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Volumn 6, Issue 4, 2005, Pages 251-256

Drosophila neoplasias: Clues towards the understanding of human cancers

Author keywords

Dlg; Drosophila; Lgl; Neoplasia; Scrib; Tumor suppressor

Indexed keywords

APC PROTEIN; BETA GALACTOSIDASE; CYTOSKELETON PROTEIN; DOUBLE STRANDED RNA; GUANYLATE KINASE; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PDZ PROTEIN; PROTEIN E6;

EID: 22144495035     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389202054395946     Document Type: Review
Times cited : (1)

References (50)
  • 2
    • 0014546984 scopus 로고
    • Neoplasms in mutant and cultured wild-type tissue of Drosophila
    • Gateff, E. and Schneiderman, H.A. Neoplasms in mutant and cultured wild-type tissue of Drosophila. Natl. Cancer Inst. Monogr. 1969, 31: 365-397.
    • (1969) Natl. Cancer Inst. Monogr. , vol.31 , pp. 365-397
    • Gateff, E.1    Schneiderman, H.A.2
  • 3
    • 0028707914 scopus 로고
    • Drosophila in cancer research: The first fifty tumor suppressor genes
    • Watson, K.L.; Justice, R.W. and Bryant, P.J. Drosophila in cancer research: the first fifty tumor suppressor genes. J. Cell Sci. Suppl. 1994, 18: 19-33.
    • (1994) J. Cell Sci. Suppl. , vol.18 , pp. 19-33
    • Watson, K.L.1    Justice, R.W.2    Bryant, P.J.3
  • 5
    • 0038795589 scopus 로고    scopus 로고
    • Dlg, Scribble, and Lgl in cell polarity, cell proliferation, and cancer
    • Humbert, P.; Russell, S. and Richardson, H. Dlg, Scribble, and Lgl in cell polarity, cell proliferation, and cancer. BioEssays 2003, 25: 542-553.
    • (2003) BioEssays , vol.25 , pp. 542-553
    • Humbert, P.1    Russell, S.2    Richardson, H.3
  • 6
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
    • Bilder, D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 2004, 18: 1909-1925.
    • (2004) Genes Dev. , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 7
    • 0034617129 scopus 로고    scopus 로고
    • Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    • Bilder, D.; Min, L. and Perrimon, N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 2000, 289: 113-116.
    • (2000) Science , vol.289 , pp. 113-116
    • Bilder, D.1    Min, L.2    Perrimon, N.3
  • 8
    • 0025941465 scopus 로고
    • The disc-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
    • Woods, D.F. and Bryant, P.J. The disc-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991, 66: 451-464.
    • (1991) Cell , vol.66 , pp. 451-464
    • Woods, D.F.1    Bryant, P.J.2
  • 9
    • 0034628471 scopus 로고    scopus 로고
    • Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    • Bilder, D. and Perrimon, N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 2000, 403: 676-680.
    • (2000) Nature , vol.403 , pp. 676-680
    • Bilder, D.1    Perrimon, N.2
  • 10
    • 0037006796 scopus 로고    scopus 로고
    • Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein
    • Mathew, D.; Gramates, L.S.; Packard, M.; Thomas, U.; Bilder, D.; Perrimon, N.; Gorczyca, M. and Budnik, V. Recruitment of Scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr. Biol. 2002, 12: 531-539.
    • (2002) Curr. Biol. , vol.12 , pp. 531-539
    • Mathew, D.1    Gramates, L.S.2    Packard, M.3    Thomas, U.4    Bilder, D.5    Perrimon, N.6    Gorczyca, M.7    Budnik, V.8
  • 11
    • 0028051486 scopus 로고
    • The lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton
    • Strand, D.; Raska, I. and Mechler, B.M. The lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton. J. Cell Biol. 1994, 127: 1345-1360.
    • (1994) J. Cell Biol. , vol.127 , pp. 1345-1360
    • Strand, D.1    Raska, I.2    Mechler, B.M.3
  • 12
    • 0023658291 scopus 로고
    • Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain
    • Jacob, L.; Opper, M.; Metzroth, B.; Phannavong, B. and Mechler, B.M. Structure of the l(2)gl gene of Drosophila and delimitation of its tumor suppressor domain. Cell 1987, 50: 215-225.
    • (1987) Cell , vol.50 , pp. 215-225
    • Jacob, L.1    Opper, M.2    Metzroth, B.3    Phannavong, B.4    Mechler, B.M.5
  • 13
    • 0028061614 scopus 로고
    • The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain
    • Strand, D.; Jakobs, R.; Merdes, G.; Neumann, B.; Kalmes, A.; Heid, H.W.; Hussmann, I. and Mechler, B.M. The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain. J. Cell Biol. 1994, 127: 1361-1373.
    • (1994) J. Cell Biol. , vol.127 , pp. 1361-1373
    • Strand, D.1    Jakobs, R.2    Merdes, G.3    Neumann, B.4    Kalmes, A.5    Heid, H.W.6    Hussmann, I.7    Mechler, B.M.8
  • 14
    • 0037456795 scopus 로고    scopus 로고
    • The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
