional factors. Immunol. Lett. 40:235-242.
79. Levine, M. M., and O. S. Levine. 1994. Changes in human ecology and behavior in relation to the emergence of diarrheal diseases, including cholera. Proc. Natl. Acad. Sci. USA 91:2390-2394.
80. Levine, W. C., J. F. Smart, D. L. Archer, N. H. Bean, and R. V. Tauxe. 1991. Foodborne disease outbreaks in nursing homes, 1975 through 1987. J. Am. Med. Assoc. 266:2105-2109.
81. Lew, J. F., R. I. Glass, R. E. Gangarosa, I. P. Cohen, C. Bern, and C. L. Moe. 1991. Diarrheal deaths in the United States, 1979 through 1987. A special problem for the elderly. J. Am. Med. Assoc. 265:3280-3284.
82. Li, J., G. S. Birkhead, D. S. Strogatz, and F. B. Coles. 1996. Impact of institution size, staffing patterns, and infection control practices on communicable disease outbreaks in New York State nursing homes. Am. J. Epidemiol. 143:1042-1049.
83. Ligthart, G. J., J. Radl, J. X. Corberand, J. A. van Neuwkoop, G. J. van Staalduinen, D. J. Wesselman van Helmond, and W. Hijmans. 1990. Monoclonal gammapathies in human aging: increased occurrence with age and correlation with health status. Mech. Ageing Dev. 52:235-243.
84. Liszewski, M. K., and J. P. Atkinson. 1993. The complement system, p. 917-939. In W. E. Paul (ed.), Fundamental immunology, 3rd ed. Raven Press, New York.
85. Lutz, W., W. Sanderson, and S. Scherbov. 1997. Doubling of the world population unlikely. Nature 387:803-805.
86. Majumdar, A. P. N., R. Jaszewski, and M. A. Dubrick. 1997. Effect of aging on the gastrointestinal tract and the pancreas. Proc. Soc. Exp. Biol. Med. 215:134-144.
87. Manton, K. G., L. Corder, and E. Stallard. 1997. Chronic disability trends in elderly United States populations: 1982-1994. Proc. Natl. Acad. Sci. USA 94:2593-2598.
88. Matour, D., M. Melnicoff, D. Kaye, and D. M. Murasko. 1989. The role of T cell phenotypes in decreased lymphoproliferation of the elderly. Clin. Immunol. Immunopathol. 50:82-99.
89. Mazzeo, R. S. 1996. Exercise, immunity, and aging, p. 199-214. In L. Hoffman-Goetz (ed.), Exercise and immune function. CRC Press, Boca Raton, Fla.
90. + CTL activity among elderly persons and the enhancing effect of IL-12. Mech. Ageing Dev. 94:25-39.
91. McElhaney, J. E., B. L. Beattie, R. Devine, R. Grynoch, E. L. Toth, and R. C. Bleackley. 1990. Age-related decline in interleukin 2 production in response to influenza vaccine. J. Am. Geriatr. Soc. 38:652-658.
92. Meydani, S. N., M. Meydani, J. B. Blumberg, L. S. Leka, G. Siber, P. Loszewski, C. Thompson, M. C. Pedrosa, R. D. Diamond, and B. D. Stollar. 1997. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. J. Am. Med. Assoc. 277:1380-1386.
93. Miletic, I. D., S. S. Schiffman, V. D. Miletic, and E. A. SattelyMiller. 1996. Salivary IgA secretion rate in young and elderly persons. Physiol. Behav. 60:243-248.
94. Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273:70-74.
95. Mishu, M., J. Koehler, L. A. Lee, D. Rodrigue, F. H. Brenner, P. Blake, and R. V. Tauxe. 1994. Outbreaks of Salmonella enteritidis infections in the United States, 1985-1991. J. Infect. Dis. 169:547-552.
96. Murasko, D. M., P. Weiner, and D. Kaye. 1987. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol. 70:440-448.
97. Nalin, D. R., R. J. Levine, M. M. Levine, D. Hoover, E. Bergquist, J. McLaughlin, J. Libonati, J. Alam, and R. B. Hornick. 1978. Cholera, non-vibrio cholera, and stomach acid. Lancet ii:856-859.
98. Neill, M. A., S. K. Rice, N. V. Ahmad, and T. P. Flanigan. 1996. Cryptosporidiosis: an unrecognized cause of diarrhea in elderly hospitalized patients. Clin. Infect. Dis. 22:168-170.
