Are Ca2+ channels targets of praziquantel action?

International Journal for Parasitology

Volumn 35, Issue 1, 2005, Pages 1-9

  Greenberg, Robert M ^a  

^a MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

Ca2+ channels; Praziquantel; Schistosoma

Indexed keywords

CALCIUM CHANNEL; PRAZIQUANTEL; VOLTAGE GATED CALCIUM CHANNEL; ANTISCHISTOSOMAL AGENT;

PARASITE;

DRUG MECHANISM; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLATYHELMINTH; REVIEW; SCHISTOSOMA; ANIMAL; CHANNEL GATING; DRUG EFFECT; STRUCTURE ACTIVITY RELATION;

PLATYHELMINTHES; SCHISTOSOMA;

ANIMALS; CALCIUM CHANNELS; ION CHANNEL GATING; PRAZIQUANTEL; SCHISTOSOMA; SCHISTOSOMICIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21644469993     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2004.09.004     Document Type: Review

References (98)

1. Andrews, P., 1985. Praziquantel: mechanisms of anti-schistosomal activity. Pharmacol. Therapeut. 29, 129-156.
2. Andrews, P., Thomas, H., Pohlke, R., Seubert, J., 1983. Praziquantel. Med. Res. Rev. 3, 147-200.
3. Arikkath, J., Campbell, K.P., 2003. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr. Opin. Neurobiol. 13, 298-307.
4. Becker, B., Mehlhorn, H., Andrews, P., Thomas, H., Eckert, J., 1980. Light and electron microscopic studies on the effect of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica (Trematoda) in vitro. Z. Parasitenkd 63, 113-128.
5. Bergquist, R., Al-Sherbiny, M., Barakat, R., Olds, R., 2002. Blueprint for schistosomiasis vaccine development. Acta Tropica 82, 183-192.
6. 1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron 25, 177-190.
7. Birnbaumer, L., Qin, N., Olcese, R., Tareilus, E., Platano, D., Costantin, J., Stefani, E., 1998. Structures and functions of calcium channel β subunits. J. Bioener. Biomembr. 30, 357-375.
8. Blair, K.L., Anderson, P.A.V., 1993. Properties of voltage-activated ionic currents in cells from the brains of the triclad flatworm Bdelloura candida. J. Exp. Biol. 185, 267-286.
9. Blair, K.L., Anderson, P.A.V., 1994. Physiological and pharmacological properties of muscle cells isolated from the flatworm Bdelloura candida (Triclada). Parasitology 109, 325-335.
10. Blair, K.L., Anderson, P.A.V., 1996. Physiology and pharmacology of turbellarian neuromuscular systems. Parasitology 113, S73-S82.
11. Blair, K.L., Bennett, J.L., Pax, R.A., 1992. Praziquantel: physiological evidence for its site(s) of action in magnesium-paralysed Schistosoma mansoni. Parasitology 104, 59-66.
12. Brindley, P.J., 1994. Drug resistance to schistosomicides and other anthelmintics of medical significance. Acta Tropica 56, 213-231.
13. Capron, A., Riveau, G.J., Bartley, P.B., McManus, D.P., 2002. Prospects for a schistosome vaccine. Curr. Drug Targets Immune Endocr. Metabol. Disorders 2, 281-290.
14. 2+ channels. Annu. Rev. Cell Dev. Biol. 16, 521-555.
15. 2+ channels. Nature 429, 675-680.
16. Chitsulo, L., Loverde, P., Engels, D., 2004. Schistosomiasis. Nat. Rev. Microbiol. 2, 12-13.
17. Chubb, J.M., Bennett, J.L., Akera, T., Brody, T.M., 1978. Effects of praziquantel, a new anthelmintic, on electromechanical properties of isolated rat atria. J. Pharmacol. Exp. Ther. 207, 284-293.
18. Cioli, D., 2000. Praziquantel: is there real resistance and are there alternatives? Curr. Opin. Infect. Dis. 13, 659-663.
19. Cioli, D., Pica-Mattoccia, L., 2003. Praziquantel. Parasitol. Res. 90, S3-S9.
20. Cioli, D., Pica-Mattoccia, L., Moroni, R., 1993. Drug resistance in schistosomes. Parasitol. Today 9, 162-166.
21. 50 values for praziquantel in praziquantel- resistant and -susceptible Schistosoma mansoni isolates. Int. J Parasitol. 34, 979-987.
22. 2+ channels in muscle fibers of the platyhelminth Dugesia tigrina. Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 134, 593-605.
23. 2+)ATPases of Schistosoma mansoni. Life Sci. 60, 289-294.
