The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors

Biochemical Pharmacology

Volumn 52, Issue 1, 1996, Pages 105-111

  Paemen, Liesbet ^a   Martens, Erik ^a   Norga, Koen ^a   Masure, Stefan ^a   Roets, Eugene ^b   Hoogmartens, Jos ^b   Opdenakker, Ghislain ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

analogues; assay; gelatinase; inhibitor; tetracycline

Indexed keywords

1,10 PHENANTHROLINE; 4 EPICHLORTETRACYCLINE; 4 EPIOXYTETRACYCLINE; ANHYDROCHLORTETRACYCLINE; ANHYDROEPITETRACYCLINE; ANHYDROTETRACYCLINE; BIOTIN DERIVATIVE; CHLORTETRACYCLINE; DEMECLOCYCLINE; DEMECYCLINE; DOXYCYCLINE; ENZYME INHIBITOR; EPITETRACYCLINE; GELATIN; GELATINASE B; GELATINASE INHIBITOR; METACYCLINE; MINOCYCLINE; MONOCLONAL ANTIBODY; OXYTETRACYCLINE; TETRACYCLINE; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RHEUMATOID ARTHRITIS;

EID: 0029888573     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00168-2     Document Type: Article

References (34)

1. Arsenis C, Moak SA and Greenwald RA, Tetracylines (TETs) inhibit the synthesis and/or activity of cartilage proteinases in vivo and in vitro. Matrix-Suppl 1: 314, 1992.
2. Golub LM, Greenwald R, Ramamurthy N, Zucker S, Ramsammy L and McNamara T, Tetracyclines (TCs) inhibit matrix metalloproteinases (MMPs): in vivo effects in arthritic and diabetic rats and new in vitro studies. Matrix-Suppl 1: 315-316, 1992.
3. Opdenakker G, Masure S, Grillet B and Van Damme J, Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis. Lymphokine Cytokine Res 10: 317-324, 1991.
4. Hirose T, Reife RA, Smith GN, Stevens RM, Mainardi CL and Hasty KA, Characterization of type IV collagenase (gelatinase) in synovial fluid of patients with inflammatory arthritis. J Rheumatol 19: 593-599, 1992.
5. Kinane DF, Metalloproteinases in the pathogenesis of periodontal disease. Curr Opin Dent 2: 25-32, 1992.
6. Gijbels KS, Masure S, Carton H and Opdenakker G, Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J Neuroimmunol 41: 29-34, 1992.
7. Paemen L, Olsson T, Söderstrom M, Van Damme J and Opdenakker G, Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases. Eur J Neural 1: 55-63, 1994.
8. Woessner FJ, Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5: 2145-2154, 1991.
9. Vallee B and Auld D, Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry 29: 5647-5659, 1990.
10. Gabler WL and Creamer HR, Suppression of human neutrophil functions by tetracyclines. J Periodont Res 26: 52-58, 1991.
11. Golub LM, Suomalainen K and Sorsa T, Host modulation with tetracyclines and their chemically modified analogs. Curr Opin Dent 2: 80-90, 1992.
12. Rifkin BR, Vernillo AT and Golub LM, Blocking periodontal disease progression by inhibiting tissue destructive enzymes: a potential therapeutic role for tetracylines and their chemically modified analogs. J Periodontol 64: 819-827, 1994.
13. Masure S, Billiau F, Van Damme J and Opdenakker G, Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate. Biochim Biophys Acta 1054: 317-325, 1990.
14. Van Ranst M, Norga K, Masure S, Proost P, Vandekerckhove P, Auwerx J, Van Damme J and Opdenakker G, The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers. Cytokine 3: 231-236, 1991.
15. Paemen L, Martens E, Masure S and Opdenakker G, Monoclonal antibodies specific for natural human neutrophil gelatinase B used for affinity purification, quantitation by two-site ELISA and inhibition of enzymatic activity. Eur J Biochem 234: 759-765, 1995.
16. Sorbi D, Fadly M, Hicks R, Alexander S and Arbeit L, Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases. Kidney Intern 44: 1266-1272, 1993.
17. Masure S, Proost P, Van Damme J and Opdenakker G, Purification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8. Eur J Biochem 198: 391-398, 1991.
18. Mitscher L, The chemistry of the tetracycline antibiotics. Marcel Dekker, Inc., New York, 1978.
19. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA and Rifkin BR, Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 2: 297-321, 1991.
20. Opdenakker G and Van Damme J, Cytokine-regulated proteases in autoimmune diseases. Immunol Today 15: 103-107, 1994.
21. Opdenakker G and Van Damme J, Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251-258, 1992.
22. Vassalli JD and Pepper M, Membrane proteases in focus. Nature 370: 14-15, 1994.
23. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E and Seiki M, A matrix metalloproteinases expressed on the surface of invasive tumour cells. Nature 370: 61-64, 1994.
24. Golub L, Lee M, Lehrer H, Nemiroff G, McNamara A, Kaplan R and Ramamurthy N, Minocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of action. J Periodont Res 18: 516-526, 1983.
25. Magnam J, Barthes D and Giraud JJ, Tetracycline complexes. Study of 1-1 complexes of iron III, cobalt II, copper II and nickel II with tetracycline, demeclocycline, doxycycline and minocycline. Ann Pharm Franc 42: 155-159, 1984.
26. Golub LM, McNamara TF, D'Angelo G, Greenwald RA and Ramamurthy NS, A non-antimicrobial chemically-modified tetracycline inhibits mamalian collagenase activity. J Dent Res 66: 1310-4, 1987.
27. Lee W, Aitkin S, Kulkarni G, Birek P, Overall CM, Sodek J and McCulloch CA, Collagenase activity in recurrent periodontitis: relationship to disease progression and doxycycline therapy. J Periodontal Res 26: 479-485, 1991.
28. Moskow BS and Tannenbaum P, Enhanced repair and regeneration of periodontal lesions in tetracycline-treated patients. Case reports. J Periodont 62: 341-350, 1991.
29. Suomalainen K, Halinen S, Ingman T, Lindy O, Saari H, Konttinen Y, Golub L and Sorsa T, Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases. Drugs Exp Clin Res 18: 99-104, 1992.
30. Golub LM, Ciancio S, Ramamurthy N, Leung M, McNamara TF, Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. J Periodont Res 25: 321-330, 1990.
31. Vernillo AT, Ramamurthy NS, Golub LM, Rifkin BR, The non-antimicrobial properties of tetracycline for the treatment of periodontal disease. Curr Opin Periodont 111: 8, 1994.
32. McNamara TF, Golub LM, Yu Z, Ramamurthy NS, Reduced doxycycline blood levels in humans fail to promote resistant organisms. In: International conference on periodontal disease: Pathogens and Host immune responses, 25-27 Sept., 1990, Osaka University Press, Osaka, Japan.
33. Lauhio A, Konttinen Y, Tschesche H, Nordström D, Salo T, Lähdevirta J, Golub L, Sorsa T, Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. Antimicrob Agents Chemother 38: 400-402, 1994.
34. McCullough CA, Birek P, Overall C, Aitken S, Lee W, Kulkarni G, Randomized controlled trial of doxycycline in prevention of recurrent periodontitis in high risk patients: antimicrobial activity and collagenase inhibition. J Clin Periodontol 17: 616-621, 1990.