99. Nicolle, L. E., L. J. Strausbaugh, and R. A. Garibaldi. 1996. Infections and antibiotic resistance in nursing homes. Clin. Microbiol. Rev. 9:1-17.
100. Nieman, D. C., and D. A. Henson. 1994. Role of endurance exercise in immune senescence. Med. Sci. Sports Exercise 26:172-181.
101. + T cell differentiation in vivo. Clin. Exp. Immunol. 96:528-534.
102. Ostroff, S. M., G. Kapperud, J. Lassen, S. Aasen, and R. V. Tauxe. 1992. Clinical features of sporadic Yersinia enterocolitica infections in Norway. J. Infect. Dis. 166:812-817.
103. Paganelli, R., E. Scala, I. Quinti, and I. J. Ansotegui. 1994. Humoral immunity in aging. Aging Clin. Exp. Res. 6:143-150.
104. Pahlavani, M. A., and A. Richardson. 1996. The effect of age on the expression of interleukin-2. Mech. Ageing Dev. 89:125-154.
105. Pawelec, G., M. Adibzadeh, H. Pohla, and K. Schaudt. 1995. Immunosenescence: aging of the immune system. Immunol. Today 16:420-427.
106. Fayette, H., M. Rola-Pleszczynski, and P. Ghadirian. 1990. Nutrition factors in relation to cellular and regulatory immune variables in a free-living elderly population. Am. J. Clin. Nutr. 52:927-932.
107. Pickering, T.-D., J. H. Gurwitz, D. Zaleznik, J. P. Noonan, and J. Avorn. 1994. The appropriateness of oral fluoroquinolone-prescribing in the long-term care setting. J. Am. Geriatr. Soc. 42:28-32.
108. Prevots, D. R., and R. W. Sutter. 1997. Assessment of Guillain-Barré syndrome mortality and morbidity in the United States: implications for acute flaccid paralysis surveillance. J. Infect. Dis. 175(suppl. 1):151-155.
109. Proust, J. J., R. A. Quadri, A. Arbogast, M.-A. Phelouzat. 1996. Mécanismes moléculaires du dysfonctionnement lymphocytaire liéà l'âge. Pathol. Biol. 44:7290-736.
110. Radl, J. 1990. Age-related monoclonal gammapathies: clinical lessons from the aging C57BL mouse. Immunol. Today 11:234-236.
111. Remarque, E. J., E. W. P. Nijhuis, B. Hinloopen, L. Nagelerken, E. A. van der Velde, and G. J. Ligthart. 1996. Correlation between the antibody response to influenze vaccine and helper T cell subsets in healthy aging. Vaccine 14:127-130.
112. Richmond, G. W., and B.-H. Yu. 1993. Autoantibodies, autoimmune diseases, and vasculitis in the aged. Immunol. Allergy Clin. N. Am. 13:647-672.
113. Roberts-Thomson, I.C., S. Whittingham, U. Youngchaiyud, and I. R. Mackay. 1974. Aging, immune response, and mortality. Lancet ii:368-370.
114. Rosenberg, I. H. 1997. Nutrition and senescence. Nutr. Rev. 55(no. 1, part II):S69-S73.
115. Rowe, J. W. 1997. The new gerontology. Science 278:367.
116. Ryan, C. A., R. V. Tauxe, G. W. Hosek, J. G. Wells, P. A. Stoesz, H. W. McFadden, P. W. Smith, G. F. Wright, and P. A. Blake. 1986. Escherichia coli O157:H7 diarrhea in a nursing home: clinical, epidemiological, and pathological findings. J. Infect. Dis. 154:631-638.
117. Ryan, M. J., P. G. Wall, G. K. Adak, H. S. Evans, and J. M. Cowdan. 1997. Outbreaks of infectious intestinal disease in residential institutions in England and Wales 1992-1994. J. Infect. 34:49-54.
118. Saebø, A., and J. Lassen. 1991. A survey of acute and chronic diseases associated with Yersinia enterocolitica infection. Scand. J. Infect. Dis. 23:517-527.
119. Schiraldi, O., V. Benvestito, C. di Bari, R. Moschetta, and G. Pastore. 1974. Gastric abnormalities in cholera: epidemiological and clinical considerations. Bull. W. H. O. 51:349-352.
120. Schlech, W. F., D. P. Chase, and A. Badley. 1993. A model of food-borne Listeria monocytogenes infection in the Sprague-Dawley rat using gastric inoculation: development and effect of gastric acidity on infective dose. Int. J. Food Microbiol. 18:15-24.