24. Danso-Appiah, A., DeVlas, S.J., 2002. Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal. Trends Parasitol. 18, 125-129.
25. Day, T.A., Bennett, J.L., Pax, R.A., 1992. Praziquantel: the enigmatic antiparasitic. Parasitology Today 8, 342-344.
26. Day, T.A., Orr, N., Bennett, J.L., Pax, R.A., 1993. Voltage-gated currents in muscle cells of Schisotosoma mansoni. Parasitology 106, 471-477.
27. Day, T.A., Bennett, J.L., Pax, R.A., 1994. Serotonin and its requirement for maintenance of contractility in muscle fibres isolated from Schistosoma mansoni. Parasitology 108, 425-432.
28. 2+ channel regulation by a conserved β subunit domain. Neuron 13, 495-503.
29. Dimitratos, S.D., Woods, D.F., Stathakis, D.G., Bryant, P.J., 1999. Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family. Bioessays 21, 912-921.
30. Doenhoff, M.J., Kusel, J.R., Coles, G.C., Cioli, D., 2002. Resistance of Schistosoma mansoni to praziquantel: is there a problem? Trans. R. Soc. Trop. Med. Hyg. 96, 465-469.
31. Dolphin, A.C., 2003. β subunits of voltage-gated calcium channels. J. Bioener. Biomembr. 35, 599-620.
32. + conduction and selectivity. Science 280, 69-77.
33. Engels, D., Chitsulo, L., Montresor, A., Savioli, L., 2002. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Tropica 82, 139-146.
34. Fallon, P.G., Doenhoff, M., 1994. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am. J. Trop. Med. Hyg. 51, 83-88.
35. Fenwick, A., Savioli, L., Engels, D., Bergquist, N.R., Todd, M.H., 2003. Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends Parasitol. 19, 509-515.
36. Fetterer, R.H., Pax, R.A., Bennett, J.L., 1980. Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni. Eur. J. Pharmacol. 64, 31-38.
37. Geerts, S., Gryseels, B., 2001. Anthelmintic resistance in human helminths: a review. Trop. Med. Int. Health 6, 915-921.
38. Gryseels, B., Stelma, F.F., Talla, I., Van Dam, G.J., Polman, K., Sow, S., Diaw, M., Sturrock, R.F., Doehring-Schwerdtfeger, E., Kardoff, R., Decam, C., Niang, M., Deelder, A.M., 1994. Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal. Trop. Geogr. Med. 46, 209-219.
39. Hagan, P., Sharaf, O., 2003. Schistosomiasis vaccines. Expert Opin. Biol. Ther. 3, 1271-1278.
40. Hagan, P., Appleton, C.C., Coles, G.C., Kusel, J.R., Tchuem-Tchuente, L.A., 2004. Schistosomiasis control: keep taking the tablets. Trends Parasitol. 20, 92-97.
41. Hanlon, M.R., Wallace, B.A., 2002. Structure and function of voltage-dependent ion channel regulatory β subunits. Biochemistry 41, 2886-2894.
42. 2+ channel β subunit as a basis for understanding its functional properties. FEBS Lett. 445, 366-370.
43. 2+ on the bilayer-isotropic-hexagonal transition of model membranes. Mol. Biochem. Parasitol. 29, 55-60.
44. Harnett, W., Kusel, J.R., 1986. Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93, 401-405.
45. Heinemann, S.H., Terlau, H., Imoto, K., 1992. Molecular basis for pharmacological differences between brain and cardiac sodium channels. Pflugers Arch. 422, 90-92.
46. Hofmann, F., Lacinova, L., Klugbauer, N., 1999. Voltage-dependent calcium channels: from structure to function. Rev. Physiol., Biochem., Pharmacol. 139, 33-87.
47. Hu, W., Brindley, P.J., McManus, D.P., Feng, Z., Han, Z.-G., 2004. Schistosome transcriptomes: new insights into the parasite and schistosomiasis. Trends Mol. Med. 10, 217-225.
48. Ismail, M., Metwally, A., Farghaly, A., Bruce, J., Tao, L.F., Bennett, J.L., 1996. Characterization of isolates of Schistosama mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am. J. Trop. Med. Hyg. 55, 214-218.
49. Ismail, M., Botros, S., Metwally, A., William, S., Farghally, A., Tao, L.F., Day, T.A., Bennett, J.L., 1999. Resistance to praziquantel: direct evidence from Schistosama mansoni isolated from Egyptian villagers. Am. J. Trop. Med. Hyg. 60, 932-935.
