Vitamin E and gene expression in immune cells

Annals of the New York Academy of Sciences

Volumn 1031, Issue , 2004, Pages 96-101

  Han, Sung Nim ^a   Adolfsson, Oskar ^a,c   Lee, Cheol Koo ^b,d   Prolla, Tomas A ^b   Ordovas, Jose ^a   Meydani, Simin Nikbin ^a  

^a TUFTS UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Gene expression; Immune cells; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CD11B ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

AGED; AGING; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; CELL CYCLE; CONFERENCE PAPER; CONTROLLED STUDY; DIETARY INTAKE; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; IMMUNOCOMPETENT CELL; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE; TRANSCRIPTION REGULATION; VITAMIN SUPPLEMENTATION;

EID: 14944355319     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1331.010     Document Type: Conference Paper

References (24)

1. MILLER, R.A. 1996. The aging immune system: primer and prospectus. Science 273: 70-74.
2. ADOLFSSON, O., B.T. HUBER & S.N. MEYDANI. 2001. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2 -producing capacity. J. Immunol. 167: 3809-3817.
3. ROGERS, P.R., C. DUBEY & S.L. SWAIN. 2000. Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen. J. Immunol. 164: 2338-2346.
4. GARCIA, G.G. & R.A. MILLER. 2001. Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice. J. Immunol. 166: 3151-3157.
5. NAGEL, I.E., R.K. CHOPRA, F.J. CHREST, et al. 1988. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81: 1096-1102.
6. VALLEJO, A.N., C.M. WEYAND & J.J. GORONZY. 2001. Functional disruption of the CD28 gene transcriptional initiator in senescent T cells. J. Biol. Chem. 276: 2565-2570.
7. CHAKRAVARTI, B. 2001. T-cell signaling-effect of age. Exp. Gerontol. 37: 33-39.
8. MO, R., J. CHEN, Y. HAN, et al. 2003. T cell chemokine receptor expression in aging. J. Immunol. 170: 895-904.
9. VISALA RAO, D., G.M. BOYLE, P.G. PARSONS, et al. 2003. Influence of ageing, heat shock treatment and in vivo total antioxidant status on gene-expression profile and protein synthesis in human peripheral lymphocytes. Mech. Ageing Dev. 124: 55-69.
10. HAN, S., O. ADOLFSSON, C. LEE, et al. 2003. Effect of age and vitamin E on gene expression profiles of T cells. FASEB J. 17: A280.
11. GLOBERSON, A. & R.B. EFFROS. 2000. Ageing of lymphocytes and lymphocytes in the aged. Immunol. Today 21: 515-521.
12. HILDEMAN, D.A., T. MITCHELL, J. KAPPLER & P. MARRACK. 2003. T cell apoptosis and reactive oxygen species. J. Clin. Invest. 111: 575-581.
13. 2 synthesis and enhances the immune response of aged mice. Mech. Ageing Dev. 34: 191-201.
14. MEYDANI, S.N., M. MEYDANI, J.B. BLUMBERG, et al. 1997. Vitamin E supplementation and in vivo immune response in healthy subjects. JAMA 277: 1380-1386.
15. WU, D., S.N. HAN & S.N. MEYDANI. 1996. Vitamin E supplementation inhibits macrophage cyclooxygenase activity of old mice. FASEB J. 10: A191.
16. HAN, S.N., D. WU, W.K. HA, et al. 2000. Vitamin E supplementation increases T helper 1 cytokine production of old mice infected with influenza virus. Immunology 100: 487-493.
17. QUADRI, R.A., A. ARBOGAST, M.A. PHELOUZAT, et al. 1998. Age-associated decline in cdk1 activity delays cell cycle progression of human T lymphocytes. J. Immunol. 161: 5203-5209.
18. ARBOGAST, A., S. BOUTET, M.A. PHELOUZAT, et al. 1999. Failure of T lymphocytes from elderly humans to enter the cell cycle is associated with low Cdk6 activity and impaired phosphorylation of Rb protein. Cell. Immunol. 197: 46-54.
19. HALE, T.J., B.C. RICHARDSON, L.I. SWEET, et al. 2002. Age-related changes in mature CD4+ T cells: cell cycle analysis. Cell. Immunol. 220: 51-62.
20. PELIZON, C. 2003. Down to the origin: Cdc6 protein and the competence to replicate. Trends Cell Biol. 13: 110-113.
21. FISCHER, A., J. PALLAUF, K. GOHIL, et al. 2001. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochem. Biophys. Res. Commun. 285: 470-475.
22. NI, J., M. CHEN, Y. ZHANG, et al. 2003. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem. Biophys. Res. Commun. 300: 357-363.
23. TURLEY, J.M., F.W. RUSCETTI, S.J. KIM, et al. 1997. Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity. Cancer Res. 57: 2668-2675.
24. LIN, K.W., S.C. CHEN, F.H. CHANG, et al. 2002. The roles of interleukin-1 and interleukin-1 receptor antagonist in antigen-specific immune responses. J. Biomed. Sci. 9:2 6-33.