121. Schmucker, D. L., M. F. Heyworth, R. L. Owen, and C. K. Daniels. 1996. Impact of aging on gastrointestinal mucosal immunity. Digest. Dis. Sci. 41:1183-1193.
122. Shinkai, S., H. Kohno, K. Kimura, T. Komura, H. Asai, R. Inai, K. Oka, Y. Kurokawa, and R. J. Shephard. 1995. Physical activity and immune senescence in men. Med. Sci. Sports Exer. 27:1516-1526.
123. Smith, J. L. 1995. Arthritis, Guillain-Barré syndrome, and other sequelae of Campylobacter jejuni enteritis. J. Food Prot. 58:1153-1170.
124. Solana, R., J. L. Villanueva, J. Peña, and M. de la Fuente. 1991. Cell mediated immunity in aging. Comp. Biochem. Physiol. 99A:1-4.
125. Song, L., Y. H. Kim, R. K. Chopra, J. J. Proust, J. E. Nagel, A. A. Nordin, and W. H. Adler. 1993. Age-related effects in T cell activation and proliferation. Exp. Gerontol. 28:313-321.
126. Stolk-Engelaar, V. M. M., and J. A. A. Hoogkamp-Korstanje. 1996. Clinical presentation and diagnosis of gastrointestinal infections by Yersinia enterocolitica in 261 Dutch patients. Scand. J. Infect. Dis. 28:571-575.
127. Stulnig, T., C. Maczek, G. Böck, O. Majdic, and G. Wick. 1995. Reference intervals for human peripheral blood lymphocyte subpopulations from 'healthy' young and aged subjects. Int. Arch. Allergy Immunol. 108:205-210.
128. Tappero, J. W., A. Schuchat, K. A. Deaver, L. Mascola, and J. D. Wenger. 1995. Reduction in the incidence of human listeriosis in the United States. Effectiveness of prevention efforts? J. Am. Med. Assoc. 273:1118-1122.
129. Tarr, P. I. 1995. Escherichia coli O157:H7: clinical, diagnostic, and epidemiological aspects of human infection. Clin. Infect. Dis. 20:1-10.
130. Tauxe, R. V. 1992. Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations, p. 9-19. In I. Nachamkin, M. J. Blaser, and L. S. Tompkins (ed.), Campylobacter jejuni: current status and future trends. American Society for Microbiology, Washington, D.C.
131. Terr, A. I., D. P. Dubey, E. J. Yunis, R. G. Slavin, and R. H. Waldman. 1991. Physiologic and environmental influences on the immune system, p. 187-199. In D. P. Stites and A. I. Terr (ed.), Basic and clinical immunology, 7th ed. Appleton & Lange, Norwalk, Conn.
132. Thompson, J. S., J. Robbins, and J. K. cooper. 1987. Nutrition and immune function in the geriatric population. Clin. Geriatr. Med. 3:309-317.
133. U.S. Bureau of the Census. 1996. Statistical abstract of the United States: 1996 (116th ed.). Washington, D.C. (Tables 16, 17, 734).
134. Venkatraman, J. T., and G. Fernandes. 1997. Exercise, immunity and aging. Aging Clin. Exp. Res. 9:42-56.
135. Walker, J., D. J. Nokes, and R. Jennings. 1992. Longitudinal study of toxoplasmosis seroprevalence in South Yorkshire. Epidemiol. Infect. 108:99-106.
136. Wallace, J. I., and R. S. Schwartz. 1994. Involuntary weight loss in the elderly, p. 99-111. In R. R. Watson (ed.), Handbook of nutrition in the aged, 2nd ed. CRC Press, Boca Raton, Fla.
137. Warren, J. W., F. B. Palumbo, L. Fitterman, and S. M. Speedie. 1991. Incidence and characteristics of antibiotic use in aged nursing home patients. J. Am. Geriatr. Soc. 39:963-972.
138. Weimer, J. P. 1997. Many elderly at nutritional risk. Food Rev. 20(1):42-48.
139. Whitehead, C., and P. Finucane. 1997. Malnutrition in elderly people. Aust. N. Z. J. Med. 27:68-74.
140. Zu, S.-X., G.-D. Fang, R. Fayer, and R. L. Guerrant. 1992. Cryptosporidiosis: pathogenesis and immunology. Immunol. Today 8:24-27.