50. Jeziorski, M.C., Greenberg, R.M., Anderson, P.A.V., 2000a. Calcium channel β subunits differentially modulate recovery of the channel from inactivation. FEBS Lett. 483, 125-130.
51. 2+ channels. J. Exp. Biol. 203, 841-856.
52. Kamp, T.J., Hell, J.W., 2000. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circul. Res. 87, 1094-1102.
53. v1.2a,b) by protein kinases. Am. J. Physiol.: Cell Physiol. 281, C1743-C1755.
54. Keenan, L., Koopowitz, H., 1984. The ionic bases of action-potentials in identified flatworm neurons. J. Comp. Physiol. 155, 197-208.
55. Kohn, A.B., Anderson, P.A.V., Roberts-Misterly, J.M., Greenberg, R.M., 2001a. Schistosome calcium channel β subunits: unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J. Biol. Chem. 276, 36873-36876.
56. 1 subunits from Schistosoma mansoni. Parasitology 123, 489-497.
57. 2+ channel. Int. J. Parasitol. 33, 1303-1308.
58. 2+ channel β subunit are key to its role in sensitivity to the antischistosomal drug praziquantel. Parasitology 127, 349-356.
59. Kumar, S., Tamura, K., Jakobsen, I.B., Nei, M., 2001. MEGA2: molecular evolutionary genetics analysis software. Bioinformatics 17, 1244-1245.
60. Liang, Y.-S., Coles, G.C., Doenhoff, M.J., Southgate, V.R., 2001. In vitro responses of praziquantel-resistant and -susceptible Schistosoma mansoni to praziquantel. Int. J. Parasitol. 31, 1227-1235.
61. Lima, S.F., Vieira, L.Q., Harder, A., Kusel, J., 1994. Effects of culture and praziquantel on membrane fluidity parameters of adult Schistosoma mansoni. Parasitology 109, 57-64.
62. Littleton, J.T., Ganetzky, B., 2000. Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26, 35-43.
63. Liu, Y.H., Qian, M.X., Wang, X.G., Jia, J., Wang, Q.N., Jiang, Y.F., Wang, R.Q., Yan, S.W., Chen, B.Y., Li, J.S., Qiu, Z.Y., Shen, J.K., 1986. Comparative efficacy of praziquantel and its optic isomers in experimental therapy of schistosomiasis japonica in rabbits. Chin. Med. J. 99, 935-940.
64. LoVerde, P.T., Hirai, H., Merrick, J.M., Lee, N.H., El-Sayed, N., 2004. Schistosoma mansoni genome project: an update. Parasitol. Int. 53, 183-192.
65. McManus, D.P., Hu, W., Brindley, P.J., Feng, Z., Han, Z.-G., 2004. Schistosome transcriptome analysis at the cutting edge. Trends Parasitol. 20, 301-304.
66. Mehlhorn, H., Becker, B., Andrews, P., Thomas, H., Frenkel, J.K., 1981. In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study. Arzneimittelforschung 31, 544-554.
67. 2+ channel β subunit functional core and its complex with the α1 interaction domain. Neuron 42, 387-399.
68. Pax, R.A., Bennett, J.L., Fetterer, J.L., 1978. A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn-Schmiedberg's Arch. Pharmacol. 304, 309-315.
69. Perez-Reyes, E., 2003. Molecular physiology of low-voltage-activated T-type calcium channels. Physiol. Rev. 83, 117-161.
70. Petegem, F.V., Clark, K.A., Chatelain, P.C., Minor, D.L., 2004. Structure of a complex between a voltage-gated calcium channel β subunit and an α-subunit domain. Nature 429, 671-675.
71. Pica-Mattoccia, L., Cioli, D., 2004. Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. Int. J. Parasitol. 34, 527-533.
72. 1-subunit. Nature 368, 67-70.
73. Puri, T.S., Gerhardstein, B.L., Zhao, X.-L., Ladner, M.B., Hosey, M.M., 1997. Differential effects of subunit interactions on protein kinase A- and C- mediated phosphorylation of L-type calcium channels. Biochemistry 36, 9605-9615.
74. 2+ channels. Mol. Cell. Neurosci. 14, 255-272.
75. Redman, C.A., Robertson, A., Fallon, P.G., Modha, J., Kusel, J.R., Doenhoff, M.J., Martin, R.J., 1996. Praziquantel: an urgent and exciting challenge. Parasitol. Today 12, 14-20.
76. Rossie, S., 1999. Regulation of voltage-sensitive sodium and calcium channels by phosphorylation. Adv. Second Messenger Phosphoryl. Res. 33, 23-48.
77. Sabah, A.A., Fletcher, C., Webbe, G., Doenhoff, M.J., 1986. Schistosoma mansoni: chemotherapy of infections of different ages. Exp. Parasitol. 61, 294-303.