    • Betschinger, J.; Mechtler, K. and Knoblich, J.A. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 2003, 422: 326-330.
    • (2003) Nature , vol.422 , pp. 326-330
    • Betschinger, J.1    Mechtler, K.2    Knoblich, J.A.3
  • 15
    • 0242641565 scopus 로고    scopus 로고
    • Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    • Brumby, A.M. and Richardson, H.E. Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003, 22: 5769-5779.
    • (2003) EMBO J. , vol.22 , pp. 5769-5779
    • Brumby, A.M.1    Richardson, H.E.2
  • 16
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • Pagliarini, R.A. and Xu, T. A genetic screen in Drosophila for metastatic behavior. Science 2003, 302: 1227-1231.
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 17
    • 0031893101 scopus 로고    scopus 로고
    • Growth, metastasis and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes
    • Woodhouse, E.; Hersperger, E. and Shearn A. Growth, metastasis and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev. Genes Evol. 1998, 207: 542-550.
    • (1998) Dev. Genes Evol. , vol.207 , pp. 542-550
    • Woodhouse, E.1    Hersperger, E.2    Shearn, A.3
  • 20
    • 0028096801 scopus 로고
    • Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1
    • Lue, R.A.; Marfatia, S.M.; Branton, D. and Chishti A.H. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc. Natl. Acad. Sci. USA 1994, 91: 9818-9822.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9818-9822
    • Lue, R.A.1    Marfatia, S.M.2    Branton, D.3    Chishti, A.H.4
  • 21
    • 0033776810 scopus 로고    scopus 로고
    • Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
    • Nakagawa, S. and Huibregtse, J.M. Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell Biol. 2000, 20: 8244-8253.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8244-8253
    • Nakagawa, S.1    Huibregtse, J.M.2
  • 23
    • 0031008787 scopus 로고    scopus 로고
    • Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: Effects on tumor suppression and synaptic bouton structure
    • Thomas, U.; Phannavong, B.; Muller, B.; Garner, C.C. and Gundelfinger, E.D. Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: effects on tumor suppression and synaptic bouton structure. Mech. Dev. 1997, 62: 161-174.
    • (1997) Mech. Dev. , vol.62 , pp. 161-174
    • Thomas, U.1    Phannavong, B.2    Muller, B.3    Garner, C.C.4    Gundelfinger, E.D.5
  • 30
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K.W. and Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 1996, 87: 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 31
    • 0030774987 scopus 로고    scopus 로고
    • Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein
    • Kiyono, T.; Hiraiwa, A.; Fujita, M.; Hayashi, Y.; Akiyama, T. and Ishibashi, M. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc. Natl. Acad. Sci. USA 1997, 94: 11612-11616.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11612-11616
    • Kiyono, T.1    Hiraiwa, A.2    Fujita, M.3    Hayashi, Y.4    Akiyama, T.5    Ishibashi, M.6
  • 32
    • 0033619139 scopus 로고    scopus 로고
    • Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation
    • Gardiol, D.; Kuhne, C.; Glausinger, B.; Lee, S.S.; Javier, R. and Banks, L. Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene 1999, 18: 5487-5496.
    • (1999) Oncogene , vol.18 , pp. 5487-5496
    • Gardiol, D.1    Kuhne, C.2    Glausinger, B.3    Lee, S.S.4    Javier, R.5    Banks, L.6
  • 33
    • 0035956215 scopus 로고    scopus 로고
    • The Human Papillomavirus E6 protein and its contribution to malignant progression
    • Mantovani, F. and Banks, L. The Human Papillomavirus E6 protein and its contribution to malignant progression. Oncogene 2001, 20: 7874-7887.
    • (2001) Oncogene , vol.20 , pp. 7874-7887
    • Mantovani, F.1    Banks, L.2
  • 34
    • 7944234859 scopus 로고    scopus 로고
    • HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumor suppressor substrates for proteasome-mediated degradation
    • Massimi, P.; Gammoh, N.; Thomas, M. and Banks, L. HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumor suppressor substrates for proteasome-mediated degradation. Oncogene 2004, 23: 8033-8039.
    • (2004) Oncogene , vol.23 , pp. 8033-8039
    • Massimi, P.1    Gammoh, N.2    Thomas, M.3    Banks, L.4
  • 35
    • 0036848432 scopus 로고    scopus 로고
    • Changes in expression of the human homologue of the Drosophila discs large tumor suppressor protein in high-grade premalignant cervical neoplasias
    • Watson, R.A.; Rollason, T.P.; Reynolds, G.M.; Murray, P.G.; Banks, L. and Roberts, S. Changes in expression of the human homologue of the Drosophila discs large tumor suppressor protein in high-grade premalignant cervical neoplasias. Carcinogenesis 2002, 23: 1791-1796.
