Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the phosphatidylinositol 3-kinase and STAT3 pathways

Neuroscience Letters

Volumn 309, Issue 1, 2001, Pages 13-16

  Kunioku, Hitomi ^a,b   Inoue, Kinji ^b   Tomida, Mikio ^a  

^a SAITAMA CANCER CENTER   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cisplatin; Interleukin 6; LY294002; Paclitaxel; PC12 cells; Phosphatidylinositol 3 kinase; Tyrphostin AG490

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTIINFECTIVE AGENT; CISPLATIN; FLUOROURACIL; INTERLEUKIN 6; JANUS KINASE TYROSINE KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; P13 KINASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SERUM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; DRUG INTERACTIONS; ENZYME INHIBITORS; GROWTH INHIBITORS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LYMPHOKINES; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0035903046     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02012-2     Document Type: Article

References (20)

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