78. Satin, J., Kyle, J.W., Chen, M., Bell, P., Cribbs, L.L., Fozzard, H.A., Rogart, R.B., 1992. A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 256, 1202-1205.
79. Staudt, U., Schmahl, G., Blaschke, G., Mehlhorn, H., 1992. Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro. Parasitol. Res. 78, 392-397.
80. Stelma, F.F., Talla, I., Sow, S., Kongs, A., Niang, M., Polman, K.B., Deelder, A.M., Gryseels, B., 1995. Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni. Am. J. Trop. Med. Hyg. 53, 167-170.
81. 2+ channels. Trends Pharmacol. Sci. 19, 108-115.
82. Tanaka, M., Ohmae, H., Utsunomiya, H., Nara, T., Irie, Y., Yasuraoka, K., 1989. A comparison of the antischistosomal effect of levo-and dextro-praziquantel on Schistosoma japonicum and S. mansoni in mice. Am. J. Trop. Med. Hyg. 41, 198-203.
83. Thompson, J.D., Gibson, T.J., Plewniak, F., Jeanmougin, F., Higgins, D.G., 1997. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucl. Acids Res. 24, 4876-4882.
84. Vais, H., Atkinson, S., Eldursi, N., Devonshire, A.L., Williamson, M.S., Usherwood, P.N., 2000. A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides. FEBS Lett. 470, 135-138.
85. Valle, C., Troiani, A.R., Festucci, A., Pica-Mattoccia, L., Liberti, P., Wolstenholme, A., Francklow, K., Doenhoff, M.J., Cioli, D., 2003. Sequence and level of endogenous expression of calcium channel β subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel. Mol. Biochem. Parasitol. 130, 111-115.
86. van der Werf, M.J., de Vlas, S.J., Brooker, S., Looman, C.W., Nagelkerke, N.J., Habbema, J.D., Engels, D., 2003. Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Tropica 86, 125-139.
87. Verjovski-Almeida, S., Leite, L.C.C., Dias-Neto, E., Menck, C.F.M., Wilson, R.A., 2004. Schistosome transcriptome: insights and perspectives for functional genomics. Trends Parsitol. 20, 304-308.
88. 2+ channels: role in channel function. Trends Neurosci. 21, 148-154.
89. 50 determination. Int. J. Parasitol. 34, 971-977.
90. William, S., Botros, S., Ismail, M., Farghally, A., Day, T.A., Bennett, J.L., 2001a. Praziquantel-induced tegumental damage in vitro is diminished in schistosomes derived from praziquantel-resistant infections. Parasitology 122, 63-66.
91. William, S., Sabra, A., Ramzy, F., Mousa, M., Demerdash, Z., Bennett, J.L., Day, T.A., Botros, S., 2001b. Stability and reproductive fitness of Schistosoma mansoni isolates with decreased sensitivity to praziquantel. Int. J. Parasitol. 31, 1093-1100.
92. Wolde Mussie, E., Vande Waa, J., Pax, R.A., Fetterer, R., Bennett, J.L., 1982. Schistosoma mansoni: calcium efflux and effects of calcium-free media on responses of the adult male musculature to praziquantel and other agents inducing contraction. Exp. Parasitol. 53, 270-278.
93. Wu, M.H., Wei, C.C., Xu, Z., Yuan, H.C., Lian, W.N., Yang, Q.J., Chen, M., Jiang, Q.W., Wang, C.Z., Zhang, S.J., 1991. Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica. Am. J. Trop. Med. Hyg. 45, 345-349.
94. Xiao, S.H., Catto, B.A., 1989. Comparative in vitro and in vivo activity of racemic praziquantel and its levorotated isomer on Schistosoma mansoni. J. Infect. Dis. 159, 589-592.
95. Xiao, S.H., Friedman, P.A., Catto, B.A., Webster, L.T., 1984. Praziquantel-induced vesicle formation in the tegument of male Schistosoma mansoni is calcium dependent. J. Parasitol. 70, 177-179.
96. Xiao, S.H., Catto, B.A., Webster, L.T., 1985. Effects of praziquantel on different developmental stages of Schistosoma mansoni in vitro and in vivo. J. Infect. Dis. 151, 1130-1137.
97. Xiao, S.H., Chollet, J., Booth, M., Weiss, N.A., Tanner, M., 1999. Therapeutic effect of praziquantel enantiomers in mice infected with Schistosoma mansoni. Trans. R. Soc. Trop. Med. Hyg. 93, 324-325.
98. Yue, D.T., 2004. The dawn of high-resolution structure for the queen of the ion channels. Neuron 42, 357-361.