    • (2002) Carcinogenesis , vol.23 , pp. 1791-1796
    • Watson, R.A.1    Rollason, T.P.2    Reynolds, G.M.3    Murray, P.G.4    Banks, L.5    Roberts, S.6
  • 36
    • 1942444618 scopus 로고    scopus 로고
    • Differential expression of human Dlg in cervical intraepithelial neoplasias
    • Lin, H.T.; Steller, M.A.; Aish, L.; Hanada, T. and Chishti, A.H. Differential expression of human Dlg in cervical intraepithelial neoplasias. Gynecol. Oncol. 2004, 93: 422-428.
    • (2004) Gynecol. Oncol. , vol.93 , pp. 422-428
    • Lin, H.T.1    Steller, M.A.2    Aish, L.3    Hanada, T.4    Chishti, A.H.5
  • 37
    • 3242889812 scopus 로고    scopus 로고
    • Differential expression of the human homolgue of Drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy
    • Cavatorta, A.L.; Fumero, G.; Chouhy, D.; Aguirre, R.; Nocito, A.L.; Giri, A.A.; Banks, L. and Gardiol, D. Differential expression of the human homolgue of Drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy. Int. J. Cancer 2004, 111: 373-380.
    • (2004) Int. J. Cancer , vol.111 , pp. 373-380
    • Cavatorta, A.L.1    Fumero, G.2    Chouhy, D.3    Aguirre, R.4    Nocito, A.L.5    Giri, A.A.6    Banks, L.7    Gardiol, D.8
  • 38
    • 0842347491 scopus 로고    scopus 로고
    • Somatic mutations and altered expression of the candidate tumor suppressors CSNKIE, DLG1, and EDD/hHYD in mammary ductal carcinomas
    • Fuja, T.J.; Lin, F.; Osann, K.E. and Bryant, P.J. Somatic mutations and altered expression of the candidate tumor suppressors CSNKIE, DLG1, and EDD/hHYD in mammary ductal carcinomas. Cancer Res. 2004, 64: 942-951.
    • (2004) Cancer Res. , vol.64 , pp. 942-951
    • Fuja, T.J.1    Lin, F.2    Osann, K.E.3    Bryant, P.J.4
  • 40
    • 0842329915 scopus 로고    scopus 로고
    • Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix
    • Nakagawa, S.; Yano, T.; Nakagawa, K.; Takizawa, S.; Suzuki, Y.; Yasugi, T.; Huibregtse, J.M. and Taketani, Y. Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix. Br. J. Cancer 2004, 90: 194-199.
    • (2004) Br. J. Cancer , vol.90 , pp. 194-199
    • Nakagawa, S.1    Yano, T.2    Nakagawa, K.3    Takizawa, S.4    Suzuki, Y.5    Yasugi, T.6    Huibregtse, J.M.7    Taketani, Y.8
  • 42
    • 0037224378 scopus 로고    scopus 로고
    • Border-cell migration: The race is on
    • Montell, D.J. Border-cell migration: the race is on. Nat. Rev. Mol. Cell Biol. 2003, 4: 13-24.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 13-24
    • Montell, D.J.1
  • 43
    • 0036052866 scopus 로고    scopus 로고
    • Myosin VI is required for E-cadherin-mediated border cell migration
    • Geisbrecht, E.R. and Montell, D.J. Myosin VI is required for E-cadherin-mediated border cell migration. Nat. Cell Biol. 2002, 4: 616-620.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 616-620
    • Geisbrecht, E.R.1    Montell, D.J.2
  • 44
    • 2542623703 scopus 로고    scopus 로고
    • Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer
    • Yoshida, H.; Cheng, W.; Hung, J.; Montell, D.; Geisbrecht, E.; Rosen, D.; Liu, J. and Naora, H. Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer. Proc. Natl. Acad. Sci. USA 2004, 101: 8144-8149.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8144-8149
    • Yoshida, H.1    Cheng, W.2    Hung, J.3    Montell, D.4    Geisbrecht, E.5    Rosen, D.6    Liu, J.7    Naora, H.8
  • 46
    • 9144272819 scopus 로고    scopus 로고
    • Using RNAi to catch Drosophila genes in a web of interactions: Insights into cancer research
    • Dasgupta, R. and Perrimon, N. Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene 2004, 23: 8359-8365.
    • (2004) Oncogene , vol.23 , pp. 8359-8365
    • Dasgupta, R.1    Perrimon, N.2
  • 47
    • 0032443021 scopus 로고    scopus 로고
    • Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
    • Kennerdell, J.R. and Carthew, R.W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 1998, 95: 1017-1026.
    • (1998) Cell , vol.95 , pp. 1017-1026
    • Kennerdell, J.R.1    Carthew, R.W.2
  • 50
    • 0842309871 scopus 로고    scopus 로고
    • Genome-wide RNAi analysis of growth and viability in Drosophila cells
    • Heidelberg Fly Array Consortium; Paro, R. and Perrimon N
    • Boutros, M.; Kiger, A.A.; Armknecht, S.; Kerr, K.; Hild, M.; Koch, B.; Haas, S.A.; Heidelberg Fly Array Consortium; Paro, R. and Perrimon, N. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 2004, 303: 832-835.
    • (2004) Science , vol.303 , pp. 832-835
    • Boutros, M.1    Kiger, A.A.2    Armknecht, S.3    Kerr, K.4    Hild, M.5    Koch, B.6    Haas, S.A.7


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